Antigens, Polyomavirus Transforming
"Antigens, Polyomavirus Transforming" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Polyomavirus antigens which cause infection and cellular transformation. The large T antigen is necessary for the initiation of viral DNA synthesis, repression of transcription of the early region and is responsible in conjunction with the middle T antigen for the transformation of primary cells. Small T antigen is necessary for the completion of the productive infection cycle.
MeSH Number(s)
D12.776.624.664.520.090
D12.776.964.700.090
D23.050.285.062.090
D23.050.327.062.090
Concept/Terms
Antigens, Polyomavirus Transforming- Antigens, Polyomavirus Transforming
- Polyomavirus Tumor Antigens
- Antigens, Polyomavirus Tumor
- Tumor Antigens, Polyomavirus
- Polyomavirus Transforming Antigens
- Transforming Antigens, Polyomavirus
SV40 T Proteins- SV40 T Proteins
- Proteins, SV40 T
- T Proteins, SV40
- SV40 T Antigens
- Antigens, SV40 T
- T Antigens, SV40
Below are MeSH descriptors whose meaning is more general than "Antigens, Polyomavirus Transforming".
- Chemicals and Drugs [D]
- Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
- Neoplasm Proteins [D12.776.624]
- Oncogene Proteins [D12.776.624.664]
- Oncogene Proteins, Viral [D12.776.624.664.520]
- Antigens, Polyomavirus Transforming [D12.776.624.664.520.090]
- Viral Proteins [D12.776.964]
- Oncogene Proteins, Viral [D12.776.964.700]
- Antigens, Polyomavirus Transforming [D12.776.964.700.090]
- Biological Factors [D23]
- Antigens [D23.050]
- Antigens, Neoplasm [D23.050.285]
- Antigens, Viral, Tumor [D23.050.285.062]
- Antigens, Polyomavirus Transforming [D23.050.285.062.090]
- Antigens, Viral [D23.050.327]
- Antigens, Viral, Tumor [D23.050.327.062]
- Antigens, Polyomavirus Transforming [D23.050.327.062.090]
Below are MeSH descriptors whose meaning is more specific than "Antigens, Polyomavirus Transforming".
This graph shows the total number of publications written about "Antigens, Polyomavirus Transforming" by people in Harvard Catalyst Profiles by year, and whether "Antigens, Polyomavirus Transforming" was a major or minor topic of these publication.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1994 | 4 | 2 | 6 |
| 1995 | 4 | 0 | 4 |
| 1996 | 4 | 4 | 8 |
| 1997 | 4 | 3 | 7 |
| 1998 | 3 | 1 | 4 |
| 1999 | 2 | 2 | 4 |
| 2000 | 3 | 2 | 5 |
| 2001 | 7 | 4 | 11 |
| 2002 | 2 | 5 | 7 |
| 2003 | 4 | 4 | 8 |
| 2004 | 3 | 4 | 7 |
| 2005 | 1 | 3 | 4 |
| 2006 | 1 | 2 | 3 |
| 2007 | 3 | 6 | 9 |
| 2008 | 5 | 0 | 5 |
| 2009 | 1 | 3 | 4 |
| 2010 | 1 | 1 | 2 |
| 2011 | 1 | 1 | 2 |
| 2012 | 1 | 3 | 4 |
| 2013 | 1 | 1 | 2 |
| 2014 | 2 | 1 | 3 |
| 2016 | 3 | 0 | 3 |
| 2017 | 0 | 3 | 3 |
| 2018 | 0 | 1 | 1 |
| 2022 | 0 | 1 | 1 |
Below are the most recent publications written about "Antigens, Polyomavirus Transforming" by people in Profiles.
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Merkel cell polyomavirus large T antigen binding to pRb promotes skin hyperplasia and tumor development. PLoS Pathog. 2022 05; 18(5):e1010551.
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Reversibly immortalized human umbilical cord-derived mesenchymal stem cells (UC-MSCs) are responsive to BMP9-induced osteogenic and adipogenic differentiation. J Cell Biochem. 2018 11; 119(11):8872-8886.
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Naked Mole Rat Cells Have a Stable Epigenome that Resists iPSC Reprogramming. Stem Cell Reports. 2017 11 14; 9(5):1721-1734.
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Merkel cell polyomavirus recruits MYCL to the EP400 complex to promote oncogenesis. PLoS Pathog. 2017 Oct; 13(10):e1006668.
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Establishment of a protocol to extend the lifespan of human hormone-secreting pituitary adenoma cells. Endocrine. 2018 01; 59(1):102-108.
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Establishment and application of a novel patient-derived KIAA1549:BRAF-driven pediatric pilocytic astrocytoma model for preclinical drug testing. Oncotarget. 2017 Feb 14; 8(7):11460-11479.
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A Transformation-Defective Polyomavirus Middle T Antigen with a Novel Defect in PI3 Kinase Signaling. J Virol. 2017 Jan 15; 91(2).
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Merkel Cell Polyomavirus Small T Antigen Promotes Pro-Glycolytic Metabolic Perturbations Required for Transformation. PLoS Pathog. 2016 Nov; 12(11):e1006020.
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p53 elevation in human cells halt SV40 infection by inhibiting T-ag expression. Oncotarget. 2016 Aug 16; 7(33):52643-52660.
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Transformation by Polyomavirus Middle T Antigen Involves a Unique Bimodal Interaction with the Hippo Effector YAP. J Virol. 2016 08 15; 90(16):7032-7045.