Bouley, Richard
eCommons Login: RB16
first name: Richard
last name: Bouley
coauthor of: Brown, Dennis
coauthor of: Cheung, Pui
coauthor of: Ausiello, Dennis
coauthor of: Babitt, Jodie
coauthor of: Babicz, Richard
full name: Richard Bouley, Ph.D.
has faculty rank: Assistant Professor
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Person ID: 37194
person in primary position: Assistant Professor of Medicine
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N- and C-terminal structure-activity study of angiotensin II on the angiotensin AT2 receptor.
PubMed Identifier: 9570482
author list: Bouley R, Pérodin J, Plante H, Rihakova L, Bernier SG, Maletínská L, Guillemette G, Escher E
published in: European journal of pharmacology
information resource reference: N- and C-terminal structure-activity study of angiotensin II on the angiotensin AT2 receptor. Eur J Pharmacol. 1998 Feb 19; 343(2-3):323-31.
journal title abbreviation: Eur J Pharmacol
publication date: 1998-02-19T00:00:00
year: 1998
type: Academic Article
type: Article
type: Document
type: Information Resource

Inhibition of endocytosis causes phosphorylation (S256)-independent plasma membrane accumulation of AQP2.
PubMed Identifier: 14519593
author list: Lu H, Sun TX, Bouley R, Blackburn K, McLaughlin M, Brown D
published in: American journal of physiology. Renal physiology
information resource reference: Inhibition of endocytosis causes phosphorylation (S256)-independent plasma membrane accumulation of AQP2. Am J Physiol Renal Physiol. 2004 Feb; 286(2):F233-43.
journal title abbreviation: Am J Physiol Renal Physiol
publication date: 2003-09-30T00:00:00
year: 2003
type: Academic Article
type: Article
type: Document
type: Information Resource

Effects of the renal medullary pH and ionic environment on vasopressin binding and signaling.
PubMed Identifier: 18813286
author list: Zalyapin EA, Bouley R, Hasler U, Vilardaga JP, Lin HY, Brown D, Ausiello DA
published in: Kidney international
information resource reference: Effects of the renal medullary pH and ionic environment on vasopressin binding and signaling. Kidney Int. 2008 Dec; 74(12):1557-67.
journal title abbreviation: Kidney Int
publication date: 2008-08-27T00:00:00
year: 2008
type: Academic Article
type: Article
type: Document
type: Information Resource

NF-kappaB modulates aquaporin-2 transcription in renal collecting duct principal cells.
PubMed Identifier: 18703515
author list: Hasler U, Leroy V, Jeon US, Bouley R, Dimitrov M, Kim JA, Brown D, Kwon HM, Martin PY, Féraille E
published in: The Journal of biological chemistry
information resource reference: NF-kappaB modulates aquaporin-2 transcription in renal collecting duct principal cells. J Biol Chem. 2008 Oct 17; 283(42):28095-105.
journal title abbreviation: J Biol Chem
publication date: 2008-08-14T00:00:00
year: 2008
type: Academic Article
type: Article
type: Document
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Sustained cyclic AMP production by parathyroid hormone receptor endocytosis.
PubMed Identifier: 19701185
author list: Ferrandon S, Feinstein TN, Castro M, Wang B, Bouley R, Potts JT, Gardella TJ, Vilardaga JP
published in: Nature chemical biology
information resource reference: Sustained cyclic AMP production by parathyroid hormone receptor endocytosis. Nat Chem Biol. 2009 Oct; 5(10):734-42.
journal title abbreviation: Nat Chem Biol
publication date: 2009-08-23T00:00:00
year: 2009
type: Academic Article
type: Article
type: Document
type: Information Resource

Aquaporin-2 localization in clathrin-coated pits: inhibition of endocytosis by dominant-negative dynamin.
PubMed Identifier: 11997316
author list: Sun TX, Van Hoek A, Huang Y, Bouley R, McLaughlin M, Brown D
published in: American journal of physiology. Renal physiology
information resource reference: Aquaporin-2 localization in clathrin-coated pits: inhibition of endocytosis by dominant-negative dynamin. Am J Physiol Renal Physiol. 2002 Jun; 282(6):F998-1011.
journal title abbreviation: Am J Physiol Renal Physiol
publication date: 2002-06-01T00:00:00
year: 2002
type: Academic Article
type: Article
type: Document
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Alix (AIP1) is a vasopressin receptor (V2R)-interacting protein that increases lysosomal degradation of the V2R.
PubMed Identifier: 17287200
author list: Yi X, Bouley R, Lin HY, Bechoua S, Sun TX, Del Re E, Shioda T, Raychowdhury MK, Lu HA, Abou-Samra AB, Brown D, Ausiello DA
published in: American journal of physiology. Renal physiology
information resource reference: Alix (AIP1) is a vasopressin receptor (V2R)-interacting protein that increases lysosomal degradation of the V2R. Am J Physiol Renal Physiol. 2007 May; 292(5):F1303-13.
journal title abbreviation: Am J Physiol Renal Physiol
publication date: 2007-02-06T00:00:00
year: 2007
type: Academic Article
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The phosphorylation state of serine 256 is dominant over that of serine 261 in the regulation of AQP2 trafficking in renal epithelial cells.
PubMed Identifier: 18434387
author list: Lu HJ, Matsuzaki T, Bouley R, Hasler U, Qin QH, Brown D
published in: American journal of physiology. Renal physiology
information resource reference: The phosphorylation state of serine 256 is dominant over that of serine 261 in the regulation of AQP2 trafficking in renal epithelial cells. Am J Physiol Renal Physiol. 2008 Jul; 295(1):F290-4.
journal title abbreviation: Am J Physiol Renal Physiol
publication date: 2008-04-23T00:00:00
year: 2008
type: Academic Article
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Angiotensin II and hypertonicity modulate proximal tubular aquaporin 1 expression.
PubMed Identifier: 19776169
author list: Bouley R, Palomino Z, Tang SS, Nunes P, Kobori H, Lu HA, Shum WW, Sabolic I, Brown D, Ingelfinger JR, Jung FF
published in: American journal of physiology. Renal physiology
information resource reference: Angiotensin II and hypertonicity modulate proximal tubular aquaporin 1 expression. Am J Physiol Renal Physiol. 2009 Dec; 297(6):F1575-86.
journal title abbreviation: Am J Physiol Renal Physiol
publication date: 2009-09-23T00:00:00
year: 2009
type: Academic Article
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Basolateral targeting and microtubule-dependent transcytosis of the aquaporin-2 water channel.
PubMed Identifier: 23015545
author list: Yui N, Lu HA, Chen Y, Nomura N, Bouley R, Brown D
published in: American journal of physiology. Cell physiology
information resource reference: Basolateral targeting and microtubule-dependent transcytosis of the aquaporin-2 water channel. Am J Physiol Cell Physiol. 2013 Jan 01; 304(1):C38-48.
journal title abbreviation: Am J Physiol Cell Physiol
publication date: 2012-09-26T00:00:00
year: 2012
type: Academic Article
type: Article
type: Document
type: Information Resource

AQP2 is necessary for vasopressin- and forskolin-mediated filamentous actin depolymerization in renal epithelial cells.
PubMed Identifier: 23213402
author list: Yui N, Lu HJ, Bouley R, Brown D
published in: Biology open
information resource reference: AQP2 is necessary for vasopressin- and forskolin-mediated filamentous actin depolymerization in renal epithelial cells. Biol Open. 2012 Feb 15; 1(2):101-8.
journal title abbreviation: Biol Open
publication date: 2011-11-04T00:00:00
year: 2011
type: Academic Article
type: Article
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Heterologous downregulation of vasopressin type 2 receptor is induced by transferrin.
PubMed Identifier: 23235478
author list: Bouley R, Nunes P, Andriopoulos B, McLaughlin M, Webber MJ, Lin HY, Babitt JL, Gardella TJ, Ausiello DA, Brown D
published in: American journal of physiology. Renal physiology
information resource reference: Heterologous downregulation of vasopressin type 2 receptor is induced by transferrin. Am J Physiol Renal Physiol. 2013 Mar 01; 304(5):F553-64.
journal title abbreviation: Am J Physiol Renal Physiol
publication date: 2012-12-12T00:00:00
year: 2012
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New insights into the dynamic regulation of water and acid-base balance by renal epithelial cells.
PubMed Identifier: 22460710
author list: Brown D, Bouley R, Paunescu TG, Breton S, Lu HA
published in: American journal of physiology. Cell physiology
information resource reference: New insights into the dynamic regulation of water and acid-base balance by renal epithelial cells. Am J Physiol Cell Physiol. 2012 May 15; 302(10):C1421-33.
journal title abbreviation: Am J Physiol Cell Physiol
publication date: 2012-03-28T00:00:00
year: 2012
type: Academic Article
type: Article
type: Document
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Methylation in positions 1 and 7 of angiotensin II. A structure-activity relationship study.
PubMed Identifier: 7875933
author list: Cordopatis P, Manessi-Zoupa E, Theodoropoulos D, Bossé R, Bouley R, Gagnon S, Escher E
published in: International journal of peptide and protein research
information resource reference: Methylation in positions 1 and 7 of angiotensin II. A structure-activity relationship study. Int J Pept Protein Res. 1994 Oct; 44(4):320-4.
journal title abbreviation: Int J Pept Protein Res
publication date: 1994-10-01T00:00:00
year: 1994
type: Academic Article
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Acute hypertonicity alters aquaporin-2 trafficking and induces a MAPK-dependent accumulation at the plasma membrane of renal epithelial cells.
PubMed Identifier: 18664568
author list: Hasler U, Nunes P, Bouley R, Lu HA, Matsuzaki T, Brown D
published in: The Journal of biological chemistry
information resource reference: Acute hypertonicity alters aquaporin-2 trafficking and induces a MAPK-dependent accumulation at the plasma membrane of renal epithelial cells. J Biol Chem. 2008 Sep 26; 283(39):26643-61.
journal title abbreviation: J Biol Chem
publication date: 2008-07-29T00:00:00
year: 2008
type: Academic Article
type: Article
type: Document
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A fluorimetry-based ssYFP secretion assay to monitor vasopressin-induced exocytosis in LLC-PK1 cells expressing aquaporin-2.
PubMed Identifier: 18799651
author list: Nunes P, Hasler U, McKee M, Lu HA, Bouley R, Brown D
published in: American journal of physiology. Cell physiology
information resource reference: A fluorimetry-based ssYFP secretion assay to monitor vasopressin-induced exocytosis in LLC-PK1 cells expressing aquaporin-2. Am J Physiol Cell Physiol. 2008 Dec; 295(6):C1476-87.
journal title abbreviation: Am J Physiol Cell Physiol
publication date: 2008-09-17T00:00:00
year: 2008
type: Academic Article
type: Article
type: Document
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Calcitonin has a vasopressin-like effect on aquaporin-2 trafficking and urinary concentration.
PubMed Identifier: 21071524
author list: Bouley R, Lu HA, Nunes P, Da Silva N, McLaughlin M, Chen Y, Brown D
published in: Journal of the American Society of Nephrology : JASN
information resource reference: Calcitonin has a vasopressin-like effect on aquaporin-2 trafficking and urinary concentration. J Am Soc Nephrol. 2011 Jan; 22(1):59-72.
journal title abbreviation: J Am Soc Nephrol
publication date: 2010-11-11T00:00:00
year: 2010
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 1116641
type: Authorship
author rank in publication: 5
linked author: Bouley, Richard
linked information resource: Inhibition of non-receptor tyrosine kinase Src induces phosphoserine 256-independent aquaporin-2 membrane accumulation.

Inhibition of non-receptor tyrosine kinase Src induces phosphoserine 256-independent aquaporin-2 membrane accumulation.
PubMed Identifier: 30488437
author list: Cheung PW, Terlouw A, Janssen SA, Brown D, Bouley R
published in: The Journal of physiology
information resource reference: Inhibition of non-receptor tyrosine kinase Src induces phosphoserine 256-independent aquaporin-2 membrane accumulation. J Physiol. 2019 03; 597(6):1627-1642.
journal title abbreviation: J Physiol
publication date: 2018-12-21T00:00:00
year: 2018
type: Academic Article
type: Article
type: Document
type: Information Resource

Molecular weight determination of the hepatic vasopressin receptor with a high-affinity photoprobe.
PubMed Identifier: 8919057
author list: Barbeau D, Bouley R, Escher E
published in: International journal of peptide and protein research
information resource reference: Molecular weight determination of the hepatic vasopressin receptor with a high-affinity photoprobe. Int J Pept Protein Res. 1996 Oct; 48(4):364-73.
journal title abbreviation: Int J Pept Protein Res
publication date: 1996-10-01T00:00:00
year: 1996
type: Academic Article
type: Article
type: Document
type: Information Resource

Nitric oxide and atrial natriuretic factor stimulate cGMP-dependent membrane insertion of aquaporin 2 in renal epithelial cells.
PubMed Identifier: 11067864
author list: Bouley R, Breton S, Sun T, McLaughlin M, Nsumu NN, Lin HY, Ausiello DA, Brown D
published in: The Journal of clinical investigation
information resource reference: Nitric oxide and atrial natriuretic factor stimulate cGMP-dependent membrane insertion of aquaporin 2 in renal epithelial cells. J Clin Invest. 2000 Nov; 106(9):1115-26.
journal title abbreviation: J Clin Invest
publication date: 2000-11-01T00:00:00
year: 2000
type: Academic Article
type: Article
type: Document
type: Information Resource

Characterization of single channel currents from primary cilia of renal epithelial cells.
PubMed Identifier: 16079132
author list: Raychowdhury MK, McLaughlin M, Ramos AJ, Montalbetti N, Bouley R, Ausiello DA, Cantiello HF
published in: The Journal of biological chemistry
information resource reference: Characterization of single channel currents from primary cilia of renal epithelial cells. J Biol Chem. 2005 Oct 14; 280(41):34718-22.
journal title abbreviation: J Biol Chem
publication date: 2005-08-03T00:00:00
year: 2005
type: Academic Article
type: Article
type: Document
type: Information Resource

Bypassing vasopressin receptor signaling pathways in nephrogenic diabetes insipidus.
PubMed Identifier: 18519087
author list: Bouley R, Hasler U, Lu HA, Nunes P, Brown D
published in: Seminars in nephrology
information resource reference: Bypassing vasopressin receptor signaling pathways in nephrogenic diabetes insipidus. Semin Nephrol. 2008 May; 28(3):266-78.
journal title abbreviation: Semin Nephrol
publication date: 2008-05-01T00:00:00
year: 2008
type: Academic Article
type: Article
type: Document
type: Information Resource

Vasopressins
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MeSH semantic group name: Chemicals & Drugs
number of authors: 169
number of publications: 348
uniqueness weight: 0.866669
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Authorship 113111
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author rank in publication: 3
linked author: Bouley, Richard
linked information resource: Simvastatin enhances aquaporin-2 surface expression and urinary concentration in vasopressin-deficient Brattleboro rats through modulation of Rho GTPase.

Kidney
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MeSH semantic group name: Anatomy
number of authors: 2186
number of publications: 7143
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Diabetes Unit
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Endocytosis
MeSH DescriptorUI: D004705
MeSH semantic group name: Physiology
number of authors: 479
number of publications: 967
uniqueness weight: 0.71742
type: Concept

Aquaporin 2
MeSH DescriptorUI: D051399
MeSH semantic group name: Chemicals & Drugs
number of authors: 28
number of publications: 128
uniqueness weight: 0.916167
type: Concept

Receptors, Vasopressin
MeSH DescriptorUI: D017483
MeSH semantic group name: Chemicals & Drugs
number of authors: 57
number of publications: 99
uniqueness weight: 0.953982
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Cell Biology
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Emeritus
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Medicine
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Hematology/Oncology
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Nephrology
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Renal
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Brigham and Women's Hospital
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Harvard Medical School
type: Organization

Immune Disease Institute
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Massachusetts General Hospital
type: Organization

Babitt, Jodie
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Breton, Sylvie
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Merkulova, Maria
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Kirchhausen, Tomas
eCommons Login: TK16
first name: Tomas
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person in primary position: Professor of Cell Biology
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Yee, Andrew
eCommons Login: AJY1
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person in primary position: Assistant Professor of Medicine
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Bonventre, Joseph
eCommons Login: JVB1
first name: Joseph
last name: Bonventre
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person in primary position: Samuel A. Levine Distinguished Professor of Medicine
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Brown, Dennis
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person in primary position: Professor of Medicine
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Ausiello, Dennis
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Soukas, Alexander
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person in primary position: Associate Professor of Medicine
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Authorship 1178616
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author rank in publication: 4
linked author: Bouley, Richard
linked information resource: Sex-dependent differences in water homeostasis in wild-type and V-ATPase B1-subunit deficient mice.

Sex-dependent differences in water homeostasis in wild-type and V-ATPase B1-subunit deficient mice.
PubMed Identifier: 31386675
author list: Nair AV, Yanhong W, Paunescu TG, Bouley R, Brown D
published in: PloS one
information resource reference: Sex-dependent differences in water homeostasis in wild-type and V-ATPase B1-subunit deficient mice. PLoS One. 2019; 14(8):e0219940.
journal title abbreviation: PLoS One
publication date: 2019-08-06T00:00:00
year: 2019
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 1192916
type: Authorship
author rank in publication: 2
linked author: Bouley, Richard
linked information resource: Targeting the Trafficking of Kidney Water Channels for Therapeutic Benefit.

Targeting the Trafficking of Kidney Water Channels for Therapeutic Benefit.
PubMed Identifier: 31561739
author list: Cheung PW, Bouley R, Brown D
published in: Annual review of pharmacology and toxicology
information resource reference: Targeting the Trafficking of Kidney Water Channels for Therapeutic Benefit. Annu Rev Pharmacol Toxicol. 2020 01 06; 60:175-194.
journal title abbreviation: Annu Rev Pharmacol Toxicol
publication date: 2019-09-27T00:00:00
year: 2019
type: Academic Article
type: Article
type: Document
type: Information Resource

Professor of Medicine
is primary position: true
position in department: Medicine
position in division: Nephrology
sort order: 1
type: Position
HR job title: Professor of Medicine
position in organization: Massachusetts General Hospital

Assistant Professor of Medicine
is primary position: true
position in department: Medicine
position in division: Hematology/Oncology
sort order: 1
type: Position
HR job title: Assistant Professor of Medicine
position in organization: Massachusetts General Hospital

Instructor in Medicine
is primary position: true
position in department: Medicine
position in division: Nephrology
sort order: 1
type: Position
HR job title: Instructor in Medicine
position in organization: Massachusetts General Hospital

Associate Professor of Medicine
is primary position: true
position in department: Medicine
position in division: Diabetes Unit
sort order: 1
type: Position
HR job title: Associate Professor of Medicine
position in organization: Massachusetts General Hospital

Samuel A. Levine Distinguished Professor of Medicine
is primary position: true
position in department: Medicine
position in division: Renal
sort order: 1
type: Position
HR job title: Samuel A. Levine Distinguished Professor of Medicine
position in organization: Brigham and Women's Hospital

Authorship 1243918
type: Authorship
author rank in publication: 1
linked author: Bouley, Richard
linked information resource: Chlorpromazine Induces Basolateral Aquaporin-2 Accumulation via F-Actin Depolymerization and Blockade of Endocytosis in Renal Epithelial Cells.

Chlorpromazine Induces Basolateral Aquaporin-2 Accumulation via F-Actin Depolymerization and Blockade of Endocytosis in Renal Epithelial Cells.
PubMed Identifier: 32340337
author list: Bouley R, Yui N, Terlouw A, Cheung PW, Brown D
published in: Cells
information resource reference: Chlorpromazine Induces Basolateral Aquaporin-2 Accumulation via F-Actin Depolymerization and Blockade of Endocytosis in Renal Epithelial Cells. Cells. 2020 04 23; 9(4).
journal title abbreviation: Cells
publication date: 2020-04-23T00:00:00
year: 2020
type: Academic Article
type: Article
type: Document
type: Information Resource

Babicz, Richard
eCommons Login: rib756
first name: Richard
last name: Babicz
full name: Richard Babicz, M.D.
has faculty rank: Instructor
Person ID: 193542
person in primary position: Instructor in Medicine
type: Agent
type: Person
preferred title: Instructor in Medicine

Authorship 232351
type: Authorship
author rank in publication: 5
linked author: Bouley, Richard
linked information resource: Characterization of single channel currents from primary cilia of renal epithelial cells.

Authorship 154161
type: Authorship
author rank in publication: 5
linked author: Bouley, Richard
linked information resource: Methylation in positions 1 and 7 of angiotensin II. A structure-activity relationship study.

Authorship 17361
type: Authorship
author rank in publication: 6
linked author: Bouley, Richard
linked information resource: Hypertonic stress promotes autophagy and microtubule-dependent autophagosomal clusters.

Authorship 1371076
type: Authorship
author rank in publication: 7
linked author: Bouley, Richard
linked information resource: Actin-related protein 2/3 complex plays a critical role in the aquaporin-2 exocytotic pathway.

Actin-related protein 2/3 complex plays a critical role in the aquaporin-2 exocytotic pathway.
PubMed Identifier: 34180716
author list: Liu CS, Cheung PW, Dinesh A, Baylor N, Paunescu TC, Nair AV, Bouley R, Brown D
published in: American journal of physiology. Renal physiology
information resource reference: Actin-related protein 2/3 complex plays a critical role in the aquaporin-2 exocytotic pathway. Am J Physiol Renal Physiol. 2021 08 01; 321(2):F179-F194.
journal title abbreviation: Am J Physiol Renal Physiol
publication date: 2021-06-28T00:00:00
year: 2021
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 1445348
type: Authorship
author rank in publication: 9
linked author: Bouley, Richard
linked information resource: Simultaneous stabilization of actin cytoskeleton in multiple nephron-specific cells protects the kidney from diverse injury.

Simultaneous stabilization of actin cytoskeleton in multiple nephron-specific cells protects the kidney from diverse injury.
PubMed Identifier: 35504916
author list: Mukherjee K, Gu C, Collins A, Mettlen M, Samelko B, Altintas MM, Sudhini YR, Wang X, Bouley R, Brown D, Pedro BP, Bane SL, Gupta V, Brinkkoetter PT, Hagmann H, Reiser J, Sever S
published in: Nature communications
information resource reference: Simultaneous stabilization of actin cytoskeleton in multiple nephron-specific cells protects the kidney from diverse injury. Nat Commun. 2022 05 03; 13(1):2422.
journal title abbreviation: Nat Commun
publication date: 2022-05-03T00:00:00
year: 2022
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 311650
type: Authorship
author rank in publication: 1
linked author: Bouley, Richard
linked information resource: Corin: a key protein of an adaptive renal mechanism to respond to salt variation?

Cheung, Pui
eCommons Login: PWC6
first name: Pui
last name: Cheung
full name: Pui Wen Cheung, M.D.
has faculty rank: Assistant Professor
Person ID: 119391
person in primary position: Assistant Professor of Medicine
type: Agent
type: Person
preferred title: Assistant Professor of Medicine

Authorship 1507604
type: Authorship
author rank in publication: 10
linked author: Bouley, Richard
linked information resource: Intracellular sites of AQP2 S256 phosphorylation identified using inhibitors of the AQP2 recycling itinerary.

Intracellular sites of AQP2 S256 phosphorylation identified using inhibitors of the AQP2 recycling itinerary.
PubMed Identifier: 36454701
author list: Cheung PW, Boukenna M, Babicz RSE, Mitra S, Kay A, Paunescu TC, Baylor N, Liu CS, Nair AV, Bouley R, Brown D
published in: American journal of physiology. Renal physiology
information resource reference: Intracellular sites of AQP2 S256 phosphorylation identified using inhibitors of the AQP2 recycling itinerary. Am J Physiol Renal Physiol. 2023 02 01; 324(2):F152-F167.
journal title abbreviation: Am J Physiol Renal Physiol
publication date: 2022-12-01T00:00:00
year: 2022
type: Academic Article
type: Article
type: Document
type: Information Resource

Professor of Medicine
is primary position: true
position in department: Medicine
position in division: Nephrology
sort order: 1
type: Position
HR job title: Professor of Medicine
position in organization: Massachusetts General Hospital

Authorship 25256
type: Authorship
author rank in publication: 5
linked author: Bouley, Richard
linked information resource: Basolateral targeting and microtubule-dependent transcytosis of the aquaporin-2 water channel.

Assistant Professor of Medicine
is primary position: true
position in department: Medicine
position in division: Nephrology
sort order: 1
type: Position
HR job title: Assistant Professor of Medicine
position in organization: Massachusetts General Hospital

Professor of Cell Biology
is primary position: true
position in department: Cell Biology
position in division: https://connects.catalyst.harvard.edu/Profiles/profile/1229413
sort order: 1
type: Position
HR job title: Professor of Cell Biology
position in organization: Immune Disease Institute

Instructor in Medicine
is primary position: true
position in department: Medicine
position in division: Renal
sort order: 1
type: Position
HR job title: Instructor in Medicine
position in organization: Massachusetts General Hospital

Assistant Professor of Medicine
is primary position: true
position in department: Medicine
position in division: Nephrology
sort order: 1
type: Position
HR job title: Assistant Professor of Medicine
position in organization: Massachusetts General Hospital

Authorship 644826
type: Authorship
author rank in publication: 4
linked author: Bouley, Richard
linked information resource: Identification of ROCK1 kinase as a critical regulator of Beclin1-mediated autophagy during metabolic stress.

Identification of ROCK1 kinase as a critical regulator of Beclin1-mediated autophagy during metabolic stress.
PubMed Identifier: 23877263
author list: Gurkar AU, Chu K, Raj L, Bouley R, Lee SH, Kim YB, Dunn SE, Mandinova A, Lee SW
published in: Nature communications
information resource reference: Identification of ROCK1 kinase as a critical regulator of Beclin1-mediated autophagy during metabolic stress. Nat Commun. 2013; 4:2189.
journal title abbreviation: Nat Commun
publication date: 2013-01-01T00:00:00
year: 2013
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 1694251
type: Authorship
author rank in publication: 6
linked author: Bouley, Richard
linked information resource: Focal Adhesion Kinase (FAK) inhibition induces membrane accumulation of aquaporin2 (AQP2) through endocytosis inhibition and actin depolymerization in renal epithelial cells.

Focal Adhesion Kinase (FAK) inhibition induces membrane accumulation of aquaporin2 (AQP2) through endocytosis inhibition and actin depolymerization in renal epithelial cells.
PubMed Identifier: 39416213
author list: Tchakal-Mesbahi A, He J, Zhu S, Huang M, Fukushima K, Bouley R, Brown D, Lu HAJ
published in: bioRxiv : the preprint server for biology
information resource reference: Focal Adhesion Kinase (FAK) inhibition induces membrane accumulation of aquaporin2 (AQP2) through endocytosis inhibition and actin depolymerization in renal epithelial cells. bioRxiv. 2024 Oct 09.
journal title abbreviation: bioRxiv
publication date: 2024-10-09T00:00:00
year: 2024
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 502065
type: Authorship
author rank in publication: 1
linked author: Bouley, Richard
linked information resource: Nitric oxide and atrial natriuretic factor stimulate cGMP-dependent membrane insertion of aquaporin 2 in renal epithelial cells.

Authorship 182977
type: Authorship
author rank in publication: 4
linked author: Bouley, Richard
linked information resource: Aquaporin 2 is a vasopressin-independent, constitutive apical membrane protein in rat vas deferens.

Authorship 92907
type: Authorship
author rank in publication: 2
linked author: Bouley, Richard
linked information resource: Membrane organization and function of M1 and M23 isoforms of aquaporin-4 in epithelial cells.

Authorship 1723595
type: Authorship
author rank in publication: 7
linked author: Bouley, Richard
linked information resource: Ribosomal s6 kinase is a mediator of aquaporin-2 S256 phosphorylation and membrane accumulation after EGFR inhibition with erlotinib.

Ribosomal s6 kinase is a mediator of aquaporin-2 S256 phosphorylation and membrane accumulation after EGFR inhibition with erlotinib.
PubMed Identifier: 39823198
author list: Babicz RSE, Baylor N, Terlouw A, Faber DA, Fukushima K, Biondi RM, Bouley R, Brown D
published in: American journal of physiology. Renal physiology
information resource reference: Ribosomal s6 kinase is a mediator of aquaporin-2 S256 phosphorylation and membrane accumulation after EGFR inhibition with erlotinib. Am J Physiol Renal Physiol. 2025 Mar 01; 328(3):F344-F359.
journal title abbreviation: Am J Physiol Renal Physiol
publication date: 2025-01-17T00:00:00
year: 2025
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 675594
type: Authorship
author rank in publication: 9
linked author: Bouley, Richard
linked information resource: Noncanonical control of vasopressin receptor type 2 signaling by retromer and arrestin.

Noncanonical control of vasopressin receptor type 2 signaling by retromer and arrestin.
PubMed Identifier: 23935101
author list: Feinstein TN, Yui N, Webber MJ, Wehbi VL, Stevenson HP, King JD, Hallows KR, Brown D, Bouley R, Vilardaga JP
published in: The Journal of biological chemistry
information resource reference: Noncanonical control of vasopressin receptor type 2 signaling by retromer and arrestin. J Biol Chem. 2013 Sep 27; 288(39):27849-60.
journal title abbreviation: J Biol Chem
publication date: 2013-08-09T00:00:00
year: 2013
type: Academic Article
type: Article
type: Document
type: Information Resource

Professor of Medicine, Emerita
is primary position: true
position in department: Emeritus
position in division: https://connects.catalyst.harvard.edu/Profiles/profile/1229413
sort order: 1
type: Position
HR job title: Professor of Medicine, Emerita
position in organization: Harvard Medical School

Authorship 209585
type: Authorship
author rank in publication: 3
linked author: Bouley, Richard
linked information resource: Inhibition of endocytosis causes phosphorylation (S256)-independent plasma membrane accumulation of AQP2.

Authorship 284651
type: Authorship
author rank in publication: 3
linked author: Bouley, Richard
linked information resource: Dragon enhances BMP signaling and increases transepithelial resistance in kidney epithelial cells.

Authorship 403409
type: Authorship
author rank in publication: 2
linked author: Bouley, Richard
linked information resource: Alix (AIP1) is a vasopressin receptor (V2R)-interacting protein that increases lysosomal degradation of the V2R.

Jackson Professor of Clinical Medicine, Emeritus
is primary position: true
position in department: Emeritus
position in division: https://connects.catalyst.harvard.edu/Profiles/profile/1229413
sort order: 1
type: Position
HR job title: Jackson Professor of Clinical Medicine, Emeritus
position in organization: Harvard Medical School

Authorship 342019
type: Authorship
author rank in publication: 3
linked author: Bouley, Richard
linked information resource: Acute hypertonicity alters aquaporin-2 trafficking and induces a MAPK-dependent accumulation at the plasma membrane of renal epithelial cells.

Authorship 761347
type: Authorship
author rank in publication: 3
linked author: Bouley, Richard
linked information resource: High-throughput chemical screening identifies AG-490 as a stimulator of aquaporin 2 membrane expression and urine concentration.

High-throughput chemical screening identifies AG-490 as a stimulator of aquaporin 2 membrane expression and urine concentration.
PubMed Identifier: 24944200
author list: Nomura N, Nunes P, Bouley R, Nair AV, Shaw S, Ueda E, Pathomthongtaweechai N, Lu HA, Brown D
published in: American journal of physiology. Cell physiology
information resource reference: High-throughput chemical screening identifies AG-490 as a stimulator of aquaporin 2 membrane expression and urine concentration. Am J Physiol Cell Physiol. 2014 Oct 01; 307(7):C597-605.
journal title abbreviation: Am J Physiol Cell Physiol
publication date: 2014-06-18T00:00:00
year: 2014
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 764040
type: Authorship
author rank in publication: 3
linked author: Bouley, Richard
linked information resource: Dnase2a deficiency uncovers lysosomal clearance of damaged nuclear DNA via autophagy.

Dnase2a deficiency uncovers lysosomal clearance of damaged nuclear DNA via autophagy.
PubMed Identifier: 25284779
author list: Lan YY, Londoño D, Bouley R, Rooney MS, Hacohen N
published in: Cell reports
information resource reference: Dnase2a deficiency uncovers lysosomal clearance of damaged nuclear DNA via autophagy. Cell Rep. 2014 Oct 09; 9(1):180-192.
journal title abbreviation: Cell Rep
publication date: 2014-10-02T00:00:00
year: 2014
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 96238
type: Authorship
author rank in publication: 3
linked author: Bouley, Richard
linked information resource: AQP2 is necessary for vasopressin- and forskolin-mediated filamentous actin depolymerization in renal epithelial cells.

Authorship 775148
type: Authorship
author rank in publication: 4
linked author: Bouley, Richard
linked information resource: Paradoxical activation of the sodium chloride cotransporter (NCC) without hypertension in kidney deficient in a regulatory subunit of Na,K-ATPase, FXYD2.

Paradoxical activation of the sodium chloride cotransporter (NCC) without hypertension in kidney deficient in a regulatory subunit of Na,K-ATPase, FXYD2.
PubMed Identifier: 25472608
author list: Arystarkhova E, Ralph DL, Liu YB, Bouley R, McDonough AA, Sweadner KJ
published in: Physiological reports
information resource reference: Paradoxical activation of the sodium chloride cotransporter (NCC) without hypertension in kidney deficient in a regulatory subunit of Na,K-ATPase, FXYD2. Physiol Rep. 2014 Dec 01; 2(12).
journal title abbreviation: Physiol Rep
publication date: 2014-12-01T00:00:00
year: 2014
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 477210
type: Authorship
author rank in publication: 1
linked author: Bouley, Richard
linked information resource: Bypassing vasopressin receptor signaling pathways in nephrogenic diabetes insipidus.

Authorship 521066
type: Authorship
author rank in publication: 1
linked author: Bouley, Richard
linked information resource: Heterologous downregulation of vasopressin type 2 receptor is induced by transferrin.

Authorship 329227
type: Authorship
author rank in publication: 1
linked author: Bouley, Richard
linked information resource: Angiotensin II and hypertonicity modulate proximal tubular aquaporin 1 expression.

Authorship 237772
type: Authorship
author rank in publication: 5
linked author: Bouley, Richard
linked information resource: A fluorimetry-based ssYFP secretion assay to monitor vasopressin-induced exocytosis in LLC-PK1 cells expressing aquaporin-2.

Authorship 201202
type: Authorship
author rank in publication: 5
linked author: Bouley, Richard
linked information resource: Hypertonicity is involved in redirecting the aquaporin-2 water channel into the basolateral, instead of the apical, plasma membrane of renal epithelial cells.

Authorship 322466
type: Authorship
author rank in publication: 2
linked author: Bouley, Richard
linked information resource: Molecular weight determination of the hepatic vasopressin receptor with a high-affinity photoprobe.

Authorship 44488
type: Authorship
author rank in publication: 5
linked author: Bouley, Richard
linked information resource: Sustained cyclic AMP production by parathyroid hormone receptor endocytosis.

Authorship 460379
type: Authorship
author rank in publication: 1
linked author: Bouley, Richard
linked information resource: Functional role of the NPxxY motif in internalization of the type 2 vasopressin receptor in LLC-PK1 cells.

Authorship 492353
type: Authorship
author rank in publication: 3
linked author: Bouley, Richard
linked information resource: The phosphorylation state of serine 256 is dominant over that of serine 261 in the regulation of AQP2 trafficking in renal epithelial cells.

Authorship 805919
type: Authorship
author rank in publication: 3
linked author: Bouley, Richard
linked information resource: Renal intercalated cells sense and mediate inflammation via the P2Y14 receptor.

Renal intercalated cells sense and mediate inflammation via the P2Y14 receptor.
PubMed Identifier: 25799465
author list: Azroyan A, Cortez-Retamozo V, Bouley R, Liberman R, Ruan YC, Kiselev E, Jacobson KA, Pittet MJ, Brown D, Breton S
published in: PloS one
information resource reference: Renal intercalated cells sense and mediate inflammation via the P2Y14 receptor. PLoS One. 2015; 10(3):e0121419.
journal title abbreviation: PLoS One
publication date: 2015-03-23T00:00:00
year: 2015
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 370363
type: Authorship
author rank in publication: 8
linked author: Bouley, Richard
linked information resource: Visualizing microtubule-dependent vasopressin type 2 receptor trafficking using a new high-affinity fluorescent vasopressin ligand.

Authorship 470177
type: Authorship
author rank in publication: 6
linked author: Bouley, Richard
linked information resource: Heat shock protein 70 interacts with aquaporin-2 and regulates its trafficking.

Authorship 41696
type: Authorship
author rank in publication: 4
linked author: Bouley, Richard
linked information resource: NF-kappaB modulates aquaporin-2 transcription in renal collecting duct principal cells.

Authorship 388791
type: Authorship
author rank in publication: 1
linked author: Bouley, Richard
linked information resource: Aquaporin 2 (AQP2) and vasopressin type 2 receptor (V2R) endocytosis in kidney epithelial cells: AQP2 is located in 'endocytosis-resistant' membrane domains after vasopressin treatment.

Authorship 434326
type: Authorship
author rank in publication: 1
linked author: Bouley, Richard
linked information resource: N- and C-terminal structure-activity study of angiotensin II on the angiotensin AT2 receptor.

Authorship 520410
type: Authorship
author rank in publication: 5
linked author: Bouley, Richard
linked information resource: Structure-activity relationship of the agonist-antagonist transition on the type 1 angiotensin II receptor; the search for inverse agonists.

Authorship 50514
type: Authorship
author rank in publication: 4
linked author: Bouley, Richard
linked information resource: Aquaporin-2 localization in clathrin-coated pits: inhibition of endocytosis by dominant-negative dynamin.

Authorship 534928
type: Authorship
author rank in publication: 2
linked author: Bouley, Richard
linked information resource: Effects of the renal medullary pH and ionic environment on vasopressin binding and signaling.

EGF Receptor Inhibition by Erlotinib Increases Aquaporin 2-Mediated Renal Water Reabsorption.
PubMed Identifier: 26961350
author list: Cheung PW, Nomura N, Nair AV, Pathomthongtaweechai N, Ueberdiek L, Jenny Lu HA, Brown D, Bouley R
published in: Journal of the American Society of Nephrology : JASN
information resource reference: EGF Receptor Inhibition by Erlotinib Increases Aquaporin 2-Mediated Renal Water Reabsorption. J Am Soc Nephrol. 2016 Mar 09.
journal title abbreviation: J Am Soc Nephrol
publication date: 2016-03-09T00:00:00
year: 2016
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 340945
type: Authorship
author rank in publication: 1
linked author: Bouley, Richard
linked information resource: Characterization of a specific binding site for angiotensin II in chicken liver.

Authorship 405262
type: Authorship
author rank in publication: 2
linked author: Bouley, Richard
linked information resource: Vasopressin-induced differential stimulation of AQP4 splice variants regulates the in-membrane assembly of orthogonal arrays.

Authorship 544289
type: Authorship
author rank in publication: 7
linked author: Bouley, Richard
linked information resource: Physical and functional connection between auxilin and dynamin during endocytosis.

Assistant Professor
sort order: 2
type: Faculty Rank

Associate Professor
sort order: 1
type: Faculty Rank

Full Professor
sort order: 0
type: Faculty Rank

Instructor
sort order: 4
type: Faculty Rank

Authorship 493095
type: Authorship
author rank in publication: 1
linked author: Bouley, Richard
linked information resource: Downregulation of the vasopressin type 2 receptor after vasopressin-induced internalization: involvement of a lysosomal degradation pathway.

Authorship 915699
type: Authorship
author rank in publication: 6
linked author: Bouley, Richard
linked information resource: Overexpression of angiotensinogen downregulates aquaporin 1 expression via modulation of Nrf2-HO-1 pathway in renal proximal tubular cells of transgenic mice.

Authorship 915700
type: Authorship
author rank in publication: 8
linked author: Bouley, Richard
linked information resource: EGF Receptor Inhibition by Erlotinib Increases Aquaporin 2-Mediated Renal Water Reabsorption.

Overexpression of angiotensinogen downregulates aquaporin 1 expression via modulation of Nrf2-HO-1 pathway in renal proximal tubular cells of transgenic mice.
PubMed Identifier: 27638854
author list: Chang SY, Lo CS, Zhao XP, Liao MC, Chenier I, Bouley R, Ingelfinger JR, Chan JS, Zhang SL
published in: Journal of the renin-angiotensin-aldosterone system : JRAAS
information resource reference: Overexpression of angiotensinogen downregulates aquaporin 1 expression via modulation of Nrf2-HO-1 pathway in renal proximal tubular cells of transgenic mice. J Renin Angiotensin Aldosterone Syst. 2016 Jul; 17(3).
journal title abbreviation: J Renin Angiotensin Aldosterone Syst
publication date: 2016-09-15T00:00:00
year: 2016
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 341449
type: Authorship
author rank in publication: 1
linked author: Bouley, Richard
linked information resource: Stimulation of AQP2 membrane insertion in renal epithelial cells in vitro and in vivo by the cGMP phosphodiesterase inhibitor sildenafil citrate (Viagra).

Authorship 919453
type: Authorship
author rank in publication: 8
linked author: Bouley, Richard
linked information resource: EGF Receptor Inhibition by Erlotinib Increases Aquaporin 2-Mediated Renal Water Reabsorption.

EGF Receptor Inhibition by Erlotinib Increases Aquaporin 2-Mediated Renal Water Reabsorption.
PubMed Identifier: 27694161
author list: Cheung PW, Nomura N, Nair AV, Pathomthongtaweechai N, Ueberdiek L, Lu HA, Brown D, Bouley R
published in: Journal of the American Society of Nephrology : JASN
information resource reference: EGF Receptor Inhibition by Erlotinib Increases Aquaporin 2-Mediated Renal Water Reabsorption. J Am Soc Nephrol. 2016 Oct; 27(10):3105-3116.
journal title abbreviation: J Am Soc Nephrol
publication date: 2016-03-09T00:00:00
year: 2016
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 474208
type: Authorship
author rank in publication: 2
linked author: Bouley, Richard
linked information resource: New insights into the dynamic regulation of water and acid-base balance by renal epithelial cells.

Authorship 481450
type: Authorship
author rank in publication: 1
linked author: Bouley, Richard
linked information resource: Calcitonin has a vasopressin-like effect on aquaporin-2 trafficking and urinary concentration.

Authorship 504394
type: Authorship
author rank in publication: 4
linked author: Bouley, Richard
linked information resource: Phosphorylation events and the modulation of aquaporin 2 cell surface expression.

Authorship 930420
type: Authorship
author rank in publication: 6
linked author: Bouley, Richard
linked information resource: Endothelial cells produce bone morphogenetic protein 6 required for iron homeostasis in mice.

Endothelial cells produce bone morphogenetic protein 6 required for iron homeostasis in mice.
PubMed Identifier: 27864295
author list: Canali S, Zumbrennen-Bullough KB, Core AB, Wang CY, Nairz M, Bouley R, Swirski FK, Babitt JL
published in: Blood
information resource reference: Endothelial cells produce bone morphogenetic protein 6 required for iron homeostasis in mice. Blood. 2017 01 26; 129(4):405-414.
journal title abbreviation: Blood
publication date: 2016-11-18T00:00:00
year: 2016
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 30716
type: Authorship
author rank in publication: 4
linked author: Bouley, Richard
linked information resource: Recycling of AQP2 occurs through a temperature- and bafilomycin-sensitive trans-Golgi-associated compartment.

Authorship 331546
type: Authorship
author rank in publication: 2
linked author: Bouley, Richard
linked information resource: Angiotensin II analogues with sulphur-containing side-chains in position 5. A structure-activity relationship study.

Aquaporin 2 is a vasopressin-independent, constitutive apical membrane protein in rat vas deferens.
PubMed Identifier: 10751327
author list: Stevens AL, Breton S, Gustafson CE, Bouley R, Nelson RD, Kohan DE, Brown D
published in: American journal of physiology. Cell physiology
information resource reference: Aquaporin 2 is a vasopressin-independent, constitutive apical membrane protein in rat vas deferens. Am J Physiol Cell Physiol. 2000 Apr; 278(4):C791-802.
journal title abbreviation: Am J Physiol Cell Physiol
publication date: 2000-04-01T00:00:00
year: 2000
type: Academic Article
type: Article
type: Document
type: Information Resource

Characterization of a specific binding site for angiotensin II in chicken liver.
PubMed Identifier: 9276130
author list: Bouley R, Gosselin M, Plante H, Servant G, Pérodin J, Arcand M, Guillemette G, Escher E
published in: Canadian journal of physiology and pharmacology
information resource reference: Characterization of a specific binding site for angiotensin II in chicken liver. Can J Physiol Pharmacol. 1997 Jun; 75(6):568-75.
journal title abbreviation: Can J Physiol Pharmacol
publication date: 1997-06-01T00:00:00
year: 1997
type: Academic Article
type: Article
type: Document
type: Information Resource

Hypertonicity is involved in redirecting the aquaporin-2 water channel into the basolateral, instead of the apical, plasma membrane of renal epithelial cells.
PubMed Identifier: 12374804
author list: van Balkom BW, van Raak M, Breton S, Pastor-Soler N, Bouley R, van der Sluijs P, Brown D, Deen PM
published in: The Journal of biological chemistry
information resource reference: Hypertonicity is involved in redirecting the aquaporin-2 water channel into the basolateral, instead of the apical, plasma membrane of renal epithelial cells. J Biol Chem. 2003 Jan 10; 278(2):1101-7.
journal title abbreviation: J Biol Chem
publication date: 2002-10-08T00:00:00
year: 2002
type: Academic Article
type: Article
type: Document
type: Information Resource

Recycling of AQP2 occurs through a temperature- and bafilomycin-sensitive trans-Golgi-associated compartment.
PubMed Identifier: 10662736
author list: Gustafson CE, Katsura T, McKee M, Bouley R, Casanova JE, Brown D
published in: American journal of physiology. Renal physiology
information resource reference: Recycling of AQP2 occurs through a temperature- and bafilomycin-sensitive trans-Golgi-associated compartment. Am J Physiol Renal Physiol. 2000 Feb; 278(2):F317-26.
journal title abbreviation: Am J Physiol Renal Physiol
publication date: 2000-02-01T00:00:00
year: 2000
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 976497
type: Authorship
author rank in publication: 4
linked author: Bouley, Richard
linked information resource: Protein phosphatase 2C is responsible for VP-induced dephosphorylation of AQP2 serine 261.

Protein phosphatase 2C is responsible for VP-induced dephosphorylation of AQP2 serine 261.
PubMed Identifier: 28381458
author list: Cheung PW, Ueberdiek L, Day J, Bouley R, Brown D
published in: American journal of physiology. Renal physiology
information resource reference: Protein phosphatase 2C is responsible for VP-induced dephosphorylation of AQP2 serine 261. Am J Physiol Renal Physiol. 2017 Aug 01; 313(2):F404-F413.
journal title abbreviation: Am J Physiol Renal Physiol
publication date: 2017-04-05T00:00:00
year: 2017
type: Academic Article
type: Article
type: Document
type: Information Resource

Aquaporin 2 (AQP2) and vasopressin type 2 receptor (V2R) endocytosis in kidney epithelial cells: AQP2 is located in 'endocytosis-resistant' membrane domains after vasopressin treatment.
PubMed Identifier: 16563128
author list: Bouley R, Hawthorn G, Russo LM, Lin HY, Ausiello DA, Brown D
published in: Biology of the cell
information resource reference: Aquaporin 2 (AQP2) and vasopressin type 2 receptor (V2R) endocytosis in kidney epithelial cells: AQP2 is located in 'endocytosis-resistant' membrane domains after vasopressin treatment. Biol Cell. 2006 Apr; 98(4):215-32.
journal title abbreviation: Biol Cell
publication date: 2006-04-01T00:00:00
year: 2006
type: Academic Article
type: Article
type: Document
type: Information Resource

Physical and functional connection between auxilin and dynamin during endocytosis.
PubMed Identifier: 16946707
author list: Sever S, Skoch J, Newmyer S, Ramachandran R, Ko D, McKee M, Bouley R, Ausiello D, Hyman BT, Bacskai BJ
published in: The EMBO journal
information resource reference: Physical and functional connection between auxilin and dynamin during endocytosis. EMBO J. 2006 Sep 20; 25(18):4163-74.
journal title abbreviation: EMBO J
publication date: 2006-08-31T00:00:00
year: 2006
type: Academic Article
type: Article
type: Document
type: Information Resource

Functional role of the NPxxY motif in internalization of the type 2 vasopressin receptor in LLC-PK1 cells.
PubMed Identifier: 12801889
author list: Bouley R, Sun TX, Chenard M, McLaughlin M, McKee M, Lin HY, Brown D, Ausiello DA
published in: American journal of physiology. Cell physiology
information resource reference: Functional role of the NPxxY motif in internalization of the type 2 vasopressin receptor in LLC-PK1 cells. Am J Physiol Cell Physiol. 2003 Oct; 285(4):C750-62.
journal title abbreviation: Am J Physiol Cell Physiol
publication date: 2003-06-11T00:00:00
year: 2003
type: Academic Article
type: Article
type: Document
type: Information Resource

Stimulation of AQP2 membrane insertion in renal epithelial cells in vitro and in vivo by the cGMP phosphodiesterase inhibitor sildenafil citrate (Viagra).
PubMed Identifier: 15644488
author list: Bouley R, Pastor-Soler N, Cohen O, McLaughlin M, Breton S, Brown D
published in: American journal of physiology. Renal physiology
information resource reference: Stimulation of AQP2 membrane insertion in renal epithelial cells in vitro and in vivo by the cGMP phosphodiesterase inhibitor sildenafil citrate (Viagra). Am J Physiol Renal Physiol. 2005 Jun; 288(6):F1103-12.
journal title abbreviation: Am J Physiol Renal Physiol
publication date: 2005-01-11T00:00:00
year: 2005
type: Academic Article
type: Article
type: Document
type: Information Resource

Dragon enhances BMP signaling and increases transepithelial resistance in kidney epithelial cells.
PubMed Identifier: 20167703
author list: Xia Y, Babitt JL, Bouley R, Zhang Y, Da Silva N, Chen S, Zhuang Z, Samad TA, Brenner GJ, Anderson JL, Hong CC, Schneyer AL, Brown D, Lin HY
published in: Journal of the American Society of Nephrology : JASN
information resource reference: Dragon enhances BMP signaling and increases transepithelial resistance in kidney epithelial cells. J Am Soc Nephrol. 2010 Apr; 21(4):666-77.
journal title abbreviation: J Am Soc Nephrol
publication date: 2010-02-18T00:00:00
year: 2010
type: Academic Article
type: Article
type: Document
type: Information Resource

Corin: a key protein of an adaptive renal mechanism to respond to salt variation?
PubMed Identifier: 22699378
author list: Bouley R
published in: Kidney international
information resource reference: Corin: a key protein of an adaptive renal mechanism to respond to salt variation? Kidney Int. 2012 Jul; 82(1):7-8.
journal title abbreviation: Kidney Int
publication date: 2012-07-01T00:00:00
year: 2012
type: Academic Article
type: Article
type: Document
type: Information Resource

Membrane organization and function of M1 and M23 isoforms of aquaporin-4 in epithelial cells.
PubMed Identifier: 15149973
author list: Silberstein C, Bouley R, Huang Y, Fang P, Pastor-Soler N, Brown D, Van Hoek AN
published in: American journal of physiology. Renal physiology
information resource reference: Membrane organization and function of M1 and M23 isoforms of aquaporin-4 in epithelial cells. Am J Physiol Renal Physiol. 2004 Sep; 287(3):F501-11.
journal title abbreviation: Am J Physiol Renal Physiol
publication date: 2004-05-18T00:00:00
year: 2004
type: Academic Article
type: Article
type: Document
type: Information Resource

Heat shock protein 70 interacts with aquaporin-2 and regulates its trafficking.
PubMed Identifier: 17636261
author list: Lu HAJ, Sun TX, Matsuzaki T, Yi XH, Eswara J, Bouley R, McKee M, Brown D
published in: The Journal of biological chemistry
information resource reference: Heat shock protein 70 interacts with aquaporin-2 and regulates its trafficking. J Biol Chem. 2007 Sep 28; 282(39):28721-28732.
journal title abbreviation: J Biol Chem
publication date: 2007-07-18T00:00:00
year: 2007
type: Academic Article
type: Article
type: Document
type: Information Resource

Structure-activity relationship of the agonist-antagonist transition on the type 1 angiotensin II receptor; the search for inverse agonists.
PubMed Identifier: 8726693
author list: Pérodin J, Bossé R, Gagnon S, Zhou LM, Bouley R, Leduc R, Escher E
published in: Advances in experimental medicine and biology
information resource reference: Structure-activity relationship of the agonist-antagonist transition on the type 1 angiotensin II receptor; the search for inverse agonists. Adv Exp Med Biol. 1996; 396:131-43.
journal title abbreviation: Adv Exp Med Biol
publication date: 1996-01-01T00:00:00
year: 1996
type: Academic Article
type: Article
type: Document
type: Information Resource

Angiotensin II analogues with sulphur-containing side-chains in position 5. A structure-activity relationship study.
PubMed Identifier: 10918944
author list: Pérodin J, Bouley R, Escher E, Assimomytis N, Magafa V, Manessi-Zoupa E, Theodoropoulos D, Cordopatis P
published in: Arzneimittel-Forschung
information resource reference: Angiotensin II analogues with sulphur-containing side-chains in position 5. A structure-activity relationship study. Arzneimittelforschung. 2000 Jun; 50(6):526-9.
journal title abbreviation: Arzneimittelforschung
publication date: 2000-06-01T00:00:00
year: 2000
type: Academic Article
type: Article
type: Document
type: Information Resource

Downregulation of the vasopressin type 2 receptor after vasopressin-induced internalization: involvement of a lysosomal degradation pathway.
PubMed Identifier: 15677378
author list: Bouley R, Lin HY, Raychowdhury MK, Marshansky V, Brown D, Ausiello DA
published in: American journal of physiology. Cell physiology
information resource reference: Downregulation of the vasopressin type 2 receptor after vasopressin-induced internalization: involvement of a lysosomal degradation pathway. Am J Physiol Cell Physiol. 2005 Jun; 288(6):C1390-401.
journal title abbreviation: Am J Physiol Cell Physiol
publication date: 2005-01-26T00:00:00
year: 2005
type: Academic Article
type: Article
type: Document
type: Information Resource

Simvastatin enhances aquaporin-2 surface expression and urinary concentration in vasopressin-deficient Brattleboro rats through modulation of Rho GTPase.
PubMed Identifier: 21511701
author list: Li W, Zhang Y, Bouley R, Chen Y, Matsuzaki T, Nunes P, Hasler U, Brown D, Lu HA
published in: American journal of physiology. Renal physiology
information resource reference: Simvastatin enhances aquaporin-2 surface expression and urinary concentration in vasopressin-deficient Brattleboro rats through modulation of Rho GTPase. Am J Physiol Renal Physiol. 2011 Aug; 301(2):F309-18.
journal title abbreviation: Am J Physiol Renal Physiol
publication date: 2011-04-20T00:00:00
year: 2011
type: Academic Article
type: Article
type: Document
type: Information Resource

Phosphorylation events and the modulation of aquaporin 2 cell surface expression.
PubMed Identifier: 18695390
author list: Brown D, Hasler U, Nunes P, Bouley R, Lu HA
published in: Current opinion in nephrology and hypertension
information resource reference: Phosphorylation events and the modulation of aquaporin 2 cell surface expression. Curr Opin Nephrol Hypertens. 2008 Sep; 17(5):491-8.
journal title abbreviation: Curr Opin Nephrol Hypertens
publication date: 2008-09-01T00:00:00
year: 2008
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 1022092
type: Authorship
author rank in publication: 2
linked author: Bouley, Richard
linked information resource: Large G protein a-subunit XLas limits clathrin-mediated endocytosis and regulates tissue iron levels in vivo.

Large G protein a-subunit XLas limits clathrin-mediated endocytosis and regulates tissue iron levels in vivo.
PubMed Identifier: 29078380
author list: He Q, Bouley R, Liu Z, Wein MN, Zhu Y, Spatz JM, Wang CY, Divieti Pajevic P, Plagge A, Babitt JL, Bastepe M
published in: Proceedings of the National Academy of Sciences of the United States of America
information resource reference: Large G protein a-subunit XLas limits clathrin-mediated endocytosis and regulates tissue iron levels in vivo. Proc Natl Acad Sci U S A. 2017 11 07; 114(45):E9559-E9568.
journal title abbreviation: Proc Natl Acad Sci U S A
publication date: 2017-10-23T00:00:00
year: 2017
type: Academic Article
type: Article
type: Document
type: Information Resource

185 Cambridge St
type: Address
address line 1: Massachusetts General Hospital
address line 2: Simches Research Center, Division of Nephrology
address line 3: 185 Cambridge St
city: Boston
postal code: 02114
state or province: MA

Authorship 1028573
type: Authorship
author rank in publication: 2
linked author: Bouley, Richard
linked information resource: Impaired AQP2 trafficking in Fxyd1 knockout mice: A role for FXYD1 in regulated vesicular transport.

Impaired AQP2 trafficking in Fxyd1 knockout mice: A role for FXYD1 in regulated vesicular transport.
PubMed Identifier: 29155857
author list: Arystarkhova E, Bouley R, Liu YB, Sweadner KJ
published in: PloS one
information resource reference: Impaired AQP2 trafficking in Fxyd1 knockout mice: A role for FXYD1 in regulated vesicular transport. PLoS One. 2017; 12(11):e0188006.
journal title abbreviation: PLoS One
publication date: 2017-11-20T00:00:00
year: 2017
type: Academic Article
type: Article
type: Document
type: Information Resource

Hypertonic stress promotes autophagy and microtubule-dependent autophagosomal clusters.
PubMed Identifier: 23380587
author list: Nunes P, Ernandez T, Roth I, Qiao X, Strebel D, Bouley R, Charollais A, Ramadori P, Foti M, Meda P, Féraille E, Brown D, Hasler U
published in: Autophagy
information resource reference: Hypertonic stress promotes autophagy and microtubule-dependent autophagosomal clusters. Autophagy. 2013 Apr; 9(4):550-67.
journal title abbreviation: Autophagy
publication date: 2013-02-04T00:00:00
year: 2013
type: Academic Article
type: Article
type: Document
type: Information Resource

Visualizing microtubule-dependent vasopressin type 2 receptor trafficking using a new high-affinity fluorescent vasopressin ligand.
PubMed Identifier: 21828182
author list: Chen S, Webber MJ, Vilardaga JP, Khatri A, Brown D, Ausiello DA, Lin HY, Bouley R
published in: Endocrinology
information resource reference: Visualizing microtubule-dependent vasopressin type 2 receptor trafficking using a new high-affinity fluorescent vasopressin ligand. Endocrinology. 2011 Oct; 152(10):3893-904.
journal title abbreviation: Endocrinology
publication date: 2011-08-09T00:00:00
year: 2011
type: Academic Article
type: Article
type: Document
type: Information Resource

Vasopressin-induced differential stimulation of AQP4 splice variants regulates the in-membrane assembly of orthogonal arrays.
PubMed Identifier: 19297454
author list: Van Hoek AN, Bouley R, Lu Y, Silberstein C, Brown D, Wax MB, Patil RV
published in: American journal of physiology. Renal physiology
information resource reference: Vasopressin-induced differential stimulation of AQP4 splice variants regulates the in-membrane assembly of orthogonal arrays. Am J Physiol Renal Physiol. 2009 Jun; 296(6):F1396-404.
journal title abbreviation: Am J Physiol Renal Physiol
publication date: 2009-03-18T00:00:00
year: 2009
type: Academic Article
type: Article
type: Document
type: Information Resource