"Apoptosis" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
One of the mechanisms by which CELL DEATH occurs (compare with NECROSIS and AUTOPHAGOCYTOSIS). Apoptosis is the mechanism responsible for the physiological deletion of cells and appears to be intrinsically programmed. It is characterized by distinctive morphologic changes in the nucleus and cytoplasm, chromatin cleavage at regularly spaced sites, and the endonucleolytic cleavage of genomic DNA; (DNA FRAGMENTATION); at internucleosomal sites. This mode of cell death serves as a balance to mitosis in regulating the size of animal tissues and in mediating pathologic processes associated with tumor growth.
Concept/Terms
Apoptosis- Apoptosis
- Programmed Cell Death, Type I
Below are MeSH descriptors whose meaning is more general than "Apoptosis".
Below are MeSH descriptors whose meaning is more specific than "Apoptosis".
This graph shows the total number of publications written about "Apoptosis" by people in Harvard Catalyst Profiles by year, and whether "Apoptosis" was a major or minor topic of these publication.
To see the data from this visualization as text,
click here.
Year | Major Topic | Minor Topic | Total |
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1994 | 13 | 7 | 20 |
1995 | 22 | 21 | 43 |
1996 | 41 | 25 | 66 |
1997 | 70 | 33 | 103 |
1998 | 75 | 64 | 139 |
1999 | 95 | 72 | 167 |
2000 | 99 | 81 | 180 |
2001 | 82 | 94 | 176 |
2002 | 101 | 133 | 234 |
2003 | 97 | 154 | 251 |
2004 | 106 | 145 | 251 |
2005 | 112 | 180 | 292 |
2006 | 113 | 164 | 277 |
2007 | 89 | 153 | 242 |
2008 | 103 | 162 | 265 |
2009 | 94 | 167 | 261 |
2010 | 94 | 167 | 261 |
2011 | 83 | 218 | 301 |
2012 | 80 | 188 | 268 |
2013 | 90 | 212 | 302 |
2014 | 76 | 206 | 282 |
2015 | 64 | 213 | 277 |
2016 | 73 | 190 | 263 |
2017 | 56 | 225 | 281 |
2018 | 63 | 168 | 231 |
2019 | 53 | 188 | 241 |
2020 | 47 | 180 | 227 |
2021 | 34 | 133 | 167 |
2022 | 13 | 65 | 78 |
2023 | 11 | 43 | 54 |
2024 | 1 | 13 | 14 |
Below are the most recent publications written about "Apoptosis" by people in Profiles.
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BH3 profiling as pharmacodynamic biomarker for the activity of BH3 mimetics. Haematologica. 2024 Apr 01; 109(4):1253-1258.
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A p53 score derived from TP53 CRISPR/Cas9 HMCLs predicts survival and reveals a major role of BAX in the response to BH3 mimetics. Blood. 2024 Mar 28; 143(13):1242-1258.
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Transformer-based spatial-temporal detection of apoptotic cell death in live-cell imaging. Elife. 2024 03 18; 12.
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Disrupting pro-survival and inflammatory pathways with dimethyl fumarate sensitizes chronic lymphocytic leukemia to cell death. Cell Death Dis. 2024 Mar 18; 15(3):224.
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Multiomic profiling of breast cancer cells uncovers stress MAPK-associated sensitivity to AKT degradation. Sci Signal. 2024 Feb 27; 17(825):eadf2670.
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Treatment with the apoptosis inhibitor Asunercept reduces clone sizes in patients with lower risk Myelodysplastic Neoplasms. Ann Hematol. 2024 Apr; 103(4):1221-1233.
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The UBE2J2/UBE2K-MARCH5 ubiquitination machinery regulates apoptosis in response to venetoclax in acute myeloid leukemia. Leukemia. 2024 Mar; 38(3):652-656.
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Exercise Inhibits Doxorubicin-Induced Cardiotoxicity via Regulating B Cells. Circ Res. 2024 03; 134(5):550-568.
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First-in-Human Study with Preclinical Data of BCL-2/BCL-xL Inhibitor Pelcitoclax in Locally Advanced or Metastatic Solid Tumors. Clin Cancer Res. 2024 02 01; 30(3):506-521.
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MITOL deficiency triggers hematopoietic stem cell apoptosis via ER stress response. EMBO J. 2024 Feb; 43(3):339-361.