Comet Assay

"Comet Assay" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A genotoxicological technique for measuring DNA damage in an individual cell using single-cell gel electrophoresis. Cell DNA fragments assume a "comet with tail" formation on electrophoresis and are detected with an image analysis system. Alkaline assay conditions facilitate sensitive detection of single-strand damage.

Descriptor ID

D020552

MeSH Number(s)

E05.196.401.153.150

E05.301.300.100.150

E05.393.560.150

E05.940.560.150

Concept/Terms

Comet Assay

Alkaline Comet Assay

Below are MeSH descriptors whose meaning is more general than "Comet Assay".

Analytical, Diagnostic and Therapeutic Techniques and Equipment [E]
Investigative Techniques [E05]
Chemistry Techniques, Analytical [E05.196]
Electrophoresis [E05.196.401]
Electrophoresis, Agar Gel [E05.196.401.153]
Comet Assay [E05.196.401.153.150]
Electrochemical Techniques [E05.301]
Electrophoresis [E05.301.300]
Electrophoresis, Agar Gel [E05.301.300.100]
Comet Assay [E05.301.300.100.150]
Genetic Techniques [E05.393]
Mutagenicity Tests [E05.393.560]
Comet Assay [E05.393.560.150]
Toxicity Tests [E05.940]
Mutagenicity Tests [E05.940.560]
Comet Assay [E05.940.560.150]

Below are MeSH descriptors whose meaning is related to "Comet Assay".

Below are MeSH descriptors whose meaning is more specific than "Comet Assay".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Comet Assay" by people in Harvard Catalyst Profiles by year, and whether "Comet Assay" was a major or minor topic of these publication.

Bar chart showing 56 publications over 19 distinct years, with a maximum of 6 publications in 2008 and 2015

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2002	2	2	4
2003	1	2	3
2004	1	2	3
2006	0	2	2
2007	0	2	2
2008	0	6	6
2009	0	2	2
2010	2	3	5
2011	0	3	3
2012	1	4	5
2013	0	4	4
2014	0	3	3
2015	0	6	6
2016	0	1	1
2017	0	1	1
2018	0	1	1
2020	0	1	1
2021	0	1	1
2022	0	3	3

Below are the most recent publications written about "Comet Assay" by people in Profiles.

Could fluoride be considered a genotoxic chemical agent in vivo? A systematic review with meta-analysis. Int J Environ Health Res. 2024 Mar; 34(3):1328-1341.

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Genotoxicity mechanism of food preservative propionic acid in the in vivo Drosophila model: gut damage, oxidative stress, cellular immune response and DNA damage. Toxicol Mech Methods. 2023 May; 33(4):327-336.

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Systematic review on primary and secondary genotoxicity of carbon black nanoparticles in mammalian cells and animals. Mutat Res Rev Mutat Res. 2022 Jul-Dec; 790:108441.

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In vivo effects of 1,4-dioxane on genotoxic parameters and behavioral alterations in Drosophila melanogaster. J Toxicol Environ Health A. 2022 05 19; 85(10):414-430.

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CometChip analysis of human primary lymphocytes enables quantification of inter-individual differences in the kinetics of repair of oxidative DNA damage. Free Radic Biol Med. 2021 10; 174:89-99.

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Pulmonary toxicity of synthetic amorphous silica - effects of porosity and copper oxide doping. Nanotoxicology. 2021 02; 15(1):96-113.

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Molecular Insights Into Di(2-Picolyl) Amine-Induced Cytotoxicity and Apoptosis in Human Kidney (HEK293) Cells. Int J Toxicol. 2020 Jul/Aug; 39(4):341-351.

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Interference of Hemoglobin A1c Due to Hemoglobin Franklin Park. J Appl Lab Med. 2019 03; 3(5):911-913.

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ST6Gal-I sialyltransferase promotes chemoresistance in pancreatic ductal adenocarcinoma by abrogating gemcitabine-mediated DNA damage. J Biol Chem. 2018 01 19; 293(3):984-994.

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A randomized placebo-controlled pilot study of N-acetylcysteine in youth with autism spectrum disorder. Mol Autism. 2016; 7:26.

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