"Lysosomes" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A class of morphologically heterogeneous cytoplasmic particles in animal and plant tissues characterized by their content of hydrolytic enzymes and the structure-linked latency of these enzymes. The intracellular functions of lysosomes depend on their lytic potential. The single unit membrane of the lysosome acts as a barrier between the enzymes enclosed in the lysosome and the external substrate. The activity of the enzymes contained in lysosomes is limited or nil unless the vesicle in which they are enclosed is ruptured. Such rupture is supposed to be under metabolic (hormonal) control. (From Rieger et al., Glossary of Genetics: Classical and Molecular, 5th ed)
MeSH Number(s)
A11.284.430.214.190.875.190.550
Below are MeSH descriptors whose meaning is more general than "Lysosomes".
Below are MeSH descriptors whose meaning is more specific than "Lysosomes".
This graph shows the total number of publications written about "Lysosomes" by people in Harvard Catalyst Profiles by year, and whether "Lysosomes" was a major or minor topic of these publication.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1994 | 2 | 3 | 5 |
| 1995 | 2 | 5 | 7 |
| 1996 | 3 | 7 | 10 |
| 1997 | 2 | 2 | 4 |
| 1998 | 2 | 3 | 5 |
| 1999 | 1 | 5 | 6 |
| 2000 | 4 | 10 | 14 |
| 2001 | 2 | 6 | 8 |
| 2002 | 5 | 8 | 13 |
| 2003 | 5 | 3 | 8 |
| 2004 | 5 | 7 | 12 |
| 2005 | 7 | 10 | 17 |
| 2006 | 4 | 5 | 9 |
| 2007 | 4 | 6 | 10 |
| 2008 | 7 | 4 | 11 |
| 2009 | 3 | 12 | 15 |
| 2010 | 6 | 11 | 17 |
| 2011 | 5 | 13 | 18 |
| 2012 | 7 | 15 | 22 |
| 2013 | 9 | 23 | 32 |
| 2014 | 5 | 20 | 25 |
| 2015 | 16 | 9 | 25 |
| 2016 | 11 | 16 | 27 |
| 2017 | 13 | 12 | 25 |
| 2018 | 15 | 19 | 34 |
| 2019 | 26 | 21 | 47 |
| 2020 | 16 | 17 | 33 |
| 2021 | 15 | 23 | 38 |
| 2022 | 5 | 13 | 18 |
| 2023 | 1 | 13 | 14 |
| 2024 | 1 | 2 | 3 |
Below are the most recent publications written about "Lysosomes" by people in Profiles.
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VPS13C regulates phospho-Rab10-mediated lysosomal function in human dopaminergic neurons. J Cell Biol. 2024 05 06; 223(5).
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A mechanism of lysosomal calcium entry. Sci Adv. 2024 Feb 16; 10(7):eadk2317.
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Phosphoglycerate kinase 1 acts as a cargo adaptor to promote EGFR transport to the lysosome. Nat Commun. 2024 Feb 03; 15(1):1021.
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Sensitivity to targeted UBA1 inhibition in a myeloid cell line model of VEXAS syndrome. Blood Adv. 2023 12 26; 7(24):7445-7456.
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Loss of Lipid Carrier ApoE Exacerbates Brain Glial and Inflammatory Responses after Lysosomal GBA1 Inhibition. Cells. 2023 11 02; 12(21).
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c.376A>G, (p.Ser126Gly) Alpha-Galactosidase A mutation induces ER stress, unfolded protein response and reduced enzyme trafficking to lysosome: Possible relevance in the pathogenesis of late-onset forms of Fabry Disease. Mol Genet Metab. 2023 11; 140(3):107700.
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Parkin regulates amino acid homeostasis at mitochondria-lysosome (M/L) contact sites in Parkinson's disease. Sci Adv. 2023 07 21; 9(29):eadh3347.
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Autophagy regulates sex steroid hormone synthesis through lysosomal degradation of lipid droplets in human ovary and testis. Cell Death Dis. 2023 05 26; 14(5):342.
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Acid ceramidase involved in pathogenic cascade leading to accumulation of a-synuclein in iPSC model of GBA1-associated Parkinson's disease. Hum Mol Genet. 2023 05 18; 32(11):1888-1900.
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A terpene nucleoside from M. tuberculosis induces lysosomal lipid storage in foamy macrophages. J Clin Invest. 2023 03 15; 133(6).