"Trypsinogen" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
The inactive proenzyme of trypsin secreted by the pancreas, activated in the duodenum via cleavage by enteropeptidase. (Stedman, 25th ed)
Below are MeSH descriptors whose meaning is more general than "Trypsinogen".
Below are MeSH descriptors whose meaning is more specific than "Trypsinogen".
This graph shows the total number of publications written about "Trypsinogen" by people in Harvard Catalyst Profiles by year, and whether "Trypsinogen" was a major or minor topic of these publication.
To see the data from this visualization as text,
click here.
Year | Major Topic | Minor Topic | Total |
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1994 | 5 | 1 | 6 |
1995 | 5 | 1 | 6 |
1996 | 1 | 1 | 2 |
1997 | 1 | 2 | 3 |
1998 | 2 | 0 | 2 |
1999 | 2 | 1 | 3 |
2000 | 0 | 1 | 1 |
2001 | 1 | 1 | 2 |
2002 | 1 | 0 | 1 |
2004 | 1 | 0 | 1 |
2005 | 2 | 0 | 2 |
2007 | 1 | 0 | 1 |
2009 | 0 | 1 | 1 |
2010 | 0 | 2 | 2 |
2011 | 1 | 0 | 1 |
2012 | 1 | 0 | 1 |
2015 | 1 | 0 | 1 |
2016 | 1 | 1 | 2 |
2018 | 1 | 0 | 1 |
2019 | 0 | 1 | 1 |
2020 | 1 | 0 | 1 |
2022 | 0 | 1 | 1 |
Below are the most recent publications written about "Trypsinogen" by people in Profiles.
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PRSS2 remodels the tumor microenvironment via repression of Tsp1 to stimulate tumor growth and progression. Nat Commun. 2022 12 27; 13(1):7959.
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Trypsin activity governs increased susceptibility to pancreatitis in mice expressing human PRSS1R122H. J Clin Invest. 2020 01 02; 130(1):189-202.
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Elevated intracellular trypsin exacerbates acute pancreatitis and chronic pancreatitis in mice. Am J Physiol Gastrointest Liver Physiol. 2019 06 01; 316(6):G816-G825.
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Trypsin-encoding PRSS1-PRSS2 variations influence the risk of asparaginase-associated pancreatitis in children with acute lymphoblastic leukemia: a Ponte di Legno toxicity working group report. Haematologica. 2019 03; 104(3):556-563.
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Chronic Pancreatitis in the 21st Century - Research Challenges and Opportunities: Summary of a National Institute of Diabetes and Digestive and Kidney Diseases Workshop. Pancreas. 2016 11; 45(10):1365-1375.
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A product of immunoreactive trypsinogen and pancreatitis-associated protein as second-tier strategy in cystic fibrosis newborn screening. J Cyst Fibros. 2016 11; 15(6):752-758.
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Pancreatic fistulae secondary to trypsinogen activation by Pseudomonas aeruginosa infection after pancreatoduodenectomy. J Hepatobiliary Pancreat Sci. 2015 Jun; 22(6):454-62.
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Pharmacological inhibition of PAR2 with the pepducin P2pal-18S protects mice against acute experimental biliary pancreatitis. Am J Physiol Gastrointest Liver Physiol. 2013 Mar 01; 304(5):G516-26.
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Common genetic variants in the CLDN2 and PRSS1-PRSS2 loci alter risk for alcohol-related and sporadic pancreatitis. Nat Genet. 2012 Dec; 44(12):1349-54.
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Impact of IVS8-(TG)m(T)n on IRT and sweat chloride levels in newborns identified by California CF newborn screening. J Cyst Fibros. 2012 May; 11(3):257-60.