"Focal Adhesions" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An anchoring junction of the cell to a non-cellular substrate. It is composed of a specialized area of the plasma membrane where bundles of the ACTIN CYTOSKELETON terminate and attach to the transmembrane linkers, INTEGRINS, which in turn attach through their extracellular domains to EXTRACELLULAR MATRIX PROTEINS.
Concept/Terms
Focal Adhesions- Focal Adhesions
- Adhesion, Focal
- Adhesions, Focal
- Focal Adhesion
- Focal Contacts
- Contact, Focal
- Contacts, Focal
- Focal Contact
- Adhesion Plaques
- Adhesion Plaque
- Plaque, Adhesion
- Plaques, Adhesion
- Cell-Matrix Adherens Junctions
- Adherens Junction, Cell-Matrix
- Adherens Junctions, Cell-Matrix
- Cell Matrix Adherens Junctions
- Cell-Matrix Adherens Junction
- Junction, Cell-Matrix Adherens
- Junctions, Cell-Matrix Adherens
Below are MeSH descriptors whose meaning is more general than "Focal Adhesions".
Below are MeSH descriptors whose meaning is more specific than "Focal Adhesions".
This graph shows the total number of publications written about "Focal Adhesions" by people in Harvard Catalyst Profiles by year, and whether "Focal Adhesions" was a major or minor topic of these publication.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2001 | 0 | 2 | 2 |
| 2002 | 0 | 5 | 5 |
| 2003 | 2 | 3 | 5 |
| 2004 | 1 | 8 | 9 |
| 2005 | 2 | 2 | 4 |
| 2006 | 4 | 3 | 7 |
| 2007 | 1 | 5 | 6 |
| 2008 | 4 | 1 | 5 |
| 2009 | 1 | 3 | 4 |
| 2010 | 2 | 2 | 4 |
| 2011 | 3 | 4 | 7 |
| 2012 | 0 | 2 | 2 |
| 2013 | 2 | 2 | 4 |
| 2014 | 2 | 3 | 5 |
| 2015 | 1 | 1 | 2 |
| 2016 | 2 | 0 | 2 |
| 2017 | 2 | 1 | 3 |
| 2018 | 3 | 1 | 4 |
| 2019 | 0 | 1 | 1 |
| 2020 | 4 | 1 | 5 |
| 2021 | 2 | 0 | 2 |
| 2023 | 0 | 1 | 1 |
| 2024 | 0 | 1 | 1 |
Below are the most recent publications written about "Focal Adhesions" by people in Profiles.
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Lithium response in bipolar disorder is associated with focal adhesion and PI3K-Akt networks: a multi-omics replication study. Transl Psychiatry. 2024 Feb 23; 14(1):109.
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Uncovering a novel role of focal adhesion and interferon-gamma in cellular rejection of kidney allografts at single cell resolution. Front Immunol. 2023; 14:1139358.
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Force-FAK signaling coupling at individual focal adhesions coordinates mechanosensing and microtissue repair. Nat Commun. 2021 04 21; 12(1):2359.
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SPEG binds with desmin and its deficiency causes defects in triad and focal adhesion proteins. Hum Mol Genet. 2021 02 25; 29(24):3882-3891.
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Biomechanical regulation of focal adhesion and invadopodia formation. J Cell Sci. 2020 10 22; 133(20).
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Mutations disrupting neuritogenesis genes confer risk for cerebral palsy. Nat Genet. 2020 10; 52(10):1046-1056.
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Focal adhesion displacement magnitude is a unifying feature of tensional homeostasis. Acta Biomater. 2020 09 01; 113:372-379.
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A distinct talin2 structure directs isoform specificity in cell adhesion. J Biol Chem. 2020 09 11; 295(37):12885-12899.
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Silencing of Growth Differentiation Factor-15 Promotes Breast Cancer Cell Invasion by Down-regulating Focal Adhesion Genes. Anticancer Res. 2020 Mar; 40(3):1375-1385.
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The focal adhesion scaffold protein Hic-5 regulates vimentin organization in fibroblasts. Mol Biol Cell. 2019 12 01; 30(25):3037-3056.