CDC2 Protein Kinase

"CDC2 Protein Kinase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

Phosphoprotein with protein kinase activity that functions in the G2/M phase transition of the CELL CYCLE. It is the catalytic subunit of the MATURATION-PROMOTING FACTOR and complexes with both CYCLIN A and CYCLIN B in mammalian cells. The maximal activity of cyclin-dependent kinase 1 is achieved when it is fully dephosphorylated.

Descriptor ID

D016203

MeSH Number(s)

D08.811.913.696.620.682.700.200.067.249

D08.811.913.696.620.682.700.200.580.500

D12.644.360.250.067.249

D12.644.360.250.580.500

D12.776.167.200.067.249

D12.776.167.200.580.500

D12.776.476.250.067.249

D12.776.476.250.580.500

D12.776.744.360

Concept/Terms

CDC2 Protein Kinase

p34cdc2 Protein

Below are MeSH descriptors whose meaning is more general than "CDC2 Protein Kinase".

Chemicals and Drugs [D]
Enzymes and Coenzymes [D08]
Enzymes [D08.811]
Transferases [D08.811.913]
Phosphotransferases [D08.811.913.696]
Phosphotransferases (Alcohol Group Acceptor) [D08.811.913.696.620]
Protein Kinases [D08.811.913.696.620.682]
Protein-Serine-Threonine Kinases [D08.811.913.696.620.682.700]
Cyclin-Dependent Kinases [D08.811.913.696.620.682.700.200]
CDC2-CDC28 Kinases [D08.811.913.696.620.682.700.200.067]
CDC2 Protein Kinase [D08.811.913.696.620.682.700.200.067.249]
Maturation-Promoting Factor [D08.811.913.696.620.682.700.200.580]
CDC2 Protein Kinase [D08.811.913.696.620.682.700.200.580.500]
Amino Acids, Peptides, and Proteins [D12]
Peptides [D12.644]
Intracellular Signaling Peptides and Proteins [D12.644.360]
Cyclin-Dependent Kinases [D12.644.360.250]
CDC2-CDC28 Kinases [D12.644.360.250.067]
CDC2 Protein Kinase [D12.644.360.250.067.249]
Maturation-Promoting Factor [D12.644.360.250.580]
CDC2 Protein Kinase [D12.644.360.250.580.500]
Proteins [D12.776]
Cell Cycle Proteins [D12.776.167]
Cyclin-Dependent Kinases [D12.776.167.200]
CDC2-CDC28 Kinases [D12.776.167.200.067]
CDC2 Protein Kinase [D12.776.167.200.067.249]
Maturation-Promoting Factor [D12.776.167.200.580]
CDC2 Protein Kinase [D12.776.167.200.580.500]
Intracellular Signaling Peptides and Proteins [D12.776.476]
Cyclin-Dependent Kinases [D12.776.476.250]
CDC2-CDC28 Kinases [D12.776.476.250.067]
CDC2 Protein Kinase [D12.776.476.250.067.249]
Maturation-Promoting Factor [D12.776.476.250.580]
CDC2 Protein Kinase [D12.776.476.250.580.500]
Phosphoproteins [D12.776.744]
CDC2 Protein Kinase [D12.776.744.360]

Below are MeSH descriptors whose meaning is related to "CDC2 Protein Kinase".

Below are MeSH descriptors whose meaning is more specific than "CDC2 Protein Kinase".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "CDC2 Protein Kinase" by people in Harvard Catalyst Profiles by year, and whether "CDC2 Protein Kinase" was a major or minor topic of these publication.

Bar chart showing 128 publications over 29 distinct years, with a maximum of 9 publications in 2003

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1994	4	2	6
1995	4	3	7
1996	1	2	3
1997	2	2	4
1998	1	1	2
1999	2	4	6
2001	2	4	6
2002	2	4	6
2003	2	7	9
2004	2	1	3
2005	2	1	3
2006	4	1	5
2007	3	3	6
2008	1	1	2
2009	4	4	8
2010	3	3	6
2011	3	2	5
2012	3	3	6
2013	0	3	3
2014	2	2	4
2015	1	1	2
2016	2	2	4
2017	2	5	7
2018	2	0	2
2019	1	1	2
2020	2	4	6
2021	2	1	3
2022	0	1	1
2023	1	0	1

Below are the most recent publications written about "CDC2 Protein Kinase" by people in Profiles.

Oncogenic CDK13 mutations impede nuclear RNA surveillance. Science. 2023 04 21; 380(6642):eabn7625.

View in: PubMed
CDK7/12/13 inhibition targets an oscillating leukemia stem cell network and synergizes with venetoclax in acute myeloid leukemia. EMBO Mol Med. 2022 04 07; 14(4):e14990.

View in: PubMed
An ADAR1-dependent RNA editing event in the cyclin-dependent kinase CDK13 promotes thyroid cancer hallmarks. Mol Cancer. 2021 09 08; 20(1):115.

View in: PubMed
Phosphorylation of the androgen receptor at Ser81 is co-sustained by CDK1 and CDK9 and leads to AR-mediated transactivation in prostate cancer. Mol Oncol. 2021 07; 15(7):1901-1920.

View in: PubMed
Structure-activity relationship study of THZ531 derivatives enables the discovery of BSJ-01-175 as a dual CDK12/13 covalent inhibitor with efficacy in Ewing sarcoma. Eur J Med Chem. 2021 Oct 05; 221:113481.

View in: PubMed
Adult-type granulosa cell tumor of the ovary: a FOXL2-centric disease. J Pathol Clin Res. 2021 05; 7(3):243-252.

View in: PubMed
Monitoring and modeling of lymphocytic leukemia cell bioenergetics reveals decreased ATP synthesis during cell division. Nat Commun. 2020 10 05; 11(1):4983.

View in: PubMed
L ARP7 Is a BRCA1 Ubiquitinase Substrate and Regulates Genome Stability and Tumorigenesis. Cell Rep. 2020 07 28; 32(4):107974.

View in: PubMed
Discovery of MFH290: A Potent and Highly Selective Covalent Inhibitor for Cyclin-Dependent Kinase 12/13. J Med Chem. 2020 07 09; 63(13):6708-6726.

View in: PubMed
YTHDF2 promotes mitotic entry and is regulated by cell cycle mediators. PLoS Biol. 2020 04; 18(4):e3000664.

View in: PubMed

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