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Claude Pierre Lechene, M.D.

TitleAssociate Professor of Medicine
InstitutionBrigham and Women's Hospital
DepartmentMedicine
AddressBrigham and Women's Hospital
Partners - Rm 535
65 Landsdowne St
Cambridge MA 02139
Phone617/732-7756
Fax617/768-8260

 Bibliographic 
 selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Steinhauser ML, Lechene CP. Quantitative imaging of subcellular metabolism with stable isotopes and multi-isotope imaging mass spectrometry. Semin Cell Dev Biol. 2013 Aug-Sep; 24(8-9):661-7.
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  2. Senyo SE, Steinhauser ML, Pizzimenti CL, Yang VK, Cai L, Wang M, Wu TD, Guerquin-Kern JL, Lechene CP, Lee RT. Mammalian heart renewal by pre-existing cardiomyocytes. Nature. 2013 Jan 17; 493(7432):433-6.
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  3. Lechene CP, Lee GY, Poczatek JC, Toner M, Biggers JD. 3D multi-isotope imaging mass spectrometry reveals penetration of 18O-trehalose in mouse sperm nucleus. PLoS One. 2012; 7(8):e42267.
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  4. Gormanns P, Reckow S, Poczatek JC, Turck CW, Lechene C. Segmentation of multi-isotope imaging mass spectrometry data for semi-automatic detection of regions of interest. PLoS One. 2012; 7(2):e30576.
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  5. Zhang DS, Piazza V, Perrin BJ, Rzadzinska AK, Poczatek JC, Wang M, Prosser HM, Ervasti JM, Corey DP, Lechene CP. Multi-isotope imaging mass spectrometry reveals slow protein turnover in hair-cell stereocilia. Nature. 2012 Jan 26; 481(7382):520-4.
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  6. Steinhauser ML, Bailey AP, Senyo SE, Guillermier C, Perlstein TS, Gould AP, Lee RT, Lechene CP. Multi-isotope imaging mass spectrometry quantifies stem cell division and metabolism. Nature. 2012 Jan 26; 481(7382):516-9.
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  7. Lechene CP, Luyten Y, McMahon G, Distel DL. Quantitative imaging of nitrogen fixation by individual bacteria within animal cells. Science. 2007 Sep 14; 317(5844):1563-6.
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  8. Luyten, Y., Lee, R., McMahon, G. Lechene, C. and Distel, D. Quantitative imaging of intracellular symbiotic N-fixation int he wood-boring bivalve Lyrodus pedicellatus (Bivalvia: Teredinidae). 5th International Symbiosis Society Congress. 2006.
  9. McMahon G, Saint-Cyr HF, Lechene C, Unkefer CJ. CN- secondary ions form by recombination as demonstrated using multi-isotope mass spectrometry of 13C- and 15N-labeled polyglycine. J Am Soc Mass Spectrom. 2006 Aug; 17(8):1181-7.
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  10. Y.A. Luyten, D.L. Distel, R. Lee, G. McMahon, C.P. Lechene. In situ Quantitative Imaging of N-Fixation by Intracellular Symbionts in the Wood-Boring Bivalve Lyrodus pedicellatus (Bivalvia: Teredinidae). American Society for Microbiology General Meeting. 2006.
  11. Lechene C, Hillion F, McMahon G, Benson D, Kleinfeld AM, Kampf JP, Distel D, Luyten Y, Bonventre J, Hentschel D, Park KM, Ito S, Schwartz M, Benichou G, Slodzian G. High-resolution quantitative imaging of mammalian and bacterial cells using stable isotope mass spectrometry. J Biol. 2006; 5(6):20.
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  12. McMahon, G., Glassner, B.J., and Lechene C.P. Quantitative Imaging of Cells with Multi Isotope Imagnig Mass Spectrometry (MIMS) - Nanoautography with Stable Isotope Tracers. Applied Surface Science. 2006; 252:6895-6906.
  13. G. McMahon and C.P. Lechene. Determination of Steady State Cs+ Implantation in Biological Samples. SIMS XV 15th International Conference on Secondary Ion Mass Spectrometry. 2005.
  14. D. Benson and C.P. Lechene. Quantitating MIMS Ratios Using Hue Saturation and Intensity Displays. SIMS XV 15th International Conference on Secondary Ion Mass Spectrometry. 2005.
  15. G. Benichou and C.P. Lechene. Stable isotopes for individual cell retrieval after transplantation. SIMS XV 15th International Conference on Secondary Ion Mass Spectrometry. 2005.
  16. D. Hentschel, J. Bonventre, and C.P. Lechene. Multi-Isotope Imaging Mass Spectrometry of Larval Zebrafish for Studying Acute Renal Failure. SIMS XV 15th International Conference on Secondary Ion Mass Spectrometry. 2005.
  17. H. Saint-Cyr, G. McMahon, B.J. Glassner, C. Unkefer, and C.P. Lechene. Molecular Specificity of CN Secondary Ion Formation using Multi-Isotope Imaging Mass Spectrometry. SIMS XV 15th International Conference on Secondary Ion Mass Spectrometry. 2005.
  18. D-S. Zhang, D. Corey, and C.P. Lechene. Multi-isotope imaging mass spectrometry (MIMS) quantitative mapping of protein turnover in the bullfrog sacula. SIMS XV 15th International Conference on Secondary Ion Mass Spectrometry. 2005.
  19. D. Cotanche and C.P. Lechene. Tectorial Membrane Protein Turnover Revealed by Multi-isotope Imaging Mass Spectrometry. SIMS XV 15th International Conference on Secondary Ion Mass Spectrometry. 2005.
  20. D. Distel, Y. Luyten, and C.P. Lechene. Multi-Isotope Imaging Mass Spectrometry (MIMS) of a Nitrogen-Fixing Bacterium. SIMS XV 15th International Conference on Secondary Ion Mass Spectrometry. 2005.
  21. A. Cohen and C.P. Lechene. High order of DNA replication identified in fibroblasts nuclei with Multi-Isotope Imaging Mass Spectrometry. SIMS XV 15th International Conference on Secondary Ion Mass Spectrometry. 2005.
  22. Kleinfeld AM, Kampf JP, Lechene C. Transport of 13C-oleate in adipocytes measured using multi imaging mass spectrometry. J Am Soc Mass Spectrom. 2004 Nov; 15(11):1572-80.
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  23. C. Guillermier, F. Hillion, A. Narayanaswamy, G. Chen and C. Lechene. Optimization of the Brightness of a Cesium Ion Source for Imaging Mass Spectrometry at High Spatial Resolution. 52nd Annual ASMS Conference. 2004.
  24. Peteranderl R, Lechene C. Measure of carbon and nitrogen stable isotope ratios in cultured cells. J Am Soc Mass Spectrom. 2004 Apr; 15(4):478-85.
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  25. Hallégot P, Peteranderl R, Lechene C. In-situ imaging mass spectrometry analysis of melanin granules in the human hair shaft. J Invest Dermatol. 2004 Feb; 122(2):381-6.
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  26. Schwartz, M. and C. Lechene. Qualitative Chemical Analysis of Subcellular Domains with Multi-Isotope Imaging Mass Spectrometry (MIMS). SIMS XIV 14th International Conference on Secondary Ion Mass Spectrometry. 2003.
  27. Cotanche, D. and C. Lechene. Protein Turnover is Faster in the Regenerating Cells of the Chick Cochlea as Shown by Multiple-isotope Imaging Mass Spectrometry (MIMS). SIMS XIV 14th International Conference on Secondary Ion Mass Spectrometry. 2003.
  28. Kleinfeld, A., P. Kampf and C. Lechene. Direct Measure of Transport of 13C Labeled Fatty Acids into Adipocytes with Multiple-isotope Imaging Mass Spectrometry (MIMS). SIMS XIV 14th International Conference on Secondary Ion Mass Spectrometry. 2003.
  29. Schwartz, M. and C. Lechene. Quantitative Chemical Analysis of Subcellular Domains with Multiple-isotope Imaging Mass Spectrometry (MIMS). SIMS XIV 14th International Conference on Secondary Ion Mass Spectrometry. 2003.
  30. Bonventre, J. and C. Lechene. DNA Replication and Protein Turnover in Post-Ischemic Kidney Repair Studied with Multiple-isotope Imaging Mass Spectrometry (MIMS). SIMS XIV 14th International Conference on Secondary Ion Mass Spectrometry. 2003.
  31. Peteranderl, R. and C. Lechene. Measure of 15N/14N and 13C/12C Isotope Ratios in Cultured Cells with Multiple-isotope Imaging Mass Spectrometry (MIMS). SIMS XIV 14th International Conference on Secondary Ion Mass Spectrometry. 2003.
  32. Lechene, C., F. Hillion and E. Mroz. Isotope Ratio Imaging of Biological Tissues with Multi-Isotope Imaging Mass Spectrometry (MIMS). SIMS XIV 14th International Conference on Secondary Ion Mass Spectrometry. 2003.
  33. Lechene, C., S. Ito and F. Hilton. Sub-Nucleolar Domains Excluding Newly Synthesized RNA Revealed by Multi-Isotope Imaging Mass Spectrometry (MIMS). SIMS XIV 14th International Conference on Secondary Ion Mass Spectrometry. 2003.
  34. Guillermier, C., C. Lechene, J. Hill and F. Hillion. Heating of a Thermo-ionization Source Using an Electron Beam Perpendicular to the Ion Trajectories. SIMS XIV 14th International Conference on Secondary Ion Mass Spectrometry. 2003.
  35. Lechene, C., E. Mroz, F. Hillion and D. Benson. Fast Turnover of Steocilia Tip Links Measured with Stable Isotope Ratio Imaging Mass Spectrometry. SIMS XIV 14th International Conference on Secondary Ion Mass Spectrometry. 2003.
  36. Mroz, E. and C. Lechene. Spatial Dynamics of Cochlear Protein Turnover Measured with Multiple-isotope Imaging Mass Spectrometry (MIMS). 2003.
  37. Hallegot, P., R. Peteranderl and C. Lechene. Melanin Granules in the Human Hair Shaft Shown with Multiple-isotope Imaging Mass Spectrometry (MIMS). SIMS XIV 14th International Conference on Secondary Ion Mass Spectrometry. 2003.
  38. Peteranderl, R. and C.P. Lechene. Measure of Nitrogen and Carbon Isotope Ratios in Subcellular Compartments. 51st Annual ASMS Conference. 2003.
  39. Guillermier, C., F. Hillion, J. Hill and C.P. Lechene. A Vacuum Bench for the Characterization of Thermo-ionization Sources. 51st Annual ASMS Conference. 2003.
  40. Lechene, C., E.A. Mroz and F. Hillion. Quantitative and High Resolution Imaging of Protein Turnover in Biological Tissues. 51st Annual ASMS Conference, June 8-12, 2003, Montreal, Quebec Canada. 2003.
  41. Guillermier, C., Lechene, C.P., Hill, J. and Hillion, F. A Vacuum Bench for the Characterization of Thermo-ionization Ion Sources. Review of Scientific Instruments. 2003; 74:3312-3316.
  42. Lechene, C., E.A. Mroz, S. Ito, G. Slodain and F. Hillion. "Quantitative Imaging of Stable Isotope Tracers". National Institutes of Health Biomedical Imaging Symposium. 1999; 54.
  43. Baltz JM, Smith SS, Biggers JD, Lechene C. Intracellular ion concentrations and their maintenance by Na+/K(+)-ATPase in preimplantation mouse embryos. Zygote. 1997 Feb; 5(1):1-9.
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  44. Mroz EA, Lechene C. Extracellular N-methyl-D-glucamine leads to loss of hair-cell sodium, potassium, and chloride. Hear Res. 1993 Nov; 70(2):146-50.
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  45. Mroz EA, Lechene C. Calcium and magnesium transport by isolated goldfish hair cells. Hear Res. 1993 Nov; 70(2):139-45.
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  46. Mroz EA, Nissim KR, Lechene C. Electron-probe analysis of isolated goldfish hair cells: implications for preparing healthy cells. Hear Res. 1993 Oct; 70(1):9-21.
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  47. Mroz EA, Nissim KR, Lechene C. Rapid resting ion fluxes in goldfish hair cells are balanced by (Na+,K+)-ATPase. Hear Res. 1993 Oct; 70(1):22-30.
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  48. Baltz JM, Biggers JD, Lechene C. A novel H+ permeability dominating intracellular pH in the early mouse embryo. Development. 1993 Aug; 118(4):1353-61.
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  49. Biggers JD, Lawitts JA, Lechene CP. The protective action of betaine on the deleterious effects of NaCl on preimplantation mouse embryos in vitro. Mol Reprod Dev. 1993 Apr; 34(4):380-90.
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  50. Schwartz MA, Lechene C. Adhesion is required for protein kinase C-dependent activation of the Na+/H+ antiporter by platelet-derived growth factor. Proc Natl Acad Sci U S A. 1992 Jul 1; 89(13):6138-41.
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  51. Lear S, Cohen BJ, Silva P, Lechene C, Epstein FH. cAMP activates the sodium pump in cultured cells of the elasmobranch rectal gland. J Am Soc Nephrol. 1992 Apr; 2(10):1523-8.
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  52. Sullivan LP, Wallace DP, Clancy RL, Lechene C, Grantham JJ. Cellular electrolyte and volume changes induced by acidosis in the rabbit proximal straight tubule. J Am Soc Nephrol. 1991 Nov; 2(5):1030-40.
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  53. Baltz JM, Biggers JD, Lechene C. Relief from alkaline load in two-cell stage mouse embryos by bicarbonate/chloride exchange. J Biol Chem. 1991 Sep 15; 266(26):17212-7.
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  54. Schwartz MA, Lechene C, Ingber DE. Insoluble fibronectin activates the Na/H antiporter by clustering and immobilizing integrin alpha 5 beta 1, independent of cell shape. Proc Natl Acad Sci U S A. 1991 Sep 1; 88(17):7849-53.
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  55. Schwartz MA, Ingber DE, Lawrence M, Springer TA, Lechene C. Multiple integrins share the ability to induce elevation of intracellular pH. Exp Cell Res. 1991 Aug; 195(2):533-5.
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  56. Storch J, Lechene C, Kleinfeld AM. Direct determination of free fatty acid transport across the adipocyte plasma membrane using quantitative fluorescence microscopy. J Biol Chem. 1991 Jul 25; 266(21):13473-6.
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  57. Baltz JM, Biggers JD, Lechene C. Two-cell stage mouse embryos appear to lack mechanisms for alleviating intracellular acid loads. J Biol Chem. 1991 Apr 5; 266(10):6052-7.
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  58. Biggers, J.D., Baltz, J.M., Lechene, C. "Ions and preimplantation development". Animal Applications of Basic Research in Mammalian Development, Current Communications in Cell and Molecular Biology series. 1991; 121-146.
  59. Baltz, J.M., J.D. Biggers and C. Lechene. "Intracellular pH Regulation by the Preimplantation Embryo: Common and Unique Features". Preimplantation Embryo Development. 1991; 97-111.
  60. Rome L, Lechene C, Grantham JJ. Proximal tubule volume regulation in hypo-osmotic media: intracellular K+, Na+, and Cl-. J Am Soc Nephrol. 1990 Aug; 1(2):211-8.
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  61. Ingber DE, Prusty D, Frangioni JV, Cragoe EJ, Lechene C, Schwartz MA. Control of intracellular pH and growth by fibronectin in capillary endothelial cells. J Cell Biol. 1990 May; 110(5):1803-11.
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  62. Baltz JM, Biggers JD, Lechene C. Apparent absence of Na+/H+ antiport activity in the two-cell mouse embryo. Dev Biol. 1990 Apr; 138(2):421-9.
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  63. Schwartz MA, Cragoe EJ, Lechene CP. pH regulation in spread cells and round cells. J Biol Chem. 1990 Jan 25; 265(3):1327-32.
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  64. Larsson SH, Rane S, Fukuda Y, Aperia A, Lechene C. Changes in Na influx precede post-natal increase in Na, K-ATPase activity in rat renal proximal tubular cells. Acta Physiol Scand. 1990 Jan; 138(1):99-100.
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  65. Cohen BJ, Lechene C. Alanine stimulation of passive potassium efflux in hepatocytes is independent of Na(+)-K+ pump activity. Am J Physiol. 1990 Jan; 258(1 Pt 1):C24-9.
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  66. Schwartz MA, Rupp EE, Frangioni JV, Lechene CP. Cytoplasmic pH and anchorage-independent growth induced by v-Ki-ras, v-src or polyoma middle T. Oncogene. 1990 Jan; 5(1):55-8.
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  67. Rome L, Grantham J, Savin V, Lohr J, Lechene C. Proximal tubule volume regulation in hyperosmotic media: intracellular K+, Na+, and Cl-. Am J Physiol. 1989 Dec; 257(6 Pt 1):C1093-100.
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  68. Gardner DK, Clarke RN, Lechene CP, Biggers JD. Development of a noninvasive ultramicrofluorometric method for measuring net uptake of glutamine by single preimplantation mouse embryos. Gamete Res. 1989 Dec; 24(4):427-38.
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  69. Mangoo-Karim R, Uchic M, Lechene C, Grantham JJ. Renal epithelial cyst formation and enlargement in vitro: dependence on cAMP. Proc Natl Acad Sci U S A. 1989 Aug; 86(15):6007-11.
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  70. Clarke RN, Baltz JM, Lechene CP, Biggers JD. Use of ultramicrofluorometric methods for the study of single preimplantation embryos. Poult Sci. 1989 Jul; 68(7):972-8.
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  71. Larsson SH, Larsson L, Lechene C, Aperia A. Studies of terminal differentiation of electrolyte transport in the renal proximal tubule using short-term primary cultures. Pediatr Nephrol. 1989 Jul; 3(3):363-8.
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  72. Schwartz MA, Both G, Lechene C. Effect of cell spreading on cytoplasmic pH in normal and transformed fibroblasts. Proc Natl Acad Sci U S A. 1989 Jun; 86(12):4525-9.
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  73. Biggers, J.D., J.E. Butler, J.M. Baltz and C. Lechene. "Studies on the Ultramicrochemistry of Single Mammalian Preimplantation Embryos". Comparative Reproduction in Mammals and Man, Nairobi, Africa. 1989; 146-154.
  74. Lechene, C., H. Cantiello, M. Crabos and B.J. Cohen. "Role of the (Na, K)-Pump in Intracellular Na Homeostasis. Microbeam Analysis In: Biological Microanalysis. 1989; 65-68.
  75. Lechene, C. "Electron probe analysis of transport properties of cultured cells". Electron Probe Microanalysis. Applications in Biology and Medicine. 1989; IV:237-249.
  76. Lechene C, Crabos M, Bianchi G, Cantiello H. [Physiologic role of the sodium pump. Implications for the study of arterial hypertension]. Nephrologie. 1989; 10(2):59-64.
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  77. Cohen BJ, Lechene C. (Na,K)-pump: cellular role and regulation in nonexcitable cells. Biol Cell. 1989; 66(1-2):191-5.
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  78. Butler JE, Lechene C, Biggers JD. Noninvasive measurement of glucose uptake by two populations of murine embryos. Biol Reprod. 1988 Nov; 39(4):779-86.
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  79. Heyman SN, Brezis M, Reubinoff CA, Greenfeld Z, Lechene C, Epstein FH, Rosen S. Acute renal failure with selective medullary injury in the rat. J Clin Invest. 1988 Aug; 82(2):401-12.
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  80. Epstein JA, Lechene C. Ouabain-resistant, amiloride-sensitive Na+-K+ pumping activity and morphological changes are inducible. Am J Physiol. 1988 Jun; 254(6 Pt 1):C847-54.
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  81. Larsson SH, Aperia A, Lechene C. Studies on terminal differentiation of rat renal proximal tubular cells in culture: ouabain-sensitive K and Na transport. Acta Physiol Scand. 1988 Feb; 132(2):129-34.
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  82. Fukuda Y, Larsson S, Celsi G, Lechene C, Aperia A. Use of experimental models to study the development of renal function. Biol Neonate. 1988; 53(4):197-200.
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  83. Lechene C. Physiological role of the Na-K pump. Prog Clin Biol Res. 1988; 268B:171-94.
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  84. Lechene, C. Physiological role of the Na-K pump. The Na+, K+ Pump. Part B: Cellular Aspects. J.C. Skou, J.G. Norby, A.B. Maunsbach and M. Esman eds. 1988; 171-194.
  85. Bolívar JJ, Lázaro A, Fernández S, Stefani E, Peña-Cruz V, Lechene C, Cereijido M. Rescue of a wild-type MDCK cell by a ouabain-resistant mutant. Am J Physiol. 1987 Jul; 253(1 Pt 1):C151-61.
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  86. Lechene, C. and Harris, R.C. Electron probe analysis of cultured renal cells. Contemporary Issues in Nephrology: Modern Techniques of Ion Transport. B.M. Brenner and J.H. Stein eds. 1987; 173-198.
  87. Jeanguillaume, C. Lechene, M. Tence and P. Trebbia. Cartographie elementaire a haute resolution spatiale. Le Courrier du CNRS. 1987; 66, 67, 68:77-78.
  88. Harris RC, Seifter JL, Lechene C. Coupling of Na-H exchange and Na-K pump activity in cultured rat proximal tubule cells. Am J Physiol. 1986 Nov; 251(5 Pt 1):C815-24.
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  89. Larsson S, Aperia A, Lechene C. Studies on final differentiation of rat renal proximal tubular cells in culture. Am J Physiol. 1986 Sep; 251(3 Pt 1):C455-64.
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  90. Mroz EA, Lechene C. Pancreatic zymogen granules differ markedly in protein composition. Science. 1986 May 16; 232(4752):871-3.
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  91. Larsson L, Aperia A, Lechene C. Ionic transport in individual renal epithelial cells from adult and young rats. Acta Physiol Scand. 1986 Mar; 126(3):321-32.
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  92. Lechene C. Electron-probe analysis of cultured cells. Ann N Y Acad Sci. 1986; 483:270-83.
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  93. Hartupee DA, Roman RJ, Lechene C. Role of renal prostaglandins in the fall in urine osmolality after papillary micropuncture. Prostaglandins. 1985 Jun; 29(6):981-90.
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  94. Lechene C. Cellular volume and cytoplasmic gel. Biol Cell. 1985; 55(3):177-80.
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  95. Abraham EH, Breslow JL, Epstein J, Chang-Sing P, Lechene C. Preparation of individual human diploid fibroblasts and study of ion transport. Am J Physiol. 1985 Jan; 248(1 Pt 1):C154-64.
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  96. Roman RJ, Skelton M, Lechene C. Prostaglandin-vasopressin interactions on the renal handling of calcium and magnesium. J Pharmacol Exp Ther. 1984 Aug; 230(2):295-301.
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  97. Leese HJ, Biggers JD, Mroz EA, Lechene C. Nucleotides in a single mammalian ovum or preimplantation embryo. Anal Biochem. 1984 Aug 1; 140(2):443-8.
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  98. Jenkins AD, Lechene CP, Howards SS. The effects of cyproterone acetate on the elements in the intraluminal fluids of the testis and epididymis of the rat. Arch Androl. 1983 Oct; 11(2):151-5.
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  99. Jenkins AD, Lechene CP, Howards SS. The effect of estrogen administration in vivo on the elemental composition of the intraluminal fluids of the seminiferous tubules, rete testis, and epididymis of the rat. J Androl. 1983 Jul-Aug; 4(4):272-5.
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  100. Jenkins AD, Lechene CP, Howards SS. The effect of spironolactone on the elemental composition of the intraluminal fluids of the seminiferous tubules, rete testis and epididymis of the rat. J Urol. 1983 Apr; 129(4):851-4.
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  101. Pastoriza-Muñoz E, Mishler DR, Lechene C. Effect of phosphate deprivation on phosphate reabsorption in rat nephron: role of PTH. Am J Physiol. 1983 Feb; 244(2):F140-9.
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  102. Lechene C. Electron probe analysis of small populations of single cells. Prog Clin Biol Res. 1983; 126:105-32.
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  103. Mroz EA, Lechene C. An NADH-coupled assay for femtogram or nanogram quantities of chymotrypsin. Anal Biochem. 1983 Jan; 128(1):181-5.
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  104. Ichikawa I, Rennke HG, Hoyer JR, Badr KF, Schor N, Troy JL, Lechene CP, Brenner BM. Role for intrarenal mechanisms in the impaired salt excretion of experimental nephrotic syndrome. J Clin Invest. 1983 Jan; 71(1):91-103.
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  105. Lechene, C. Electron probe analysis of small populations of single cells. Membrane Biophysics II: Physical Methods in the Study of Epithelia. M.A. Dinno, A.B. Callahan and T.C. Rozzell eds. 1983; 105-132.
  106. Warner RR, Lechene C. Analysis of standing droplets in rat proximal tubules. J Gen Physiol. 1982 Apr; 79(4):709-35.
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  107. Mroz EA, Roman RJ, Lechene C. Fluorescence assay for picomole quantities of ammonia. Kidney Int. 1982 Mar; 21(3):524-7.
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  108. Lechene, C. "Analysis of attomole quantities of chemical elements, metabolytes and enzymes in cellular and subcellular volumes.". First International Workshop on Developmental Renal Physiology. 1982; 41-52.
  109. Lechene, C. "Elemental and biochemical microanalysis of the male reproductive tract". The Cell Biology of the Testis, New York Academy of Science. 1982.
  110. Graber ML, Bengele HH, Mroz E, Lechene C, Alexander EA. Acute metabolic acidosis augments collecting duct acidification rate in the rat. Am J Physiol. 1981 Dec; 241(6):F669-76.
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  111. Holt WF, Lechene C. ADH-PGE2 interactions in cortical collecting tubule. II. inhibition of Ca and P reabsorption. Am J Physiol. 1981 Oct; 241(4):F461-7.
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  112. Holt WF, Lechene C. ADH-PGE2 interactions in cortical collecting tubule. I. Depression of sodium transport. Am J Physiol. 1981 Oct; 241(4):F452-60.
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  113. Roman RJ, Bonventre JV, Silva P, Lechene C. Sodium orthovanadate diuresis in rats. J Pharmacol Exp Ther. 1981 Jul; 218(1):168-74.
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  114. Roman RJ, Lechene C. Prostaglandin E2 and F2 alpha reduces urea reabsorption from the rat collecting duct. Am J Physiol. 1981 Jul; 241(1):F53-60.
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  115. Roman RJ, Lechene C. Meclofenamate and urine concentration with and without exposure of the renal papilla. Am J Physiol. 1981 May; 240(5):F423-9.
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  116. Couch, A., T. Gantz, C. Lusk and C. Lechene. "Automation of electron-probe microanalysis with the use of microprocessor control". Proc. 16th Annual Conference, Microbeam Analysis Society. 1981; 49-52.
  117. Lechene, c., R. Roman, J. Bonventre and R. Warner. "Electron probe microanalysis of frozen hydrated kidneys, isolated cells, and cultured cells". 2nd International Meeting on Low Temperature Biological Microscopy and Analysis. 1981.
  118. Bonventre JV, Roman RJ, Lechene C. Effect of urea concentration of pelvic fluid on renal concentrating ability. Am J Physiol. 1980 Dec; 239(6):F609-18.
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  119. Bonventre JV, Lechene C. Renal medullary concentrating process: an integrative hypothesis. Am J Physiol. 1980 Dec; 239(6):F578-88.
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  120. Jenkins AD, Lechene CP, Howards SS. Concentrations of seven elements in the intraluminal fluids of the rat seminiferous tubules, rate testis, and epididymis. Biol Reprod. 1980 Dec; 23(5):981-7.
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  121. Warner RR, Lechene C. Isosmotic volume reabsorption in rat proximal tubule. J Gen Physiol. 1980 Nov; 76(5):559-86.
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  122. Lechene C. Electron probe microanalysis of biological soft tissues: principle and technique. Fed Proc. 1980 Sep; 39(11):2871-80.
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  123. Bengele HH, Alexander EA, Lechene CP. Calcium and magnesium transport along the inner medullary collecting duct of the rat. Am J Physiol. 1980 Jul; 239(1):F24-9.
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  124. Bengele HH, Lechene C, Alexander EA. Sodium and chloride transport along the inner medullary collecting duct: effect of saline expansion. Am J Physiol. 1980 Jun; 238(6):F504-8.
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  125. Borland RM, Biggers JD, Lechene CP, Taymor ML. Elemental composition of fluid in the human Fallopian tube. J Reprod Fertil. 1980 Mar; 58(2):479-82.
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  126. Mroz EA, Lechene C. Fluorescence analysis of picoliter samples. Anal Biochem. 1980 Feb; 102(1):90-6.
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  127. Pastoriza-Munoz, E., R.E. Colindres, W.E. Lassiter and C. Lechene. "Effect of state of hydration on segmental phosphate reabsorption in rat nephron". Mineral Electrolyte Metabolism. 1980; 4:246-257.
  128. Roman, R. and C. Lechene. "Electron Probe Microanalysis in Health Research". 1980 EST Year Book of Science and Technology. 1980; 52-61.
  129. Lechene, C. and R. Warner. "An overview of the applications of microdroplet analysis: past, present, future.". Microbeam Analysis. 1980; 108-112.
  130. Lechene, C., R.R. Warner and T.H. Strunk. "Electron probe analysis of ultra small volumes in physiology". Science Press. 1980; 443-445.
  131. Warner, R.R. and C. Lechene. "Details of the liquid droplet technique". Microbeam Analysis. 1980; 120-125.
  132. Bonventre, J.V., Blouch, K., Lechene, C. Biological sample preparation for electron probe analysis: Liquid droplets and isolated cells. X-ray Microscopy in Biology. 1980; 307-366.
  133. Burgoyne PS, Borland RM, Biggers JD, Lechene CP. Elemental composition of rabbit antral fluid during preovulatory follicular swelling. J Reprod Fertil. 1979 Nov; 57(2):515-23.
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  134. Roman RJ, Cowley AW, Lechene C. Water diuretic and natriuretic effect of clonidine in the rat. J Pharmacol Exp Ther. 1979 Nov; 211(2):385-93.
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  135. Roman RJ, Bonventre JV, Lechene CP. Fluorometric assay for urea in urine, plasma, and tubular fluid. Anal Biochem. 1979 Sep 15; 98(1):136-41.
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  136. Bengele HH, Lechene CP, Alexander EA. Phosphate transport along the inner medullary collecting duct of the rat. Am J Physiol. 1979 Jul; 237(1):F48-54.
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  137. Warner RR, Strunk T, Lechene C. Analysis of proximal tubule salt and water transport in standing droplets. J Theor Biol. 1979 Apr 21; 77(4):453-71.
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  138. Lechene, C. "Electron probe microanalysis of bulk frozen hydrated biological samples". Microbeam Analysis. 1979; 59-60.
  139. Skadhauge, E., C. Lechene and G.M.O. Maloiy. "Tilapia Grahami: Role of intestine in osmoregulation under conditions of extreme alkalinity". Epithelial Transport in Lower Vertebrates. 1979; 133-142.
  140. Howards, S., C. Lechene and R. Vigersky. "The fluid environment of the maturing spermatozoon". The Spermatozoon. 1979; 35-41.
  141. WArner, R.R. and C. Lechene. Quantitative microprobe analysis in biology. Microbeam Analysis in Biology. 1979; 161-169.
  142. Lechene, C., Bonventre, J.V. and R.R. Warner. Electron probe analysis of frozen hydrated biological samples. Microbeam Analysis in Biology. 1979; 409-426.
  143. Lechene, C.P. and R.R. Warner eds. Microbeam Analysis in Biology. 1979.
  144. Lechene, C. and R.R. Warner. Electron probe analysis of liquid droplets. Microbeam Analysis in Biology. 1979; 279-298.
  145. Pastoriza-Muñoz E, Colindres RE, Lassiter WE, Lechene C. Effect of parathyroid hormone on phosphate reabsorption in rat distal convolution. Am J Physiol. 1978 Oct; 235(4):F321-30.
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  146. Biggers JD, Borland RM, Lechene CP. Ouabain-sensitive fluid accumulation and ion transport by rabbit blastocysts. J Physiol. 1978 Jul; 280:319-30.
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  147. Bonventre JV, Karnovsky MJ, Lechene CP. Renal papillary epithelial morphology in antidiuresis and water diuresis. Am J Physiol. 1978 Jul; 235(1):F69-76.
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  148. Lechene C. Analysis of ultra small volumes in physiology with electron probe microanalysis. Microsc Acta Suppl. 1978; (2):228-35.
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  149. Lang, F., Greger, R., Lechene, C., Knox, F.G. Micropuncture techniques. Methods in Pharmacology, M. Martinez-Maldonado ed. 1978; 4B:75-103.
  150. Greger, R., Lang, F., Knox, F.G., Lechene, C. Analysis of tubule fluid. Methods in Pharmacology. M. Martinez-Maldonado ed. 1978; 4B:105-140.
  151. Peterson, S.K., L.S. Frishkopf, C. Lechene, C.M. Oman and T.F. Weiss. "Element composition of inner ear lymphs in cats, lizards and skates by electron probe microanalysis of liquid samples". J. Comp. Physiol. 1978; 126:1-14.
  152. Lechene, C. "Element determination in biological materials using electron probe microanalysis". New Trends in Bioinorganic Chemstry". 1978; 437-448.
  153. Cantley LC, Josephson L, Warner R, Yanagisawa M, Lechene C, Guidotti G. Vanadate is a potent (Na,K)-ATPase inhibitor found in ATP derived from muscle. J Biol Chem. 1977 Nov 10; 252(21):7421-3.
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  154. Borland RM, Biggers JD, Lechene CP. Fluid transport by rabbit preimplantation blastocysts in vitro. J Reprod Fertil. 1977 Sep; 51(1):131-5.
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  155. Chong AP, Taymor ML, Lechene CP. Electron probe microanalysis of the chemical elemental content of human follicular fluid. Am J Obstet Gynecol. 1977 May 15; 128(2):209-11.
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  156. Lechene CP. Electron probe microanalysis: its present, its future. Am J Physiol. 1977 May; 232(5):F391-6.
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  157. Stolte H, Galaske RG, Eisenbach GM, Lechene C, Schmidt-Nielson B, Boylan JW. Renal tubule ion transport and collecting duct function in the elasmobranch little skate, Raja erinacea. J Exp Zool. 1977 Mar; 199(3):403-10.
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  158. Borland RM, Hazra S, Biggers JD, Lechene CP. The elemental composition of the environments of the gametes and preimplantation embryo during the initiation of pregnancy. Biol Reprod. 1977 Mar; 16(2):147-57.
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  159. Greger RF, Lang FC, Knox FG, Lechene CP. Absence of significant secretory flux of phosphate in the proximal convoluted tubule. Am J Physiol. 1977 Mar; 232(3):F235-8.
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  160. Chong, A.P., M.L. Taymor and C. Lechene. "Electron probe microanalysis of the chemical elemental content of human follicular fluid". Am. J. Obstet. and Gynec. 1977; 128(2):209-211.
  161. Lechene CP, Warner RR. Ultramicroanalysis: x-ray spectrometry by electron probe excitation. Annu Rev Biophys Bioeng. 1977; 6:57-85.
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  162. Borland RM, Biggers JD, Lechene CP. Studies on the composition and formation of mouse blastocoele fluid using electron probe microanalysis. Dev Biol. 1977 Jan; 55(1):1-8.
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  163. Lechene, C., R.E. Colindres and F.G. Knox. "Electron probe microanalysis of the renal effect of parathyroid hormone". Excerpta Medica, Amsterdam, Int. Cong. 1977; 421:230-233.
  164. Lechene, C., R.R. Warner and T. H. Strunk. "Electron probe analysis of ultra small volumes in physiology". 8th Int. Conf. on X-ray Optics and Microanalysis and 12th Annual Conference of the Microbeam Analysis Society. 1977; 161A-161E.
  165. Lechene CP, Bronner C, Kirk RG. Electron probe microanalysis of chemical elemental content of single human red cells. J Cell Physiol. 1977 Jan; 90(1):117-26.
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  166. Horowitz P, Aronson M, Grodzins L, Ladd W, Ryan J, Merriam G, Lechene C. Elemental analysis of biological specimens in air with a proton microprobe. Science. 1976 Dec 10; 194(4270):1162-5.
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  167. Knox FG, Haas JA, Lechene CP. Effect of parathyroid hormone on phosphate reabsorption in the presence of acetazolamide. Kidney Int. 1976 Sep; 10(3):216-20.
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  168. Borland RM, Biggers JD, Lechene CP. Kinetic aspects of rabbit blastocoele fluid accumulation: an application of electron probe microanalysis. Dev Biol. 1976 May; 50(1):201-11.
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  169. Roblero L, Biggers JD, Lechene CP. Electron probe analysis of the elemental microenvironment of oviducal mouse embryos. J Reprod Fertil. 1976 Mar; 46(2):431-4.
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  170. Warner, R.R. and C. Lechene. "Electron probe analysis of limiting transepithelial inorganic ion concentrating idfferences across the rat proximal tubule". Proc. 11th Annual Conference, Microbeam Analysis Society. 1976; 59A-59E.
  171. Lechene, C. and J.V. Bonventre. "Electron probe study of the urinary concentrating mechanism. Elemental cortico-papillary gradient in frozen hydrated rat kidney". Proc. 11th Annual Conference, Microbeam Analysis Society. 1976; 61A-61G.
  172. Stolte, H., R.G. Galaske, B. Schmidt-NIelsen and C. Lechene. "Single nephron handling of electrolytes (Na, K, Mg, Ca, Cl, P, S) in the little skate, Raja erinacea". Mt. Desert Island Biological Laboratory Bulletin. 1975.
  173. Knox FG, Lechene C. Distal site of action of parathyroid hormone on phosphate reabsorption. Am J Physiol. 1975 Dec; 229(6):1556-60.
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  174. Abraham, E., R.R. Warner and C. Lechene. "Electron probe analysis of the effect of parathyroid hormone on inorganic ions int he rat kidney". Proc. 10th Annual Conference, Microbeam Analysis Society, Las Vegas. 1975; 47A-47F.
  175. Lechene, C. "Applications of electron probe microanalysis in physiology". Proc. 10th Annual Conference, Microbeam Analysis Society. 1975; 40A-40G.
  176. Moher, T. and C. Lechene. "Automated electron probe analysis of biological samples. Process control and data reduction by interactive graphic display.". Biosciences Communication. 1975; 1:314-329.
  177. Lechene, C., T. Strunk, R. R. Warner and C. Conty. "Perspectives in electron probe microanalysis of biological samples kept frozen". Proc. 10th Annual Conference, Microbeam Analysis Society. 1975; 49A-49E.
  178. Lechene C. Electron probe microanalysis of picoliter liquid samples. Microprobe Analysis as Applied to Cells and Tissues. Patrick Echlin and Rudolf Kaufmann eds. 1974; 351-368.
  179. Bonventre, J.V. and C. Lechene. "A method for electron probe microanalysis of organic components in picoliter samples". Proceedings of the Microbeam Analysis Society Ninth Annual Conference. 1974; 8A-8D.
  180. Lechene, C., C. Bronner and R.G. Kirk. "Electron probe microanalysis of isolated cells: red blood cells". Proceedings of the Microbeam Analysis Society Ninth Annual conference. 1974; 9A-9E.
  181. Moher, T., C. M. Aden, R. Beeukes, A. Sanderson and C. Lechene. "Automation of an electron probe for biological analyses". Proceedings of the Microbeam Analysis Society Ninth Annual Conference. 1974; 34A-34D.
  182. Colindres RE, Lechene C. Technical problems associated with collection of distal tubular fluid in the rat. Yale J Biol Med. 1972 Jun-Aug; 45(3-4):233-9.
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  183. Lechene, C. "The use of the electron microprobe to analyze very minute amounts liquid samples". Proc. Fifth Nat. Conf. Electron Probe Analysis. 1970; 32A-32C.
  184. Lechène C, Morel F, Guinnebault M, De Rouffignac C. [Micropuncture study of urine formation. I. In the rat during various diuretic states]. Nephron. 1969; 6(4):457-77.
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  185. Morel F, de Rouffignac C, Marsh D, Guinnebault M, Lechene C. [Micropuncture study of urine formation. II. In the non diuretic Psammomys]. Nephron. 1969; 6(5):553-70.
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  186. deRouffignac, C., C. Lechene, M. Guinnebault and F. Morel. "Etude par microponction de l'elaboration de l'urine. III. Chez le merion non diuretique et en diurese par le mannitol.". Nephron. 1969; 6:643-666.
  187. Lechène C. [The effect produced on the rat nephron by microinjections of angiotensin II in the peritubular capillaries]. Pathol Biol. 1968 May; 16(9):529.
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  188. Morel, F., C. de Rouffignac and C. Lechene. "Role physiologique du segment grele des nephrons dans le mecanisme de concentration de l'urine.". Actualites Nephrologiques de l'Hopital Necker, Medicals Flammarion. 1968; 223-248.
  189. Lechene, C., M. Guinnebault and F. Morel. Localisation tubulaire de la secretion de l'hippuran etudiee chez le rat par la technique des microponctions. J. Physiol. (Paris). 1966; 58:577.
  190. Lechene, C. Etude a l'aide d'indicateurs nucleaires (HRO, Uree, 14C et 24Na), du renouvellement de l'eau, de l'uree et du sodium dans les differentes regions du rein de rat en diurese aquese et de merion en diurese osmotique ou en oligurie". French Atomic Energy Commission. 1966; (Report #2933).
  191. deRouffignac, C., M. Guinnebault, C. Lechene and F. Morel. Microinjections intratubulaires de 22Na chez le psammomys en diurese saline. J. Physiol. (Paris). 1966; 58:606-607.
  192. Lechene, C., C. Corby and F. Morel. "Distribution des nephrons accessibles a la surface du rein en foction de la longueur de leur anse de Hanle chez le rat, le hamster, le merion, et le psammomys". C.R. Acad. Sci., Paris. 1966; 262:1126.
  193. Guinnebault M, Lechene C, de Rouffignac C, Morel F. [The permeability of nephrons studied by use of a nuclear indicator micro-injection method]. J Physiol (Paris). 1965 Sep-Oct; 57(5):621-2.
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  194. Lechène C, Morel F. [Microinjections of tagged sodium and insulin into the renal capillaries of the hamster. I. Permeability of cortical tubular segments to sodium]. Nephron. 1965; 2(4):207-18.
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  195. Morel F, Lechène C. [Microinjections of tagged sodium and inulin into renal capillaries of the hamster. II. Permeability of tubular medullary segments to sodium]. Nephron. 1965; 2(4):219-29.
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  196. Guinnebault, M., C. deRouffignac, C. Lechene and F. Morel. Mise in evidence d'un segment de nephrons permeable au sodium chez diverses especes de mammiferes. Med Int Cong. 1964; 78:126-129.
  197. Morel, F., R. McLean, C. Lechene and M. . Etude comparee des mecanismes d'excretion du potassium a l'aide du 42K chez diverses especes de mammiferes. Med Int Cong. 1964; 78:552-554.
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