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Last Name
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Victor Wee Hsu, M.D.

TitleAssociate Professor of Medicine
InstitutionBrigham and Women's Hospital
DepartmentMedicine
AddressBrigham and Women's Hospital
Smith Building, Rm 538B
1 Jimmy Fund Way
Boston MA 02115
Phone617/525-1103
Fax617/525-1104

 Bibliographic 
 selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Barral DC, Garg S, Casalou C, Watts GF, Sandoval JL, Ramalho JS, Hsu VW, Brenner MB. Arl13b regulates endocytic recycling traffic. Proc Natl Acad Sci U S A. 2012 Dec 26; 109(52):21354-9.
    View in: PubMed
  2. Chen Y, Rice W, Gu Z, Li J, Huang J, Brenner MB, Van Hoek A, Xiong J, Gundersen GG, Norman JC, Hsu VW, Fenton RA, Brown D, Lu HA. Aquaporin 2 promotes cell migration and epithelial morphogenesis. J Am Soc Nephrol. 2012 Sep; 23(9):1506-17.
    View in: PubMed
  3. Bai M, Pang X, Lou J, Zhou Q, Zhang K, Ma J, Li J, Sun F, Hsu VW. Mechanistic insights into regulated cargo binding by ACAP1 protein. J Biol Chem. 2012 Aug 17; 287(34):28675-85.
    View in: PubMed
  4. Li J, Malaby AW, Famulok M, Sabe H, Lambright DG, Hsu VW. Grp1 plays a key role in linking insulin signaling to glut4 recycling. Dev Cell. 2012 Jun 12; 22(6):1286-98.
    View in: PubMed
  5. Hsu VW, Bai M, Li J. Getting active: protein sorting in endocytic recycling. Nat Rev Mol Cell Biol. 2012 May; 13(5):323-8.
    View in: PubMed
  6. Zhang L, Hong Z, Lin W, Shao RX, Goto K, Hsu VW, Chung RT. ARF1 and GBF1 generate a PI4P-enriched environment supportive of hepatitis C virus replication. PLoS One. 2012; 7(2):e32135.
    View in: PubMed
  7. Fleishman SJ, Whitehead TA, Strauch EM, Corn JE, Qin S, Zhou HX, Mitchell JC, Demerdash ON, Takeda-Shitaka M, Terashi G, Moal IH, Li X, Bates PA, Zacharias M, Park H, Ko JS, Lee H, Seok C, Bourquard T, Bernauer J, Poupon A, Azé J, Soner S, Ovali SK, Ozbek P, Tal NB, Haliloglu T, Hwang H, Vreven T, Pierce BG, Weng Z, Pérez-Cano L, Pons C, Fernández-Recio J, Jiang F, Yang F, Gong X, Cao L, Xu X, Liu B, Wang P, Li C, Wang C, Robert CH, Guharoy M, Liu S, Huang Y, Li L, Guo D, Chen Y, Xiao Y, London N, Itzhaki Z, Schueler-Furman O, Inbar Y, Potapov V, Cohen M, Schreiber G, Tsuchiya Y, Kanamori E, Standley DM, Nakamura H, Kinoshita K, Driggers CM, Hall RG, Morgan JL, Hsu VL, Zhan J, Yang Y, Zhou Y, Kastritis PL, Bonvin AM, Zhang W, Camacho CJ, Kilambi KP, Sircar A, Gray JJ, Ohue M, Uchikoga N, Matsuzaki Y, Ishida T, Akiyama Y, Khashan R, Bush S, Fouches D, Tropsha A, Esquivel-Rodríguez J, Kihara D, Stranges PB, Jacak R, Kuhlman B, Huang SY, Zou X, Wodak SJ, Janin J, Baker D. Community-wide assessment of protein-interface modeling suggests improvements to design methodology. J Mol Biol. 2011 Nov 25; 414(2):289-302.
    View in: PubMed
  8. Yang JS, Valente C, Polishchuk RS, Turacchio G, Layre E, Moody DB, Leslie CC, Gelb MH, Brown WJ, Corda D, Luini A, Hsu VW. COPI acts in both vesicular and tubular transport. Nat Cell Biol. 2011 Aug; 13(8):996-1003.
    View in: PubMed
  9. Bai M, Gad H, Turacchio G, Cocucci E, Yang JS, Li J, Beznoussenko GV, Nie Z, Luo R, Fu L, Collawn JF, Kirchhausen T, Luini A, Hsu VW. ARFGAP1 promotes AP-2-dependent endocytosis. Nat Cell Biol. 2011 May; 13(5):559-67.
    View in: PubMed
  10. Gu Z, Noss EH, Hsu VW, Brenner MB. Integrins traffic rapidly via circular dorsal ruffles and macropinocytosis during stimulated cell migration. J Cell Biol. 2011 Apr 4; 193(1):61-70.
    View in: PubMed
  11. Hsu VW, Prekeris R. Transport at the recycling endosome. Curr Opin Cell Biol. 2010 Aug; 22(4):528-34.
    View in: PubMed
  12. Hsu VW, Yang JS. Mechanisms of COPI vesicle formation. FEBS Lett. 2009 Dec 3; 583(23):3758-63.
    View in: PubMed
  13. Hsu VW, Lee SY, Yang JS. The evolving understanding of COPI vesicle formation. Nat Rev Mol Cell Biol. 2009 May; 10(5):360-4.
    View in: PubMed
  14. Zhang L, Lee SY, Beznoussenko GV, Peters PJ, Yang JS, Gilbert HY, Brass AL, Elledge SJ, Isaacs SN, Moss B, Mironov A, Hsu VW. A role for the host coatomer and KDEL receptor in early vaccinia biogenesis. Proc Natl Acad Sci U S A. 2009 Jan 6; 106(1):163-8.
    View in: PubMed
  15. Yang JS, Gad H, Lee SY, Mironov A, Zhang L, Beznoussenko GV, Valente C, Turacchio G, Bonsra AN, Du G, Baldanzi G, Graziani A, Bourgoin S, Frohman MA, Luini A, Hsu VW. A role for phosphatidic acid in COPI vesicle fission yields insights into Golgi maintenance. Nat Cell Biol. 2008 Oct; 10(10):1146-53.
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  16. Pulvirenti T, Giannotta M, Capestrano M, Capitani M, Pisanu A, Polishchuk RS, San Pietro E, Beznoussenko GV, Mironov AA, Turacchio G, Hsu VW, Sallese M, Luini A. A traffic-activated Golgi-based signalling circuit coordinates the secretory pathway. Nat Cell Biol. 2008 Aug; 10(8):912-22.
    View in: PubMed
  17. Li J, Peters PJ, Bai M, Dai J, Bos E, Kirchhausen T, Kandror KV, Hsu VW. An ACAP1-containing clathrin coat complex for endocytic recycling. J Cell Biol. 2007 Jul 30; 178(3):453-64.
    View in: PubMed
  18. Yang JS, Zhang L, Lee SY, Gad H, Luini A, Hsu VW. Key components of the fission machinery are interchangeable. Nat Cell Biol. 2006 Dec; 8(12):1376-82.
    View in: PubMed
  19. Balestrieri B, Hsu VW, Gilbert H, Leslie CC, Han WK, Bonventre JV, Arm JP. Group V secretory phospholipase A2 translocates to the phagosome after zymosan stimulation of mouse peritoneal macrophages and regulates phagocytosis. J Biol Chem. 2006 Mar 10; 281(10):6691-8.
    View in: PubMed
  20. Yang JS, Lee SY, Spanò S, Gad H, Zhang L, Nie Z, Bonazzi M, Corda D, Luini A, Hsu VW. A role for BARS at the fission step of COPI vesicle formation from Golgi membrane. EMBO J. 2005 Dec 7; 24(23):4133-43.
    View in: PubMed
  21. Li J, Ballif BA, Powelka AM, Dai J, Gygi SP, Hsu VW. Phosphorylation of ACAP1 by Akt regulates the stimulation-dependent recycling of integrin beta1 to control cell migration. Dev Cell. 2005 Nov; 9(5):663-73.
    View in: PubMed
  22. Bonazzi M, Spanò S, Turacchio G, Cericola C, Valente C, Colanzi A, Kweon HS, Hsu VW, Polishchuck EV, Polishchuck RS, Sallese M, Pulvirenti T, Corda D, Luini A. CtBP3/BARS drives membrane fission in dynamin-independent transport pathways. Nat Cell Biol. 2005 Jun; 7(6):570-80.
    View in: PubMed
  23. Lee SY, Yang JS, Hong W, Premont RT, Hsu VW. ARFGAP1 plays a central role in coupling COPI cargo sorting with vesicle formation. J Cell Biol. 2005 Jan 17; 168(2):281-90.
    View in: PubMed
  24. Dai J, Li J, Bos E, Porcionatto M, Premont RT, Bourgoin S, Peters PJ, Hsu VW. ACAP1 promotes endocytic recycling by recognizing recycling sorting signals. Dev Cell. 2004 Nov; 7(5):771-6.
    View in: PubMed
  25. Powelka AM, Sun J, Li J, Gao M, Shaw LM, Sonnenberg A, Hsu VW. Stimulation-dependent recycling of integrin beta1 regulated by ARF6 and Rab11. Traffic. 2004 Jan; 5(1):20-36.
    View in: PubMed
  26. Yang JS, Lee SY, Gao M, Bourgoin S, Randazzo PA, Premont RT, Hsu VW. ARFGAP1 promotes the formation of COPI vesicles, suggesting function as a component of the coat. J Cell Biol. 2002 Oct 14; 159(1):69-78.
    View in: PubMed
  27. Peters PJ, Gao M, Gaschet J, Ambach A, van Donselaar E, Traverse JF, Bos E, Wolffe EJ, Hsu VW. Characterization of coated vesicles that participate in endocytic recycling. Traffic. 2001 Dec; 2(12):885-95.
    View in: PubMed
  28. Yamamoto K, Fujii R, Toyofuku Y, Saito T, Koseki H, Hsu VW, Aoe T. The KDEL receptor mediates a retrieval mechanism that contributes to quality control at the endoplasmic reticulum. EMBO J. 2001 Jun 15; 20(12):3082-91.
    View in: PubMed
  29. Randazzo PA, Nie Z, Miura K, Hsu VW. Molecular aspects of the cellular activities of ADP-ribosylation factors. Sci STKE. 2000 Nov 21; 2000(59):re1.
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  30. Jackson TR, Brown FD, Nie Z, Miura K, Foroni L, Sun J, Hsu VW, Donaldson JG, Randazzo PA. ACAPs are arf6 GTPase-activating proteins that function in the cell periphery. J Cell Biol. 2000 Oct 30; 151(3):627-38.
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  31. Lill NL, Douillard P, Awwad RA, Ota S, Lupher ML, Miyake S, Meissner-Lula N, Hsu VW, Band H. The evolutionarily conserved N-terminal region of Cbl is sufficient to enhance down-regulation of the epidermal growth factor receptor. J Biol Chem. 2000 Jan 7; 275(1):367-77.
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  32. Sugita M, Grant EP, van Donselaar E, Hsu VW, Rogers RA, Peters PJ, Brenner MB. Separate pathways for antigen presentation by CD1 molecules. Immunity. 1999 Dec; 11(6):743-52.
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  33. Aoe T, Huber I, Vasudevan C, Watkins SC, Romero G, Cassel D, Hsu VW. The KDEL receptor regulates a GTPase-activating protein for ADP-ribosylation factor 1 by interacting with its non-catalytic domain. J Biol Chem. 1999 Jul 16; 274(29):20545-9.
    View in: PubMed
  34. Gaschet J, Hsu VW. Distribution of ARF6 between membrane and cytosol is regulated by its GTPase cycle. J Biol Chem. 1999 Jul 9; 274(28):20040-5.
    View in: PubMed
  35. Huber I, Cukierman E, Rotman M, Aoe T, Hsu VW, Cassel D. Requirement for both the amino-terminal catalytic domain and a noncatalytic domain for in vivo activity of ADP-ribosylation factor GTPase-activating protein. J Biol Chem. 1998 Sep 18; 273(38):24786-91.
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  36. Aoe T, Lee AJ, van Donselaar E, Peters PJ, Hsu VW. Modulation of intracellular transport by transported proteins: insight from regulation of COPI-mediated transport. Proc Natl Acad Sci U S A. 1998 Feb 17; 95(4):1624-9.
    View in: PubMed
  37. D'Souza-Schorey C, van Donselaar E, Hsu VW, Yang C, Stahl PD, Peters PJ. ARF6 targets recycling vesicles to the plasma membrane: insights from an ultrastructural investigation. J Cell Biol. 1998 Feb 9; 140(3):603-16.
    View in: PubMed
  38. Hsu VW, Peters PJ. Current views in intracellular transport: insights from studies in immunology. Adv Immunol. 1998; 70:369-415.
    View in: PubMed
  39. Aoe T, Cukierman E, Lee A, Cassel D, Peters PJ, Hsu VW. The KDEL receptor, ERD2, regulates intracellular traffic by recruiting a GTPase-activating protein for ARF1. EMBO J. 1997 Dec 15; 16(24):7305-16.
    View in: PubMed
  40. Peters PJ, Hsu VW, Ooi CE, Finazzi D, Teal SB, Oorschot V, Donaldson JG, Klausner RD. Overexpression of wild-type and mutant ARF1 and ARF6: distinct perturbations of nonoverlapping membrane compartments. J Cell Biol. 1995 Mar; 128(6):1003-17.
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  41. Teal SB, Hsu VW, Peters PJ, Klausner RD, Donaldson JG. An activating mutation in ARF1 stabilizes coatomer binding to Golgi membranes. J Biol Chem. 1994 Feb 4; 269(5):3135-8.
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  42. Hsu VW, Shah N, Klausner RD. A brefeldin A-like phenotype is induced by the overexpression of a human ERD-2-like protein, ELP-1. Cell. 1992 May 15; 69(4):625-35.
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  43. Hsu VW, Yuan LC, Nuchtern JG, Lippincott-Schwartz J, Hammerling GJ, Klausner RD. A recycling pathway between the endoplasmic reticulum and the Golgi apparatus for retention of unassembled MHC class I molecules. Nature. 1991 Aug 1; 352(6334):441-4.
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  44. Baniyash M, Hsu VW, Seldin MF, Klausner RD. The isolation and characterization of the murine T cell antigen receptor zeta chain gene. J Biol Chem. 1989 Aug 5; 264(22):13252-7.
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  45. Jordan JM, Hsu VW, Allen NB. Pyomyositis and polyarticular septic arthritis from Hemophilus influenzae in a nonimmunocompromised adult. J Rheumatol. 1987 Dec; 14(6):1190-2.
    View in: PubMed
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