Receptors, N-Methyl-D-Aspartate
"Receptors, N-Methyl-D-Aspartate" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A class of ionotropic glutamate receptors characterized by affinity for N-methyl-D-aspartate. NMDA receptors have an allosteric binding site for glycine which must be occupied for the channel to open efficiently and a site within the channel itself to which magnesium ions bind in a voltage-dependent manner. The positive voltage dependence of channel conductance and the high permeability of the conducting channel to calcium ions (as well as to monovalent cations) are important in excitotoxicity and neuronal plasticity.
MeSH Number(s)
D12.776.157.530.400.400.500.500
D12.776.543.550.425.500.200.500
D12.776.543.585.400.500.200.500
D12.776.543.750.720.200.450.400.500
Concept/Terms
Receptors, N-Methyl-D-Aspartate- Receptors, N-Methyl-D-Aspartate
- Receptors, N Methyl D Aspartate
- N-Methylaspartate Receptors
- N Methylaspartate Receptors
- Receptors, NMDA
- NMDA Receptors
- Receptors, N-Methylaspartate
- Receptors, N Methylaspartate
- N-Methyl-D-Aspartate Receptors
- N Methyl D Aspartate Receptors
- NMDA Receptor-Ionophore Complex
- NMDA Receptor Ionophore Complex
Below are MeSH descriptors whose meaning is more general than "Receptors, N-Methyl-D-Aspartate".
- Chemicals and Drugs [D]
- Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
- Carrier Proteins [D12.776.157]
- Membrane Transport Proteins [D12.776.157.530]
- Ion Channels [D12.776.157.530.400]
- Ligand-Gated Ion Channels [D12.776.157.530.400.400]
- Receptors, Ionotropic Glutamate [D12.776.157.530.400.400.500]
- Receptors, N-Methyl-D-Aspartate [D12.776.157.530.400.400.500.500]
- Membrane Proteins [D12.776.543]
- Membrane Glycoproteins [D12.776.543.550]
- Ion Channels [D12.776.543.550.425]
- Ligand-Gated Ion Channels [D12.776.543.550.425.500]
- Receptors, Ionotropic Glutamate [D12.776.543.550.425.500.200]
- Receptors, N-Methyl-D-Aspartate [D12.776.543.550.425.500.200.500]
- Membrane Transport Proteins [D12.776.543.585]
- Ion Channels [D12.776.543.585.400]
- Ligand-Gated Ion Channels [D12.776.543.585.400.500]
- Receptors, Ionotropic Glutamate [D12.776.543.585.400.500.200]
- Receptors, N-Methyl-D-Aspartate [D12.776.543.585.400.500.200.500]
- Receptors, Cell Surface [D12.776.543.750]
- Receptors, Neurotransmitter [D12.776.543.750.720]
- Receptors, Amino Acid [D12.776.543.750.720.200]
- Receptors, Glutamate [D12.776.543.750.720.200.450]
- Receptors, Ionotropic Glutamate [D12.776.543.750.720.200.450.400]
- Receptors, N-Methyl-D-Aspartate [D12.776.543.750.720.200.450.400.500]
Below are MeSH descriptors whose meaning is more specific than "Receptors, N-Methyl-D-Aspartate".
This graph shows the total number of publications written about "Receptors, N-Methyl-D-Aspartate" by people in Harvard Catalyst Profiles by year, and whether "Receptors, N-Methyl-D-Aspartate" was a major or minor topic of these publication.
To see the data from this visualization as text,
click here.
Year | Major Topic | Minor Topic | Total |
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1994 | 9 | 9 | 18 |
1995 | 11 | 9 | 20 |
1996 | 12 | 6 | 18 |
1997 | 11 | 2 | 13 |
1998 | 13 | 11 | 24 |
1999 | 6 | 13 | 19 |
2000 | 9 | 8 | 17 |
2001 | 4 | 9 | 13 |
2002 | 9 | 9 | 18 |
2003 | 18 | 3 | 21 |
2004 | 18 | 10 | 28 |
2005 | 10 | 11 | 21 |
2006 | 8 | 11 | 19 |
2007 | 13 | 5 | 18 |
2008 | 15 | 8 | 23 |
2009 | 15 | 12 | 27 |
2010 | 7 | 11 | 18 |
2011 | 16 | 12 | 28 |
2012 | 19 | 6 | 25 |
2013 | 13 | 8 | 21 |
2014 | 11 | 13 | 24 |
2015 | 19 | 7 | 26 |
2016 | 12 | 10 | 22 |
2017 | 15 | 6 | 21 |
2018 | 10 | 7 | 17 |
2019 | 16 | 3 | 19 |
2020 | 10 | 5 | 15 |
2021 | 6 | 10 | 16 |
2022 | 6 | 11 | 17 |
2023 | 4 | 5 | 9 |
Below are the most recent publications written about "Receptors, N-Methyl-D-Aspartate" by people in Profiles.
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Characterization of (R)- and (S)-[18F]OF-NB1 in Rodents as Positron Emission Tomography Probes for Imaging GluN2B Subunit-Containing N-Methyl-d-Aspartate Receptors. ACS Chem Neurosci. 2023 Dec 20; 14(24):4323-4334.
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Synthesis and Biological Evaluation of Enantiomerically Pure (R)- and (S)-[18F]OF-NB1 for Imaging the GluN2B Subunit-Containing NMDA Receptors. J Med Chem. 2023 12 14; 66(23):16018-16031.
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Cross species review of the physiological role of D-serine in translationally relevant behaviors. Amino Acids. 2023 Nov; 55(11):1501-1517.
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Multivariate GWAS of Alzheimer's disease CSF biomarker profiles implies GRIN2D in synaptic functioning. Genome Med. 2023 10 04; 15(1):79.
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Brain-region-specific changes in neurons and glia and dysregulation of dopamine signaling in Grin2a mutant mice. Neuron. 2023 11 01; 111(21):3378-3396.e9.
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Optimizing animal models of autoimmune encephalitis using active immunization. Front Immunol. 2023; 14:1177672.
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The novel uncompetitive NMDA receptor antagonist esmethadone (REL-1017) has no meaningful abuse potential in recreational drug users. Transl Psychiatry. 2023 06 07; 13(1):192.
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Dual orexin/hypocretin receptor antagonism attenuates NMDA receptor hypofunction-induced attentional impairments in a rat model of schizophrenia. Behav Brain Res. 2023 07 26; 450:114497.
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Characterizing brain dynamics during ketamine-induced dissociation and subsequent interactions with propofol using human intracranial neurophysiology. Nat Commun. 2023 03 29; 14(1):1748.
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Endogenous d-serine exists in the mammalian brain independent of synthesis by serine racemase. Biochem Biophys Res Commun. 2023 01 22; 641:186-191.