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Last Name
Institution

William Cameron Aird, M.D.

TitleProfessor of Medicine
InstitutionBeth Israel Deaconess Medical Center
DepartmentMedicine
AddressBeth Israel Deaconess Med Ctr
Molecular Medicine, RW-663
330 Brookline Ave
Boston MA 02215
Phone617/667-1031
Fax617/667-2913

 Mentoring 
 completed student projects
Hagfish: A Model for Early Endothelium?
Summer, 05/30/05 - 08/19/05

 Bibliographic 
 selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Yoshikawa M, Mukai Y, Okada Y, Tsumori Y, Tsunoda S, Tsutsumi Y, Aird WC, Yoshioka Y, Okada N, Doi T, Nakagawa S. Robo4 is an effective tumor endothelial marker for antibody-drug conjugates based on the rapid isolation of the anti-Robo4 cell-internalizing antibody. Blood. 2013 Apr 4; 121(14):2804-13.
    View in: PubMed
  2. O'Donnell RK, Goldstein WE, Perruzzi C, Benjamin LE, Aird W. Overexpression of MyrAkt1 in Endothelial Cells Leads to Erythropoietin- and BMP4-Independent Splenic Erythropoiesis in Mice. PLoS One. 2013; 8(1):e55095.
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  3. Vijayaraj P, Le Bras A, Mitchell N, Kondo M, Juliao S, Wasserman M, Beeler D, Spokes K, Aird WC, Baldwin HS, Oettgen P. Erg is a crucial regulator of endocardial-mesenchymal transformation during cardiac valve morphogenesis. Development. 2012 Nov; 139(21):3973-85.
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  4. Regan ER, Aird WC. Dynamical systems approach to endothelial heterogeneity. Circ Res. 2012 Jun 22; 111(1):110-30.
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  5. Schuetz P, Kennedy M, Lucas JM, Howell MD, Aird WC, Yealy DM, Shapiro NI. Initial management of septic patients with hyperglycemia in the noncritical care inpatient setting. Am J Med. 2012 Jul; 125(7):670-8.
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  6. van Meurs M, Castro P, Shapiro NI, Lu S, Yano M, Maeda N, Funahashi T, Shimomura I, Zijlstra JG, Molema G, Parikh SM, Aird WC, Yano K. Adiponectin diminishes organ-specific microvascular endothelial cell activation associated with sepsis. Shock. 2012 Apr; 37(4):392-8.
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  7. Herzig SJ, Aird WC, Shah BJ, McKernan M, Zeidel ML. From hagfish to humans: teaching comparative physiology to internal medicine residents. Acad Med. 2012 Mar; 87(3):372-7.
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  8. Molema G, Aird WC. Vascular heterogeneity in the kidney. Semin Nephrol. 2012 Mar; 32(2):145-55.
    View in: PubMed
  9. Okada Y, Yonekura M, Watanabe M, Nakai T, Wakimura A, Shimizu M, Kamikawa Y, Kitayama M, Kitajima K, Aird WC, Doi T. Embryonic stem cell differentiation system for evaluating gene functions involved in physiological megakaryocytic differentiation. Biochem Biophys Res Commun. 2012 Mar 16; 419(3):477-81.
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  10. Yuan L, Le Bras A, Sacharidou A, Itagaki K, Zhan Y, Kondo M, Carman CV, Davis GE, Aird WC, Oettgen P. ETS-related gene (ERG) controls endothelial cell permeability via transcriptional regulation of the claudin 5 (CLDN5) gene. J Biol Chem. 2012 Feb 24; 287(9):6582-91.
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  11. Aird WC. Endothelial cell heterogeneity. Cold Spring Harb Perspect Med. 2012 Jan; 2(1):a006429.
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  12. Okada Y, Nobori H, Shimizu M, Watanabe M, Yonekura M, Nakai T, Kamikawa Y, Wakimura A, Funahashi N, Naruse H, Watanabe A, Yamasaki D, Fukada S, Yasui K, Matsumoto K, Sato T, Kitajima K, Nakano T, Aird WC, Doi T. Multiple ETS family proteins regulate PF4 gene expression by binding to the same ETS binding site. PLoS One. 2011; 6(9):e24837.
    View in: PubMed
  13. Schuetz P, Jones AE, Aird WC, Shapiro NI. Endothelial cell activation in emergency department patients with sepsis-related and non-sepsis-related hypotension. Shock. 2011 Aug; 36(2):104-8.
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  14. Aird WC. Discovery of the cardiovascular system: from Galen to William Harvey. J Thromb Haemost. 2011 Jul; 9 Suppl 1:118-29.
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  15. Schuetz P, Jones AE, Howell MD, Trzeciak S, Ngo L, Younger JG, Aird W, Shapiro NI. Diabetes is not associated with increased mortality in emergency department patients with sepsis. Ann Emerg Med. 2011 Nov; 58(5):438-44.
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  16. Yuan L, Sacharidou A, Stratman AN, Le Bras A, Zwiers PJ, Spokes K, Bhasin M, Shih SC, Nagy JA, Molema G, Aird WC, Davis GE, Oettgen P. RhoJ is an endothelial cell-restricted Rho GTPase that mediates vascular morphogenesis and is regulated by the transcription factor ERG. Blood. 2011 Jul 28; 118(4):1145-53.
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  17. Tozawa H, Kanki Y, Suehiro J, Tsutsumi S, Kohro T, Wada Y, Aburatani H, Aird WC, Kodama T, Minami T. Genome-wide approaches reveal functional interleukin-4-inducible STAT6 binding to the vascular cell adhesion molecule 1 promoter. Mol Cell Biol. 2011 Jun; 31(11):2196-209.
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  18. Shapiro NI, Aird WC. Sepsis and the broken endothelium. Crit Care. 2011; 15(2):135.
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  19. Schuetz P, Yano K, Sorasaki M, Ngo L, St Hilaire M, Lucas JM, Aird W, Shapiro NI. Influence of diabetes on endothelial cell response during sepsis. Diabetologia. 2011 May; 54(5):996-1003.
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  20. Liu J, Yuan L, Molema G, Regan E, Janes L, Beeler D, Spokes KC, Okada Y, Minami T, Oettgen P, Aird WC. Vascular bed-specific regulation of the von Willebrand factor promoter in the heart and skeletal muscle. Blood. 2011 Jan 6; 117(1):342-51.
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  21. Wada Y, Li D, Merley A, Zukauskas A, Aird WC, Dvorak HF, Shih SC. A multi-gene transcriptional profiling approach to the discovery of cell signature markers. Cytotechnology. 2011 Jan; 63(1):25-33.
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  22. Shapiro NI, Schuetz P, Yano K, Sorasaki M, Parikh SM, Jones AE, Trzeciak S, Ngo L, Aird WC. The association of endothelial cell signaling, severity of illness, and organ dysfunction in sepsis. Crit Care. 2010; 14(5):R182.
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  23. Fischer CM, Yano K, Aird WC, Shapiro NI. Abnormal coagulation tests obtained in the emergency department are associated with mortality in patients with suspected infection. J Emerg Med. 2012 Feb; 42(2):127-32.
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  24. Lee M, Spokes KC, Aird WC, Abid MR. Intracellular Ca2+ can compensate for the lack of NADPH oxidase-derived ROS in endothelial cells. FEBS Lett. 2010 Jul 16; 584(14):3131-6.
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  25. Aird WC. Proximate and evolutionary causation of endothelial heterogeneity. Semin Thromb Hemost. 2010 Apr; 36(3):276-85.
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  26. Aird WC, Kwaan HC. Under-recognized significance of endothelial heterogeneity: hemostasis, thrombosis, and beyond. Semin Thromb Hemost. 2010 Apr; 36(3):225-6.
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  27. Nassiri M, Liu J, Kulak S, Uwiera RR, Aird WC, Ballermann BJ, Jahroudi N. Repressors NFI and NFY participate in organ-specific regulation of von Willebrand factor promoter activity in transgenic mice. Arterioscler Thromb Vasc Biol. 2010 Jul; 30(7):1423-9.
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  28. Damrauer SM, Fisher MD, Wada H, Siracuse JJ, da Silva CG, Moon K, Csizmadia E, Maccariello ER, Patel VI, Studer P, Essayagh S, Aird WC, Daniel S, Ferran C. A20 inhibits post-angioplasty restenosis by blocking macrophage trafficking and decreasing adventitial neovascularization. Atherosclerosis. 2010 Aug; 211(2):404-8.
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  29. Eagle KA, Ginsburg GS, Musunuru K, Aird WC, Balaban RS, Bennett SK, Blumenthal RS, Coughlin SR, Davidson KW, Frohlich ED, Greenland P, Jarvik GP, Libby P, Pepine CJ, Ruskin JN, Stillman AE, Van Eyk JE, Tolunay HE, McDonald CL, Smith SC. Identifying patients at high risk of a cardiovascular event in the near future: current status and future directions: report of a national heart, lung, and blood institute working group. Circulation. 2010 Mar 30; 121(12):1447-54.
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  30. Suehiro J, Hamakubo T, Kodama T, Aird WC, Minami T. Vascular endothelial growth factor activation of endothelial cells is mediated by early growth response-3. Blood. 2010 Mar 25; 115(12):2520-32.
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  31. Jin E, Liu J, Suehiro J, Yuan L, Okada Y, Nikolova-Krstevski V, Yano K, Janes L, Beeler D, Spokes KC, Li D, Regan E, Shih SC, Oettgen P, Minami T, Aird WC. Differential roles for ETS, CREB, and EGR binding sites in mediating VEGF receptor 1 expression in vivo. Blood. 2009 Dec 24; 114(27):5557-66.
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  32. Song H, Suehiro J, Kanki Y, Kawai Y, Inoue K, Daida H, Yano K, Ohhashi T, Oettgen P, Aird WC, Kodama T, Minami T. Critical role for GATA3 in mediating Tie2 expression and function in large vessel endothelial cells. J Biol Chem. 2009 Oct 16; 284(42):29109-24.
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  33. Minami T, Yano K, Miura M, Kobayashi M, Suehiro J, Reid PC, Hamakubo T, Ryeom S, Aird WC, Kodama T. The Down syndrome critical region gene 1 short variant promoters direct vascular bed-specific gene expression during inflammation in mice. J Clin Invest. 2009 Aug; 119(8):2257-70.
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  34. Liu J, Kanki Y, Okada Y, Jin E, Yano K, Shih SC, Minami T, Aird WC. A +220 GATA motif mediates basal but not endotoxin-repressible expression of the von Willebrand factor promoter in Hprt-targeted transgenic mice. J Thromb Haemost. 2009 Aug; 7(8):1384-92.
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  35. Baek KH, Zaslavsky A, Lynch RC, Britt C, Okada Y, Siarey RJ, Lensch MW, Park IH, Yoon SS, Minami T, Korenberg JR, Folkman J, Daley GQ, Aird WC, Galdzicki Z, Ryeom S. Down's syndrome suppression of tumour growth and the role of the calcineurin inhibitor DSCR1. Nature. 2009 Jun 25; 459(7250):1126-30.
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  36. Yuan L, Nikolova-Krstevski V, Zhan Y, Kondo M, Bhasin M, Varghese L, Yano K, Carman CV, Aird WC, Oettgen P. Antiinflammatory effects of the ETS factor ERG in endothelial cells are mediated through transcriptional repression of the interleukin-8 gene. Circ Res. 2009 May 8; 104(9):1049-57.
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  37. Shapiro NI, Yano K, Sorasaki M, Fischer C, Shih SC, Aird WC. Skin biopsies demonstrate site-specific endothelial activation in mouse models of sepsis. J Vasc Res. 2009; 46(5):495-502.
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  38. Choi EY, Chavakis E, Czabanka MA, Langer HF, Fraemohs L, Economopoulou M, Kundu RK, Orlandi A, Zheng YY, Prieto DA, Ballantyne CM, Constant SL, Aird WC, Papayannopoulou T, Gahmberg CG, Udey MC, Vajkoczy P, Quertermous T, Dimmeler S, Weber C, Chavakis T. Del-1, an endogenous leukocyte-endothelial adhesion inhibitor, limits inflammatory cell recruitment. Science. 2008 Nov 14; 322(5904):1101-4.
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  39. Yano K, Okada Y, Beldi G, Shih SC, Bodyak N, Okada H, Kang PM, Luscinskas W, Robson SC, Carmeliet P, Karumanchi SA, Aird WC. Elevated levels of placental growth factor represent an adaptive host response in sepsis. J Exp Med. 2008 Oct 27; 205(11):2623-31.
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  40. Abid MR, Nadeau RJ, Spokes KC, Minami T, Li D, Shih SC, Aird WC. Hepatocyte growth factor inhibits VEGF-forkhead-dependent gene expression in endothelial cells. Arterioscler Thromb Vasc Biol. 2008 Nov; 28(11):2042-8.
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  41. Aird WC. Molecular heterogeneity of tumor endothelium. Cell Tissue Res. 2009 Jan; 335(1):271-81.
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  42. Ganopolsky JG, Abid MR, Aird WC, Blostein MD. GAS6-induced signaling in human endothelial cells is mediated by FOXO1a. J Thromb Haemost. 2008 Oct; 6(10):1804-11.
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  43. Okada Y, Jin E, Nikolova-Krstevski V, Yano K, Liu J, Beeler D, Spokes K, Kitayama M, Funahashi N, Doi T, Janes L, Minami T, Oettgen P, Aird WC. A GABP-binding element in the Robo4 promoter is necessary for endothelial expression in vivo. Blood. 2008 Sep 15; 112(6):2336-9.
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  44. Yoshikawa M, Mukai Y, Okada Y, Yoshioka Y, Tsunoda S, Tsutsumi Y, Okada N, Aird WC, Doi T, Nakagawa S. Ligand-independent assembly of purified soluble magic roundabout (Robo4), a tumor-specific endothelial marker. Protein Expr Purif. 2008 Sep; 61(1):78-82.
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  45. Séguin C, Abid MR, Spokes KC, Aird WC. Thrombin downregulates thrombomodulin expression and activity in primary human endothelial cells. Endothelium. 2008 May-Jun; 15(3):143-8.
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  46. Shapiro NI, Yano K, Okada H, Fischer C, Howell M, Spokes KC, Ngo L, Angus DC, Aird WC. A prospective, observational study of soluble FLT-1 and vascular endothelial growth factor in sepsis. Shock. 2008 Apr; 29(4):452-7.
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  47. Séguin C, Abid MR, Spokes KC, Schoots IG, Brkovic A, Sirois MG, Aird WC. Priming effect of homocysteine on inducible vascular cell adhesion molecule-1 expression in endothelial cells. Biomed Pharmacother. 2008 Jul-Aug; 62(6):395-400.
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  48. Lee CW, Lin CC, Luo SF, Lee HC, Lee IT, Aird WC, Hwang TL, Yang CM. Tumor necrosis factor-alpha enhances neutrophil adhesiveness: induction of vascular cell adhesion molecule-1 via activation of Akt and CaM kinase II and modifications of histone acetyltransferase and histone deacetylase 4 in human tracheal smooth muscle cells. Mol Pharmacol. 2008 May; 73(5):1454-64.
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  49. Aird WC. Endothelium in health and disease. Pharmacol Rep. 2008 Jan-Feb; 60(1):139-43.
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  50. Abid MR, Spokes KC, Shih SC, Aird WC. NADPH oxidase activity selectively modulates vascular endothelial growth factor signaling pathways. J Biol Chem. 2007 Nov 30; 282(48):35373-85.
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  51. Hawkins BJ, Solt LA, Chowdhury I, Kazi AS, Abid MR, Aird WC, May MJ, Foskett JK, Madesh M. G protein-coupled receptor Ca2+-linked mitochondrial reactive oxygen species are essential for endothelial/leukocyte adherence. Mol Cell Biol. 2007 Nov; 27(21):7582-93.
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  52. Hwa C, Aird WC. The history of the capillary wall: doctors, discoveries, and debates. Am J Physiol Heart Circ Physiol. 2007 Nov; 293(5):H2667-79.
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  53. Aird WC. Vascular bed-specific thrombosis. J Thromb Haemost. 2007 Jul; 5 Suppl 1:283-91.
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  54. Feng J, Yano K, Monahan-Earley R, Morgan ES, Dvorak AM, Sellke FW, Aird WC. Vascular bed-specific endothelium-dependent vasomomotor relaxation in the hagfish, Myxine glutinosa. Am J Physiol Regul Integr Comp Physiol. 2007 Aug; 293(2):R894-900.
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  55. Okada Y, Yano K, Jin E, Funahashi N, Kitayama M, Doi T, Spokes K, Beeler DL, Shih SC, Okada H, Danilov TA, Maynard E, Minami T, Oettgen P, Aird WC. A three-kilobase fragment of the human Robo4 promoter directs cell type-specific expression in endothelium. Circ Res. 2007 Jun 22; 100(12):1712-22.
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  56. Aird WC. Endothelium as a therapeutic target in sepsis. Curr Drug Targets. 2007 Apr; 8(4):501-7.
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  57. Aird WC. Phenotypic heterogeneity of the endothelium: I. Structure, function, and mechanisms. Circ Res. 2007 Feb 2; 100(2):158-73.
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  58. Aird WC. Phenotypic heterogeneity of the endothelium: II. Representative vascular beds. Circ Res. 2007 Feb 2; 100(2):174-90.
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  59. Inoue K, Kobayashi M, Yano K, Miura M, Izumi A, Mataki C, Doi T, Hamakubo T, Reid PC, Hume DA, Yoshida M, Aird WC, Kodama T, Minami T. Histone deacetylase inhibitor reduces monocyte adhesion to endothelium through the suppression of vascular cell adhesion molecule-1 expression. Arterioscler Thromb Vasc Biol. 2006 Dec; 26(12):2652-9.
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  60. Yano K, Gale D, Massberg S, Cheruvu PK, Monahan-Earley R, Morgan ES, Haig D, von Andrian UH, Dvorak AM, Aird WC. Phenotypic heterogeneity is an evolutionarily conserved feature of the endothelium. Blood. 2007 Jan 15; 109(2):613-5.
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  61. Abid MR, Shih SC, Otu HH, Spokes KC, Okada Y, Curiel DT, Minami T, Aird WC. A novel class of vascular endothelial growth factor-responsive genes that require forkhead activity for expression. J Biol Chem. 2006 Nov 17; 281(46):35544-53.
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  62. Abid MR, Yi X, Yano K, Shih SC, Aird WC. Vascular endocan is preferentially expressed in tumor endothelium. Microvasc Res. 2006 Nov; 72(3):136-45.
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  63. Aird WC. Endothelium and allotransplantation. Transplantation. 2006 Jul 15; 82(1 Suppl):S6-8.
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  64. Yano K, Liaw PC, Mullington JM, Shih SC, Okada H, Bodyak N, Kang PM, Toltl L, Belikoff B, Buras J, Simms BT, Mizgerd JP, Carmeliet P, Karumanchi SA, Aird WC. Vascular endothelial growth factor is an important determinant of sepsis morbidity and mortality. J Exp Med. 2006 Jun 12; 203(6):1447-58.
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  65. Minami T, Miura M, Aird WC, Kodama T. Thrombin-induced autoinhibitory factor, Down syndrome critical region-1, attenuates NFAT-dependent vascular cell adhesion molecule-1 expression and inflammation in the endothelium. J Biol Chem. 2006 Jul 21; 281(29):20503-20.
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  66. Aird WC. Mechanisms of endothelial cell heterogeneity in health and disease. Circ Res. 2006 Feb 3; 98(2):159-62.
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  67. Aird WC. Endothelial cell heterogeneity and atherosclerosis. Curr Atheroscler Rep. 2006 Jan; 8(1):69-75.
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  68. Aird WC. Coagulation. Crit Care Med. 2005 Dec; 33(12 Suppl):S485-7.
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  69. Wada Y, Otu H, Wu S, Abid MR, Okada H, Libermann T, Kodama T, Shih SC, Minami T, Aird WC. Preconditioning of primary human endothelial cells with inflammatory mediators alters the "set point" of the cell. FASEB J. 2005 Nov; 19(13):1914-6.
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  70. Minami T, Aird WC. Endothelial cell gene regulation. Trends Cardiovasc Med. 2005 Jul; 15(5):174-84.
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  71. Aird WC. Sepsis and coagulation. Crit Care Clin. 2005 Jul; 21(3):417-31.
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  72. Abid MR, Yano K, Guo S, Patel VI, Shrikhande G, Spokes KC, Ferran C, Aird WC. Forkhead transcription factors inhibit vascular smooth muscle cell proliferation and neointimal hyperplasia. J Biol Chem. 2005 Aug 19; 280(33):29864-73.
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  73. Aird WC. Spatial and temporal dynamics of the endothelium. J Thromb Haemost. 2005 Jul; 3(7):1392-406.
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  74. Hwa C, Sebastian A, Aird WC. Endothelial biomedicine: its status as an interdisciplinary field, its progress as a basic science, and its translational bench-to-bedside gap. Endothelium. 2005 May-Jun; 12(3):139-51.
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  75. Wu SQ, Aird WC. Thrombin, TNF-alpha, and LPS exert overlapping but nonidentical effects on gene expression in endothelial cells and vascular smooth muscle cells. Am J Physiol Heart Circ Physiol. 2005 Aug; 289(2):H873-85.
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  76. Rice L, Orlow D, Ceonzo K, Stahl GL, Tzianabos AO, Wada H, Aird WC, Buras JA. CpG oligodeoxynucleotide protection in polymicrobial sepsis is dependent on interleukin-17. J Infect Dis. 2005 Apr 15; 191(8):1368-76.
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  77. Minami T, Horiuchi K, Miura M, Abid MR, Takabe W, Noguchi N, Kohro T, Ge X, Aburatani H, Hamakubo T, Kodama T, Aird WC. Vascular endothelial growth factor- and thrombin-induced termination factor, Down syndrome critical region-1, attenuates endothelial cell proliferation and angiogenesis. J Biol Chem. 2004 Nov 26; 279(48):50537-54.
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  78. Abid MR, Schoots IG, Spokes KC, Wu SQ, Mawhinney C, Aird WC. Vascular endothelial growth factor-mediated induction of manganese superoxide dismutase occurs through redox-dependent regulation of forkhead and IkappaB/NF-kappaB. J Biol Chem. 2004 Oct 15; 279(42):44030-8.
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  79. Aird WC. Endothelium as an organ system. Crit Care Med. 2004 May; 32(5 Suppl):S271-9.
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  80. Rothermel AL, Wang Y, Schechner J, Mook-Kanamori B, Aird WC, Pober JS, Tellides G, Johnson DR. Endothelial cells present antigens in vivo. BMC Immunol. 2004 Mar 16; 5:5.
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  81. Minami T, Murakami T, Horiuchi K, Miura M, Noguchi T, Miyazaki J, Hamakubo T, Aird WC, Kodama T. Interaction between hex and GATA transcription factors in vascular endothelial cells inhibits flk-1/KDR-mediated vascular endothelial growth factor signaling. J Biol Chem. 2004 May 14; 279(20):20626-35.
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  82. Aird WC. Natural anticoagulant inhibitors: activated Protein C. Best Pract Res Clin Haematol. 2004 Mar; 17(1):161-82.
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  83. Abid MR, Guo S, Minami T, Spokes KC, Ueki K, Skurk C, Walsh K, Aird WC. Vascular endothelial growth factor activates PI3K/Akt/forkhead signaling in endothelial cells. Arterioscler Thromb Vasc Biol. 2004 Feb; 24(2):294-300.
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  84. Hameed SM, Aird WC, Cohn SM. Oxygen delivery. Crit Care Med. 2003 Dec; 31(12 Suppl):S658-67.
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  85. Minami T, Sugiyama A, Wu SQ, Abid R, Kodama T, Aird WC. Thrombin and phenotypic modulation of the endothelium. Arterioscler Thromb Vasc Biol. 2004 Jan; 24(1):41-53.
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  86. Skurk C, Maatz H, Kim HS, Yang J, Abid MR, Aird WC, Walsh K. The Akt-regulated forkhead transcription factor FOXO3a controls endothelial cell viability through modulation of the caspase-8 inhibitor FLIP. J Biol Chem. 2004 Jan 9; 279(2):1513-25.
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  87. Minami T, Kuivenhoven JA, Evans V, Kodama T, Rosenberg RD, Aird WC. Ets motifs are necessary for endothelial cell-specific expression of a 723-bp Tie-2 promoter/enhancer in Hprt targeted transgenic mice. Arterioscler Thromb Vasc Biol. 2003 Nov 1; 23(11):2041-7.
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  88. Aird WC. The hematologic system as a marker of organ dysfunction in sepsis. Mayo Clin Proc. 2003 Jul; 78(7):869-81.
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  89. Aird WC. Endothelial cell heterogeneity. Crit Care Med. 2003 Apr; 31(4 Suppl):S221-30.
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  90. Aird WC. Hemostasis and irreducible complexity. J Thromb Haemost. 2003 Feb; 1(2):227-30.
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  91. Pawlinski R, Pedersen B, Kehrle B, Aird WC, Frank RD, Guha M, Mackman N. Regulation of tissue factor and inflammatory mediators by Egr-1 in a mouse endotoxemia model. Blood. 2003 May 15; 101(10):3940-7.
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  92. Aird WC. The role of the endothelium in severe sepsis and multiple organ dysfunction syndrome. Blood. 2003 May 15; 101(10):3765-77.
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  93. Warkentin TE, Aird WC, Rand JH. Platelet-endothelial interactions: sepsis, HIT, and antiphospholipid syndrome. Hematology Am Soc Hematol Educ Program. 2003; 497-519.
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  94. Minami T, Abid MR, Zhang J, King G, Kodama T, Aird WC. Thrombin stimulation of vascular adhesion molecule-1 in endothelial cells is mediated by protein kinase C (PKC)-delta-NF-kappa B and PKC-zeta-GATA signaling pathways. J Biol Chem. 2003 Feb 28; 278(9):6976-84.
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  95. Minami T, Donovan DJ, Tsai JC, Rosenberg RD, Aird WC. Differential regulation of the von Willebrand factor and Flt-1 promoters in the endothelium of hypoxanthine phosphoribosyltransferase-targeted mice. Blood. 2002 Dec 1; 100(12):4019-25.
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  96. Aird WC, Glueck SB, Dzau VJ, Pratt RE. Separating the wheat from the chaff: focus on "in silico data filtering to identify new angiogenesis targets from a large in vitro gene profile data set". Physiol Genomics. 2002 Jul 12; 10(1):1-3.
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  97. Wu SQ, Minami T, Donovan DJ, Aird WC. The proximal serum response element in the Egr-1 promoter mediates response to thrombin in primary human endothelial cells. Blood. 2002 Dec 15; 100(13):4454-61.
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  98. Aird WC, Mark EJ. Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 15-200. A 53-year-old man with a myocardial infarct and thromboses after coronary-artery bypass grafting. N Engl J Med. 2002 May 16; 346(20):1562-70.
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  99. Aird WC. Endothelial cell dynamics and complexity theory. Crit Care Med. 2002 May; 30(5 Suppl):S180-5.
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  100. Tsai JC, Zhang J, Minami T, Voland C, Zhao S, Yi X, Lassalle P, Oettgen P, Aird WC. Cloning and characterization of the human lung endothelial-cell-specific molecule-1 promoter. J Vasc Res. 2002 Mar-Apr; 39(2):148-59.
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  101. Bao J, Sato K, Li M, Gao Y, Abid R, Aird W, Simons M, Post MJ. PR-39 and PR-11 peptides inhibit ischemia-reperfusion injury by blocking proteasome-mediated I kappa B alpha degradation. Am J Physiol Heart Circ Physiol. 2001 Dec; 281(6):H2612-8.
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  102. Stevens T, Rosenberg R, Aird W, Quertermous T, Johnson FL, Garcia JG, Hebbel RP, Tuder RM, Garfinkel S. NHLBI workshop report: endothelial cell phenotypes in heart, lung, and blood diseases. Am J Physiol Cell Physiol. 2001 Nov; 281(5):C1422-33.
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  103. Tsai JC, Liu L, Zhang J, Spokes KC, Topper JN, Aird WC. Epidermal growth factor induces Egr-1 promoter activity in hepatocytes in vitro and in vivo. Am J Physiol Gastrointest Liver Physiol. 2001 Nov; 281(5):G1271-8.
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  104. Minami T, Aird WC. Thrombin stimulation of the vascular cell adhesion molecule-1 promoter in endothelial cells is mediated by tandem nuclear factor-kappa B and GATA motifs. J Biol Chem. 2001 Dec 14; 276(50):47632-41.
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  105. Abid MR, Tsai JC, Spokes KC, Deshpande SS, Irani K, Aird WC. Vascular endothelial growth factor induces manganese-superoxide dismutase expression in endothelial cells by a Rac1-regulated NADPH oxidase-dependent mechanism. FASEB J. 2001 Nov; 15(13):2548-50.
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  106. Aird WC. Vascular bed-specific hemostasis: role of endothelium in sepsis pathogenesis. Crit Care Med. 2001 Jul; 29(7 Suppl):S28-34; discussion S34-5.
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  107. Abid MR, Kachra Z, Spokes KC, Aird WC. NADPH oxidase activity is required for endothelial cell proliferation and migration. FEBS Lett. 2000 Dec 15; 486(3):252-6.
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  108. Minami T, Rosenberg RD, Aird WC. Transforming growth factor-beta 1-mediated inhibition of the flk-1/KDR gene is mediated by a 5'-untranslated region palindromic GATA site. J Biol Chem. 2001 Feb 16; 276(7):5395-402.
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  109. Tsai JC, Liu L, Guan J, Aird WC. The Egr-1 gene is induced by epidermal growth factor in ECV304 cells and primary endothelial cells. Am J Physiol Cell Physiol. 2000 Nov; 279(5):C1414-24.
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  110. Tsai JC, Liu L, Cooley BC, DiChiara MR, Topper JN, Aird WC. The Egr-1 promoter contains information for constitutive and inducible expression in transgenic mice. FASEB J. 2000 Oct; 14(13):1870-2.
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  111. Liu L, Tsai JC, Aird WC. Egr-1 gene is induced by the systemic administration of the vascular endothelial growth factor and the epidermal growth factor. Blood. 2000 Sep 1; 96(5):1772-81.
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  112. Sternberg DW, Aird W, Neuberg D, Thompson L, MacNeill K, Amrein P, Shulman LN. Treatment of patients with recurrent and primary refractory acute myelogenous leukemia using mitoxantrone and intermediate-dose cytarabine: a pharmacologically based regimen. Cancer. 2000 May 1; 88(9):2037-41.
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  113. Evans V, Hatzopoulos A, Aird WC, Rayburn HB, Rosenberg RD, Kuivenhoven JA. Targeting the Hprt locus in mice reveals differential regulation of Tie2 gene expression in the endothelium. Physiol Genomics. 2000 Mar 13; 2(2):67-75.
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  114. Guillot PV, Liu L, Kuivenhoven JA, Guan J, Rosenberg RD, Aird WC. Targeting of human eNOS promoter to the Hprt locus of mice leads to tissue-restricted transgene expression. Physiol Genomics. 2000 Mar 13; 2(2):77-83.
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  115. Li J, Post M, Volk R, Gao Y, Li M, Metais C, Sato K, Tsai J, Aird W, Rosenberg RD, Hampton TG, Sellke F, Carmeliet P, Simons M. PR39, a peptide regulator of angiogenesis. Nat Med. 2000 Jan; 6(1):49-55.
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  116. Gross PL, Aird WC. The endothelium and thrombosis. Semin Thromb Hemost. 2000; 26(5):463-78.
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  117. Guan J, Guillot PV, Aird WC. Characterization of the mouse von Willebrand factor promoter. Blood. 1999 Nov 15; 94(10):3405-12.
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  118. Rosenberg RD, Aird WC. Vascular-bed--specific hemostasis and hypercoagulable states. N Engl J Med. 1999 May 20; 340(20):1555-64.
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  119. Guillot PV, Guan J, Liu L, Kuivenhoven JA, Rosenberg RD, Sessa WC, Aird WC. A vascular bed-specific pathway. J Clin Invest. 1999 Mar; 103(6):799-805.
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  120. Edelberg JM, Aird WC, Wu W, Rayburn H, Mamuya WS, Mercola M, Rosenberg RD. PDGF mediates cardiac microvascular communication. J Clin Invest. 1998 Aug 15; 102(4):837-43.
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  121. Edelberg JM, Aird WC, Rosenberg RD. Enhancement of murine cardiac chronotropy by the molecular transfer of the human beta2 adrenergic receptor cDNA. J Clin Invest. 1998 Jan 15; 101(2):337-43.
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  122. Aird WC, Edelberg JM, Weiler-Guettler H, Simmons WW, Smith TW, Rosenberg RD. Vascular bed-specific expression of an endothelial cell gene is programmed by the tissue microenvironment. J Cell Biol. 1997 Sep 8; 138(5):1117-24.
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  123. Weiler-Guettler H, Aird WC, Rayburn H, Husain M, Rosenberg RD. Developmentally regulated gene expression of thrombomodulin in postimplantation mouse embryos. Development. 1996 Jul; 122(7):2271-81.
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  124. Weiler-Guettler H, Aird WC, Husain M, Rayburn H, Rosenberg RD. Targeting of transgene expression to the vascular endothelium of mice by homologous recombination at the thrombomodulin locus. Circ Res. 1996 Feb; 78(2):180-7.
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  125. Aird WC, Jahroudi N, Weiler-Guettler H, Rayburn HB, Rosenberg RD. Human von Willebrand factor gene sequences target expression to a subpopulation of endothelial cells in transgenic mice. Proc Natl Acad Sci U S A. 1995 May 9; 92(10):4567-71.
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  126. Aird WC, Parvin JD, Sharp PA, Rosenberg RD. The interaction of GATA-binding proteins and basal transcription factors with GATA box-containing core promoters. A model of tissue-specific gene expression. J Biol Chem. 1994 Jan 14; 269(2):883-9.
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  127. Aird W, Labopin M, Gorin NC, Antin JH. Long-term cryopreservation of human stem cells. Bone Marrow Transplant. 1992 Jun; 9(6):487-90.
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  128. Aird W, Cheema-Dhadli S, Sonnenberg B, Vandenbroucke A, Halperin M. Can oxygen consumption in blood in vitro be detected by a change in PCO2? Clin Invest Med. 1991 Apr; 14(2):125-30.
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  129. Aird W, Douek K, Halperin ML. Profound hypokalemia secondary to modest potassium depletion in a patient with coexisting hyponatremia: therapeutic implications. Am J Kidney Dis. 1988 Aug; 12(2):164-6.
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