Contact, publication, and social network information about Harvard faculty and fellows. Harvard Catalyst Profiles
Keywords
Last Name
Institution

Edward Thomas Ryan, D.T.M.&H., M.D.

TitleProfessor of Medicine
InstitutionMassachusetts General Hospital
DepartmentMedicine
AddressMassachusetts General Hospital
Infectious Disease - Jackson 504
55 Fruit St
Boston MA 02114
Phone617/726-6175
Fax617/726-7416
Other Positions
TitleProfessor in the Department of Immunology and Infectious Diseases
InstitutionHarvard School of Public Health
DepartmentMalaria/Wirth


 Mentoring 
 current student opportunities
Available: 09/01/11, Expires: 06/01/15

Globally, one in five people dies of an infection, and this reality is projected to continue for the next 50 years. Intestinal and respiratory infections are the two leading infectious causes of death, far exceeding malaria, TB and HIV. Our research focuses on understanding host-pathogen interactions during two intestinal infections that disproportionally affect the most impoverished and disenfranchised, typhoid and cholera. These two illnesses affect over 25 million people each year, killing 300,000. Our research focuses on studying these human-restricted infections, especially regarding the discovery and development of improved vaccines, improved immunization strategies, and improved diagnostics. We perform this work through an established collaborative effort with researchers at the International Centre for Diarrhoeal Disease Research in Dhaka, Bangladesh (ICDDR,B). Particular areas of focus include the application of high throughput genomic, proteomic, and immunoproteomic platform technologies to infections. Students would be welcome to join an active NIH-funded research program. Research would be bench-based in Boston, with potential in Bangladesh. Interested students can contact Dr. Ryan to discuss potential involvement and projects.

 completed student projects
Development of an improved cholera vaccine: evaluation of a combination oral prime-intramuscular cholera conjugate vaccine boost approach
Summer, 05/07/12 - 08/10/12

 Bibliographic 
 selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
List All   |   Timeline
  1. LaRocque RC, Deshpande BR, Rao SR, Brunette GW, Sotir MJ, Jentes ES, Ryan ET. Pre-travel health care of immigrants returning home to visit friends and relatives. Am J Trop Med Hyg. 2013 Feb; 88(2):376-80.
    View in: PubMed
  2. Alam MM, Arifuzzaman M, Ahmad SM, Hosen MI, Rahman MA, Rashu R, Sheikh A, Ryan ET, Calderwood SB, Qadri F. Study of Avidity of Antigen-Specific Antibody as a Means of Understanding Development of Long-Term Immunological Memory after Vibrio cholerae O1 Infection. Clin Vaccine Immunol. 2013 Jan; 20(1):17-23.
    View in: PubMed
  3. Johnson RA, Uddin T, Aktar A, Mohasin M, Alam MM, Chowdhury F, Harris JB, Larocque RC, Kelly Bufano M, Yu Y, Wu-Freeman Y, Leung DT, Sarracino D, Krastins B, Charles RC, Xu P, Kovác P, Calderwood SB, Qadri F, Ryan ET. Comparison of Immune Responses to the O-Specific Polysaccharide and Lipopolysaccharide of Vibrio cholerae O1 in Bangladeshi Adult Patients with Cholera. Clin Vaccine Immunol. 2012 Nov; 19(11):1712-21.
    View in: PubMed
  4. Sealfon R, Gire S, Ellis C, Calderwood S, Qadri F, Hensley L, Kellis M, Ryan ET, Larocque RC, Harris JB, Sabeti PC. High depth, whole-genome sequencing of cholera isolates from Haiti and the Dominican Republic. BMC Genomics. 2012; 13:468.
    View in: PubMed
  5. Weil AA, Chowdhury F, Khan AI, Leung DT, Uddin T, Begum YA, Saha NC, Charles RC, Larocque RC, Harris JB, Ryan ET, Qadri F, Calderwood SB. Frequency of Reexposure to Vibrio cholerae O1 Evaluated by Subsequent Vibriocidal Titer Rise after an Episode of Severe Cholera in a Highly Endemic Area in Bangladesh. Am J Trop Med Hyg. 2012 Nov; 87(5):921-6.
    View in: PubMed
  6. Harris JB, LaRocque RC, Qadri F, Ryan ET, Calderwood SB. Cholera. Lancet. 2012 Jun 30; 379(9835):2466-76.
    View in: PubMed
  7. Arifuzzaman M, Rashu R, Leung DT, Hosen MI, Bhuiyan TR, Bhuiyan MS, Rahman MA, Khanam F, Saha A, Charles RC, LaRocque RC, Weil AA, Clements JD, Holmes RK, Calderwood SB, Harris JB, Ryan ET, Qadri F. Antigen-specific memory T cell responses after vaccination with an oral killed cholera vaccine in Bangladeshi children and comparison to responses in patients with naturally acquired cholera. Clin Vaccine Immunol. 2012 Aug; 19(8):1304-11.
    View in: PubMed
  8. Schwartz BS, Larocque RC, Ryan ET. In the clinic. Travel medicine. Ann Intern Med. 2012 Jun 5; 156(11):ITC6-1, ITC6-2, ITC6-3, ITC6-4, ITC6-5, ITC6-6, ITC6-7, ITC6-8, ITC6-9, ITC6-10, ITC6-11, ITC6-12, ITC6-13, ITC6-14, ITC6-15; quiz ITC6-16.
    View in: PubMed
  9. Patel SM, Rahman MA, Mohasin M, Riyadh MA, Leung DT, Alam MM, Chowdhury F, Khan AI, Weil AA, Aktar A, Nazim M, LaRocque RC, Ryan ET, Calderwood SB, Qadri F, Harris JB. Memory B cell responses to Vibrio cholerae O1 lipopolysaccharide are associated with protection against infection from household contacts of patients with cholera in Bangladesh. Clin Vaccine Immunol. 2012 Jun; 19(6):842-8.
    View in: PubMed
  10. Leung DT, Chowdhury F, Calderwood SB, Qadri F, Ryan ET. Immune responses to cholera in children. Expert Rev Anti Infect Ther. 2012 Apr; 10(4):435-44.
    View in: PubMed
  11. Leung DT, Bogetz J, Itoh M, Ganapathi L, Pietroni MA, Ryan ET, Chisti MJ. Factors associated with encephalopathy in patients with Salmonella enterica serotype Typhi bacteremia presenting to a diarrheal hospital in Dhaka, Bangladesh. Am J Trop Med Hyg. 2012 Apr; 86(4):698-702.
    View in: PubMed
  12. Leung DT, Rahman MA, Mohasin M, Patel SM, Aktar A, Khanam F, Uddin T, Riyadh MA, Saha A, Alam MM, Chowdhury F, Khan AI, Charles R, LaRocque R, Harris JB, Calderwood SB, Qadri F, Ryan ET. Memory B cell and other immune responses in children receiving two doses of an oral killed cholera vaccine compared to responses following natural cholera infection in Bangladesh. Clin Vaccine Immunol. 2012 May; 19(5):690-8.
    View in: PubMed
  13. Borad AJ, Allison GM, Wang D, Ahmed S, Karim MM, Kane AV, Moy J, Hibberd PL, Ajjampur SS, Kang G, Calderwood SB, Ryan ET, Naumova E, Khan WA, Ward HD. Systemic antibody responses to the immunodominant p23 antigen and p23 polymorphisms in children with cryptosporidiosis in Bangladesh. Am J Trop Med Hyg. 2012 Feb; 86(2):214-22.
    View in: PubMed
  14. Arifuzzaman M, Ahmed T, Rahman MA, Chowdhury F, Rashu R, Khan AI, LaRocque RC, Harris JB, Bhuiyan TR, Ryan ET, Calderwood SB, Qadri F. Individuals with Le(a+b-) blood group have increased susceptibility to symptomatic vibrio cholerae O1 infection. PLoS Negl Trop Dis. 2011 Dec; 5(12):e1413.
    View in: PubMed
  15. Ryan ET, Cronin CG, Branda JA. Case records of the Massachusetts General Hospital. Case 38-2011. A 34-year-old man with diarrhea and weakness. N Engl J Med. 2011 Dec 15; 365(24):2306-16.
    View in: PubMed
  16. Sheikh A, Charles RC, Sharmeen N, Rollins SM, Harris JB, Bhuiyan MS, Arifuzzaman M, Khanam F, Bukka A, Kalsy A, Porwollik S, Leung DT, Brooks WA, LaRocque RC, Hohmann EL, Cravioto A, Logvinenko T, Calderwood SB, McClelland M, Graham JE, Qadri F, Ryan ET. In vivo expression of Salmonella enterica serotype Typhi genes in the blood of patients with typhoid fever in Bangladesh. PLoS Negl Trop Dis. 2011 Dec; 5(12):e1419.
    View in: PubMed
  17. LaRocque RC, Rao SR, Lee J, Ansdell V, Yates JA, Schwartz BS, Knouse M, Cahill J, Hagmann S, Vinetz J, Connor BA, Goad JA, Oladele A, Alvarez S, Stauffer W, Walker P, Kozarsky P, Franco-Paredes C, Dismukes R, Rosen J, Hynes NA, Jacquerioz F, McLellan S, Hale D, Sofarelli T, Schoenfeld D, Marano N, Brunette G, Jentes ES, Yanni E, Sotir MJ, Ryan ET. Global TravEpiNet: a national consortium of clinics providing care to international travelers--analysis of demographic characteristics, travel destinations, and pretravel healthcare of high-risk US international travelers, 2009-2011. Clin Infect Dis. 2012 Feb 15; 54(4):455-62.
    View in: PubMed
  18. Ryan ET. Haiti in the context of the current global cholera pandemic. Emerg Infect Dis. 2011 Nov; 17(11):2175-6.
    View in: PubMed
  19. Charles RC, Ryan ET. Cholera in the 21st century. Curr Opin Infect Dis. 2011 Oct; 24(5):472-7.
    View in: PubMed
  20. Xu P, Alam MM, Kalsy A, Charles RC, Calderwood SB, Qadri F, Ryan ET, Kovác P. Simple, direct conjugation of bacterial O-SP-core antigens to proteins: development of cholera conjugate vaccines. Bioconjug Chem. 2011 Oct 19; 22(10):2179-85.
    View in: PubMed
  21. Shin OS, Uddin T, Citorik R, Wang JP, Della Pelle P, Kradin RL, Bingle CD, Bingle L, Camilli A, Bhuiyan TR, Shirin T, Ryan ET, Calderwood SB, Finberg RW, Qadri F, Larocque RC, Harris JB. LPLUNC1 modulates innate immune responses to Vibrio cholerae. J Infect Dis. 2011 Nov; 204(9):1349-57.
    View in: PubMed
  22. Allison GM, Rogers KA, Borad A, Ahmed S, Karim MM, Kane AV, Hibberd PL, Naumova EN, Calderwood SB, Ryan ET, Khan WA, Ward HD. Antibody responses to the immunodominant Cryptosporidium gp15 antigen and gp15 polymorphisms in a case-control study of cryptosporidiosis in children in Bangladesh. Am J Trop Med Hyg. 2011 Jul; 85(1):97-104.
    View in: PubMed
  23. Ryan ET, Madoff LC, Ferraro MJ. Case records of the Massachusetts General Hospital. Case 20-2011. A 30-year-old man with diarrhea after a trip to the Dominican Republic. N Engl J Med. 2011 Jun 30; 364(26):2536-41.
    View in: PubMed
  24. Kuchta A, Rahman T, Sennott EL, Bhuyian TR, Uddin T, Rashu R, Chowdhury F, Kahn AI, Arifuzzaman M, Weil AA, Podolsky M, LaRocque RC, Ryan ET, Calderwood SB, Qadri F, Harris JB. Vibrio cholerae O1 infection induces proinflammatory CD4+ T-cell responses in blood and intestinal mucosa of infected humans. Clin Vaccine Immunol. 2011 Aug; 18(8):1371-7.
    View in: PubMed
  25. Leung DT, Rahman MA, Mohasin M, Riyadh MA, Patel SM, Alam MM, Chowdhury F, Khan AI, Kalivoda EJ, Aktar A, Bhuiyan MS, LaRocque RC, Harris JB, Calderwood SB, Qadri F, Ryan ET. Comparison of memory B cell, antibody-secreting cell, and plasma antibody responses in young children, older children, and adults with infection caused by Vibrio cholerae O1 El Tor Ogawa in Bangladesh. Clin Vaccine Immunol. 2011 Aug; 18(8):1317-25.
    View in: PubMed
  26. Sheikh A, Khanam F, Sayeed MA, Rahman T, Pacek M, Hu Y, Rollins A, Bhuiyan MS, Rollins S, Kalsy A, Arifuzzaman M, Leung DT, Sarracino DA, Krastins B, Charles RC, Larocque RC, Cravioto A, Calderwood SB, Brooks WA, Harris JB, Labaer J, Qadri F, Ryan ET. Interferon-? and proliferation responses to Salmonella enterica Serotype Typhi proteins in patients with S. Typhi Bacteremia in Dhaka, Bangladesh. PLoS Negl Trop Dis. 2011 Jun; 5(6):e1193.
    View in: PubMed
  27. Farmer P, Almazor CP, Bahnsen ET, Barry D, Bazile J, Bloom BR, Bose N, Brewer T, Calderwood SB, Clemens JD, Cravioto A, Eustache E, Jérôme G, Gupta N, Harris JB, Hiatt HH, Holstein C, Hotez PJ, Ivers LC, Kerry VB, Koenig SP, Larocque RC, Léandre F, Lambert W, Lyon E, Mekalanos JJ, Mukherjee JS, Oswald C, Pape JW, Gretchko Prosper A, Rabinovich R, Raymonville M, Réjouit JR, Ronan LJ, Rosenberg ML, Ryan ET, Sachs JD, Sack DA, Surena C, Suri AA, Ternier R, Waldor MK, Walton D, Weigel JL. Meeting cholera's challenge to Haiti and the world: a joint statement on cholera prevention and care. PLoS Negl Trop Dis. 2011; 5(5):e1145.
    View in: PubMed
  28. Hira KG, Mackay MR, Hempstead AD, Ahmed S, Karim MM, O'Connor RM, Hibberd PL, Calderwood SB, Ryan ET, Khan WA, Ward HD. Genetic diversity of Cryptosporidium spp. from Bangladeshi children. J Clin Microbiol. 2011 Jun; 49(6):2307-10.
    View in: PubMed
  29. Alam MM, Riyadh MA, Fatema K, Rahman MA, Akhtar N, Ahmed T, Chowdhury MI, Chowdhury F, Calderwood SB, Harris JB, Ryan ET, Qadri F. Antigen-specific memory B-cell responses in Bangladeshi adults after one- or two-dose oral killed cholera vaccination and comparison with responses in patients with naturally acquired cholera. Clin Vaccine Immunol. 2011 May; 18(5):844-50.
    View in: PubMed
  30. Ryan ET. The cholera pandemic, still with us after half a century: time to rethink. PLoS Negl Trop Dis. 2011; 5(1):e1003.
    View in: PubMed
  31. Uddin T, Harris JB, Bhuiyan TR, Shirin T, Uddin MI, Khan AI, Chowdhury F, LaRocque RC, Alam NH, Ryan ET, Calderwood SB, Qadri F. Mucosal immunologic responses in cholera patients in Bangladesh. Clin Vaccine Immunol. 2011 Mar; 18(3):506-12.
    View in: PubMed
  32. Sheikh A, Charles RC, Rollins SM, Harris JB, Bhuiyan MS, Khanam F, Bukka A, Kalsy A, Porwollik S, Brooks WA, LaRocque RC, Hohmann EL, Cravioto A, Logvinenko T, Calderwood SB, McClelland M, Graham JE, Qadri F, Ryan ET. Analysis of Salmonella enterica serotype paratyphi A gene expression in the blood of bacteremic patients in Bangladesh. PLoS Negl Trop Dis. 2010; 4(12):e908.
    View in: PubMed
  33. Chowdhury F, Khan AI, Faruque AS, Ryan ET. Severe, acute watery diarrhea in an adult. PLoS Negl Trop Dis. 2010; 4(11):e898.
    View in: PubMed
  34. LaRocque RC, Rao SR, Tsibris A, Lawton T, Barry MA, Marano N, Brunette G, Yanni E, Ryan ET. Pre-travel health advice-seeking behavior among US international travelers departing from Boston Logan International Airport. J Travel Med. 2010 Nov-Dec; 17(6):387-91.
    View in: PubMed
  35. Bahrani HM, Fazelat AA, Thomas M, Hirose T, Kroll AJ, Lou PL, Ryan EA. Endophthalmitis in the era of small gauge transconjunctival sutureless vitrectomy--meta analysis and review of literature. Semin Ophthalmol. 2010 Sep-Nov; 25(5-6):275-82.
    View in: PubMed
  36. Kendall EA, Chowdhury F, Begum Y, Khan AI, Li S, Thierer JH, Bailey J, Kreisel K, Tacket CO, LaRocque RC, Harris JB, Ryan ET, Qadri F, Calderwood SB, Stine OC. Relatedness of Vibrio cholerae O1/O139 isolates from patients and their household contacts, determined by multilocus variable-number tandem-repeat analysis. J Bacteriol. 2010 Sep; 192(17):4367-76.
    View in: PubMed
  37. Charles RC, Sheikh A, Krastins B, Harris JB, Bhuiyan MS, LaRocque RC, Logvinenko T, Sarracino DA, Kudva IT, Eisenstein J, Podolsky MJ, Kalsy A, Brooks WA, Ludwig A, John M, Calderwood SB, Qadri F, Ryan ET. Characterization of anti-Salmonella enterica serotype Typhi antibody responses in bacteremic Bangladeshi patients by an immunoaffinity proteomics-based technology. Clin Vaccine Immunol. 2010 Aug; 17(8):1188-95.
    View in: PubMed
  38. Penrose K, de Castro MC, Werema J, Ryan ET. Informal urban settlements and cholera risk in Dar es Salaam, Tanzania. PLoS Negl Trop Dis. 2010; 4(3):e631.
    View in: PubMed
  39. Chowdhury F, Begum YA, Alam MM, Khan AI, Ahmed T, Bhuiyan MS, Harris JB, LaRocque RC, Faruque AS, Endtz H, Ryan ET, Cravioto A, Svennerholm AM, Calderwood SB, Qadri F. Concomitant enterotoxigenic Escherichia coli infection induces increased immune responses to Vibrio cholerae O1 antigens in patients with cholera in Bangladesh. Infect Immun. 2010 May; 78(5):2117-24.
    View in: PubMed
  40. Khan AI, Chowdhury F, Harris JB, Larocque RC, Faruque AS, Ryan ET, Calderwood SB, Qadri F. Comparison of clinical features and immunological parameters of patients with dehydrating diarrhoea infected with Inaba or Ogawa serotypes of Vibrio cholerae O1. Scand J Infect Dis. 2010; 42(1):48-56.
    View in: PubMed
  41. Rahman KM, Duggal P, Harris JB, Saha SK, Streatfield PK, Ryan ET, Calderwood SB, Qadri F, Yunus M, LaRocque RC. Familial aggregation of Vibrio cholerae-associated infection in Matlab, Bangladesh. J Health Popul Nutr. 2009 Dec; 27(6):733-8.
    View in: PubMed
  42. Weil AA, Khan AI, Chowdhury F, Larocque RC, Faruque AS, Ryan ET, Calderwood SB, Qadri F, Harris JB. Clinical outcomes in household contacts of patients with cholera in Bangladesh. Clin Infect Dis. 2009 Nov 15; 49(10):1473-9.
    View in: PubMed
  43. Kendall EA, Tarique AA, Hossain A, Alam MM, Arifuzzaman M, Akhtar N, Chowdhury F, Khan AI, Larocque RC, Harris JB, Ryan ET, Qadri F, Calderwood SB. Development of immunoglobulin M memory to both a T-cell-independent and a T-cell-dependent antigen following infection with Vibrio cholerae O1 in Bangladesh. Infect Immun. 2010 Jan; 78(1):253-9.
    View in: PubMed
  44. Charles RC, Harris JB, Chase MR, Lebrun LM, Sheikh A, LaRocque RC, Logvinenko T, Rollins SM, Tarique A, Hohmann EL, Rosenberg I, Krastins B, Sarracino DA, Qadri F, Calderwood SB, Ryan ET. Comparative proteomic analysis of the PhoP regulon in Salmonella enterica serovar Typhi versus Typhimurium. PLoS One. 2009; 4(9):e6994.
    View in: PubMed
  45. Sheikh A, Bhuiyan MS, Khanam F, Chowdhury F, Saha A, Ahmed D, Jamil KM, LaRocque RC, Harris JB, Ahmad MM, Charles R, Brooks WA, Calderwood SB, Cravioto A, Ryan ET, Qadri F. Salmonella enterica serovar Typhi-specific immunoglobulin A antibody responses in plasma and antibody in lymphocyte supernatant specimens in Bangladeshi patients with suspected typhoid fever. Clin Vaccine Immunol. 2009 Nov; 16(11):1587-94.
    View in: PubMed
  46. Weil AA, Arifuzzaman M, Bhuiyan TR, LaRocque RC, Harris AM, Kendall EA, Hossain A, Tarique AA, Sheikh A, Chowdhury F, Khan AI, Murshed F, Parker KC, Banerjee KK, Ryan ET, Harris JB, Qadri F, Calderwood SB. Memory T-cell responses to Vibrio cholerae O1 infection. Infect Immun. 2009 Nov; 77(11):5090-6.
    View in: PubMed
  47. Gaston JS, Inman RD, Ryan ET, Venkatesan MM, Barry EM, Hale TL, Bourgeois AL, Walker RI. Vaccination of children in low-resource countries against Shigella is unlikely to present an undue risk of reactive arthritis. Vaccine. 2009 Sep 4; 27(40):5432-4.
    View in: PubMed
  48. Rollenhagen JE, Kalsy A, Saksena R, Sheikh A, Alam MM, Qadri F, Calderwood SB, Kovác P, Ryan ET. Transcutaneous immunization with a synthetic hexasaccharide-protein conjugate induces anti-Vibrio cholerae lipopolysaccharide responses in mice. Vaccine. 2009 Aug 6; 27(36):4917-22.
    View in: PubMed
  49. Harris AM, Bhuiyan MS, Chowdhury F, Khan AI, Hossain A, Kendall EA, Rahman A, LaRocque RC, Wrammert J, Ryan ET, Qadri F, Calderwood SB, Harris JB. Antigen-specific memory B-cell responses to Vibrio cholerae O1 infection in Bangladesh. Infect Immun. 2009 Sep; 77(9):3850-6.
    View in: PubMed
  50. Harris JB, Podolsky MJ, Bhuiyan TR, Chowdhury F, Khan AI, Larocque RC, Logvinenko T, Kendall J, Faruque AS, Nagler CR, Ryan ET, Qadri F, Calderwood SB. Immunologic responses to Vibrio cholerae in patients co-infected with intestinal parasites in Bangladesh. PLoS Negl Trop Dis. 2009; 3(3):e403.
    View in: PubMed
  51. Lin KL, Hirose T, Kroll AJ, Lou PL, Ryan EA. Prospects for treatment of pediatric vitreoretinal diseases with vascular endothelial growth factor inhibition. Semin Ophthalmol. 2009 Mar-Apr; 24(2):70-6.
    View in: PubMed
  52. Larocque RC, Sabeti P, Duggal P, Chowdhury F, Khan AI, Lebrun LM, Harris JB, Ryan ET, Qadri F, Calderwood SB. A variant in long palate, lung and nasal epithelium clone 1 is associated with cholera in a Bangladeshi population. Genes Immun. 2009 Apr; 10(3):267-72.
    View in: PubMed
  53. Patronas M, Kroll AJ, Lou PL, Ryan EA. A review of vitreoretinal interface pathology. Int Ophthalmol Clin. 2009; 49(1):133-43.
    View in: PubMed
  54. Chowdhury F, Khan AI, Harris JB, LaRocque RC, Chowdhury MI, Ryan ET, Faruque AS, Calderwood SB, Qadri F. A comparison of clinical and immunologic features in children and older patients hospitalized with severe cholera in Bangladesh. Pediatr Infect Dis J. 2008 Nov; 27(11):986-92.
    View in: PubMed
  55. Harris AM, Chowdhury F, Begum YA, Khan AI, Faruque AS, Svennerholm AM, Harris JB, Ryan ET, Cravioto A, Calderwood SB, Qadri F. Shifting prevalence of major diarrheal pathogens in patients seeking hospital care during floods in 1998, 2004, and 2007 in Dhaka, Bangladesh. Am J Trop Med Hyg. 2008 Nov; 79(5):708-14.
    View in: PubMed
  56. Hill DR, Ryan ET. Management of travellers' diarrhoea. BMJ. 2008; 337:a1746.
    View in: PubMed
  57. Jayasekera CR, Harris JB, Bhuiyan S, Chowdhury F, Khan AI, Faruque AS, Larocque RC, Ryan ET, Ahmed R, Qadri F, Calderwood SB. Cholera toxin-specific memory B cell responses are induced in patients with dehydrating diarrhea caused by Vibrio cholerae O1. J Infect Dis. 2008 Oct 1; 198(7):1055-61.
    View in: PubMed
  58. LaRocque RC, Krastins B, Harris JB, Lebrun LM, Parker KC, Chase M, Ryan ET, Qadri F, Sarracino D, Calderwood SB. Proteomic analysis of Vibrio cholerae in human stool. Infect Immun. 2008 Sep; 76(9):4145-51.
    View in: PubMed
  59. Harris JB, LaRocque RC, Chowdhury F, Khan AI, Logvinenko T, Faruque AS, Ryan ET, Qadri F, Calderwood SB. Susceptibility to Vibrio cholerae infection in a cohort of household contacts of patients with cholera in Bangladesh. PLoS Negl Trop Dis. 2008; 2(4):e221.
    View in: PubMed
  60. Rollins SM, Peppercorn A, Young JS, Drysdale M, Baresch A, Bikowski MV, Ashford DA, Quinn CP, Handfield M, Hillman JD, Lyons CR, Koehler TM, Calderwood SB, Ryan ET. Application of in vivo induced antigen technology (IVIAT) to Bacillus anthracis. PLoS One. 2008; 3(3):e1824.
    View in: PubMed
  61. Nelson EJ, Chowdhury A, Harris JB, Begum YA, Chowdhury F, Khan AI, Larocque RC, Bishop AL, Ryan ET, Camilli A, Qadri F, Calderwood SB. Complexity of rice-water stool from patients with Vibrio cholerae plays a role in the transmission of infectious diarrhea. Proc Natl Acad Sci U S A. 2007 Nov 27; 104(48):19091-6.
    View in: PubMed
  62. Ryan ET, Aquino SL, Kradin RL. Case records of the Massachusetts General Hospital. Case 29-2007. A 51-year-old man with gastric cancer and lung nodules. N Engl J Med. 2007 Sep 20; 357(12):1239-46.
    View in: PubMed
  63. Eremeeva ME, Gerns HL, Lydy SL, Goo JS, Ryan ET, Mathew SS, Ferraro MJ, Holden JM, Nicholson WL, Dasch GA, Koehler JE. Bacteremia, fever, and splenomegaly caused by a newly recognized bartonella species. N Engl J Med. 2007 Jun 7; 356(23):2381-7.
    View in: PubMed
  64. Ghose C, Kalsy A, Sheikh A, Rollenhagen J, John M, Young J, Rollins SM, Qadri F, Calderwood SB, Kelly CP, Ryan ET. Transcutaneous immunization with Clostridium difficile toxoid A induces systemic and mucosal immune responses and toxin A-neutralizing antibodies in mice. Infect Immun. 2007 Jun; 75(6):2826-32.
    View in: PubMed
  65. Smith SR, Kroll AJ, Lou PL, Ryan EA. Endogenous bacterial and fungal endophthalmitis. Int Ophthalmol Clin. 2007; 47(2):173-83.
    View in: PubMed
  66. Esfandiari N, Khazaei M, Ai J, Bielecki R, Gotlieb L, Ryan E, Casper RF. Effect of a statin on an in vitro model of endometriosis. Fertil Steril. 2007 Feb; 87(2):257-62.
    View in: PubMed
  67. Hill DR, Ericsson CD, Pearson RD, Keystone JS, Freedman DO, Kozarsky PE, DuPont HL, Bia FJ, Fischer PR, Ryan ET. The practice of travel medicine: guidelines by the Infectious Diseases Society of America. Clin Infect Dis. 2006 Dec 15; 43(12):1499-539.
    View in: PubMed
  68. Rollenhagen JE, Kalsy A, Cerda F, John M, Harris JB, Larocque RC, Qadri F, Calderwood SB, Taylor RK, Ryan ET. Transcutaneous immunization with toxin-coregulated pilin A induces protective immunity against Vibrio cholerae O1 El Tor challenge in mice. Infect Immun. 2006 Oct; 74(10):5834-9.
    View in: PubMed
  69. Ivers LC, Ryan ET. Infectious diseases of severe weather-related and flood-related natural disasters. Curr Opin Infect Dis. 2006 Oct; 19(5):408-14.
    View in: PubMed
  70. Harris JB, Baresch-Bernal A, Rollins SM, Alam A, LaRocque RC, Bikowski M, Peppercorn AF, Handfield M, Hillman JD, Qadri F, Calderwood SB, Hohmann E, Breiman RF, Brooks WA, Ryan ET. Identification of in vivo-induced bacterial protein antigens during human infection with Salmonella enterica serovar Typhi. Infect Immun. 2006 Sep; 74(9):5161-8.
    View in: PubMed
  71. Hill DR, Baird JK, Parise ME, Lewis LS, Ryan ET, Magill AJ. Primaquine: report from CDC expert meeting on malaria chemoprophylaxis I. Am J Trop Med Hyg. 2006 Sep; 75(3):402-15.
    View in: PubMed
  72. Ryan ET, Calderwood SB, Qadri F. Live attenuated oral cholera vaccines. Expert Rev Vaccines. 2006 Aug; 5(4):483-94.
    View in: PubMed
  73. LaRocque RC, Harris JB, Ryan ET, Qadri F, Calderwood SB. Postgenomic approaches to cholera vaccine development. Expert Rev Vaccines. 2006 Jun; 5(3):337-46.
    View in: PubMed
  74. Schwartz BS, Harris JB, Khan AI, Larocque RC, Sack DA, Malek MA, Faruque AS, Qadri F, Calderwood SB, Luby SP, Ryan ET. Diarrheal epidemics in Dhaka, Bangladesh, during three consecutive floods: 1988, 1998, and 2004. Am J Trop Med Hyg. 2006 Jun; 74(6):1067-73.
    View in: PubMed
  75. Ryan ET, Felsenstein D, Aquino SL, Branda JA, Morgan JG. Case records of the Massachusetts General Hospital. Case 39-2005. A 63-year-old woman with a positive serologic test for syphilis and persistent eosinophilia. N Engl J Med. 2005 Dec 22; 353(25):2697-705.
    View in: PubMed
  76. Bennish ML, Khan WA, Begum M, Bridges EA, Ahmed S, Saha D, Salam MA, Acheson D, Ryan ET. Low risk of hemolytic uremic syndrome after early effective antimicrobial therapy for Shigella dysenteriae type 1 infection in Bangladesh. Clin Infect Dis. 2006 Feb 1; 42(3):356-62.
    View in: PubMed
  77. Harris JB, Khan AI, LaRocque RC, Dorer DJ, Chowdhury F, Faruque AS, Sack DA, Ryan ET, Qadri F, Calderwood SB. Blood group, immunity, and risk of infection with Vibrio cholerae in an area of endemicity. Infect Immun. 2005 Nov; 73(11):7422-7.
    View in: PubMed
  78. Alam A, Larocque RC, Harris JB, Vanderspurt C, Ryan ET, Qadri F, Calderwood SB. Hyperinfectivity of human-passaged Vibrio cholerae can be modeled by growth in the infant mouse. Infect Immun. 2005 Oct; 73(10):6674-9.
    View in: PubMed
  79. Qadri F, Svennerholm AM, Shamsuzzaman S, Bhuiyan TR, Harris JB, Ghosh AN, Nair GB, Weintraub A, Faruque SM, Ryan ET, Sack DA, Calderwood SB. Reduction in capsular content and enhanced bacterial susceptibility to serum killing of Vibrio cholerae O139 associated with the 2002 cholera epidemic in Bangladesh. Infect Immun. 2005 Oct; 73(10):6577-83.
    View in: PubMed
  80. Shnayderman M, Mansfield B, Yip P, Clark HA, Krebs MD, Cohen SJ, Zeskind JE, Ryan ET, Dorkin HL, Callahan MV, Stair TO, Gelfand JA, Gill CJ, Hitt B, Davis CE. Species-specific bacteria identification using differential mobility spectrometry and bioinformatics pattern recognition. Anal Chem. 2005 Sep 15; 77(18):5930-7.
    View in: PubMed
  81. Larocque RC, Harris JB, Dziejman M, Li X, Khan AI, Faruque AS, Faruque SM, Nair GB, Ryan ET, Qadri F, Mekalanos JJ, Calderwood SB. Transcriptional profiling of Vibrio cholerae recovered directly from patient specimens during early and late stages of human infection. Infect Immun. 2005 Aug; 73(8):4488-93.
    View in: PubMed
  82. Kao AY, Munandar R, Ferrara SL, Systrom DM, Sheridan RL, Cash SS, Ryan ET. Case records of the Massachusetts General Hospital. Case 19-2005. A 17-year-old girl with respiratory distress and hemiparesis after surviving a tsunami. N Engl J Med. 2005 Jun 23; 352(25):2628-36.
    View in: PubMed
  83. Beck AP, Ryan EA, Lou PL, Kroll AJ. Controversies regarding radial optic neurotomy for central retinal vein occlusion. Int Ophthalmol Clin. 2005; 45(4):153-61.
    View in: PubMed
  84. Kotton CN, Ryan ET, Fishman JA. Prevention of infection in adult travelers after solid organ transplantation. Am J Transplant. 2005 Jan; 5(1):8-14.
    View in: PubMed
  85. Rollins SM, Peppercorn A, Hang L, Hillman JD, Calderwood SB, Handfield M, Ryan ET. In vivo induced antigen technology (IVIAT). Cell Microbiol. 2005 Jan; 7(1):1-9.
    View in: PubMed
  86. Khan WA, Rogers KA, Karim MM, Ahmed S, Hibberd PL, Calderwood SB, Ryan ET, Ward HD. Cryptosporidiosis among Bangladeshi children with diarrhea: a prospective, matched, case-control study of clinical features, epidemiology and systemic antibody responses. Am J Trop Med Hyg. 2004 Oct; 71(4):412-9.
    View in: PubMed
  87. Asaduzzaman M, Ryan ET, John M, Hang L, Khan AI, Faruque AS, Taylor RK, Calderwood SB, Qadri F. The major subunit of the toxin-coregulated pilus TcpA induces mucosal and systemic immunoglobulin A immune responses in patients with cholera caused by Vibrio cholerae O1 and O139. Infect Immun. 2004 Aug; 72(8):4448-54.
    View in: PubMed
  88. Saha D, LaRocque RC, Khan AI, Harris JB, Begum YA, Akramuzzaman SM, Faruque AS, Ryan ET, Qadri F, Calderwood SB. Incomplete correlation of serum vibriocidal antibody titer with protection from Vibrio cholerae infection in urban Bangladesh. J Infect Dis. 2004 Jun 15; 189(12):2318-22.
    View in: PubMed
  89. Ivers LC, Ryan ET. Vaccination strategies. Clin Occup Environ Med. 2004 Feb; 4(1):27-43.
    View in: PubMed
  90. Hochberg N, Ryan ET. Medical problems in the returning expatriate. Clin Occup Environ Med. 2004 Feb; 4(1):205-19.
    View in: PubMed
  91. Saha D, LaRocque RC, Khan AI, Harris JB, Begun YA, Akramuzzaman SM, Faruque ASG, Ryan ET, Qadri F, Calderwood SB. Incomplete correlation of the serum vibriocidal antibody titer with protection from Vibrio cholerae infection in urban Bangladesh. J Infect Diseases. 2004.
  92. Qadri F, Ryan ET, Faruque AS, Ahmed F, Khan AI, Islam MM, Akramuzzaman SM, Sack DA, Calderwood SB. Antigen-specific immunoglobulin A antibodies secreted from circulating B cells are an effective marker for recent local immune responses in patients with cholera: comparison to antibody-secreting cell responses and other immunological markers. Infect Immun. 2003 Aug; 71(8):4808-14.
    View in: PubMed
  93. Hang L, John M, Asaduzzaman M, Bridges EA, Vanderspurt C, Kirn TJ, Taylor RK, Hillman JD, Progulske-Fox A, Handfield M, Ryan ET, Calderwood SB. Use of in vivo-induced antigen technology (IVIAT) to identify genes uniquely expressed during human infection with Vibrio cholerae. Proc Natl Acad Sci U S A. 2003 Jul 8; 100(14):8508-13.
    View in: PubMed
  94. Rollins SE, Rollins SM, Ryan ET. Yersinia pestis and the plague. Am J Clin Pathol. 2003 Jun; 119 Suppl:S78-85.
    View in: PubMed
  95. Brainard DM, Ryan ET. Images in clinical medicine. Thoracic echinococcosis. N Engl J Med. 2003 Feb 6; 348(6):528.
    View in: PubMed
  96. Wang RC, Lou PL, Ryan EA, Kroll AJ. Antibiotic therapy in post-operative endophthalmitis. Semin Ophthalmol. 2002 Sep-Dec; 17(3-4):153-61.
    View in: PubMed
  97. Ryan ET, Wilson ME, Kain KC. Illness after international travel. N Engl J Med. 2002 Aug 15; 347(7):505-16.
    View in: PubMed
  98. Moore AC, Ryan ET, Waldron MA. Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 20-2002. A 37-year-old man with fever, hepatosplenomegaly, and a cutaneous foot lesion after a trip to Africa. N Engl J Med. 2002 Jun 27; 346(26):2069-76.
    View in: PubMed
  99. John M, Bridges EA, Miller AO, Calderwood SB, Ryan ET. Comparison of mucosal and systemic humoral immune responses after transcutaneous and oral immunization strategies. Vaccine. 2002 Jun 21; 20(21-22):2720-6.
    View in: PubMed
  100. Ryan ET, Bridges EA, Crean TI, Gausia K, Hamadani JD, Aziz A, Hawkes S, Begum M, Bogaerts J, Faruque SM, Salam MA, Fuchs GJ, Calderwood SB. Local production of anti-vibrio cholerae mucosal antibody in reproductive tract tissues after cholera. J Infect Dis. 2001 Sep 1; 184(5):643-7.
    View in: PubMed
  101. Ryan ET, Calderwood SB. Cholera vaccines. J Travel Med. 2001 Mar-Apr; 8(2):82-91.
    View in: PubMed
  102. Mylonakis E, Ryan ET, Calderwood SB. Clostridium difficile--Associated diarrhea: A review. Arch Intern Med. 2001 Feb 26; 161(4):525-33.
    View in: PubMed
  103. Ryan ET, Bridges EA, Crean TI, Gausia K, Hamadani JD, Aziz A, Hawkes S, Begum M, Bogaerts J, Faruque SM, Salam MA, Fuchs GJ, Calderwood SB. Local production of anti-Vibrio cholerae mucosal antibody in reproductive tract tissues following cholera. J Infect Diseases. 2001; 184:643-7.
  104. Ryan ET. Malaria: epidemiology, pathogenesis, diagnosis, prevention, and treatment--an update. Curr Clin Top Infect Dis. 2001; 21:83-113.
    View in: PubMed
  105. Ryan ET, Calderwood SB. Cholera vaccines. Clin Infect Dis. 2000 Aug; 31(2):561-5.
    View in: PubMed
  106. Ryan ET, Dhar U, Khan WA, Salam MA, Faruque AS, Fuchs GJ, Calderwood SB, Bennish ML. Mortality, morbidity, and microbiology of endemic cholera among hospitalized patients in Dhaka, Bangladesh. Am J Trop Med Hyg. 2000 Jul-Aug; 63(1-2):12-20.
    View in: PubMed
  107. Ryan ET, Kain KC. Health advice and immunizations for travelers. N Engl J Med. 2000 Jun 8; 342(23):1716-25.
    View in: PubMed
  108. John M, Crean TI, Calderwood SB, Ryan ET. In vitro and in vivo analyses of constitutive and in vivo-induced promoters in attenuated vaccine and vector strains of Vibrio cholerae. Infect Immun. 2000 Mar; 68(3):1171-5.
    View in: PubMed
  109. Crean TI, John M, Calderwood SB, Ryan ET. Optimizing the germfree mouse model for in vivo evaluation of oral Vibrio cholerae vaccine and vector strains. Infect Immun. 2000 Feb; 68(2):977-81.
    View in: PubMed
  110. Ryan ET, Crean TI, Kochi SK, John M, Luciano AA, Killeen KP, Klose KE, Calderwood SB. Development of a DeltaglnA balanced lethal plasmid system for expression of heterologous antigens by attenuated vaccine vector strains of Vibrio cholerae. Infect Immun. 2000 Jan; 68(1):221-6.
    View in: PubMed
  111. Ryan ET, Crean TI, John M, Butterton JR, Clements JD, Calderwood SB. In vivo expression and immunoadjuvancy of a mutant of heat-labile enterotoxin of Escherichia coli in vaccine and vector strains of Vibrio cholerae. Infect Immun. 1999 Apr; 67(4):1694-701.
    View in: PubMed
  112. Ryan ET, Butterton JR, Zhang T, Baker MA, Stanley SL, Calderwood SB. Oral immunization with attenuated vaccine strains of Vibrio cholerae expressing a dodecapeptide repeat of the serine-rich Entamoeba histolytica protein fused to the cholera toxin B subunit induces systemic and mucosal antiamebic and anti-V. cholerae antibody responses in mice. Infect Immun. 1997 Aug; 65(8):3118-25.
    View in: PubMed
  113. Ryan ET, Butterton JR, Smith RN, Carroll PA, Crean TI, Calderwood SB. Protective immunity against Clostridium difficile toxin A induced by oral immunization with a live, attenuated Vibrio cholerae vector strain. Infect Immun. 1997 Jul; 65(7):2941-9.
    View in: PubMed
  114. Butterton JR, Ryan ET, Acheson DW, Calderwood SB. Coexpression of the B subunit of Shiga toxin 1 and EaeA from enterohemorrhagic Escherichia coli in Vibrio cholerae vaccine strains. Infect Immun. 1997 Jun; 65(6):2127-35.
    View in: PubMed
  115. Butterton JR, Ryan ET, Shahin RA, Calderwood SB. Development of a germfree mouse model of Vibrio cholerae infection. Infect Immun. 1996 Oct; 64(10):4373-7.
    View in: PubMed
  116. Young JA, Ryan ET. Parasitic infections of the anterior segment. Int Ophthalmol Clin. 1996; 36(3):49-71.
    View in: PubMed
  117. Ryan ET, Pak PH, DeSanctis RW. Myocardial infarction mimicked by acute cholecystitis. Ann Intern Med. 1992 Feb 1; 116(3):218-20.
    View in: PubMed
  118. Ryan ET, Ecker JL, Christakis NA, Folkman J. Hirschsprung's disease: associated abnormalities and demography. J Pediatr Surg. 1992 Jan; 27(1):76-81.
    View in: PubMed
  119. Marti GE, Ryan ET, Papadopoulos NM, Filling-Katz M, Barton N, Fleischer TA, Rick M, Gralnick HR. Polyclonal B-cell lymphocytosis and hypergammaglobulinemia in patients with Gaucher disease. Am J Hematol. 1988 Dec; 29(4):189-94.
    View in: PubMed
Local representatives can answer questions about the Profiles website or help with editing a profile or issues with profile data. For assistance with this profile: HMS/HSDM faculty should contact Human Resources at faculty_serviceshms.harvard.edu. SPH faculty should contact Maria Maxell (mmaxellhsph.harvard.edu).
Ryan's Networks
Click the "See All" links for more information and interactive visualizations!
Concepts
See all (466) concept(s)
_
Co-Authors
See all (54) people
_
Similar People
See all (60) people
_
Same Department
Search Department
Physical Neighbors
_