"alpha-Synuclein" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A synuclein that is a major component of LEWY BODIES that plays a role in neurodegeneration and neuroprotection.
Concept/Terms
alpha-Synuclein- alpha-Synuclein
- alpha Synuclein
- Non-AB Component of AD Amyloid Protein
- Non AB Component of AD Amyloid Protein
Below are MeSH descriptors whose meaning is more general than "alpha-Synuclein".
Below are MeSH descriptors whose meaning is more specific than "alpha-Synuclein".
This graph shows the total number of publications written about "alpha-Synuclein" by people in Harvard Catalyst Profiles by year, and whether "alpha-Synuclein" was a major or minor topic of these publication.
To see the data from this visualization as text,
click here.
Year | Major Topic | Minor Topic | Total |
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1995 | 0 | 1 | 1 |
1998 | 0 | 3 | 3 |
1999 | 0 | 3 | 3 |
2000 | 0 | 11 | 11 |
2001 | 0 | 10 | 10 |
2002 | 0 | 15 | 15 |
2003 | 0 | 10 | 10 |
2004 | 0 | 8 | 8 |
2005 | 4 | 4 | 8 |
2006 | 10 | 3 | 13 |
2007 | 11 | 2 | 13 |
2008 | 8 | 2 | 10 |
2009 | 18 | 5 | 23 |
2010 | 9 | 6 | 15 |
2011 | 14 | 2 | 16 |
2012 | 7 | 6 | 13 |
2013 | 19 | 4 | 23 |
2014 | 19 | 3 | 22 |
2015 | 18 | 3 | 21 |
2016 | 13 | 5 | 18 |
2017 | 27 | 5 | 32 |
2018 | 12 | 6 | 18 |
2019 | 26 | 7 | 33 |
2020 | 18 | 5 | 23 |
2021 | 21 | 5 | 26 |
2022 | 10 | 17 | 27 |
2023 | 8 | 20 | 28 |
2024 | 2 | 4 | 6 |
Below are the most recent publications written about "alpha-Synuclein" by people in Profiles.
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Sequential CRISPR screening reveals partial NatB inhibition as a strategy to mitigate alpha-synuclein levels in human neurons. Sci Adv. 2024 Feb 09; 10(6):eadj4767.
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The LRRK2 kinase substrates RAB8a and RAB10 contribute complementary but distinct disease-relevant phenotypes in human neurons. Stem Cell Reports. 2024 Feb 13; 19(2):163-173.
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Discovery of small molecule benzothiazole and indole derivatives tackling tau 2N4R and a-synuclein fibrils. Bioorg Med Chem. 2024 Feb 15; 100:117613.
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Toward the quantification of a-synuclein aggregates with digital seed amplification assays. Proc Natl Acad Sci U S A. 2024 Jan 16; 121(3):e2312031121.
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Alpha-Synuclein Pre-Formed Fibrils Injected into Prefrontal Cortex Primarily Spread to Cortical and Subcortical Structures. J Parkinsons Dis. 2024; 14(1):81-94.
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Defining a Lewy Body: Running Up the Hill of Shifting Definitions and Evolving Concepts. J Parkinsons Dis. 2024; 14(1):17-33.
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a-Synuclein emulsifies TDP-43 prion-like domain-RNA liquid droplets to promote heterotypic amyloid fibrils. Commun Biol. 2023 12 05; 6(1):1227.
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Enhanced mTORC1 signaling and protein synthesis in pathologic a-synuclein cellular and animal models of Parkinson's disease. Sci Transl Med. 2023 11 29; 15(724):eadd0499.
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Adding hydrophobicity or positive charges to the cytosolic half of the a-synuclein 3-11 helix increases membrane association and S129 phosphorylation. FEBS Lett. 2024 01; 598(2):210-219.
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Multiplexed Digital Characterization of Misfolded Protein Oligomers via Solid-State Nanopores. J Am Chem Soc. 2023 11 29; 145(47):25776-25788.