src Homology Domains

"src Homology Domains" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

Regions of AMINO ACID SEQUENCE similarity in the SRC-FAMILY TYROSINE KINASES that fold into specific functional tertiary structures. The SH1 domain is a CATALYTIC DOMAIN. SH2 and SH3 domains are protein interaction domains. SH2 usually binds PHOSPHOTYROSINE-containing proteins and SH3 interacts with CYTOSKELETAL PROTEINS.

Descriptor ID

D018909

MeSH Number(s)

G02.111.570.790.709.610.640.750

Concept/Terms

Below are MeSH descriptors whose meaning is more general than "src Homology Domains".

Biological Sciences [G]
Chemical Phenomena [G02]
Biochemical Phenomena [G02.111]
Molecular Structure [G02.111.570]
Molecular Conformation [G02.111.570.790]
Protein Conformation [G02.111.570.790.709]
Protein Structure, Tertiary [G02.111.570.790.709.610]
Protein Interaction Domains and Motifs [G02.111.570.790.709.610.640]
src Homology Domains [G02.111.570.790.709.610.640.750]

Below are MeSH descriptors whose meaning is related to "src Homology Domains".

Below are MeSH descriptors whose meaning is more specific than "src Homology Domains".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "src Homology Domains" by people in Harvard Catalyst Profiles by year, and whether "src Homology Domains" was a major or minor topic of these publication.

Bar chart showing 278 publications over 28 distinct years, with a maximum of 31 publications in 1996

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1994	1	0	1
1995	5	4	9
1996	14	17	31
1997	7	21	28
1998	6	12	18
1999	7	15	22
2000	5	21	26
2001	6	9	15
2002	2	17	19
2003	3	17	20
2004	4	10	14
2005	0	7	7
2006	4	10	14
2007	0	4	4
2008	1	2	3
2009	2	1	3
2010	2	5	7
2011	4	1	5
2012	1	4	5
2013	1	2	3
2014	0	4	4
2015	0	2	2
2016	2	2	4
2018	0	2	2
2019	1	4	5
2020	0	4	4
2021	1	1	2
2022	1	0	1

Below are the most recent publications written about "src Homology Domains" by people in Profiles.

Structure of a Janus kinase cytokine receptor complex reveals the basis for dimeric activation. Science. 2022 04 08; 376(6589):163-169.

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SH2-Domain Protein Isolation Using Synthetic Phosphorylated Peptides to Study VEGFR2 Signaling. Methods Mol Biol. 2022; 2475:97-111.

View in: PubMed
Characterization of unique functionalities in c-Src domains required for osteoclast podosome belt formation. J Biol Chem. 2021 Jan-Jun; 296:100790.

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Time-resolved phosphoproteomics reveals scaffolding and catalysis-responsive patterns of SHP2-dependent signaling. Elife. 2021 03 23; 10.

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Targeting the Interaction between the SH3 Domain of Grb2 and Gab2. Cells. 2020 11 07; 9(11).

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Cytosolic delivery of peptidic STAT3 SH2 domain inhibitors. Bioorg Med Chem. 2020 06 15; 28(12):115542.

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Glycine substitution in SH3-SH2 connector of Hck tyrosine kinase causes population shift from assembled to disassembled state. Biochim Biophys Acta Gen Subj. 2020 07; 1864(7):129604.

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Interaction of SHP-2 SH2 domains with PD-1 ITSM induces PD-1 dimerization and SHP-2 activation. Commun Biol. 2020 03 17; 3(1):128.

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Unveiling the Molecular Basis of the Noonan Syndrome-Causing Mutation T42A of SHP2. Int J Mol Sci. 2020 Jan 10; 21(2).

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Biophysical prediction of protein-peptide interactions and signaling networks using machine learning. Nat Methods. 2020 02; 17(2):175-183.

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