Ribonucleoprotein, U2 Small Nuclear
"Ribonucleoprotein, U2 Small Nuclear" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A nuclear RNA-protein complex that plays a role in RNA processing. In the nucleoplasm, the U2 snRNP along with other small nuclear ribonucleoproteins (U1, U4-U6, and U5) assemble into SPLICEOSOMES that remove introns from pre-mRNA by splicing. The U2 snRNA forms base pairs with conserved sequence motifs at the branch point, which associates with a heat- and RNAase-sensitive factor in an early step of splicing.
MeSH Number(s)
D12.776.157.725.500.875.605
D12.776.664.962.500.875.605
Concept/Terms
Ribonucleoprotein, U2 Small Nuclear- Ribonucleoprotein, U2 Small Nuclear
- U2 Small Nuclear Ribonucleoproteins
- Ribonucleoproteins, Small, U2
- Small Nuclear Ribonucleoproteins, U2
- U2 snRNP
Below are MeSH descriptors whose meaning is more general than "Ribonucleoprotein, U2 Small Nuclear".
Below are MeSH descriptors whose meaning is more specific than "Ribonucleoprotein, U2 Small Nuclear".
This graph shows the total number of publications written about "Ribonucleoprotein, U2 Small Nuclear" by people in Harvard Catalyst Profiles by year, and whether "Ribonucleoprotein, U2 Small Nuclear" was a major or minor topic of these publication.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1994 | 0 | 1 | 1 |
| 1999 | 1 | 0 | 1 |
| 2004 | 0 | 1 | 1 |
| 2008 | 0 | 1 | 1 |
| 2011 | 1 | 0 | 1 |
| 2013 | 1 | 0 | 1 |
| 2014 | 0 | 2 | 2 |
| 2015 | 0 | 2 | 2 |
| 2016 | 0 | 1 | 1 |
| 2017 | 0 | 1 | 1 |
Below are the most recent publications written about "Ribonucleoprotein, U2 Small Nuclear" by people in Profiles.
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A U2-snRNP-independent role of SF3b in promoting mRNA export. Proc Natl Acad Sci U S A. 2019 04 16; 116(16):7837-7846.
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Evidence that C9ORF72 Dipeptide Repeat Proteins Associate with U2 snRNP to Cause Mis-splicing in ALS/FTD Patients. Cell Rep. 2017 06 13; 19(11):2244-2256.
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Crystal structure of U2 snRNP SF3b components: Hsh49p in complex with Cus1p-binding domain. RNA. 2017 06; 23(6):968-981.
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Targeting Splicing in the Treatment of Myelodysplastic Syndromes and Other Myeloid Neoplasms. Curr Hematol Malig Rep. 2016 12; 11(6):408-415.
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Comprehensive genomic analysis of malignant pleural mesothelioma identifies recurrent mutations, gene fusions and splicing alterations. Nat Genet. 2016 Apr; 48(4):407-16.
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Functional Genomic Screening Reveals Splicing of the EWS-FLI1 Fusion Transcript as a Vulnerability in Ewing Sarcoma. Cell Rep. 2016 Jan 26; 14(3):598-610.
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The spliceosome is a therapeutic vulnerability in MYC-driven cancer. Nature. 2015 Sep 17; 525(7569):384-8.
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Presence of multiple recurrent mutations confers poor trial outcome of relapsed/refractory CLL. Blood. 2015 Oct 29; 126(18):2110-7.
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SF3B1 mutation identifies a distinct subset of myelodysplastic syndrome with ring sideroblasts. Blood. 2015 Jul 09; 126(2):233-41.
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Reclassifying myelodysplastic syndromes: what's where in the new WHO and why. Hematology Am Soc Hematol Educ Program. 2015; 2015:294-8.