Protein Tyrosine Phosphatase, Non-Receptor Type 11
"Protein Tyrosine Phosphatase, Non-Receptor Type 11" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A subtype of non-receptor protein tyrosine phosphatases that contain two SRC HOMOLOGY DOMAINS. Mutations in the gene for protein tyrosine phosphatase, non-receptor type 11 are associated with NOONAN SYNDROME.
MeSH Number(s)
D08.811.277.352.650.775.300.800
D08.811.277.352.650.775.700.800
D12.644.360.585.800
D12.776.476.564.800
D12.776.476.800.800
Concept/Terms
Protein Tyrosine Phosphatase, Non-Receptor Type 11- Protein Tyrosine Phosphatase, Non-Receptor Type 11
- Protein Tyrosine Phosphatase, Non Receptor Type 11
- Protein Tyrosine Phosphatase PTP3
- Protein-Tyrosine-Phosphatase 2C
- Protein Tyrosine Phosphatase 2C
- Shp-2 Tyrosine Phosphatase
- Phosphatase, Shp-2 Tyrosine
- Shp 2 Tyrosine Phosphatase
- Tyrosine Phosphatase, Shp-2
- SHP2 Phosphatase
- Phosphatase, SHP2
- SHPTP2
- Phosphotyrosine Phosphatase Syp
- SH Protein-Tyrosine Phosphatase
- Protein-Tyrosine Phosphatase, SH
- SH Protein Tyrosine Phosphatase
Below are MeSH descriptors whose meaning is more general than "Protein Tyrosine Phosphatase, Non-Receptor Type 11".
- Chemicals and Drugs [D]
- Enzymes and Coenzymes [D08]
- Enzymes [D08.811]
- Hydrolases [D08.811.277]
- Esterases [D08.811.277.352]
- Phosphoric Monoester Hydrolases [D08.811.277.352.650]
- Protein Tyrosine Phosphatases [D08.811.277.352.650.775]
- Protein Tyrosine Phosphatases, Non-Receptor [D08.811.277.352.650.775.300]
- Protein Tyrosine Phosphatase, Non-Receptor Type 11 [D08.811.277.352.650.775.300.800]
- SH2 Domain-Containing Protein Tyrosine Phosphatases [D08.811.277.352.650.775.700]
- Protein Tyrosine Phosphatase, Non-Receptor Type 11 [D08.811.277.352.650.775.700.800]
- Amino Acids, Peptides, and Proteins [D12]
- Peptides [D12.644]
- Intracellular Signaling Peptides and Proteins [D12.644.360]
- Protein Tyrosine Phosphatases, Non-Receptor [D12.644.360.585]
- Protein Tyrosine Phosphatase, Non-Receptor Type 11 [D12.644.360.585.800]
- Proteins [D12.776]
- Intracellular Signaling Peptides and Proteins [D12.776.476]
- Protein Tyrosine Phosphatases, Non-Receptor [D12.776.476.564]
- Protein Tyrosine Phosphatase, Non-Receptor Type 11 [D12.776.476.564.800]
- SH2 Domain-Containing Protein Tyrosine Phosphatases [D12.776.476.800]
- Protein Tyrosine Phosphatase, Non-Receptor Type 11 [D12.776.476.800.800]
Below are MeSH descriptors whose meaning is more specific than "Protein Tyrosine Phosphatase, Non-Receptor Type 11".
This graph shows the total number of publications written about "Protein Tyrosine Phosphatase, Non-Receptor Type 11" by people in Harvard Catalyst Profiles by year, and whether "Protein Tyrosine Phosphatase, Non-Receptor Type 11" was a major or minor topic of these publication.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1994 | 0 | 3 | 3 |
| 1995 | 0 | 4 | 4 |
| 1996 | 0 | 5 | 5 |
| 1997 | 0 | 8 | 8 |
| 1998 | 0 | 5 | 5 |
| 1999 | 0 | 6 | 6 |
| 2000 | 0 | 11 | 11 |
| 2001 | 0 | 7 | 7 |
| 2002 | 0 | 2 | 2 |
| 2003 | 0 | 3 | 3 |
| 2004 | 0 | 2 | 2 |
| 2005 | 0 | 3 | 3 |
| 2006 | 0 | 4 | 4 |
| 2007 | 0 | 4 | 4 |
| 2008 | 1 | 2 | 3 |
| 2009 | 2 | 1 | 3 |
| 2010 | 4 | 4 | 8 |
| 2011 | 4 | 0 | 4 |
| 2012 | 4 | 0 | 4 |
| 2013 | 3 | 3 | 6 |
| 2014 | 3 | 1 | 4 |
| 2015 | 1 | 0 | 1 |
| 2016 | 7 | 3 | 10 |
| 2017 | 6 | 2 | 8 |
| 2018 | 6 | 2 | 8 |
| 2019 | 1 | 4 | 5 |
| 2020 | 2 | 2 | 4 |
| 2021 | 4 | 1 | 5 |
| 2022 | 2 | 2 | 4 |
| 2023 | 1 | 0 | 1 |
Below are the most recent publications written about "Protein Tyrosine Phosphatase, Non-Receptor Type 11" by people in Profiles.
-
SHP2: A Pleiotropic Target at the Interface of Cancer and Its Microenvironment. Cancer Discov. 2023 11 01; 13(11):2339-2355.
-
PTPN11 Mosaicism Causes a Spectrum of Pigmentary and Vascular Neurocutaneous Disorders and Predisposes to Melanoma. J Invest Dermatol. 2023 06; 143(6):1042-1051.e3.
-
Phosphorylation of SHP2 at Tyr62 Enables Acquired Resistance to SHP2 Allosteric Inhibitors in FLT3-ITD-Driven AML. Cancer Res. 2022 06 06; 82(11):2141-2155.
-
Inflammatory response in hematopoietic stem and progenitor cells triggered by activating SHP2 mutations evokes blood defects. Elife. 2022 05 10; 11.
-
Molecular, clinical, and prognostic implications of PTPN11 mutations in acute myeloid leukemia. Blood Adv. 2022 03 08; 6(5):1371-1380.
-
Epithelial cells remove precancerous cells by cell competition via MHC class I-LILRB3 interaction. Nat Immunol. 2021 11; 22(11):1391-1402.
-
The tyrosine phosphatase SHP2 increases robustness and information transfer within IL-6-induced JAK/STAT signalling. Cell Commun Signal. 2021 09 16; 19(1):94.
-
Targeted Degradation of the Oncogenic Phosphatase SHP2. Biochemistry. 2021 08 31; 60(34):2593-2609.
-
Time-resolved phosphoproteomics reveals scaffolding and catalysis-responsive patterns of SHP2-dependent signaling. Elife. 2021 03 23; 10.
-
Congenital polyvalvular disease expands the cardiac phenotype of the RASopathies. Am J Med Genet A. 2021 05; 185(5):1486-1493.