Interferons

"Interferons" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

Proteins secreted by vertebrate cells in response to a wide variety of inducers. They confer resistance against many different viruses, inhibit proliferation of normal and malignant cells, impede multiplication of intracellular parasites, enhance macrophage and granulocyte phagocytosis, augment natural killer cell activity, and show several other immunomodulatory functions.

Descriptor ID

D007372

MeSH Number(s)

D12.644.276.374.440

D12.644.276.718

D12.776.467.374.440

D12.776.467.718

D23.529.374.440

D23.529.718

Concept/Terms

Interferons

Below are MeSH descriptors whose meaning is more general than "Interferons".

Chemicals and Drugs [D]
Amino Acids, Peptides, and Proteins [D12]
Peptides [D12.644]
Intercellular Signaling Peptides and Proteins [D12.644.276]
Cytokines [D12.644.276.374]
Interferons [D12.644.276.374.440]
Interferons [D12.644.276.718]
Proteins [D12.776]
Intercellular Signaling Peptides and Proteins [D12.776.467]
Cytokines [D12.776.467.374]
Interferons [D12.776.467.374.440]
Interferons [D12.776.467.718]
Biological Factors [D23]
Intercellular Signaling Peptides and Proteins [D23.529]
Cytokines [D23.529.374]
Interferons [D23.529.374.440]
Interferons [D23.529.718]

Below are MeSH descriptors whose meaning is related to "Interferons".

Below are MeSH descriptors whose meaning is more specific than "Interferons".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Interferons" by people in Harvard Catalyst Profiles by year, and whether "Interferons" was a major or minor topic of these publication.

Bar chart showing 357 publications over 31 distinct years, with a maximum of 28 publications in 2020

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1994	0	2	2
1995	0	3	3
1996	0	2	2
1997	0	3	3
1998	2	2	4
1999	2	3	5
2000	0	3	3
2001	2	5	7
2002	4	6	10
2003	1	3	4
2004	0	4	4
2005	3	9	12
2006	1	4	5
2007	5	5	10
2008	4	6	10
2009	1	6	7
2010	5	15	20
2011	2	13	15
2012	3	17	20
2013	5	14	19
2014	3	8	11
2015	5	4	9
2016	7	12	19
2017	6	11	17
2018	10	10	20
2019	7	12	19
2020	12	16	28
2021	14	13	27
2022	4	23	27
2023	0	11	11
2024	2	2	4

Below are the most recent publications written about "Interferons" by people in Profiles.

Human otic progenitor cell models of congenital hearing loss reveal potential pathophysiologic mechanisms of Zika virus and cytomegalovirus infections. mBio. 2024 Apr 10; 15(4):e0019924.

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Pro-inflammatory feedback loops define immune responses to pathogenic Lentivirus infection. Genome Med. 2024 Feb 05; 16(1):24.

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The population context is a driver of the heterogeneous response of epithelial cells to interferons. Mol Syst Biol. 2024 Mar; 20(3):242-275.

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XRN1 deletion induces PKR-dependent cell lethality in interferon-activated cancer cells. Cell Rep. 2024 Feb 27; 43(2):113600.

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Structures, functions and adaptations of the human LINE-1 ORF2 protein. Nature. 2024 Feb; 626(7997):194-206.

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Aurora A kinase inhibition induces accumulation of SCLC tumor cells in mitosis with restored interferon signaling to increase response to PD-L1. Cell Rep Med. 2023 11 21; 4(11):101282.

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Nuclear interferon-stimulated gene product maintains heterochromatin on the herpes simplex viral genome to limit lytic infection. Proc Natl Acad Sci U S A. 2023 Nov 07; 120(45):e2310996120.

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The PTPN2/PTPN1 inhibitor ABBV-CLS-484 unleashes potent anti-tumour immunity. Nature. 2023 Oct; 622(7984):850-862.

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The time-course of cancer cachexia onset reveals biphasic transcriptional disruptions in female skeletal muscle distinct from males. BMC Genomics. 2023 Jul 04; 24(1):374.

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Single cell transcriptomics identifies distinct profiles in pediatric acute respiratory distress syndrome. Nat Commun. 2023 06 30; 14(1):3870.

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