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Association of dietary folate and vitamin B-12 intake with genome-wide DNA methylation in blood: a large-scale epigenome-wide association analysis in 5841 individuals.
Michael and Lee Bell Professor of Women's Health
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Post-Hip Fracture Mortality in Nursing Home Residents by Obesity Status.
Maurice Edmond Mueller Professor of Orthopedic Surgery
Fritz Bradley Talbot and Nathan Bill Talbot Professor of Pediatrics, Emerita
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A Lot of Progress, With More to Be Done: A Response to NIH Pathways to Prevention Report "Research Gaps for Long-Term Drug Therapies for Osteoporotic Fracture Prevention". J Bone Miner Res. 2019 09; 34(9):1549-1551.
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Association Between Abdominal Aortic Calcification, Bone Mineral Density, and Fracture in Older Women.
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Body Composition and Genetic Lipodystrophy Risk Score Associate With Nonalcoholic Fatty Liver Disease and Liver Fibrosis. Hepatol Commun. 2019 Aug; 3(8):1073-1084.
Body Composition and Genetic Lipodystrophy Risk Score Associate With Nonalcoholic Fatty Liver Disease and Liver Fibrosis.
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A meta-analysis of genome-wide association studies identifies multiple longevity genes. Nat Commun. 2019 08 14; 10(1):3669.
A meta-analysis of genome-wide association studies identifies multiple longevity genes.
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Validation of the FRAiL model to predict non-vertebral and hip fractures in nursing home residents.
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Secondary Fracture Prevention: Consensus Clinical Recommendations from a Multistakeholder Coalition.
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Age-related DNA hydroxymethylation is enriched for gene expression and immune system processes in human peripheral blood. Epigenetics. 2020 03; 15(3):294-306.
Age-related DNA hydroxymethylation is enriched for gene expression and immune system processes in human peripheral blood.
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Fellow of the American Geriatrics Society
Fellow of the Gerontological Society of America
Chair Skin, Bone, Muscle and Joint Working Group
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A regulatory variant at 3q21.1 confers an increased pleiotropic risk for hyperglycemia and altered bone mineral density.
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Publisher Correction: A meta-analysis of genome-wide association studies identifies multiple longevity genes. Nat Commun. 2021 Apr 23; 12(1):2463.
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An executive summary on the Global conceptual definition of Sarcopenia.
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Network Analysis of Brain and Bone Tissue Transcripts Reveals Shared Molecular Mechanisms Underlying Alzheimer's Disease and Related Dementias and Osteoporosis. J Gerontol A Biol Sci Med Sci. 2024 11 01; 79(11).
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Association of heat shock proteins with all-cause mortality.
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Dynamic parameters of balance which correlate to elderly persons with a history of falls.
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WITHDRAWN: Impact of Provision of Abdominal Aortic Calcification Results on Cardiovascular Risk Reducing Behaviours: A 12-Week RCT.
Ye C, Leslie WD, Bouxsein ML, Dufour AB, Guermazi A, Habtemariam D, Jarraya M, Kiel DP, Suri P, Samelson EJ
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DiVasta AD, Stamoulis C, Rubin CT, Gallagher JS, Kiel DP, Snyder BD, Gordon CM
Low-Magnitude Mechanical Signals to Preserve Skeletal Health in Female Adolescents With Anorexia Nervosa: A Randomized Clinical Trial. JAMA Netw Open. 2024 10 01; 7(10):e2441779.
Low-Magnitude Mechanical Signals to Preserve Skeletal Health in Female Adolescents With Anorexia Nervosa: A Randomized Clinical Trial.
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Bonewald LF, Kiel DP, Clemens TL, Esser K, Orwoll ES, O'Keefe RJ, Fielding RA
Forum on bone and skeletal muscle interactions: summary of the proceedings of an ASBMR workshop. J Bone Miner Res. 2013 Sep; 28(9):1857-65.
Forum on bone and skeletal muscle interactions: summary of the proceedings of an ASBMR workshop.
Anderson DE, Demissie S, Allaire BT, Bruno AG, Kopperdahl DL, Keaveny TM, Kiel DP, Bouxsein ML
The associations between QCT-based vertebral bone measurements and prevalent vertebral fractures depend on the spinal locations of both bone measurement and fracture. Osteoporos Int. 2014 Feb; 25(2):559-66.
The associations between QCT-based vertebral bone measurements and prevalent vertebral fractures depend on the spinal locations of both bone measurement and fracture.
Coordinating Multidisciplinary Care - Improving Outcomes after Fragility Fractures. N Engl J Med. 2025 Jan 09; 392(2):109-111.
Coordinating Multidisciplinary Care - Improving Outcomes after Fragility Fractures.
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Better Mental Health and Fewer Depressive Symptoms Are Associated With Greater Psychological Resilience After Hip Fracture. J Gerontol A Biol Sci Med Sci. 2025 05 05; 80(6).
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Common genetic loci influencing plasma homocysteine concentrations and their effect on risk of coronary artery disease.
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Repeat bone mineral density screening and prediction of hip and major osteoporotic fracture. JAMA. 2013 Sep 25; 310(12):1256-62.
Repeat bone mineral density screening and prediction of hip and major osteoporotic fracture.
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American journal of physical medicine & rehabilitation
Is kyphosis related to mobility, balance, and disability? Am J Phys Med Rehabil. 2013 Nov; 92(11):980-9.
Is kyphosis related to mobility, balance, and disability?
Journal of science and medicine in sport
Safety and severity of accelerations delivered from whole body vibration exercise devices to standing adults. J Sci Med Sport. 2013 Nov; 16(6):526-31.
Safety and severity of accelerations delivered from whole body vibration exercise devices to standing adults.
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Selecting Appropriate Clinical Trial Endpoints for Geroscience Trials: A Path Towards Consensus.
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medRxiv : the preprint server for health sciences
OPPORTUNISTIC ASSESSMENT OF CARDIOVASCULAR RISK USING AI-DERIVED STRUCTURAL AORTIC AND CARDIAC PHENOTYPES FROM NON-CONTRAST CHEST COMPUTED TOMOGRAPHY. medRxiv. 2025 Jan 29.
OPPORTUNISTIC ASSESSMENT OF CARDIOVASCULAR RISK USING AI-DERIVED STRUCTURAL AORTIC AND CARDIAC PHENOTYPES FROM NON-CONTRAST CHEST COMPUTED TOMOGRAPHY.
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Rheumatoid arthritis and subsequent fracture risk: an individual person meta-analysis to update FRAX.
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Combining Exercise Training and Testosterone Therapy in Older Women After Hip Fracture: The STEP-HI Randomized Clinical Trial. JAMA Netw Open. 2025 05 01; 8(5):e2510512.
Combining Exercise Training and Testosterone Therapy in Older Women After Hip Fracture: The STEP-HI Randomized Clinical Trial.
Zhang X, Su KJ, Banerjee B, Eres I, Hsu YH, Crandall CJ, Donaka R, Han Z, Jackson RD, Liu H, Luo Z, Mitchell BD, Qiu C, Tian Q, Shen H, Tsai MJ, Wiggins KL, Xu H, Yau M, Zhao LJ, Zhang X, Montasser ME, Kiel DP, Deng HW, Liu CT, Karasik D
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Multi-ancestry whole genome sequencing analysis of lean body mass.
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The association of gut microbiome composition with musculoskeletal features in middle-aged and older adults: a two-cohort joint study. medRxiv. 2025 Feb 22.
The association of gut microbiome composition with musculoskeletal features in middle-aged and older adults: a two-cohort joint study.
Concerns about the paper, "Benefits of targeted vibration for bone strength and bone density in postmenopausal women with osteopenia: a randomized, sham-controlled trial". JBMR Plus. 2025 May; 9(5):ziaf051.
Concerns about the paper, "Benefits of targeted vibration for bone strength and bone density in postmenopausal women with osteopenia: a randomized, sham-controlled trial".
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The heritability of circulating testosterone, oestradiol, oestrone and sex hormone binding globulin concentrations in men: the Framingham Heart Study. Clin Endocrinol (Oxf). 2014 Feb; 80(2):277-82.
The heritability of circulating testosterone, oestradiol, oestrone and sex hormone binding globulin concentrations in men: the Framingham Heart Study.
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Erratum to: Milk and yogurt consumption are linked with higher bone mineral density but not with hip fracture: the Framingham Offspring Study. Arch Osteoporos. 2013 Dec; 8(1-2):132.
Erratum to: Milk and yogurt consumption are linked with higher bone mineral density but not with hip fracture: the Framingham Offspring Study.
Oei L, Hsu YH, Styrkarsdottir U, Eussen BH, de Klein A, Peters MJ, Halldorsson B, Liu CT, Alonso N, Kaptoge SK, Thorleifsson G, Hallmans G, Hocking LJ, Husted LB, Jameson KA, Kruk M, Lewis JR, Patel MS, Scollen S, Svensson O, Trompet S, van Schoor NM, Zhu K, Buckley BM, Cooper C, Ford I, Goltzman D, González-Macías J, Langdahl BL, Leslie WD, Lips P, Lorenc RS, Olmos JM, Pettersson-Kymmer U, Reid DM, Riancho JA, Slagboom PE, Garcia-Ibarbia C, Ingvarsson T, Johannsdottir H, Luben R, Medina-Gómez C, Arp P, Nandakumar K, Palsson ST, Sigurdsson G, van Meurs JB, Zhou Y, Hofman A, Jukema JW, Pols HA, Prince RL, Cupples LA, Marshall CR, Pinto D, Sato D, Scherer SW, Reeve J, Thorsteinsdottir U, Karasik D, Richards JB, Stefansson K, Uitterlinden AG, Ralston SH, Ioannidis JP, Kiel DP, Rivadeneira F, Estrada K
A genome-wide copy number association study of osteoporotic fractures points to the 6p25.1 locus. J Med Genet. 2014 Feb; 51(2):122-31.
A genome-wide copy number association study of osteoporotic fractures points to the 6p25.1 locus.
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Erratum to: Vitamin D Status and Bone Mineral Density Changes During Alendronate Treatment in Postmenopausal Osteoporosis. Calcif Tissue Int. 2014 Feb; 94(2):158.
Erratum to: Vitamin D Status and Bone Mineral Density Changes During Alendronate Treatment in Postmenopausal Osteoporosis.
Roux C, Binkley N, Boonen S, Kiel DP, Ralston SH, Reginster JY, Regnister JY, Pong A, Rosenberg E, Santora A
Vitamin D status and bone mineral density changes during alendronate treatment in postmenopausal osteoporosis. Calcif Tissue Int. 2014 Feb; 94(2):153-7.
Vitamin D status and bone mineral density changes during alendronate treatment in postmenopausal osteoporosis.
Samelson EJ, Miller PD, Christiansen C, Daizadeh NS, Grazette L, Anthony MS, Egbuna O, Wang A, Siddhanti SR, Cheung AM, Franchimont N, Kiel DP
RANKL inhibition with denosumab does not influence 3-year progression of aortic calcification or incidence of adverse cardiovascular events in postmenopausal women with osteoporosis and high cardiovascular risk. J Bone Miner Res. 2014 Feb; 29(2):450-7.
RANKL inhibition with denosumab does not influence 3-year progression of aortic calcification or incidence of adverse cardiovascular events in postmenopausal women with osteoporosis and high cardiovascular risk.
Sahni S, Broe KE, Tucker KL, McLean RR, Kiel DP, Cupples LA, Hannan MT
Association of total protein intake with bone mineral density and bone loss in men and women from the Framingham Offspring Study. Public Health Nutr. 2014 Nov; 17(11):2570-6.
Association of total protein intake with bone mineral density and bone loss in men and women from the Framingham Offspring Study.
Bruno AG, Broe KE, Zhang X, Samelson EJ, Meng CA, Manoharan R, D'Agostino J, Cupples LA, Kiel DP, Bouxsein ML
Vertebral size, bone density, and strength in men and women matched for age and areal spine BMD. J Bone Miner Res. 2014 Mar; 29(3):562-9.
Vertebral size, bone density, and strength in men and women matched for age and areal spine BMD.
Oei L, Estrada K, Duncan EL, Christiansen C, Liu CT, Langdahl BL, Obermayer-Pietsch B, Riancho JA, Prince RL, van Schoor NM, McCloskey E, Hsu YH, Evangelou E, Ntzani E, Evans DM, Alonso N, Husted LB, Valero C, Hernandez JL, Lewis JR, Kaptoge SK, Zhu K, Cupples LA, Medina-Gómez C, Vandenput L, Kim GS, Hun Lee S, Castaño-Betancourt MC, Oei EH, Martinez J, Daroszewska A, van der Klift M, Mellström D, Herrera L, Karlsson MK, Hofman A, Ljunggren Ö, Pols HA, Stolk L, van Meurs JB, Ioannidis JP, Zillikens MC, Lips P, Karasik D, Uitterlinden AG, Styrkarsdottir U, Brown MA, Koh JM, Richards JB, Reeve J, Ohlsson C, Ralston SH, Kiel DP, Rivadeneira F
Genome-wide association study for radiographic vertebral fractures: a potential role for the 16q24 BMD locus. Bone. 2014 Feb; 59:20-7.
Genome-wide association study for radiographic vertebral fractures: a potential role for the 16q24 BMD locus.
Alley DE, Shardell MD, Peters KW, McLean RR, Dam TT, Kenny AM, Fragala MS, Harris TB, Kiel DP, Guralnik JM, Ferrucci L, Kritchevsky SB, Studenski SA, Vassileva MT, Cawthon PM
Grip strength cutpoints for the identification of clinically relevant weakness. J Gerontol A Biol Sci Med Sci. 2014 May; 69(5):559-66.
Grip strength cutpoints for the identification of clinically relevant weakness.
Studenski SA, Peters KW, Alley DE, Cawthon PM, McLean RR, Harris TB, Ferrucci L, Guralnik JM, Fragala MS, Kenny AM, Kiel DP, Kritchevsky SB, Shardell MD, Dam TT, Vassileva MT
The FNIH sarcopenia project: rationale, study description, conference recommendations, and final estimates. J Gerontol A Biol Sci Med Sci. 2014 May; 69(5):547-58.
The FNIH sarcopenia project: rationale, study description, conference recommendations, and final estimates.
McLean RR, Shardell MD, Alley DE, Cawthon PM, Fragala MS, Harris TB, Kenny AM, Peters KW, Ferrucci L, Guralnik JM, Kritchevsky SB, Kiel DP, Vassileva MT, Xue QL, Perera S, Studenski SA, Dam TT
Criteria for clinically relevant weakness and low lean mass and their longitudinal association with incident mobility impairment and mortality: the foundation for the National Institutes of Health (FNIH) sarcopenia project. J Gerontol A Biol Sci Med Sci. 2014 May; 69(5):576-83.
Criteria for clinically relevant weakness and low lean mass and their longitudinal association with incident mobility impairment and mortality: the foundation for the National Institutes of Health (FNIH) sarcopenia project.
Erratum to: The factor-of-risk biomechanical approach predicts hip fracture in men and women: the Framingham Study. Osteoporos Int. 2014 May; 25(5):1657.
Erratum to: The factor-of-risk biomechanical approach predicts hip fracture in men and women: the Framingham Study.
Cawthon PM, Peters KW, Shardell MD, McLean RR, Dam TT, Kenny AM, Fragala MS, Harris TB, Kiel DP, Guralnik JM, Ferrucci L, Kritchevsky SB, Vassileva MT, Studenski SA, Alley DE
Cutpoints for low appendicular lean mass that identify older adults with clinically significant weakness. J Gerontol A Biol Sci Med Sci. 2014 May; 69(5):567-75.
Cutpoints for low appendicular lean mass that identify older adults with clinically significant weakness.
Dam TT, Peters KW, Fragala M, Cawthon PM, Harris TB, McLean R, Shardell M, Alley DE, Kenny A, Ferrucci L, Guralnik J, Kiel DP, Kritchevsky S, Vassileva MT, Studenski S
An evidence-based comparison of operational criteria for the presence of sarcopenia. J Gerontol A Biol Sci Med Sci. 2014 May; 69(5):584-90.
An evidence-based comparison of operational criteria for the presence of sarcopenia.
Treating hypertension in the elderly: should the risk of falls be part of the equation? JAMA Intern Med. 2014 Apr; 174(4):596-7.
Treating hypertension in the elderly: should the risk of falls be part of the equation?
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Genetic determinants of heel bone properties: genome-wide association meta-analysis and replication in the GEFOS/GENOMOS consortium. Hum Mol Genet. 2014 Jun 01; 23(11):3054-68.
Genetic determinants of heel bone properties: genome-wide association meta-analysis and replication in the GEFOS/GENOMOS consortium.
Misra D, Zhang Y, Peloquin C, Choi HK, Kiel DP, Neogi T
Incident long-term warfarin use and risk of osteoporotic fractures: propensity-score matched cohort of elders with new onset atrial fibrillation. Osteoporos Int. 2014 Jun; 25(6):1677-84.
Incident long-term warfarin use and risk of osteoporotic fractures: propensity-score matched cohort of elders with new onset atrial fibrillation.
Hughes RJ, Anderson KL, Kiel D, Insel PA
Cloning of GRK2 cDNA from S49 murine lymphoma cells. Am J Physiol. 1996 Mar; 270(3 Pt 1):C885-91.
Cloning of GRK2 cDNA from S49 murine lymphoma cells.
Han T, Qu Y, Zhu J, Sha L, Lei B, Xiang R, Zhao X, Hou J, Deng Q, Zheng S, Zhou J, Yu T, Song X, Yang B, Zhong Y, Xia M, Kiel DP, Jiang X
A comprehensive multi-layered analysis reveals genetic pleiotropy underlying coronary artery calcification and bone mineral density. Bone. 2026 Feb; 203:117719.
A comprehensive multi-layered analysis reveals genetic pleiotropy underlying coronary artery calcification and bone mineral density.
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Vitamin D Supplementation and Increased Risk of Falling: A Cautionary Tale of Vitamin Supplements Retold. JAMA Intern Med. 2016 Feb; 176(2):171-2.
Vitamin D Supplementation and Increased Risk of Falling: A Cautionary Tale of Vitamin Supplements Retold.
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Associations of Computed Tomography-Based Trunk Muscle Size and Density With Balance and Falls in Older Adults. J Gerontol A Biol Sci Med Sci. 2016 06; 71(6):811-6.
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European journal of human genetics : EJHG
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Evaluation of power of the Illumina HumanOmni5M-4v1 BeadChip to detect risk variants for human complex diseases.
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Severity of Kyphosis and Decline in Lung Function: The Framingham Study. J Gerontol A Biol Sci Med Sci. 2017 May 01; 72(5):689-694.
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Incidence of Hip Fracture in U.S. Nursing Homes. J Gerontol A Biol Sci Med Sci. 2016 09; 71(9):1230-4.
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OSTEOGENIC MECHANICAL STIMULI-PREVENT/REVERSE BONE LOSS
Low Magnitude Mechanical Stimulation to Improve BMD
Novel Molecular Biomarkers of Bone Microarchitecture
Harvard Older Americans Independence Center
Trochanteric Padding to Prevent Hip Fractures
Targeted Sequencing of 3 Loci Associated with BMD in the Framingham Osteoporosis
The Gut Microbiome and Bone Microarchitecture
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GWAS analysis of handgrip and lower body strength in older adults in the CHARGE consortium. Aging Cell. 2016 10; 15(5):792-800.
GWAS analysis of handgrip and lower body strength in older adults in the CHARGE consortium.
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DNA methylation-based measures of biological age: meta-analysis predicting time to death.
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Intermittent Nitrate Use and Risk of Hip Fracture. Am J Med. 2017 02; 130(2):229.e15-229.e20.
Intermittent Nitrate Use and Risk of Hip Fracture.
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Epigenetic Signatures of Cigarette Smoking.
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European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society
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Goal-Directed Treatment for Osteoporosis: A Progress Report From the ASBMR-NOF Working Group on Goal-Directed Treatment for Osteoporosis.
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Targeted sequencing of genome wide significant loci associated with bone mineral density (BMD) reveals significant novel and rare variants: the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) targeted sequencing study.
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A combined reference panel from the 1000?Genomes and UK10K projects improved rare variant imputation in European and Chinese samples. Sci Rep. 2016 12 22; 6:39313.
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The complex genetics of gait speed: genome-wide meta-analysis approach. Aging (Albany NY). 2017 01 10; 9(1):209-246.
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Novel Genetic Variants Associated With Increased Vertebral Volumetric BMD, Reduced Vertebral Fracture Risk, and Increased Expression of SLC1A3 and EPHB2. J Bone Miner Res. 2016 12; 31(12):2085-2097.
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American Society for Bone and Mineral Research
NIH Ad Hoc Reviewer Epidemiology and Disease Control-2, NRRC, and Geriatrics & Rehab Study Sections
Henry J. Kaiser Family Foundation Faculty Scholar in General Internal Medicine
Faculty Scholar in General Internal Medicine
Surgeon General's Report on Women and Smoking
Nominated for Excellence in Mentoring Award, nominee
Appointment to NIA Clinical Trials Advisory Panel
Clifford Barger Excellence in Mentoring Award
"Feasibility and Dosing Study of Bone Density Changes with and without PEMF..."
Annual Center for Faculty Development Membership Award for Excellence Mentoring
NIH Study Section, Epidemiology and Disease Control 3
The Surgeon General's Workshop on Osteoporosis and Bone Health
Nominated for Excellence in Mentoring Award
The Surgeon General's Report on Osteoporosis and Bone Health
Outstanding Excellence in Geriatric Research All Categories
The Journal of pharmacology and experimental therapeutics
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Epigenome-wide Association of DNA Methylation in Whole Blood With Bone Mineral Density.
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