Zhou, Jing
eCommons Login: JZ6
first name: Jing
last name: Zhou
coauthor of: Takakura, Ayumi
coauthor of: Kreidberg, Jordan
coauthor of: Ingber, Don
coauthor of: Bonventre, Joseph
coauthor of: Brown, Edward
full name: Jing Zhou, M.D., Ph.D.
has faculty rank: Full Professor
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latitude: 42.33837200000000
longitude: -71.10326900000000
Person ID: 38106
person in primary position: Professor of Medicine
physical neighbor: Aikawa, Elena
physical neighbor: Denker, Bradley
physical neighbor: Sabbisetti, Venkata
physical neighbor: Sage, Peter
physical neighbor: Takakura, Ayumi
similar to: Alkuraya, Fowzan
similar to: Hildebrandt, Friedhelm
similar to: Bonventre, Joseph
similar to: Clapham, David
similar to: Alper, Seth
type: Agent
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selected publications: Authorship 780044
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Magnetic resonance imaging assessment of a murine model of recessive polycystic kidney disease.
PubMed Identifier: 12405636
author list: Sun Y, Zhou J, Stayner C, Munasinghe J, Shen X, Beier DR, Albert MS
published in: Comparative medicine
information resource reference: Magnetic resonance imaging assessment of a murine model of recessive polycystic kidney disease. Comp Med. 2002 Oct; 52(5):433-8.
journal title abbreviation: Comp Med
publication date: 2002-10-01T00:00:00
year: 2002
type: Academic Article
type: Article
type: Document
type: Information Resource

Polycystic kidney disease: the complete structure of the PKD1 gene and its protein. The International Polycystic Kidney Disease Consortium.
PubMed Identifier: 7736581
published in: Cell
information resource reference: Polycystic kidney disease: the complete structure of the PKD1 gene and its protein. The International Polycystic Kidney Disease Consortium. Cell. 1995 Apr 21; 81(2):289-98.
journal title abbreviation: Cell
publication date: 1995-04-21T00:00:00
year: 1995
type: Academic Article
type: Article
type: Document
type: Information Resource

Transport function of the naturally occurring pathogenic polycystin-2 mutant, R742X.
PubMed Identifier: 11302751
author list: Chen XZ, Segal Y, Basora N, Guo L, Peng JB, Babakhanlou H, Vassilev PM, Brown EM, Hediger MA, Zhou J
published in: Biochemical and biophysical research communications
information resource reference: Transport function of the naturally occurring pathogenic polycystin-2 mutant, R742X. Biochem Biophys Res Commun. 2001 Apr 20; 282(5):1251-6.
journal title abbreviation: Biochem Biophys Res Commun
publication date: 2001-04-20T00:00:00
year: 2001
type: Academic Article
type: Article
type: Document
type: Information Resource

Deletions in the COL4A5 collagen gene in X-linked Alport syndrome. Characterization of the pathological transcripts in nonrenal cells and correlation with disease expression.
PubMed Identifier: 8132760
author list: Antignac C, Knebelmann B, Drouot L, Gros F, Deschênes G, Hors-Cayla MC, Zhou J, Tryggvason K, Grünfeld JP, Broyer M
published in: The Journal of clinical investigation
information resource reference: Deletions in the COL4A5 collagen gene in X-linked Alport syndrome. Characterization of the pathological transcripts in nonrenal cells and correlation with disease expression. J Clin Invest. 1994 Mar; 93(3):1195-207.
journal title abbreviation: J Clin Invest
publication date: 1994-03-01T00:00:00
year: 1994
type: Academic Article
type: Article
type: Document
type: Information Resource

Structure of the human type IV collagen COL4A6 gene, which is mutated in Alport syndrome-associated leiomyomatosis.
PubMed Identifier: 8661006
author list: Zhang X, Zhou J, Reeders ST, Tryggvason K
published in: Genomics
information resource reference: Structure of the human type IV collagen COL4A6 gene, which is mutated in Alport syndrome-associated leiomyomatosis. Genomics. 1996 May 01; 33(3):473-9.
journal title abbreviation: Genomics
publication date: 1996-05-01T00:00:00
year: 1996
type: Academic Article
type: Article
type: Document
type: Information Resource

Renal injury is a third hit promoting rapid development of adult polycystic kidney disease.
PubMed Identifier: 19342421
author list: Takakura A, Contrino L, Zhou X, Bonventre JV, Sun Y, Humphreys BD, Zhou J
published in: Human molecular genetics
information resource reference: Renal injury is a third hit promoting rapid development of adult polycystic kidney disease. Hum Mol Genet. 2009 Jul 15; 18(14):2523-31.
journal title abbreviation: Hum Mol Genet
publication date: 2009-04-02T00:00:00
year: 2009
type: Academic Article
type: Article
type: Document
type: Information Resource

Polycystins and primary cilia: primers for cell cycle progression.
PubMed Identifier: 19572811
author list: Zhou J
published in: Annual review of physiology
information resource reference: Polycystins and primary cilia: primers for cell cycle progression. Annu Rev Physiol. 2009; 71:83-113.
journal title abbreviation: Annu Rev Physiol
publication date: 2009-01-01T00:00:00
year: 2009
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 110391
type: Authorship
author rank in publication: 7
linked author: Zhou, Jing
linked information resource: Tissue and cellular localization of a novel polycystic kidney disease-like gene product, polycystin-L.

Polycystic kidney disease protein fibrocystin localizes to the mitotic spindle and regulates spindle bipolarity.
PubMed Identifier: 20554582
author list: Zhang J, Wu M, Wang S, Shah JV, Wilson PD, Zhou J
published in: Human molecular genetics
information resource reference: Polycystic kidney disease protein fibrocystin localizes to the mitotic spindle and regulates spindle bipolarity. Hum Mol Genet. 2010 Sep 01; 19(17):3306-19.
journal title abbreviation: Hum Mol Genet
publication date: 2010-06-16T00:00:00
year: 2010
type: Academic Article
type: Article
type: Document
type: Information Resource

Smooth muscle tumors associated with X-linked Alport syndrome: carrier detection in females.
PubMed Identifier: 8587250
author list: Dahan K, Heidet L, Zhou J, Mettler G, Leppig KA, Proesmans W, David A, Roussel B, Mongeau JG, Gould JM
published in: Kidney international
information resource reference: Smooth muscle tumors associated with X-linked Alport syndrome: carrier detection in females. Kidney Int. 1995 Dec; 48(6):1900-6.
journal title abbreviation: Kidney Int
publication date: 1995-12-01T00:00:00
year: 1995
type: Academic Article
type: Article
type: Document
type: Information Resource

Pyrimethamine inhibits adult polycystic kidney disease by modulating STAT signaling pathways.
PubMed Identifier: 21821671
author list: Takakura A, Nelson EA, Haque N, Humphreys BD, Zandi-Nejad K, Frank DA, Zhou J
published in: Human molecular genetics
information resource reference: Pyrimethamine inhibits adult polycystic kidney disease by modulating STAT signaling pathways. Hum Mol Genet. 2011 Nov 01; 20(21):4143-54.
journal title abbreviation: Hum Mol Genet
publication date: 2011-08-05T00:00:00
year: 2011
type: Academic Article
type: Article
type: Document
type: Information Resource

Polycystins and mechanosensation in renal and nodal cilia.
PubMed Identifier: 15273987
author list: Nauli SM, Zhou J
published in: BioEssays : news and reviews in molecular, cellular and developmental biology
information resource reference: Polycystins and mechanosensation in renal and nodal cilia. Bioessays. 2004 Aug; 26(8):844-56.
journal title abbreviation: Bioessays
publication date: 2004-08-01T00:00:00
year: 2004
type: Academic Article
type: Article
type: Document
type: Information Resource

Polycystin-1 and polycystin-2 regulate the cell cycle through the helix-loop-helix inhibitor Id2.
PubMed Identifier: 16311606
author list: Li X, Luo Y, Starremans PG, McNamara CA, Pei Y, Zhou J
published in: Nature cell biology
information resource reference: Polycystin-1 and polycystin-2 regulate the cell cycle through the helix-loop-helix inhibitor Id2. Nat Cell Biol. 2005 Dec; 7(12):1202-12.
journal title abbreviation: Nat Cell Biol
publication date: 2005-11-27T00:00:00
year: 2005
type: Academic Article
type: Article
type: Document
type: Information Resource

More than colocalizing with polycystin-1, polycystin-L is in the centrosome.
PubMed Identifier: 16609150
author list: Bui-Xuan EF, Li Q, Chen XZ, Boucher CA, Sandford R, Zhou J, Basora N
published in: American journal of physiology. Renal physiology
information resource reference: More than colocalizing with polycystin-1, polycystin-L is in the centrosome. Am J Physiol Renal Physiol. 2006 Aug; 291(2):F395-406.
journal title abbreviation: Am J Physiol Renal Physiol
publication date: 2006-04-11T00:00:00
year: 2006
type: Academic Article
type: Article
type: Document
type: Information Resource

Tissue-engineered three-dimensional in vitro models for normal and diseased kidney.
PubMed Identifier: 20486787
author list: Subramanian B, Rudym D, Cannizzaro C, Perrone R, Zhou J, Kaplan DL
published in: Tissue engineering. Part A
information resource reference: Tissue-engineered three-dimensional in vitro models for normal and diseased kidney. Tissue Eng Part A. 2010 Sep; 16(9):2821-31.
journal title abbreviation: Tissue Eng Part A
publication date: 2010-09-01T00:00:00
year: 2010
type: Academic Article
type: Article
type: Document
type: Information Resource

Differential expression of Cux-1 and p21 in polycystic kidneys from Pkd1 null and cpk mice.
PubMed Identifier: 15673290
author list: Sharma M, Brantley JG, Alcalay NI, Zhou J, Heystek E, Maser RL, Vanden Heuvel GB
published in: Kidney international
information resource reference: Differential expression of Cux-1 and p21 in polycystic kidneys from Pkd1 null and cpk mice. Kidney Int. 2005 Feb; 67(2):432-42.
journal title abbreviation: Kidney Int
publication date: 2005-02-01T00:00:00
year: 2005
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 116307
type: Authorship
author rank in publication: 4
linked author: Zhou, Jing
linked information resource: COL4A5 splice site mutation and alpha 5(IV) collagen mRNA in Alport syndrome.

Deletion of the paired alpha 5(IV) and alpha 6(IV) collagen genes in inherited smooth muscle tumors.
PubMed Identifier: 8356449
author list: Zhou J, Mochizuki T, Smeets H, Antignac C, Laurila P, de Paepe A, Tryggvason K, Reeders ST
published in: Science (New York, N.Y.)
information resource reference: Deletion of the paired alpha 5(IV) and alpha 6(IV) collagen genes in inherited smooth muscle tumors. Science. 1993 Aug 27; 261(5125):1167-9.
journal title abbreviation: Science
publication date: 1993-08-27T00:00:00
year: 1993
type: Academic Article
type: Article
type: Document
type: Information Resource

Molecular genetics of Alport syndrome.
PubMed Identifier: 8433568
author list: Tryggvason K, Zhou J, Hostikka SL, Shows TB
published in: Kidney international
information resource reference: Molecular genetics of Alport syndrome. Kidney Int. 1993 Jan; 43(1):38-44.
journal title abbreviation: Kidney Int
publication date: 1993-01-01T00:00:00
year: 1993
type: Academic Article
type: Article
type: Document
type: Information Resource

Growth of cranial synchondroses and sutures requires polycystin-1.
PubMed Identifier: 18652813
author list: Kolpakova-Hart E, McBratney-Owen B, Hou B, Fukai N, Nicolae C, Zhou J, Olsen BR
published in: Developmental biology
information resource reference: Growth of cranial synchondroses and sutures requires polycystin-1. Dev Biol. 2008 Sep 15; 321(2):407-19.
journal title abbreviation: Dev Biol
publication date: 2008-07-09T00:00:00
year: 2008
type: Academic Article
type: Article
type: Document
type: Information Resource

Acceleration of polycystic kidney disease progression in cpk mice carrying a deletion in the homeodomain protein Cux1.
PubMed Identifier: 18829740
author list: Alcalay NI, Sharma M, Vassmer D, Chapman B, Paul B, Zhou J, Brantley JG, Wallace DP, Maser RL, Vanden Heuvel GB
published in: American journal of physiology. Renal physiology
information resource reference: Acceleration of polycystic kidney disease progression in cpk mice carrying a deletion in the homeodomain protein Cux1. Am J Physiol Renal Physiol. 2008 Dec; 295(6):F1725-34.
journal title abbreviation: Am J Physiol Renal Physiol
publication date: 2008-10-01T00:00:00
year: 2008
type: Academic Article
type: Article
type: Document
type: Information Resource

Aberrant regulation of planar cell polarity in polycystic kidney disease.
PubMed Identifier: 20705705
author list: Luyten A, Su X, Gondela S, Chen Y, Rompani S, Takakura A, Zhou J
published in: Journal of the American Society of Nephrology : JASN
information resource reference: Aberrant regulation of planar cell polarity in polycystic kidney disease. J Am Soc Nephrol. 2010 Sep; 21(9):1521-32.
journal title abbreviation: J Am Soc Nephrol
publication date: 2010-08-12T00:00:00
year: 2010
type: Academic Article
type: Article
type: Document
type: Information Resource

Systems biology approach to identify transcriptome reprogramming and candidate microRNA targets during the progression of polycystic kidney disease.
PubMed Identifier: 21518438
author list: Pandey P, Qin S, Ho J, Zhou J, Kreidberg JA
published in: BMC systems biology
information resource reference: Systems biology approach to identify transcriptome reprogramming and candidate microRNA targets during the progression of polycystic kidney disease. BMC Syst Biol. 2011 Apr 25; 5:56.
journal title abbreviation: BMC Syst Biol
publication date: 2011-04-25T00:00:00
year: 2011
type: Academic Article
type: Article
type: Document
type: Information Resource

c-Met and NF-?B-dependent overexpression of Wnt7a and -7b and Pax2 promotes cystogenesis in polycystic kidney disease.
PubMed Identifier: 22677559
author list: Qin S, Taglienti M, Cai L, Zhou J, Kreidberg JA
published in: Journal of the American Society of Nephrology : JASN
information resource reference: c-Met and NF-?B-dependent overexpression of Wnt7a and -7b and Pax2 promotes cystogenesis in polycystic kidney disease. J Am Soc Nephrol. 2012 Aug; 23(8):1309-18.
journal title abbreviation: J Am Soc Nephrol
publication date: 2012-06-07T00:00:00
year: 2012
type: Academic Article
type: Article
type: Document
type: Information Resource

COL4A5 deletions in three patients with Alport syndrome and posttransplant antiglomerular basement membrane nephritis.
PubMed Identifier: 7993995
author list: Ding J, Zhou J, Tryggvason K, Kashtan CE
published in: Journal of the American Society of Nephrology : JASN
information resource reference: COL4A5 deletions in three patients with Alport syndrome and posttransplant antiglomerular basement membrane nephritis. J Am Soc Nephrol. 1994 Aug; 5(2):161-8.
journal title abbreviation: J Am Soc Nephrol
publication date: 1994-08-01T00:00:00
year: 1994
type: Academic Article
type: Article
type: Document
type: Information Resource

Loss of PKD1 and loss of Bcl-2 elicit polycystic kidney disease through distinct mechanisms.
PubMed Identifier: 16282979
author list: Hughes P, Robati M, Lu W, Zhou J, Strasser A, Bouillet P
published in: Cell death and differentiation
information resource reference: Loss of PKD1 and loss of Bcl-2 elicit polycystic kidney disease through distinct mechanisms. Cell Death Differ. 2006 Jul; 13(7):1123-7.
journal title abbreviation: Cell Death Differ
publication date: 2005-11-11T00:00:00
year: 2005
type: Academic Article
type: Article
type: Document
type: Information Resource

A mouse model for polycystic kidney disease through a somatic in-frame deletion in the 5' end of Pkd1.
PubMed Identifier: 18385665
author list: Starremans PG, Li X, Finnerty PE, Guo L, Takakura A, Neilson EG, Zhou J
published in: Kidney international
information resource reference: A mouse model for polycystic kidney disease through a somatic in-frame deletion in the 5' end of Pkd1. Kidney Int. 2008 Jun; 73(12):1394-405.
journal title abbreviation: Kidney Int
publication date: 2008-04-02T00:00:00
year: 2008
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 110893
type: Authorship
author rank in publication: 6
linked author: Zhou, Jing
linked information resource: Polycystin-1 and polycystin-2 regulate the cell cycle through the helix-loop-helix inhibitor Id2.

A nonsense mutation in the COL4A5 collagen gene in a family with X-linked juvenile Alport syndrome.
PubMed Identifier: 7731166
author list: Hertz JM, Heiskari N, Zhou J, Jensen UB, Tryggvason K
published in: Kidney international
information resource reference: A nonsense mutation in the COL4A5 collagen gene in a family with X-linked juvenile Alport syndrome. Kidney Int. 1995 Jan; 47(1):327-32.
journal title abbreviation: Kidney Int
publication date: 1995-01-01T00:00:00
year: 1995
type: Academic Article
type: Article
type: Document
type: Information Resource

Mutations in the codon for a conserved arginine-1563 in the COL4A5 collagen gene in Alport syndrome.
PubMed Identifier: 8455372
author list: Zhou J, Gregory MC, Hertz JM, Barker DF, Atkin C, Spencer ES, Tryggvason K
published in: Kidney international
information resource reference: Mutations in the codon for a conserved arginine-1563 in the COL4A5 collagen gene in Alport syndrome. Kidney Int. 1993 Mar; 43(3):722-9.
journal title abbreviation: Kidney Int
publication date: 1993-03-01T00:00:00
year: 1993
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 1111842
type: Authorship
linked author: Zhou, Jing
linked information resource: Inhibition of aldehyde reductase isoenzymes in human and rat brain.

Authorship 1111843
type: Authorship
linked author: Zhou, Jing
linked information resource: Atomic models for the polypeptide backbones of myohemerythrin and hemerythrin.

Authorship 1111844
type: Authorship
linked author: Zhou, Jing
linked information resource: Comparison between procaine and isocarboxazid metabolism in vitro by a liver microsomal amidase-esterase.

Authorship 1111845
type: Authorship
linked author: Zhou, Jing
linked information resource: Studies of oxygen binding energy to hemoglobin molecule.

Structure of the human type IV collagen COL4A5 gene.
PubMed Identifier: 8120014
author list: Zhou J, Leinonen A, Tryggvason K
published in: The Journal of biological chemistry
information resource reference: Structure of the human type IV collagen COL4A5 gene. J Biol Chem. 1994 Mar 04; 269(9):6608-14.
journal title abbreviation: J Biol Chem
publication date: 1994-03-04T00:00:00
year: 1994
type: Academic Article
type: Article
type: Document
type: Information Resource

Complete primary structure of the sixth chain of human basement membrane collagen, alpha 6(IV). Isolation of the cDNAs for alpha 6(IV) and comparison with five other type IV collagen chains.
PubMed Identifier: 8175748
author list: Zhou J, Ding M, Zhao Z, Reeders ST
published in: The Journal of biological chemistry
information resource reference: Complete primary structure of the sixth chain of human basement membrane collagen, alpha 6(IV). Isolation of the cDNAs for alpha 6(IV) and comparison with five other type IV collagen chains. J Biol Chem. 1994 May 06; 269(18):13193-9.
journal title abbreviation: J Biol Chem
publication date: 1994-05-06T00:00:00
year: 1994
type: Academic Article
type: Article
type: Document
type: Information Resource

Identification of four novel mutations in the COL4A5 gene of patients with Alport syndrome.
PubMed Identifier: 8406498
author list: Lemmink HH, Schröder CH, Brunner HG, Nelen MR, Zhou J, Tryggvason K, Haagsma-Schouten WA, Roodvoets AP, Rascher W, van Oost BA
published in: Genomics
information resource reference: Identification of four novel mutations in the COL4A5 gene of patients with Alport syndrome. Genomics. 1993 Aug; 17(2):485-9.
journal title abbreviation: Genomics
publication date: 1993-08-01T00:00:00
year: 1993
type: Academic Article
type: Article
type: Document
type: Information Resource

Pax2 gene dosage influences cystogenesis in autosomal dominant polycystic kidney disease.
PubMed Identifier: 17082250
author list: Stayner C, Iglesias DM, Goodyer PR, Ellis L, Germino G, Zhou J, Eccles MR
published in: Human molecular genetics
information resource reference: Pax2 gene dosage influences cystogenesis in autosomal dominant polycystic kidney disease. Hum Mol Genet. 2006 Dec 15; 15(24):3520-8.
journal title abbreviation: Hum Mol Genet
publication date: 2006-11-02T00:00:00
year: 2006
type: Academic Article
type: Article
type: Document
type: Information Resource

Col2-Cre recombinase is co-expressed with endogenous type II collagen in embryonic renal epithelium and drives development of polycystic kidney disease following inactivation of ciliary genes.
PubMed Identifier: 18579360
author list: Kolpakova-Hart E, Nicolae C, Zhou J, Olsen BR
published in: Matrix biology : journal of the International Society for Matrix Biology
information resource reference: Col2-Cre recombinase is co-expressed with endogenous type II collagen in embryonic renal epithelium and drives development of polycystic kidney disease following inactivation of ciliary genes. Matrix Biol. 2008 Jul; 27(6):505-12.
journal title abbreviation: Matrix Biol
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A human PKD1 transgene generates functional polycystin-1 in mice and is associated with a cystic phenotype.
PubMed Identifier: 11063721
author list: Pritchard L, Sloane-Stanley JA, Sharpe JA, Aspinwall R, Lu W, Buckle V, Strmecki L, Walker D, Ward CJ, Alpers CE, Zhou J, Wood WG, Harris PC
published in: Human molecular genetics
information resource reference: A human PKD1 transgene generates functional polycystin-1 in mice and is associated with a cystic phenotype. Hum Mol Genet. 2000 Nov 01; 9(18):2617-27.
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Polycystin channels and kidney disease.
PubMed Identifier: 11698076
author list: Stayner C, Zhou J
published in: Trends in pharmacological sciences
information resource reference: Polycystin channels and kidney disease. Trends Pharmacol Sci. 2001 Nov; 22(11):543-6.
journal title abbreviation: Trends Pharmacol Sci
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Polycystins 1 and 2 mediate mechanosensation in the primary cilium of kidney cells.
PubMed Identifier: 12514735
author list: Nauli SM, Alenghat FJ, Luo Y, Williams E, Vassilev P, Li X, Elia AE, Lu W, Brown EM, Quinn SJ, Ingber DE, Zhou J
published in: Nature genetics
information resource reference: Polycystins 1 and 2 mediate mechanosensation in the primary cilium of kidney cells. Nat Genet. 2003 Feb; 33(2):129-37.
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Native polycystin 2 functions as a plasma membrane Ca2+-permeable cation channel in renal epithelia.
PubMed Identifier: 12640140
author list: Luo Y, Vassilev PM, Li X, Kawanabe Y, Zhou J
published in: Molecular and cellular biology
information resource reference: Native polycystin 2 functions as a plasma membrane Ca2+-permeable cation channel in renal epithelia. Mol Cell Biol. 2003 Apr; 23(7):2600-7.
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Characterization of the 3' half of the human type IV collagen alpha 5 gene that is affected in the Alport syndrome.
PubMed Identifier: 2004755
author list: Zhou J, Hostikka SL, Chow LT, Tryggvason K
published in: Genomics
information resource reference: Characterization of the 3' half of the human type IV collagen alpha 5 gene that is affected in the Alport syndrome. Genomics. 1991 Jan; 9(1):1-9.
journal title abbreviation: Genomics
publication date: 1991-01-01T00:00:00
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Co-inheritance of a PKD1 mutation and homozygous PKD2 variant: a potential modifier in autosomal dominant polycystic kidney disease.
PubMed Identifier: 18257781
author list: Dedoussis GV, Luo Y, Starremans P, Rossetti S, Ramos AJ, Cantiello HF, Katsareli E, Ziroyannis P, Lamnissou K, Harris PC, Zhou J
published in: European journal of clinical investigation
information resource reference: Co-inheritance of a PKD1 mutation and homozygous PKD2 variant: a potential modifier in autosomal dominant polycystic kidney disease. Eur J Clin Invest. 2008 Mar; 38(3):180-90.
journal title abbreviation: Eur J Clin Invest
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Identification of polycystin-1 and Ga12 binding regions necessary for regulation of apoptosis.
PubMed Identifier: 20837139
author list: Yu W, Ritchie BJ, Su X, Zhou J, Meigs TE, Denker BM
published in: Cellular signalling
information resource reference: Identification of polycystin-1 and Ga12 binding regions necessary for regulation of apoptosis. Cell Signal. 2011 Jan; 23(1):213-21.
journal title abbreviation: Cell Signal
publication date: 2010-09-17T00:00:00
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type: Academic Article
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Polycystic Kidney Diseases
MeSH DescriptorUI: D007690
MeSH semantic group name: Anatomy
MeSH semantic group name: Disorders
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number of publications: 127
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Polycystic Kidney, Autosomal Dominant
MeSH DescriptorUI: D016891
MeSH semantic group name: Disorders
number of authors: 71
number of publications: 142
uniqueness weight: 0.905316
type: Concept

TRPP Cation Channels
MeSH DescriptorUI: D050396
MeSH semantic group name: Chemicals & Drugs
number of authors: 62
number of publications: 173
uniqueness weight: 0.921769
type: Concept

Cilia
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MeSH semantic group name: Anatomy
number of authors: 246
number of publications: 510
uniqueness weight: 0.715777
type: Concept

Nephritis, Hereditary
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number of publications: 81
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Emeritus
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Medicine
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Pediatrics
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Surgery
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Cardiology
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Nephrology
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Genetics
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Renal
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Beth Israel Deaconess Medical Center
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Brigham and Women's Hospital
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Boston Children's Hospital
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Harvard Medical School
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Authorship 144483
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linked information resource: Distribution and developmentally regulated expression of murine polycystin.

Authorship 122975
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linked information resource: X-linked Alport syndrome: an SSCP-based mutation survey over all 51 exons of the COL4A5 gene.

Samuel A. Levine Distinguished Professor of Medicine
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Authorship 169252
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linked information resource: Identification and localization of polycystin, the PKD1 gene product.

Authorship 156319
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linked information resource: Polycystic kidney disease: the complete structure of the PKD1 gene and its protein. The International Polycystic Kidney Disease Consortium.

Authorship 195877
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linked author: Zhou, Jing
linked information resource: Overexpression of innate immune response genes in a model of recessive polycystic kidney disease.

Authorship 225749
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linked information resource: The sequence, expression, and chromosomal localization of a novel polycystic kidney disease 1-like gene, PKD1L1, in human.

Authorship 227429
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linked information resource: Pax2 gene dosage influences cystogenesis in autosomal dominant polycystic kidney disease.

Authorship 165403
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linked information resource: CECIL: a database for storing and retrieving clinical and molecular information on patients with Alport syndrome.

Authorship 193722
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linked information resource: Polycystin-2 is a novel cation channel implicated in defective intracellular Ca(2+) homeostasis in polycystic kidney disease.

Authorship 186040
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linked information resource: Evidence for genetic heterogeneity in benign familial hematuria.

Authorship 378623
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linked information resource: Expression of mRNA for type IV collagen alpha1, alpha5 and alpha6 chains by cultured dermal fibroblasts from patients with X-linked Alport syndrome.

Associate Professor of Medicine
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Authorship 180074
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Professor of Medicine
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Authorship 575238
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linked information resource: Growth of cranial synchondroses and sutures requires polycystin-1.

Modulation of cystogenesis
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Principal Investigator
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Authorship 367891
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linked information resource: Complete primary structure of the sixth chain of human basement membrane collagen, alpha 6(IV). Isolation of the cDNAs for alpha 6(IV) and comparison with five other type IV collagen chains.

Authorship 370359
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linked information resource: Structure of the human type IV collagen COL4A5 gene.

Instructor in Medicine
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Authorship 298231
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linked information resource: Regulation of the paired type IV collagen genes COL4A5 and COL4A6. Role of the proximal promoter region.

Authorship 299881
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linked information resource: LINE-1 elements at the sites of molecular rearrangements in Alport syndrome-diffuse leiomyomatosis.

Authorship 517728
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linked information resource: Perinatal lethality with kidney and pancreas defects in mice with a targetted Pkd1 mutation.

Authorship 573731
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linked information resource: Smooth muscle tumors associated with X-linked Alport syndrome: carrier detection in females.

Authorship 230752
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linked information resource: Loss of PKD1 and loss of Bcl-2 elicit polycystic kidney disease through distinct mechanisms.

Authorship 217910
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linked information resource: Loss of polycystin-1 in human cyst-lining epithelia leads to ciliary dysfunction.

Reduced ciliary polycystin-2 in induced pluripotent stem cells from polycystic kidney disease patients with PKD1 mutations.
PubMed Identifier: 24009235
author list: Freedman BS, Lam AQ, Sundsbak JL, Iatrino R, Su X, Koon SJ, Wu M, Daheron L, Harris PC, Zhou J, Bonventre JV
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Professor of Medicine, Emeritus
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Authorship 355419
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linked information resource: A human PKD1 transgene generates functional polycystin-1 in mice and is associated with a cystic phenotype.

Comparison between procaine and isocarboxazid metabolism in vitro by a liver microsomal amidase-esterase.
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Inhibition of aldehyde reductase isoenzymes in human and rat brain.
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Authorship 425574
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linked information resource: Deletion mapping in Alport syndrome and Alport syndrome-diffuse leiomyomatosis reveals potential mechanisms of visceral smooth muscle overgrowth.

Authorship 438893
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linked information resource: COL4A5 deletions in three patients with Alport syndrome and posttransplant antiglomerular basement membrane nephritis.

Authorship 29196
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linked information resource: Deletions of both alpha 5(IV) and alpha 6(IV) collagen genes in Alport syndrome and in Alport syndrome associated with smooth muscle tumours.

Polycystin-1 regulates actin cytoskeleton organization and directional cell migration through a novel PC1-Pacsin 2-N-Wasp complex.
PubMed Identifier: 24385601
author list: Yao G, Su X, Nguyen V, Roberts K, Li X, Takakura A, Plomann M, Zhou J
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information resource reference: Polycystin-1 regulates actin cytoskeleton organization and directional cell migration through a novel PC1-Pacsin 2-N-Wasp complex. Hum Mol Genet. 2014 May 15; 23(10):2769-79.
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Authorship 272650
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linked information resource: Different mutations in the COL4A5 collagen gene in two patients with different features of Alport syndrome.

Authorship 345058
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linked information resource: Modulation of the human polycystin-L channel by voltage and divalent cations.

The cytoplasmic tail of FPC antagonizes the full-length protein in the regulation of mTOR pathway.
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Authorship 35588
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Authorship 181367
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linked information resource: Seminiferous tubule basement membrane. Composition and organization of type IV collagen chains, and the linkage of alpha3(IV) and alpha5(IV) chains.

Professor of Medicine, Part-time
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Professor of Medicine
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Professor of Medicine
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Judah Folkman Professor of Vascular Biology in the Department of Surgery
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Authorship 37552
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Authorship 570925
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linked information resource: Alport syndrome: a genetic study of 31 families.

Bardet-Biedl syndrome proteins 1 and 3 regulate the ciliary trafficking of polycystic kidney disease 1 protein.
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Authorship 472559
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Authorship 780044
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linked information resource: Effects of Shiga toxin type 2 on a bioengineered three-dimensional model of human renal tissue.

Authorship 780045
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linked information resource: Bardet-Biedl syndrome proteins 1 and 3 regulate the ciliary trafficking of polycystic kidney disease 1 protein.

Authorship 780046
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linked information resource: L-type calcium channel modulates cystic kidney phenotype.

Authorship 780047
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linked information resource: Aberrant glycosylation and localization of polycystin-1 cause polycystic kidney in an AQP11 knockout model.

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author rank in publication: 5
linked author: Zhou, Jing
linked information resource: The cytoplasmic tail of FPC antagonizes the full-length protein in the regulation of mTOR pathway.

Authorship 780049
type: Authorship
author rank in publication: 8
linked author: Zhou, Jing
linked information resource: Polycystin-1 regulates actin cytoskeleton organization and directional cell migration through a novel PC1-Pacsin 2-N-Wasp complex.

Authorship 780050
type: Authorship
author rank in publication: 12
linked author: Zhou, Jing
linked information resource: Survivin-induced abnormal ploidy contributes to cystic kidney and aneurysm formation.

Authorship 780051
type: Authorship
author rank in publication: 10
linked author: Zhou, Jing
linked information resource: Reduced ciliary polycystin-2 in induced pluripotent stem cells from polycystic kidney disease patients with PKD1 mutations.

Authorship 780052
type: Authorship
author rank in publication: 6
linked author: Zhou, Jing
linked information resource: Non-motile primary cilia as fluid shear stress mechanosensors.

Authorship 780053
type: Authorship
author rank in publication: 6
linked author: Zhou, Jing
linked information resource: The regulation of cystogenesis in a tissue engineered kidney disease system by abnormal matrix interactions.

Authorship 780054
type: Authorship
author rank in publication: 4
linked author: Zhou, Jing
linked information resource: c-Met and NF-?B-dependent overexpression of Wnt7a and -7b and Pax2 promotes cystogenesis in polycystic kidney disease.

Authorship 780055
type: Authorship
author rank in publication: 5
linked author: Zhou, Jing
linked information resource: The cytoplasmic protein Pacsin 2 in kidney development and injury repair.

The regulation of cystogenesis in a tissue engineered kidney disease system by abnormal matrix interactions.
PubMed Identifier: 22940218
author list: Subramanian B, Ko WC, Yadav V, DesRochers TM, Perrone RD, Zhou J, Kaplan DL
published in: Biomaterials
information resource reference: The regulation of cystogenesis in a tissue engineered kidney disease system by abnormal matrix interactions. Biomaterials. 2012 Nov; 33(33):8383-94.
journal title abbreviation: Biomaterials
publication date: 2012-08-30T00:00:00
year: 2012
type: Academic Article
type: Article
type: Document
type: Information Resource

Survivin-induced abnormal ploidy contributes to cystic kidney and aneurysm formation.
PubMed Identifier: 24235270
author list: Aboualaiwi WA, Muntean BS, Ratnam S, Joe B, Liu L, Booth RL, Rodriguez I, Herbert BS, Bacallao RL, Fruttiger M, Mak TW, Zhou J, Nauli SM
published in: Circulation
information resource reference: Survivin-induced abnormal ploidy contributes to cystic kidney and aneurysm formation. Circulation. 2014 Feb 11; 129(6):660-72.
journal title abbreviation: Circulation
publication date: 2013-11-14T00:00:00
year: 2013
type: Academic Article
type: Article
type: Document
type: Information Resource

Aberrant glycosylation and localization of polycystin-1 cause polycystic kidney in an AQP11 knockout model.
PubMed Identifier: 24854278
author list: Inoue Y, Sohara E, Kobayashi K, Chiga M, Rai T, Ishibashi K, Horie S, Su X, Zhou J, Sasaki S, Uchida S
published in: Journal of the American Society of Nephrology : JASN
information resource reference: Aberrant glycosylation and localization of polycystin-1 cause polycystic kidney in an AQP11 knockout model. J Am Soc Nephrol. 2014 Dec; 25(12):2789-99.
journal title abbreviation: J Am Soc Nephrol
publication date: 2014-05-22T00:00:00
year: 2014
type: Academic Article
type: Article
type: Document
type: Information Resource

Effects of Shiga toxin type 2 on a bioengineered three-dimensional model of human renal tissue.
PubMed Identifier: 25312954
author list: DesRochers TM, Kimmerling EP, Jandhyala DM, El-Jouni W, Zhou J, Thorpe CM, Leong JM, Kaplan DL
published in: Infection and immunity
information resource reference: Effects of Shiga toxin type 2 on a bioengineered three-dimensional model of human renal tissue. Infect Immun. 2015 Jan; 83(1):28-38.
journal title abbreviation: Infect Immun
publication date: 2014-10-13T00:00:00
year: 2014
type: Academic Article
type: Article
type: Document
type: Information Resource

Non-motile primary cilia as fluid shear stress mechanosensors.
PubMed Identifier: 23522462
author list: Nauli SM, Jin X, AbouAlaiwi WA, El-Jouni W, Su X, Zhou J
published in: Methods in enzymology
information resource reference: Non-motile primary cilia as fluid shear stress mechanosensors. Methods Enzymol. 2013; 525:1-20.
journal title abbreviation: Methods Enzymol
publication date: 2013-01-01T00:00:00
year: 2013
type: Academic Article
type: Article
type: Document
type: Information Resource

L-type calcium channel modulates cystic kidney phenotype.
PubMed Identifier: 24925129
author list: Jin X, Muntean BS, Aal-Aaboda MS, Duan Q, Zhou J, Nauli SM
published in: Biochimica et biophysica acta
information resource reference: L-type calcium channel modulates cystic kidney phenotype. Biochim Biophys Acta. 2014 Sep; 1842(9):1518-26.
journal title abbreviation: Biochim Biophys Acta
publication date: 2014-06-09T00:00:00
year: 2014
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 61832
type: Authorship
author rank in publication: 5
linked author: Zhou, Jing
linked information resource: Polycystin-1L2 is a novel G-protein-binding protein.

Authorship 548486
type: Authorship
author rank in publication: 4
linked author: Zhou, Jing
linked information resource: Differential expression of Cux-1 and p21 in polycystic kidneys from Pkd1 null and cpk mice.

Authorship 67874
type: Authorship
author rank in publication: 6
linked author: Zhou, Jing
linked information resource: Acceleration of polycystic kidney disease progression in cpk mice carrying a deletion in the homeodomain protein Cux1.

Authorship 421034
type: Authorship
author rank in publication: 1
linked author: Zhou, Jing
linked information resource: Mutation in the alpha 5(IV) collagen chain in juvenile-onset Alport syndrome without hearing loss or ocular lesions: detection by denaturing gradient gel electrophoresis of a PCR product.

Authorship 158752
type: Authorship
author rank in publication: 4
linked author: Zhou, Jing
linked information resource: Pkd1 inactivation induced in adulthood produces focal cystic disease.

Authorship 267193
type: Authorship
author rank in publication: 1
linked author: Zhou, Jing
linked information resource: Characterization of the 3' half of the human type IV collagen alpha 5 gene that is affected in the Alport syndrome.

Authorship 382335
type: Authorship
author rank in publication: 3
linked author: Zhou, Jing
linked information resource: Col2-Cre recombinase is co-expressed with endogenous type II collagen in embryonic renal epithelium and drives development of polycystic kidney disease following inactivation of ciliary genes.

Authorship 487734
type: Authorship
author rank in publication: 6
linked author: Zhou, Jing
linked information resource: https://connects.catalyst.harvard.edu/Profiles/profile/992849

Authorship 194253
type: Authorship
author rank in publication: 6
linked author: Zhou, Jing
linked information resource: Failure to ubiquitinate c-Met leads to hyperactivation of mTOR signaling in a mouse model of autosomal dominant polycystic kidney disease.

Authorship 436836
type: Authorship
author rank in publication: 3
linked author: Zhou, Jing
linked information resource: Identification of mutations in the COL4A5 collagen gene in Alport syndrome.

Authorship 559079
type: Authorship
author rank in publication: 3
linked author: Zhou, Jing
linked information resource: Identification of 17 mutations in ten exons in the COL4A5 collagen gene, but no mutations found in four exons in COL4A6: a study of 250 patients with hematuria and suspected of having Alport syndrome.

Authorship 245018
type: Authorship
author rank in publication: 5
linked author: Zhou, Jing
linked information resource: The autosomal recessive polycystic kidney disease protein is localized to primary cilia, with concentration in the basal body area.

Authorship 343381
type: Authorship
author rank in publication: 5
linked author: Zhou, Jing
linked information resource: Identification of four novel mutations in the COL4A5 gene of patients with Alport syndrome.

Authorship 414230
type: Authorship
author rank in publication: 6
linked author: Zhou, Jing
linked information resource: More than colocalizing with polycystin-1, polycystin-L is in the centrosome.

Authorship 286540
type: Authorship
author rank in publication: 2
linked author: Zhou, Jing
linked information resource: Magnetic resonance imaging assessment of a murine model of recessive polycystic kidney disease.

Authorship 286815
type: Authorship
author rank in publication: 5
linked author: Zhou, Jing
linked information resource: Immortalized epithelial cells from human autosomal dominant polycystic kidney cysts.

Authorship 329819
type: Authorship
author rank in publication: 5
linked author: Zhou, Jing
linked information resource: Native polycystin 2 functions as a plasma membrane Ca2+-permeable cation channel in renal epithelia.

Authorship 344818
type: Authorship
author rank in publication: 7
linked author: Zhou, Jing
linked information resource: Pyrimethamine inhibits adult polycystic kidney disease by modulating STAT signaling pathways.

Authorship 354628
type: Authorship
author rank in publication: 4
linked author: Zhou, Jing
linked information resource: Polycystic kidney disease evaluation by magnetic resonance imaging in ischemia-reperfusion injured PKD1 knockout mouse model: comparison of T2-weighted FSE and true-FISP.

Authorship 499160
type: Authorship
author rank in publication: 10
linked author: Zhou, Jing
linked information resource: The multimeric structure of polycystin-2 (TRPP2): structural-functional correlates of homo- and hetero-multimers with TRPC1.

Authorship 50545
type: Authorship
author rank in publication: 1
linked author: Zhou, Jing
linked information resource: Polycystins and primary cilia: primers for cell cycle progression.

Authorship 381934
type: Authorship
author rank in publication: 6
linked author: Zhou, Jing
linked information resource: Identification and characterization of a novel polycystin family member, polycystin-L2, in mouse and human: sequence, expression, alternative splicing, and chromosomal localization.

Authorship 262377
type: Authorship
author rank in publication: 4
linked author: Zhou, Jing
linked information resource: The human polycystic kidney disease 2-like (PKDL) gene: exon/intron structure and evidence for a novel splicing mechanism.

Authorship 218803
type: Authorship
author rank in publication: 10
linked author: Zhou, Jing
linked information resource: Late onset of renal and hepatic cysts in Pkd1-targeted heterozygotes.

Authorship 570987
type: Authorship
author rank in publication: 7
linked author: Zhou, Jing
linked information resource: Aberrant regulation of planar cell polarity in polycystic kidney disease.

Authorship 572892
type: Authorship
author rank in publication: 1
linked author: Zhou, Jing
linked information resource: Mutations in the codon for a conserved arginine-1563 in the COL4A5 collagen gene in Alport syndrome.

Authorship 322815
type: Authorship
author rank in publication: 2
linked author: Zhou, Jing
linked information resource: Polycystin channels and kidney disease.

Authorship 335619
type: Authorship
author rank in publication: 4
linked author: Zhou, Jing
linked information resource: Identification of signaling pathways regulating primary cilium length and flow-mediated adaptation.

Authorship 350459
type: Authorship
author rank in publication: 2
linked author: Zhou, Jing
linked information resource: Molecular complexes formed with polycystins.

Authorship 378467
type: Authorship
author rank in publication: 11
linked author: Zhou, Jing
linked information resource: Identification of PKDL, a novel polycystic kidney disease 2-like gene whose murine homologue is deleted in mice with kidney and retinal defects.

Authorship 514746
type: Authorship
author rank in publication: 5
linked author: Zhou, Jing
linked information resource: Tissue-engineered three-dimensional in vitro models for normal and diseased kidney.

Authorship 570635
type: Authorship
author rank in publication: 6
linked author: Zhou, Jing
linked information resource: Nek8 regulates the expression and localization of polycystin-1 and polycystin-2.

Authorship 325167
type: Authorship
author rank in publication: 6
linked author: Zhou, Jing
linked information resource: Inhibition of HER-2(neu/ErbB2) restores normal function and structure to polycystic kidney disease (PKD) epithelia.

Authorship 342236
type: Authorship
author rank in publication: 1
linked author: Zhou, Jing
linked information resource: Deletion of the paired alpha 5(IV) and alpha 6(IV) collagen genes in inherited smooth muscle tumors.

Authorship 474453
type: Authorship
author rank in publication: 7
linked author: Zhou, Jing
linked information resource: Deletions in the COL4A5 collagen gene in X-linked Alport syndrome. Characterization of the pathological transcripts in nonrenal cells and correlation with disease expression.

Authorship 546099
type: Authorship
author rank in publication: 10
linked author: Zhou, Jing
linked information resource: Comparison of Pkd1-targeted mutants reveals that loss of polycystin-1 causes cystogenesis and bone defects.

Authorship 55051
type: Authorship
author rank in publication: 8
linked author: Zhou, Jing
linked information resource: Gating of the polycystin ion channel signaling complex in neurons and kidney cells.

Authorship 576812
type: Authorship
author rank in publication: 4
linked author: Zhou, Jing
linked information resource: Global cytoskeletal control of mechanotransduction in kidney epithelial cells.

Authorship 259873
type: Authorship
author rank in publication: 10
linked author: Zhou, Jing
linked information resource: Polycystin-L is a calcium-regulated cation channel permeable to calcium ions.

Authorship 289504
type: Authorship
author rank in publication: 7
linked author: Zhou, Jing
linked information resource: Renal injury is a third hit promoting rapid development of adult polycystic kidney disease.

Authorship 378046
type: Authorship
author rank in publication: 8
linked author: Zhou, Jing
linked information resource: Fibrocystin/polyductin, found in the same protein complex with polycystin-2, regulates calcium responses in kidney epithelia.

Authorship 469338
type: Authorship
author rank in publication: 9
linked author: Zhou, Jing
linked information resource: TAZ promotes PC2 degradation through a SCFbeta-Trcp E3 ligase complex.

Authorship 463618
type: Authorship
author rank in publication: 6
linked author: Zhou, Jing
linked information resource: Endothelial cilia are fluid shear sensors that regulate calcium signaling and nitric oxide production through polycystin-1.

Authorship 533470
type: Authorship
author rank in publication: 2
linked author: Zhou, Jing
linked information resource: Polycystins and mechanosensation in renal and nodal cilia.

Authorship 84695
type: Authorship
author rank in publication: 2
linked author: Zhou, Jing
linked information resource: Structure of the human type IV collagen COL4A6 gene, which is mutated in Alport syndrome-associated leiomyomatosis.

Authorship 91220
type: Authorship
author rank in publication: 3
linked author: Zhou, Jing
linked information resource: Deletions of the COL4A5 gene in patients with Alport syndrome.

Associate Professor
sort order: 1
type: Faculty Rank

Full Professor
sort order: 0
type: Faculty Rank

Instructor
sort order: 4
type: Faculty Rank

Authorship 577128
type: Authorship
author rank in publication: 10
linked author: Zhou, Jing
linked information resource: Transport function of the naturally occurring pathogenic polycystin-2 mutant, R742X.

Authorship 536464
type: Authorship
author rank in publication: 11
linked author: Zhou, Jing
linked information resource: Co-inheritance of a PKD1 mutation and homozygous PKD2 variant: a potential modifier in autosomal dominant polycystic kidney disease.

South Carolina COBRE for Oral Health Research
end date: 2013-07-31
principal investigator name: KIRKWOOD, KEITH L
start date: 2002-09-30
type: Grant
sponsor award id: P20RR017696

KIDNEY DEVELOPMENT AND CYSTOGENESIS
end date: 2005-02-28
principal investigator name: ARNAOUT, M. AMIN
start date: 1999-03-01
type: Grant
sponsor award id: P01DK054711

Cell biology of autosomal dominant polycystic kidney disease
end date: 2017-05-31
principal investigator name: ZHOU, JING
start date: 2014-09-02
type: Grant
sponsor award id: R01DK099532

Harvard Center of Polycystic Kidney Disease Research
end date: 2011-08-31
principal investigator name: ZHOU, JING
start date: 2005-09-30
type: Grant
sponsor award id: P50DK074030

Mouse model of polycystic kidney disease
end date: 2016-04-30
principal investigator name: ZHOU, JING
start date: 1995-09-30
type: Grant
sponsor award id: R37DK051050

Molecular Pathology in Polycystic Kidney Disease
end date: 2012-07-31
principal investigator name: ZHOU, JING
start date: 1989-01-01
type: Grant
sponsor award id: R01DK040703

Molecular pathophysiology of Pkd2 mutations
end date: 2013-01-31
principal investigator name: ZHOU, JING
start date: 1998-02-21
type: Grant
sponsor award id: R01DK053357

MOLECULAR BASIS OF X-LINKED ALPORT SYNDROME
end date: 2002-04-30
principal investigator name: ZHOU, JING
start date: 1995-05-01
type: Grant
sponsor award id: R01DK048317

MODEL OF AUTOSOMAL DOMINANT POLYCYSTIC KIDNEY DISEASE
end date: 2004-11-30
principal investigator name: ZHOU, JING
start date: 1995-09-30
type: Grant
sponsor award id: R01DK051050

Principal Investigator
type: Researcher Role
researcher role of: Zhou, Jing
contributes to: MODEL OF AUTOSOMAL DOMINANT POLYCYSTIC KIDNEY DISEASE

Co-Principal Investigator
type: Researcher Role
researcher role of: Zhou, Jing
contributes to: South Carolina COBRE for Oral Health Research

Principal Investigator
type: Researcher Role
researcher role of: Zhou, Jing
contributes to: MOLECULAR BASIS OF X-LINKED ALPORT SYNDROME

Principal Investigator
type: Researcher Role
researcher role of: Zhou, Jing
contributes to: Molecular Pathology in Polycystic Kidney Disease

Principal Investigator
type: Researcher Role
researcher role of: Zhou, Jing
contributes to: Cell biology of autosomal dominant polycystic kidney disease

Principal Investigator
type: Researcher Role
researcher role of: Zhou, Jing
contributes to: Molecular pathophysiology of Pkd2 mutations

Principal Investigator
type: Researcher Role
researcher role of: Zhou, Jing
contributes to: Mouse model of polycystic kidney disease

Principal Investigator
type: Researcher Role
researcher role of: Zhou, Jing
contributes to: Harvard Center of Polycystic Kidney Disease Research

Co-Principal Investigator
type: Researcher Role
researcher role of: Zhou, Jing
contributes to: KIDNEY DEVELOPMENT AND CYSTOGENESIS

Authorship 523383
type: Authorship
author rank in publication: 4
linked author: Zhou, Jing
linked information resource: A gene similar to PKD1 maps to chromosome 4q22: a candidate gene for PKD2.

Authorship 540812
type: Authorship
author rank in publication: 3
linked author: Zhou, Jing
linked information resource: High mutation detection rate in the COL4A5 collagen gene in suspected Alport syndrome using PCR and direct DNA sequencing.

Authorship 85923
type: Authorship
author rank in publication: 3
linked author: Zhou, Jing
linked information resource: Detection of 12 novel mutations in the collagenous domain of the COL4A5 gene in Alport syndrome patients.

Authorship 204976
type: Authorship
author rank in publication: 7
linked author: Zhou, Jing
linked information resource: A mouse model for polycystic kidney disease through a somatic in-frame deletion in the 5' end of Pkd1.

Authorship 569132
type: Authorship
author rank in publication: 6
linked author: Zhou, Jing
linked information resource: Polycystic kidney disease protein fibrocystin localizes to the mitotic spindle and regulates spindle bipolarity.

Authorship 571159
type: Authorship
author rank in publication: 2
linked author: Zhou, Jing
linked information resource: Alport syndrome and diffuse leiomyomatosis: deletions in the 5' end of the COL4A5 collagen gene.

Authorship 58560
type: Authorship
author rank in publication: 20
linked author: Zhou, Jing
linked information resource: Autosomal recessive polycystic kidney disease and congenital hepatic fibrosis: summary statement of a first National Institutes of Health/Office of Rare Diseases conference.

Authorship 75354
type: Authorship
author rank in publication: 3
linked author: Zhou, Jing
linked information resource: A nonsense mutation in the COL4A5 collagen gene in a family with X-linked juvenile Alport syndrome.

77 Avenue Louis Pasteur
type: Address
address line 1: Harvard Institutes of Medicine
address line 2: Room 522
address line 3: 77 Avenue Louis Pasteur
city: Boston
postal code: 02115
state or province: MA

Identification of 17 mutations in ten exons in the COL4A5 collagen gene, but no mutations found in four exons in COL4A6: a study of 250 patients with hematuria and suspected of having Alport syndrome.
PubMed Identifier: 8738805
author list: Heiskari N, Zhang X, Zhou J, Leinonen A, Barker D, Gregory M, Atkin CL, Netzer KO, Weber M, Reeders S, Grönhagen-Riska C, Neumann HP, Trembath R, Tryggvason K
published in: Journal of the American Society of Nephrology : JASN
information resource reference: Identification of 17 mutations in ten exons in the COL4A5 collagen gene, but no mutations found in four exons in COL4A6: a study of 250 patients with hematuria and suspected of having Alport syndrome. J Am Soc Nephrol. 1996 May; 7(5):702-9.
journal title abbreviation: J Am Soc Nephrol
publication date: 1996-05-01T00:00:00
year: 1996
type: Academic Article
type: Article
type: Document
type: Information Resource

A gene similar to PKD1 maps to chromosome 4q22: a candidate gene for PKD2.
PubMed Identifier: 8954772
author list: Schneider MC, Rodriguez AM, Nomura H, Zhou J, Morton CC, Reeders ST, Weremowicz S
published in: Genomics
information resource reference: A gene similar to PKD1 maps to chromosome 4q22: a candidate gene for PKD2. Genomics. 1996 Nov 15; 38(1):1-4.
journal title abbreviation: Genomics
publication date: 1996-11-15T00:00:00
year: 1996
type: Academic Article
type: Article
type: Document
type: Information Resource

Deletions of the COL4A5 gene in patients with Alport syndrome.
PubMed Identifier: 1474765
author list: Netzer KO, Renders L, Zhou J, Pullig O, Tryggvason K, Weber M
published in: Kidney international
information resource reference: Deletions of the COL4A5 gene in patients with Alport syndrome. Kidney Int. 1992 Dec; 42(6):1336-44.
journal title abbreviation: Kidney Int
publication date: 1992-12-01T00:00:00
year: 1992
type: Academic Article
type: Article
type: Document
type: Information Resource

Alport syndrome: a genetic study of 31 families.
PubMed Identifier: 1483700
author list: M'Rad R, Sanak M, Deschenes G, Zhou J, Bonaiti-Pellie C, Holvoet-Vermaut L, Heuertz S, Gubler MC, Broyer M, Grunfeld JP
published in: Human genetics
information resource reference: Alport syndrome: a genetic study of 31 families. Hum Genet. 1992 Dec; 90(4):420-6.
journal title abbreviation: Hum Genet
publication date: 1992-12-01T00:00:00
year: 1992
type: Academic Article
type: Article
type: Document
type: Information Resource

Immortalized epithelial cells from human autosomal dominant polycystic kidney cysts.
PubMed Identifier: 12734101
author list: Loghman-Adham M, Nauli SM, Soto CE, Kariuki B, Zhou J
published in: American journal of physiology. Renal physiology
information resource reference: Immortalized epithelial cells from human autosomal dominant polycystic kidney cysts. Am J Physiol Renal Physiol. 2003 Sep; 285(3):F397-412.
journal title abbreviation: Am J Physiol Renal Physiol
publication date: 2003-05-06T00:00:00
year: 2003
type: Academic Article
type: Article
type: Document
type: Information Resource

Gating of the polycystin ion channel signaling complex in neurons and kidney cells.
PubMed Identifier: 14766803
author list: Delmas P, Nauli SM, Li X, Coste B, Osorio N, Crest M, Brown DA, Zhou J
published in: FASEB journal : official publication of the Federation of American Societies for Experimental Biology
information resource reference: Gating of the polycystin ion channel signaling complex in neurons and kidney cells. FASEB J. 2004 Apr; 18(6):740-2.
journal title abbreviation: FASEB J
publication date: 2004-02-06T00:00:00
year: 2004
type: Academic Article
type: Article
type: Document
type: Information Resource

Identification of PKDL, a novel polycystic kidney disease 2-like gene whose murine homologue is deleted in mice with kidney and retinal defects.
PubMed Identifier: 9748274
author list: Nomura H, Turco AE, Pei Y, Kalaydjieva L, Schiavello T, Weremowicz S, Ji W, Morton CC, Meisler M, Reeders ST, Zhou J
published in: The Journal of biological chemistry
information resource reference: Identification of PKDL, a novel polycystic kidney disease 2-like gene whose murine homologue is deleted in mice with kidney and retinal defects. J Biol Chem. 1998 Oct 02; 273(40):25967-73.
journal title abbreviation: J Biol Chem
publication date: 1998-10-02T00:00:00
year: 1998
type: Academic Article
type: Article
type: Document
type: Information Resource

Late onset of renal and hepatic cysts in Pkd1-targeted heterozygotes.
PubMed Identifier: 9988265
author list: Lu W, Fan X, Basora N, Babakhanlou H, Law T, Rifai N, Harris PC, Perez-Atayde AR, Rennke HG, Zhou J
published in: Nature genetics
information resource reference: Late onset of renal and hepatic cysts in Pkd1-targeted heterozygotes. Nat Genet. 1999 Feb; 21(2):160-1.
journal title abbreviation: Nat Genet
publication date: 1999-02-01T00:00:00
year: 1999
type: Academic Article
type: Article
type: Document
type: Information Resource

Comparison of Pkd1-targeted mutants reveals that loss of polycystin-1 causes cystogenesis and bone defects.
PubMed Identifier: 11689485
author list: Lu W, Shen X, Pavlova A, Lakkis M, Ward CJ, Pritchard L, Harris PC, Genest DR, Perez-Atayde AR, Zhou J
published in: Human molecular genetics
information resource reference: Comparison of Pkd1-targeted mutants reveals that loss of polycystin-1 causes cystogenesis and bone defects. Hum Mol Genet. 2001 Oct 01; 10(21):2385-96.
journal title abbreviation: Hum Mol Genet
publication date: 2001-10-01T00:00:00
year: 2001
type: Academic Article
type: Article
type: Document
type: Information Resource

Constitutive activation of G-proteins by polycystin-1 is antagonized by polycystin-2.
PubMed Identifier: 11786542
author list: Delmas P, Nomura H, Li X, Lakkis M, Luo Y, Segal Y, Fernández-Fernández JM, Harris P, Frischauf AM, Brown DA, Zhou J
published in: The Journal of biological chemistry
information resource reference: Constitutive activation of G-proteins by polycystin-1 is antagonized by polycystin-2. J Biol Chem. 2002 Mar 29; 277(13):11276-83.
journal title abbreviation: J Biol Chem
publication date: 2002-01-10T00:00:00
year: 2002
type: Academic Article
type: Article
type: Document
type: Information Resource

Identification of mutations in the COL4A5 collagen gene in Alport syndrome.
PubMed Identifier: 2349482
author list: Barker DF, Hostikka SL, Zhou J, Chow LT, Oliphant AR, Gerken SC, Gregory MC, Skolnick MH, Atkin CL, Tryggvason K
published in: Science (New York, N.Y.)
information resource reference: Identification of mutations in the COL4A5 collagen gene in Alport syndrome. Science. 1990 Jun 08; 248(4960):1224-7.
journal title abbreviation: Science
publication date: 1990-06-08T00:00:00
year: 1990
type: Academic Article
type: Article
type: Document
type: Information Resource

The sequence, expression, and chromosomal localization of a novel polycystic kidney disease 1-like gene, PKD1L1, in human.
PubMed Identifier: 11863367
author list: Yuasa T, Venugopal B, Weremowicz S, Morton CC, Guo L, Zhou J
published in: Genomics
information resource reference: The sequence, expression, and chromosomal localization of a novel polycystic kidney disease 1-like gene, PKD1L1, in human. Genomics. 2002 Mar; 79(3):376-86.
journal title abbreviation: Genomics
publication date: 2002-03-01T00:00:00
year: 2002
type: Academic Article
type: Article
type: Document
type: Information Resource

Alport syndrome and diffuse leiomyomatosis: deletions in the 5' end of the COL4A5 collagen gene.
PubMed Identifier: 1453602
author list: Antignac C, Zhou J, Sanak M, Cochat P, Roussel B, Deschênes G, Gros F, Knebelmann B, Hors-Cayla MC, Tryggvason K
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Evidence for genetic heterogeneity in benign familial hematuria.
PubMed Identifier: 10460935
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Polycystin-L is a calcium-regulated cation channel permeable to calcium ions.
PubMed Identifier: 10517637
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Polycystin-1L2 is a novel G-protein-binding protein.
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Inhibition of HER-2(neu/ErbB2) restores normal function and structure to polycystic kidney disease (PKD) epithelia.
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Regulation of the paired type IV collagen genes COL4A5 and COL4A6. Role of the proximal promoter region.
PubMed Identifier: 11096082
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Tissue and cellular localization of a novel polycystic kidney disease-like gene product, polycystin-L.
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Single base mutation in alpha 5(IV) collagen chain gene converting a conserved cysteine to serine in Alport syndrome.
PubMed Identifier: 1672282
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Novel COL4A5/COL4A6 deletions and further characterization of the diffuse leiomyomatosis-Alport syndrome (DL-AS) locus define the DL critical region.
PubMed Identifier: 9465897
author list: Heidet L, Cohen-Solal L, Boye E, Thorner P, Kemper MJ, David A, Larget Piet L, Zhou J, Flinter F, Zhang X, Gubler MC, Antignac C
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Polycystin-2 is a novel cation channel implicated in defective intracellular Ca(2+) homeostasis in polycystic kidney disease.
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author list: Vassilev PM, Guo L, Chen XZ, Segal Y, Peng JB, Basora N, Babakhanlou H, Cruger G, Kanazirska M, Brown EM, Hediger MA, Zhou J
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Different mutations in the COL4A5 collagen gene in two patients with different features of Alport syndrome.
PubMed Identifier: 1635357
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Identification and localization of polycystin, the PKD1 gene product.
PubMed Identifier: 8981910
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Seminiferous tubule basement membrane. Composition and organization of type IV collagen chains, and the linkage of alpha3(IV) and alpha5(IV) chains.
PubMed Identifier: 9202017
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Identification and characterization of a novel polycystin family member, polycystin-L2, in mouse and human: sequence, expression, alternative splicing, and chromosomal localization.
PubMed Identifier: 10756092
author list: Guo L, Schreiber TH, Weremowicz S, Morton CC, Lee C, Zhou J
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https://connects.catalyst.harvard.edu/Profiles/profile/825440
PubMed Identifier: 1352287
author list: Zhou J, Hertz JM, Leinonen A, Tryggvason K
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label: Complete amino acid sequence of the human alpha 5 (IV) collagen chain and identification of a single-base mutation in exon 23 converting glycine 521 in the collagenous domain to cysteine in an Alport syndrome patient.

The multimeric structure of polycystin-2 (TRPP2): structural-functional correlates of homo- and hetero-multimers with TRPC1.
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author list: Zhang P, Luo Y, Chasan B, González-Perrett S, Montalbetti N, Timpanaro GA, Cantero Mdel R, Ramos AJ, Goldmann WH, Zhou J, Cantiello HF
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Endothelial cilia are fluid shear sensors that regulate calcium signaling and nitric oxide production through polycystin-1.
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LINE-1 elements at the sites of molecular rearrangements in Alport syndrome-diffuse leiomyomatosis.
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Failure to ubiquitinate c-Met leads to hyperactivation of mTOR signaling in a mouse model of autosomal dominant polycystic kidney disease.
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The autosomal recessive polycystic kidney disease protein is localized to primary cilia, with concentration in the basal body area.
PubMed Identifier: 14978161
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Identification of signaling pathways regulating primary cilium length and flow-mediated adaptation.
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Distribution and developmentally regulated expression of murine polycystin.
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Pkd1 inactivation induced in adulthood produces focal cystic disease.
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Atomic models for the polypeptide backbones of myohemerythrin and hemerythrin.
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COL4A5 splice site mutation and alpha 5(IV) collagen mRNA in Alport syndrome.
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Expression of mRNA for type IV collagen alpha1, alpha5 and alpha6 chains by cultured dermal fibroblasts from patients with X-linked Alport syndrome.
PubMed Identifier: 9749944
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Molecular complexes formed with polycystins.
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The cytoplasmic protein Pacsin 2 in kidney development and injury repair.
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Detection of 12 novel mutations in the collagenous domain of the COL4A5 gene in Alport syndrome patients.
PubMed Identifier: 7599631
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CECIL: a database for storing and retrieving clinical and molecular information on patients with Alport syndrome.
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X-linked Alport syndrome: an SSCP-based mutation survey over all 51 exons of the COL4A5 gene.
PubMed Identifier: 8651296
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Mutation in the alpha 5(IV) collagen chain in juvenile-onset Alport syndrome without hearing loss or ocular lesions: detection by denaturing gradient gel electrophoresis of a PCR product.
PubMed Identifier: 1598909
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Global cytoskeletal control of mechanotransduction in kidney epithelial cells.
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TAZ promotes PC2 degradation through a SCFbeta-Trcp E3 ligase complex.
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Modulation of the human polycystin-L channel by voltage and divalent cations.
PubMed Identifier: 12163164
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Loss of polycystin-1 in human cyst-lining epithelia leads to ciliary dysfunction.
PubMed Identifier: 16565258
author list: Nauli SM, Rossetti S, Kolb RJ, Alenghat FJ, Consugar MB, Harris PC, Ingber DE, Loghman-Adham M, Zhou J
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Autosomal recessive polycystic kidney disease and congenital hepatic fibrosis: summary statement of a first National Institutes of Health/Office of Rare Diseases conference.
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Overexpression of innate immune response genes in a model of recessive polycystic kidney disease.
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Polycystic kidney disease evaluation by magnetic resonance imaging in ischemia-reperfusion injured PKD1 knockout mouse model: comparison of T2-weighted FSE and true-FISP.
PubMed Identifier: 19996760
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Deletion mapping in Alport syndrome and Alport syndrome-diffuse leiomyomatosis reveals potential mechanisms of visceral smooth muscle overgrowth.
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Fibrocystin/polyductin, found in the same protein complex with polycystin-2, regulates calcium responses in kidney epithelia.
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Studies of oxygen binding energy to hemoglobin molecule.
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Nek8 regulates the expression and localization of polycystin-1 and polycystin-2.
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Perinatal lethality with kidney and pancreas defects in mice with a targetted Pkd1 mutation.
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High mutation detection rate in the COL4A5 collagen gene in suspected Alport syndrome using PCR and direct DNA sequencing.
PubMed Identifier: 9848783
author list: Martin P, Heiskari N, Zhou J, Leinonen A, Tumelius T, Hertz JM, Barker D, Gregory M, Atkin C, Styrkarsdottir U, Neumann H, Springate J, Shows T, Pettersson E, Tryggvason K
published in: Journal of the American Society of Nephrology : JASN
information resource reference: High mutation detection rate in the COL4A5 collagen gene in suspected Alport syndrome using PCR and direct DNA sequencing. J Am Soc Nephrol. 1998 Dec; 9(12):2291-301.
journal title abbreviation: J Am Soc Nephrol
publication date: 1998-12-01T00:00:00
year: 1998
type: Academic Article
type: Article
type: Document
type: Information Resource

The human polycystic kidney disease 2-like (PKDL) gene: exon/intron structure and evidence for a novel splicing mechanism.
PubMed Identifier: 10602992
author list: Guo L, Chen M, Basora N, Zhou J
published in: Mammalian genome : official journal of the International Mammalian Genome Society
information resource reference: The human polycystic kidney disease 2-like (PKDL) gene: exon/intron structure and evidence for a novel splicing mechanism. Mamm Genome. 2000 Jan; 11(1):46-50.
journal title abbreviation: Mamm Genome
publication date: 2000-01-01T00:00:00
year: 2000
type: Academic Article
type: Article
type: Document
type: Information Resource

https://connects.catalyst.harvard.edu/Profiles/profile/992849
PubMed Identifier: 1376965
author list: Knebelmann B, Deschenes G, Gros F, Hors MC, Grünfeld JP, Zhou J, Tryggvason K, Gubler MC, Antignac C
published in: American journal of human genetics
information resource reference: Substitution of arginine for glycine 325 in the collagen alpha 5 (IV) chain associated with X-linked Alport syndrome: characterization of the mutation by direct sequencing of PCR-amplified lymphoblast cDNA fragments. Am J Hum Genet. 1992 Jul; 51(1):135-42.
journal title abbreviation: Am J Hum Genet
publication date: 1992-07-01T00:00:00
year: 1992
type: Academic Article
type: Article
type: Document
type: Information Resource
label: Substitution of arginine for glycine 325 in the collagen alpha 5 (IV) chain associated with X-linked Alport syndrome: characterization of the mutation by direct sequencing of PCR-amplified lymphoblast cDNA fragments.

Deletions of both alpha 5(IV) and alpha 6(IV) collagen genes in Alport syndrome and in Alport syndrome associated with smooth muscle tumours.
PubMed Identifier: 7711741
author list: Heidet L, Dahan K, Zhou J, Xu Z, Cochat P, Gould JD, Leppig KA, Proesmans W, Guyot C, Guillot M
published in: Human molecular genetics
information resource reference: Deletions of both alpha 5(IV) and alpha 6(IV) collagen genes in Alport syndrome and in Alport syndrome associated with smooth muscle tumours. Hum Mol Genet. 1995 Jan; 4(1):99-108.
journal title abbreviation: Hum Mol Genet
publication date: 1995-01-01T00:00:00
year: 1995
type: Academic Article
type: Article
type: Document
type: Information Resource