Receptor, Macrophage Colony-Stimulating Factor
"Receptor, Macrophage Colony-Stimulating Factor" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A receptor for MACROPHAGE COLONY-STIMULATING FACTOR encoded by the c-fms proto-oncogene (GENES, FMS). It contains an intrinsic protein-tyrosine kinase activity. When activated the receptor undergoes autophosphorylation, phosphorylation of down-stream signaling molecules and rapid down-regulation.
MeSH Number(s)
D08.811.913.696.620.682.725.400.500
D12.776.543.750.060.492
D12.776.543.750.705.852.150.150
D12.776.543.750.750.400.200.200
D12.776.624.664.700.800
D23.050.301.264.035.597
D23.101.100.110.597
Concept/Terms
Receptor, Macrophage Colony-Stimulating Factor- Receptor, Macrophage Colony-Stimulating Factor
- Receptor, Macrophage Colony Stimulating Factor
- c-fms Protein
- c fms Protein
- CD115 Antigen
- Antigen, CD115
- CD115 Antigens
- CSF-1 Receptor
- Receptors, Macrophage Colony-Stimulating Factor
- Receptors, Macrophage Colony Stimulating Factor
- M-CSF Receptors
- Macrophage Colony-Stimulating Factor Receptors
- Macrophage Colony Stimulating Factor Receptors
- Proto-Oncogene Protein fms
- Receptor, CSF-1
- Receptor, CSF 1
- Receptors, CSF-1
- CSF-1 Receptors
- Receptors, CSF 1
- Receptors, M-CSF
- Receptors, M CSF
- Antigens, CD115
- fms Proto-Oncogene Protein
- Proto-Oncogene Protein, fms
- fms Proto Oncogene Protein
Below are MeSH descriptors whose meaning is more general than "Receptor, Macrophage Colony-Stimulating Factor".
- Chemicals and Drugs [D]
- Enzymes and Coenzymes [D08]
- Enzymes [D08.811]
- Transferases [D08.811.913]
- Phosphotransferases [D08.811.913.696]
- Phosphotransferases (Alcohol Group Acceptor) [D08.811.913.696.620]
- Protein Kinases [D08.811.913.696.620.682]
- Protein-Tyrosine Kinases [D08.811.913.696.620.682.725]
- Receptor Protein-Tyrosine Kinases [D08.811.913.696.620.682.725.400]
- Receptor, Macrophage Colony-Stimulating Factor [D08.811.913.696.620.682.725.400.500]
- Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
- Membrane Proteins [D12.776.543]
- Receptors, Cell Surface [D12.776.543.750]
- Receptor Protein-Tyrosine Kinases [D12.776.543.750.060]
- Receptor, Macrophage Colony-Stimulating Factor [D12.776.543.750.060.492]
- Receptors, Immunologic [D12.776.543.750.705]
- Receptors, Cytokine [D12.776.543.750.705.852]
- Receptors, Colony-Stimulating Factor [D12.776.543.750.705.852.150]
- Receptor, Macrophage Colony-Stimulating Factor [D12.776.543.750.705.852.150.150]
- Receptors, Peptide [D12.776.543.750.750]
- Receptors, Growth Factor [D12.776.543.750.750.400]
- Receptors, Colony-Stimulating Factor [D12.776.543.750.750.400.200]
- Receptor, Macrophage Colony-Stimulating Factor [D12.776.543.750.750.400.200.200]
- Neoplasm Proteins [D12.776.624]
- Oncogene Proteins [D12.776.624.664]
- Proto-Oncogene Proteins [D12.776.624.664.700]
- Receptor, Macrophage Colony-Stimulating Factor [D12.776.624.664.700.800]
- Biological Factors [D23]
- Antigens [D23.050]
- Antigens, Surface [D23.050.301]
- Antigens, Differentiation [D23.050.301.264]
- Antigens, CD [D23.050.301.264.035]
- Receptor, Macrophage Colony-Stimulating Factor [D23.050.301.264.035.597]
- Biological Markers [D23.101]
- Antigens, Differentiation [D23.101.100]
- Antigens, CD [D23.101.100.110]
- Receptor, Macrophage Colony-Stimulating Factor [D23.101.100.110.597]
Below are MeSH descriptors whose meaning is more specific than "Receptor, Macrophage Colony-Stimulating Factor".
This graph shows the total number of publications written about "Receptor, Macrophage Colony-Stimulating Factor" by people in Harvard Catalyst Profiles by year, and whether "Receptor, Macrophage Colony-Stimulating Factor" was a major or minor topic of these publication.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1994 | 2 | 2 | 4 |
| 1995 | 1 | 0 | 1 |
| 1996 | 3 | 2 | 5 |
| 1998 | 1 | 2 | 3 |
| 1999 | 2 | 2 | 4 |
| 2002 | 1 | 2 | 3 |
| 2004 | 2 | 0 | 2 |
| 2005 | 0 | 1 | 1 |
| 2006 | 0 | 1 | 1 |
| 2007 | 1 | 0 | 1 |
| 2009 | 0 | 1 | 1 |
| 2010 | 1 | 1 | 2 |
| 2011 | 0 | 2 | 2 |
| 2012 | 1 | 0 | 1 |
| 2013 | 2 | 0 | 2 |
| 2014 | 2 | 3 | 5 |
| 2015 | 3 | 2 | 5 |
| 2016 | 1 | 2 | 3 |
| 2019 | 0 | 1 | 1 |
| 2020 | 1 | 0 | 1 |
Below are the most recent publications written about "Receptor, Macrophage Colony-Stimulating Factor" by people in Profiles.
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Medulloblastoma recurrence and metastatic spread are independent of colony-stimulating factor 1 receptor signaling and macrophage survival. J Neurooncol. 2021 Jun; 153(2):225-237.
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The Inhibitory Role of Rab11b in Osteoclastogenesis through Triggering Lysosome-Induced Degradation of c-Fms and RANK Surface Receptors. Int J Mol Sci. 2020 Dec 08; 21(24).
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Rab11A Functions as a Negative Regulator of Osteoclastogenesis through Dictating Lysosome-Induced Proteolysis of c-fms and RANK Surface Receptors. Cells. 2020 10 31; 9(11).
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Cerebrospinal fluid penetration of the colony-stimulating factor-1 receptor (CSF-1R) inhibitor, pexidartinib. Cancer Chemother Pharmacol. 2020 05; 85(5):1003-1007.
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CSF-1 controls cerebellar microglia and is required for motor function and social interaction. J Exp Med. 2019 10 07; 216(10):2265-2281.
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Beyond the M-CSF receptor - novel therapeutic targets in tumor-associated macrophages. FEBS J. 2018 02; 285(4):777-787.
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Macrophage Migration Inhibitory Factor (MIF) Supports Homing of Osteoclast Precursors to Peripheral Osteolytic Lesions. J Bone Miner Res. 2016 09; 31(9):1688-700.
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Resident corneal c-fms(+) macrophages and dendritic cells mediate early cellular infiltration in adenovirus keratitis. Exp Eye Res. 2016 06; 147:144-147.
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CSF1R mosaicism in a family with hereditary diffuse leukoencephalopathy with spheroids. Brain. 2016 06; 139(Pt 6):1666-72.
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Structural Approaches to Cancer Drug Development. N Engl J Med. 2015 Jul 30; 373(5):402-3.