Werner Syndrome

"Werner Syndrome" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

An autosomal recessive disorder that causes premature aging in adults, characterized by sclerodermal skin changes, cataracts, subcutaneous calcification, muscular atrophy, a tendency to diabetes mellitus, aged appearance of the face, baldness, and a high incidence of neoplastic disease.

Descriptor ID

D014898

MeSH Number(s)

C16.320.925

C18.452.284.960

Concept/Terms

Werner Syndrome

Below are MeSH descriptors whose meaning is more general than "Werner Syndrome".

Diseases [C]
Congenital, Hereditary, and Neonatal Diseases and Abnormalities [C16]
Genetic Diseases, Inborn [C16.320]
Werner Syndrome [C16.320.925]
Nutritional and Metabolic Diseases [C18]
Metabolic Diseases [C18.452]
DNA Repair-Deficiency Disorders [C18.452.284]
Werner Syndrome [C18.452.284.960]

Below are MeSH descriptors whose meaning is related to "Werner Syndrome".

Below are MeSH descriptors whose meaning is more specific than "Werner Syndrome".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Werner Syndrome" by people in Harvard Catalyst Profiles by year, and whether "Werner Syndrome" was a major or minor topic of these publication.

Bar chart showing 10 publications over 9 distinct years, with a maximum of 2 publications in 2007

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1997	0	1	1
1998	0	1	1
2001	0	1	1
2003	1	0	1
2007	2	0	2
2009	1	0	1
2012	0	1	1
2018	1	0	1
2022	1	0	1

Below are the most recent publications written about "Werner Syndrome" by people in Profiles.

A high prevalence of myeloid malignancies in progeria with Werner syndrome is associated with p53 insufficiency. Exp Hematol. 2022 05; 109:11-17.

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Everolimus rescues multiple cellular defects in laminopathy-patient fibroblasts. Proc Natl Acad Sci U S A. 2018 04 17; 115(16):4206-4211.

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WRN Mutation Update: Mutation Spectrum, Patient Registries, and Translational Prospects. Hum Mutat. 2017 01; 38(1):7-15.

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Atypical Aicardi-Goutieres syndrome: is the WRN locus a modifier? Am J Med Genet A. 2014 Oct; 164A(10):2510-3.

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Endocrine and metabolic abnormalities in a girl with childhood Werner syndrome: case report. J Am Geriatr Soc. 2014 Jul; 62(7):1404-5.

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Search and insights into novel genetic alterations leading to classical and atypical Werner syndrome. Gerontology. 2014; 60(3):239-46.

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The heat shock transcription factor Hsf1 is downregulated in DNA damage-associated senescence, contributing to the maintenance of senescence phenotype. Aging Cell. 2012 Aug; 11(4):617-27.

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Clinical utility gene card for: Werner syndrome. Eur J Hum Genet. 2012 May; 20(5).

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Coronary artery disease in a Werner syndrome-like form of progeria characterized by low levels of progerin, a splice variant of lamin A. Am J Med Genet A. 2011 Dec; 155A(12):3002-6.

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Telomere sister chromatid exchange and the process of aging. Aging (Albany NY). 2010 Oct; 2(10):727-30.

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