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Institution

J A Jeevendra Martyn, M.B.,B.S.

TitleProfessor of Anaesthesia
InstitutionMassachusetts General Hospital
DepartmentAnaesthesia
AddressMassachusetts General Hospital
Dept of Anaesthesia
55 Fruit St
Boston MA 02114
Phone617/726-8807
Fax617/371-4821

 Bibliographic 
 selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Lee S, Yang HS, Sasakawa T, Khan MA, Khatri A, Kaneki M, Martyn JA. Immobilization with Atrophy Induces De Novo Expression of Neuronal Nicotinic a7 Acetylcholine Receptors in Muscle Contributing to Neurotransmission. Anesthesiology. 2014 Jan; 120(1):76-85.
    View in: PubMed
  2. Tzika AA, Constantinou C, Bandyopadhaya A, Psychogios N, Lee S, Mindrinos M, Martyn JA, Tompkins RG, Rahme LG. A small volatile bacterial molecule triggers mitochondrial dysfunction in murine skeletal muscle. PLoS One. 2013; 8(9):e74528.
    View in: PubMed
  3. Khan MA, Sahani N, Neville KA, Nagashima M, Lee S, Sasakawa T, Kaneki M, Martyn JA. Nonsurgically induced disuse muscle atrophy and neuromuscular dysfunction upregulates alpha7 acetylcholine receptors. Can J Physiol Pharmacol. 2014 Jan; 92(1):1-8.
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  4. Richtsfeld M, Yasuhara S, Fink H, Blobner M, Martyn JA. Prolonged administration of pyridostigmine impairs neuromuscular function with and without down-regulation of acetylcholine receptors. Anesthesiology. 2013 Aug; 119(2):412-21.
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  5. Bittner EA, Martyn JA, Gronert GA. The decision to use succinylcholine for critically ill patients should not be based on duration of time in the intensive care unit alone. Anesth Analg. 2013 May; 116(5):1182.
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  6. Shank ES, Sheridan RL, Ryan CM, Keaney TJ, Martyn JA. Hemodynamic responses to dexmedetomidine in critically injured intubated pediatric burned patients: a preliminary study. J Burn Care Res. 2013 May-Jun; 34(3):311-7.
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  7. Hosokawa S, Koseki H, Nagashima M, Maeyama Y, Yomogida K, Mehr C, Rutledge M, Greenfeld H, Kaneki M, Tompkins RG, Martyn JA, Yasuhara SE. Title efficacy of phosphodiesterase 5 inhibitor on distant burn-induced muscle autophagy, microcirculation, and survival rate. J Cell Biol. 2013 May 1; 304(9):E922-33.
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  8. Nagashima M, Yasuhara S, Martyn JA. Train-of-Four and Tetanic Fade Are Not Always a Prejunctional Phenomenon as Evaluated by Toxins Having Highly Specific Pre- and Postjunctional Actions. Anesth Analg. 2013 May; 116(5):994-1000.
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  9. Zhu S, Nagashima M, Khan MA, Yasuhara S, Kaneki M, Martyn JA. Lack of caspase-3 attenuates immobilization-induced muscle atrophy and loss of tension generation along with mitigation of apoptosis and inflammation. Muscle Nerve. 2013 May; 47(5):711-21.
    View in: PubMed
  10. Yasuda Y, Fukushima Y, Kaneki M, Martyn JA. Anesthesia with propofol induces insulin resistance systemically in skeletal and cardiac muscles and liver of rats. Biochem Biophys Res Commun. 2013 Feb 1; 431(1):81-5.
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  11. Kaneki M, Fukushima Y, Shinozaki S, Fukaya M, Habiro M, Shimizu N, Chang K, Yasuhara S, Martyn JA. iNOS inhibitor, L-NIL, reverses burn-induced glycogen synthase kinase-3ß activation in skeletal muscle of rats. Metabolism. 2013 Mar; 62(3):341-6.
    View in: PubMed
  12. Khan MA, Farkhondeh M, Crombie J, Jacobson L, Kaneki M, Martyn JA. Lipopolysaccharide upregulates a7 acetylcholine receptors: stimulation with GTS-21 mitigates growth arrest of macrophages and improves survival in burned mice. Shock. 2012 Aug; 38(2):213-9.
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  13. Lee HY, Kaneki M, Andreas J, Tompkins RG, Martyn JA. Novel mitochondria-targeted antioxidant peptide ameliorates burn-induced apoptosis and endoplasmic reticulum stress in the skeletal muscle of mice. Shock. 2011 Dec; 36(6):580-5.
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  14. Mabasa VH, Yokoyama S, Man D, Martyn J. Analysis of Orders for QTc-Prolonging Medication for Intensive and Cardiac Care Unit Patients with Pre-existing QTc Prolongation (QTIPPP Study). Can J Hosp Pharm. 2011 Nov; 64(6):412-8.
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  15. Frick CG, Fink H, Blobner M, Martyn J. A single injection of botulinum toxin decreases the margin of safety of neurotransmission at local and distant sites. Anesth Analg. 2012 Jan; 114(1):102-9.
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  16. Sugita M, Sugita H, Kim M, Mao J, Yasuda Y, Habiro M, Shinozaki S, Yasuhara S, Shimizu N, Martyn JA, Kaneki M. Inducible nitric oxide synthase deficiency ameliorates skeletal muscle insulin resistance but does not alter unexpected lower blood glucose levels after burn injury in C57BL/6 mice. Metabolism. 2012 Jan; 61(1):127-36.
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  17. Han TH, Martyn JA. Neuromuscular pharmacodynamics of mivacurium in adults with major burns. Br J Anaesth. 2011 May; 106(5):675-9.
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  18. Frick CG, Helming M, Martyn JA, Blobner M, Fink H. Continuous administration of pyridostigmine improves immobilization-induced neuromuscular weakness. Crit Care Med. 2010 Mar; 38(3):922-7.
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  19. Bittner EA, Martyn JA, George E, Frontera WR, Eikermann M. Measurement of muscle strength in the intensive care unit. Crit Care Med. 2009 Oct; 37(10 Suppl):S321-30.
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  20. Han TH, Greenblatt DJ, Martyn JA. Propofol clearance and volume of distribution are increased in patients with major burns. J Clin Pharmacol. 2009 Jul; 49(7):768-72.
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  21. Ginsburg G, Forde R, Martyn JA, Eikermann M. Increased sensitivity to a nondepolarizing muscle relaxant in a patient with acquired neuromyotonia. Muscle Nerve. 2009 Jul; 40(1):139-42.
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  22. Martyn JA, Fagerlund MJ, Eriksson LI. Basic principles of neuromuscular transmission. Anaesthesia. 2009 Mar; 64 Suppl 1:1-9.
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  23. Shear TD, Martyn JA. Physiology and biology of neuromuscular transmission in health and disease. J Crit Care. 2009 Mar; 24(1):5-10.
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  24. Han TH, Martyn JA. Onset and effectiveness of rocuronium for rapid onset of paralysis in patients with major burns: priming or large bolus. Br J Anaesth. 2009 Jan; 102(1):55-60.
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  25. Martyn JA, Kaneki M, Yasuhara S. Obesity-induced insulin resistance and hyperglycemia: etiologic factors and molecular mechanisms. Anesthesiology. 2008 Jul; 109(1):137-48.
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  26. Fink H, Helming M, Unterbuchner C, Lenz A, Neff F, Martyn JA, Blobner M. Systemic inflammatory response syndrome increases immobility-induced neuromuscular weakness. Crit Care Med. 2008 Mar; 36(3):910-6.
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  27. Sheridan RL, Ryan DP, Fuzaylov G, Nimkin K, Martyn JA. Case records of the Massachusetts General Hospital. Case 2-2008. Case 5-2008. An 18-month-old girl with an advanced neck contracture after a burn. N Engl J Med. 2008 Feb 14; 358(7):729-35.
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  28. Frick CG, Fink H, Gordan ML, Eckel B, Martyn JA, Blobner M. Chronic Escherichia coli infection induces muscle wasting without changing acetylcholine receptor numbers. Intensive Care Med. 2008 Mar; 34(3):561-7.
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  29. Yasuhara S, Asai A, Sahani ND, Martyn JA. Mitochondria, endoplasmic reticulum, and alternative pathways of cell death in critical illness. Crit Care Med. 2007 Sep; 35(9 Suppl):S488-95.
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  30. Asai A, Sahani N, Kaneki M, Ouchi Y, Martyn JA, Yasuhara SE. Primary role of functional ischemia, quantitative evidence for the two-hit mechanism, and phosphodiesterase-5 inhibitor therapy in mouse muscular dystrophy. PLoS One. 2007; 2(8):e806.
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  31. Frick CG, Richtsfeld M, Sahani ND, Kaneki M, Blobner M, Martyn JA. Long-term effects of botulinum toxin on neuromuscular function. Anesthesiology. 2007 Jun; 106(6):1139-46.
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  32. Asai A, Sahani N, Ouchi Y, Martyn J, Yasuhara S. In vivo micro-circulation measurement in skeletal muscle by intra-vital microscopy. J Vis Exp. 2007; (4):210.
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  33. Han T, Harmatz JS, Greenblatt DJ, Martyn JA. Fentanyl clearance and volume of distribution are increased in patients with major burns. J Clin Pharmacol. 2007 Jun; 47(6):674-80.
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  34. Yasuhara S, Kaneki M, Sugita H, Sugita M, Asai A, Sahani N, Chon JY, Tompkins RG, Martyn JA. Adipocyte apoptosis after burn injury is associated with altered fat metabolism. J Burn Care Res. 2006 May-Jun; 27(3):367-76.
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  35. Martyn J, Durieux ME. Succinylcholine: new insights into mechanisms of action of an old drug. Anesthesiology. 2006 Apr; 104(4):633-4.
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  36. Martyn JA, Richtsfeld M. Succinylcholine-induced hyperkalemia in acquired pathologic states: etiologic factors and molecular mechanisms. Anesthesiology. 2006 Jan; 104(1):158-69.
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  37. Fink H, Bogdanski R, Luppa P, Martyn JA, Blobner M. Nitric oxide is not a mediator of inflammation-induced resistance to atracurium. Anesth Analg. 2005 Nov; 101(5):1362-7.
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  38. Astrakas LG, Goljer I, Yasuhara S, Padfield KE, Zhang Q, Gopalan S, Mindrinos MN, Dai G, Yu YM, Martyn JA, Tompkins RG, Rahme LG, Tzika AA. Proton NMR spectroscopy shows lipids accumulate in skeletal muscle in response to burn trauma-induced apoptosis. FASEB J. 2005 Sep; 19(11):1431-40.
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  39. Fujimoto M, Shimizu N, Kunii K, Martyn JA, Ueki K, Kaneki M. A role for iNOS in fasting hyperglycemia and impaired insulin signaling in the liver of obese diabetic mice. Diabetes. 2005 May; 54(5):1340-8.
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  40. Sugita H, Fujimoto M, Yasukawa T, Shimizu N, Sugita M, Yasuhara S, Martyn JA, Kaneki M. Inducible nitric-oxide synthase and NO donor induce insulin receptor substrate-1 degradation in skeletal muscle cells. J Biol Chem. 2005 Apr 8; 280(14):14203-11.
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  41. Yasukawa T, Tokunaga E, Ota H, Sugita H, Martyn JA, Kaneki M. S-nitrosylation-dependent inactivation of Akt/protein kinase B in insulin resistance. J Biol Chem. 2005 Mar 4; 280(9):7511-8.
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  42. Sugita H, Kaneki M, Sugita M, Yasukawa T, Yasuhara S, Martyn JA. Burn injury impairs insulin-stimulated Akt/PKB activation in skeletal muscle. Am J Physiol Endocrinol Metab. 2005 Mar; 288(3):E585-91.
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  43. Han T, Kim H, Bae J, Kim K, Martyn JA. Neuromuscular pharmacodynamics of rocuronium in patients with major burns. Anesth Analg. 2004 Aug; 99(2):386-92, table of contents.
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  44. Yasukawa T, Kaneki M, Yasuhara S, Lee SL, Martyn JA. Steroidal nondepolarizing muscle relaxants do not simulate the effects of glucocorticoids on glucocorticoid receptor-mediated transcription in cultured skeletal muscle cells. Anesthesiology. 2004 Jun; 100(6):1615-9.
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  45. Fink H, Yasuhara S, Blobner M, Martyn JA. Up-regulation of acetylcholine receptors during subchronic infusion of pancuronium is caused by a posttranscriptional mechanism related to disuse. Crit Care Med. 2004 Feb; 32(2):509-13.
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  46. Soriano SG, Martyn JA. Antiepileptic-induced resistance to neuromuscular blockers: mechanisms and clinical significance. Clin Pharmacokinet. 2004; 43(2):71-81.
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  47. Yasuhara S, Zhu Y, Matsui T, Tipirneni N, Yasuhara Y, Kaneki M, Rosenzweig A, Martyn JA. Comparison of comet assay, electron microscopy, and flow cytometry for detection of apoptosis. J Histochem Cytochem. 2003 Jul; 51(7):873-85.
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  48. Fink H, Luppa P, Mayer B, Rosenbrock H, Metzger J, Martyn JA, Blobner M. Systemic inflammation leads to resistance to atracurium without increasing membrane expression of acetylcholine receptors. Anesthesiology. 2003 Jan; 98(1):82-8.
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  49. Lydon A, Martyn JA. Apoptosis in critical illness. Int Anesthesiol Clin. 2003; 41(1):65-77.
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  50. Martyn JA, Chang Y, Goudsouzian NG, Patel SS. Pharmacodynamics of mivacurium chloride in 13- to 18-yr-old adolescents with thermal injury. Br J Anaesth. 2002 Oct; 89(4):580-5.
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  51. Hirose M, Martyn JA, Kuroda Y, Marunaka Y, Tanaka Y. Mechanism of suppression of insulin signalling with lignocaine. Br J Pharmacol. 2002 May; 136(1):76-80.
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  52. Stoddard FJ, Sheridan RL, Saxe GN, King BS, King BH, Chedekel DS, Schnitzer JJ, Martyn JA. Treatment of pain in acutely burned children. J Burn Care Rehabil. 2002 Mar-Apr; 23(2):135-56.
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  53. Sugita H, Kaneki M, Tokunaga E, Sugita M, Koike C, Yasuhara S, Tompkins RG, Martyn JA. Inducible nitric oxide synthase plays a role in LPS-induced hyperglycemia and insulin resistance. Am J Physiol Endocrinol Metab. 2002 Feb; 282(2):E386-94.
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  54. Ibebunjo C, Martyn J. Disparate dysfunction of skeletal muscles located near and distant from burn site in the rat. Muscle Nerve. 2001 Oct; 24(10):1283-94.
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  55. Oldham JM, Martyn JA, Sharma M, Jeanplong F, Kambadur R, Bass JJ. Molecular expression of myostatin and MyoD is greater in double-muscled than normal-muscled cattle fetuses. Am J Physiol Regul Integr Comp Physiol. 2001 May; 280(5):R1488-93.
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  56. Hirose M, Kaneki M, Sugita H, Yasuhara S, Ibebunjo C, Martyn JA, Iebunjo C. Long-term denervation impairs insulin receptor substrate-1-mediated insulin signaling in skeletal muscle. Metabolism. 2001 Feb; 50(2):216-22.
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  57. Soriano SG, Sullivan LJ, Venkatakrishnan K, Greenblatt DJ, Martyn JA. Pharmacokinetics and pharmacodynamics of vecuronium in children receiving phenytoin or carbamazepine for chronic anticonvulsant therapy. Br J Anaesth. 2001 Feb; 86(2):223-9.
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  58. Hirose M, Kaneki M, Sugita H, Yasuhara S, Martyn JA. Immobilization depresses insulin signaling in skeletal muscle. Am J Physiol Endocrinol Metab. 2000 Dec; 279(6):E1235-41.
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  59. Ibebunjo C, Martyn JA. Thermal injury induces greater resistance to d-tubocurarine in local rather than in distant muscles in the rat. Anesth Analg. 2000 Nov; 91(5):1243-9.
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  60. Smith HK, Maxwell L, Martyn JA, Bass JJ. Nuclear DNA fragmentation and morphological alterations in adult rabbit skeletal muscle after short-term immobilization. Cell Tissue Res. 2000 Nov; 302(2):235-41.
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  61. Yasuhara S, Perez ME, Kanakubo E, Yasuhara Y, Shin YS, Kaneki M, Fujita T, Martyn JA. Skeletal muscle apoptosis after burns is associated with activation of proapoptotic signals. Am J Physiol Endocrinol Metab. 2000 Nov; 279(5):E1114-21.
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  62. Shin YS, Fink H, Khiroya R, Ibebunjo C, Martyn J. Prednisolone-induced muscle dysfunction is caused more by atrophy than by altered acetylcholine receptor expression. Anesth Analg. 2000 Aug; 91(2):322-8.
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  63. Soriano SG, Kaus SJ, Sullivan LJ, Martyn JA. Onset and duration of action of rocuronium in children receiving chronic anticonvulsant therapy. Paediatr Anaesth. 2000; 10(2):133-6.
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  64. Martyn JA, Goudsouzian NG, Chang Y, Szyfelbein SK, Schwartz AE, Patel SS. Neuromuscular effects of mivacurium in 2- to 12-yr-old children with burn injury. Anesthesiology. 2000 Jan; 92(1):31-7.
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  65. Yasuhara S, Kanakubo E, Perez ME, Kaneki M, Fujita T, Okamoto T, Martyn JA. The 1999 Moyer award. Burn injury induces skeletal muscle apoptosis and the activation of caspase pathways in rats. J Burn Care Rehabil. 1999 Nov-Dec; 20(6):462-70.
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  66. Ikezu T, Yasuhara S, Granneman JG, Kraemer FB, Okamoto T, Tompkins RG, Martyn JA. A unique mechanism of desensitization to lipolysis mediated by beta(3)-adrenoceptor in rats with thermal injury. Am J Physiol. 1999 Aug; 277(2 Pt 1):E316-24.
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  67. Martyn JA, Vincent A. A new twist to myopathy of critical illness. Anesthesiology. 1999 Aug; 91(2):337-9.
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  68. Ibebunjo C, Martyn JA. Fiber atrophy, but not changes in acetylcholine receptor expression, contributes to the muscle dysfunction after immobilization. Crit Care Med. 1999 Feb; 27(2):275-85.
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  69. Ibebunjo C, Nosek MT, Itani MS, Martyn JA. Mechanisms for the paradoxical resistance to d-tubocurarine during immobilization-induced muscle atrophy. J Pharmacol Exp Ther. 1997 Nov; 283(2):443-51.
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  70. Ikezu T, Okamoto T, Yonezawa K, Tompkins RG, Martyn JA. Analysis of thermal injury-induced insulin resistance in rodents. Implication of postreceptor mechanisms. J Biol Chem. 1997 Oct 3; 272(40):25289-95.
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  71. Sheridan RL, Hinson M, Nackel A, Blaquiere M, Daley W, Querzoli B, Spezzafaro J, Lybarger P, Martyn J, Szyfelbein S, Tompkins R. Development of a pediatric burn pain and anxiety management program. J Burn Care Rehabil. 1997 Sep-Oct; 18(5):455-9; discussion 453-4.
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  72. Goudsouzian N, Martyn JA. Potentiation of mivacurium by rocuronium is age- and time-dependent: a study in children, adolescents, and young and elderly adults. J Clin Pharmacol. 1997 Jul; 37(7):649-55.
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  73. du Sart D, Cancilla MR, Earle E, Mao JI, Saffery R, Tainton KM, Kalitsis P, Martyn J, Barry AE, Choo KH. A functional neo-centromere formed through activation of a latent human centromere and consisting of non-alpha-satellite DNA. Nat Genet. 1997 Jun; 16(2):144-53.
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  74. Nosek MT, Martyn JA. Na+ channel and acetylcholine receptor changes in muscle at sites distant from burns do not simulate denervation. J Appl Physiol. 1997 Apr; 82(4):1333-9.
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  75. Oldham JM, Martyn JA, Napier JR, Bass JJ. Postnatal age and food intake alter insulin-like growth factor-II/mannose-6-phosphate receptors in ovine skeletal muscles. Growth Regul. 1996 Jun; 6(2):88-95.
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  76. Ikezu T, Okamoto T, Komatsuzaki K, Matsui T, Martyn JA, Nishimoto I. Negative transactivation of cAMP response element by familial Alzheimer's mutants of APP. EMBO J. 1996 May 15; 15(10):2468-75.
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  77. Yang HS, Goudsouzian N, Martyn JA. Pseudocholinesterase-mediated hydrolysis is superior to neostigmine for reversal of mivacurium-induced paralysis in vitro. Anesthesiology. 1996 Apr; 84(4):936-44.
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  78. Oldham JM, Martyn JA, Kirk SP, Napier JR, Bass JJ. Regulation of type 1 insulin-like growth factor (IGF) receptors and IGF-I mRNA by age and nutrition in ovine skeletal muscles. J Endocrinol. 1996 Feb; 148(2):337-46.
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  79. Yanez P, Martyn JA. Prolonged d-tubocurarine infusion and/or immobilization cause upregulation of acetylcholine receptors and hyperkalemia to succinylcholine in rats. Anesthesiology. 1996 Feb; 84(2):384-91.
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  80. Yang HS, Goudsouzian NG, Cheng M, Martyn JA. The influence of the age of the rat on the neuromuscular response to mivacurium in vitro. Paediatr Anaesth. 1996; 6(5):367-72.
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  81. Wang C, Martyn JA. Burn injury alters beta-adrenergic receptor and second messenger function in rat ventricular muscle. Crit Care Med. 1996 Jan; 24(1):118-24.
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  82. Kim C, Hirose M, Martyn JA. d-Tubocurarine accentuates the burn-induced upregulation of nicotinic acetylcholine receptors at the muscle membrane. Anesthesiology. 1995 Aug; 83(2):309-15.
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  83. Martyn JA. Basic and clinical pharmacology of the acetylcholine receptor: implications for the use of neuromuscular relaxants. Keio J Med. 1995 Mar; 44(1):1-8.
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  84. Tomera JF, Kukulka SP, Lilford K, Martyn JA. E. coli endotoxin affinity at the nicotinic2 receptor: receptor theory revisited, ilumina nostros occulae. Methods Find Exp Clin Pharmacol. 1994 Apr; 16(3):191-201.
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  85. Ward JM, Rosen KM, Martyn JA. Acetylcholine receptor subunit mRNA changes in burns are different from those seen after denervation: the 1993 Lindberg Award. J Burn Care Rehabil. 1993 Nov-Dec; 14(6):595-601.
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  86. Tomera JF, Lilford K, Martyn JA. Diaphragm acetylcholinesterase multimeric forms in mice in response to burn trauma. J Burn Care Rehabil. 1993 Jul-Aug; 14(4):406-19.
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  87. Ward JM, Martyn JA. Burn injury-induced nicotinic acetylcholine receptor changes on muscle membrane. Muscle Nerve. 1993 Apr; 16(4):348-54.
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  88. Kim CS, Arnold FJ, Itani MS, Martyn JA. Decreased sensitivity to metocurine during long-term phenytoin therapy may be attributable to protein binding and acetylcholine receptor changes. Anesthesiology. 1992 Sep; 77(3):500-6.
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  89. Martyn JA, White DA, Gronert GA, Jaffe RS, Ward JM. Up-and-down regulation of skeletal muscle acetylcholine receptors. Effects on neuromuscular blockers. Anesthesiology. 1992 May; 76(5):822-43.
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  90. Martyn JA, Bishop AL, Oliveri MF. Pharmacokinetics and pharmacodynamics of ranitidine after burn injury. Clin Pharmacol Ther. 1992 Apr; 51(4):408-14.
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  91. Hogue CW, Ward JM, Itani MS, Martyn JA. Tolerance and upregulation of acetylcholine receptors follow chronic infusion of d-tubocurarine. J Appl Physiol. 1992 Apr; 72(4):1326-31.
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  92. Tomera JF, Martyn J. Gastrocnemius acetylcholinesterase activity in response to burn trauma in the mouse. Burns. 1991 Oct; 17(5):371-9.
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  93. Hogue CW, Martyn J, Baker TR, Vouros P. Recovery of pancuronium from peritoneal dialysate in a severely burned child. Anesth Analg. 1991 Jul; 73(1):83-6.
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  94. Ward JM, Martyn J. Alterations in neuromuscular function following thermal injury. Biochem Soc Trans. 1991 Apr; 19(2):191S.
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  95. Tomera JF, Martyn J. Effects of endotoxin infection on cyclic nucleotides in ventricular and gastrocnemius muscle. Circ Shock. 1990 Dec; 32(4):281-92.
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  96. Hogue CW, Itani MS, Martyn JA. Resistance to d-tubocurarine in lower motor neuron injury is related to increased acetylcholine receptors at the neuromuscular junction. Anesthesiology. 1990 Oct; 73(4):703-9.
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  97. Tomera JF, Martyn JA. Thermal trauma alters myocardial cyclic nucleotides and protein content in mice. Br J Pharmacol. 1990 Oct; 101(2):263-8.
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  98. Annan RS, Kim C, Martyn J. Measurement of D-tubocurarine chloride in human urine using solid-phase extraction and reversed-phase high-performance liquid chromatography with ultraviolet detection. J Chromatogr. 1990 Mar 16; 526(1):228-34.
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  99. Baker TR, Vouros P, Rindgen D, Martyn JA. Mass spectrometric assay for determination of pancuronium and vecuronium in biological fluids utilizing the moving belt introduction system. Biomed Environ Mass Spectrom. 1990 Feb; 19(2):69-74.
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  100. Tomera JF, Martyn J. Mediators of burn-induced neuromuscular changes in mice. Br J Pharmacol. 1989 Nov; 98(3):921-9.
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  101. Martyn JA, Tomera JF. Acetylcholine receptor density and acetylcholinesterase enzyme activity in skeletal muscle of rats following thermal injury. Anesthesiology. 1989 Oct; 71(4):625-7.
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  102. Mills AK, Martyn JA. Neuromuscular blockade with vecuronium in paediatric patients with burn injury. Br J Clin Pharmacol. 1989 Aug; 28(2):155-9.
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  103. Tomera JF, Martyn J. Intraperitoneal endotoxin but not protein malnutrition shifts d-tubocurarine dose-response curves in mouse gastrocnemius muscle. J Pharmacol Exp Ther. 1989 Jul; 250(1):216-20.
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  104. Martyn JA, Greenblatt DJ, Hagen J, Hoaglin DC. Alteration by burn injury of the pharmacokinetics and pharmacodynamics of cimetidine in children. Eur J Clin Pharmacol. 1989; 36(4):361-7.
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  105. Tomera JF, Martyn J, Hoaglin DC. Neuromuscular dysfunction in burns and its relationship to burn size, hypermetabolism, and immunosuppression. J Trauma. 1988 Oct; 28(10):1499-504.
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  106. Kim C, Martyn J, Fuke N. Burn injury to trunk of rat causes denervation-like responses in the gastrocnemius muscle. J Appl Physiol. 1988 Oct; 65(4):1745-51.
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  107. Tomera JF, Martyn J. Systemic effects of single hindlimb burn injury on skeletal muscle function and cyclic nucleotide levels in the murine model. Burns Incl Therm Inj. 1988 Jun; 14(3):210-9.
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  108. Glidden RS, Martyn JA, Tomera JF. Azathioprine fails to alter the dose-response curve of d-tubocurarine in rats. Anesthesiology. 1988 Apr; 68(4):595-8.
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  109. Kim C, Fuke N, Martyn JA. Burn injury to rat increases nicotinic acetylcholine receptors in the diaphragm. Anesthesiology. 1988 Mar; 68(3):401-6.
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  110. Mills AK, Martyn JA. Evaluation of atracurium neuromuscular blockade in paediatric patients with burn injury. Br J Anaesth. 1988 Mar; 60(4):450-5.
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  111. Martyn J, Greenblatt DJ. Lorazepam conjugation is unimpaired in burn trauma. Clin Pharmacol Ther. 1988 Mar; 43(3):250-5.
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  112. Storella RJ, Martyn JA, Bierkamper GG. Anti-curare effect of plasma from patients with thermal injury. Life Sci. 1988; 43(1):35-40.
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  113. Goldhill DR, Martyn JA. Beta blockade, suxamethonium and potassium. Anaesthesia. 1987 Jun; 42(6):670-1.
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  114. Goldhill DR, Martyn JA, Hoaglin DC. Beta-adrenoceptor blockade, alpha-stimulation and changes in plasma potassium concentration after suxamethonium administration in dogs. Br J Anaesth. 1987 May; 59(5):611-6.
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  115. Fuke N, Martyn J, Kim CS, Basta S. Concentration-dependent interaction of theophylline with d-tubocurarine. J Appl Physiol. 1987 May; 62(5):1970-4.
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  116. Martyn JA, Goldhill DR. Cold injury and hyperkalaemia. Anaesthesia. 1987 May; 42(5):561.
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  117. Martyn JA. Burn care protocols: administration of ketamine. Ketamine pharmacology and therapeutics. J Burn Care Rehabil. 1987 Mar-Apr; 8(2):146-8.
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  118. Hagen J, Martyn J, Szyfelbein SK, Goudsouzian NG. Cardiovascular and neuromuscular responses to high-dose pancuronium-metocurine in pediatric burned and reconstructive patients. Anesth Analg. 1986 Dec; 65(12):1340-4.
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  119. Martyn J, Goldhill DR, Goudsouzian NG. Clinical pharmacology of muscle relaxants in patients with burns. J Clin Pharmacol. 1986 Nov-Dec; 26(8):680-5.
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  120. Martyn J. Clinical pharmacology and drug therapy in the burned patient. Anesthesiology. 1986 Jul; 65(1):67-75.
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  121. Martyn JA, McKusick K, Strauss HW, Burke JF. Ventricular volume and ejection fraction in the diagnosis of the aetiology of low cardiac output in burned patients. Anaesthesia. 1986 May; 41(5):511-5.
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  122. Martyn J, Wilson RS, Burke JF. Right ventricular function and pulmonary hemodynamics during dopamine infusion in burned patients. Chest. 1986 Mar; 89(3):357-60.
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  123. Goudsouzian N, Martyn J, Rudd GD, Liu LM, Lineberry CG. Continuous infusion of atracurium in children. Anesthesiology. 1986 Feb; 64(2):171-4.
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  124. Martyn JA, Greenblatt DJ, Abernethy DR. Increased cimetidine clearance in burn patients. JAMA. 1985 Mar 1; 253(9):1288-91.
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  125. Martyn JA. Cimetidine and/or antacid for the control of gastric acidity in pediatric burn patients. Crit Care Med. 1985 Jan; 13(1):1-3.
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  126. Satwicz PR, Martyn JA, Szyfelbein SK, Firestone S. Potentiation of neuromuscular blockade using a combination of pancuronium and dimethyltubocurarine. Studies in children following acute burn injury or during reconstructive surgery. Br J Anaesth. 1984 May; 56(5):479-84.
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  127. Martyn JA, Abernethy DR, Greenblatt DJ. Plasma protein binding of drugs after severe burn injury. Clin Pharmacol Ther. 1984 Apr; 35(4):535-9.
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  128. Martyn JA, Liu LM, Szyfelbein SK, Ambalavanar ES, Goudsouzian NG. The neuromuscular effects of pancuronium in burned children. Anesthesiology. 1983 Dec; 59(6):561-4.
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  129. Martyn JA, Goudsouzian NG, Matteo RS, Liu LM, Szyfelbein SK, Kaplan RF. Metocurine requirements and plasma concentrations in burned paediatric patients. Br J Anaesth. 1983 Apr; 55(4):263-8.
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  130. Martyn JA, Greenblatt DJ, Quinby WC. Diazepam kinetics in patients with severe burns. Anesth Analg. 1983 Mar; 62(3):293-7.
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  131. Martyn JA, Leibel WS, Matteo RS. Competitive nonspecific binding does not explain the potentiating effects of muscle relaxant combinations. Anesth Analg. 1983 Feb; 62(2):160-3.
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  132. Lebowitz PW, Cote ME, Daniels AL, Martyn JA, Teplick RS, Davison JK, Sunder N. Cardiovascular effects of midazolam and thiopentone for induction of anaesthesia in ill surgical patients. Can Anaesth Soc J. 1983 Jan; 30(1):19-23.
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  133. Lebowitz PW, Cote ME, Daniels AL, Ramsey FM, Martyn JA, Teplick RS, Davison JK. Comparative cardiovascular effects of midazolam and thiopental in healthy patients. Anesth Analg. 1982 Sep; 61(9):771-5.
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  134. Martyn JA, Matteo RS, Szyfelbein SK, Kaplan RF. Unprecedented resistance to neuromuscular blocking effects of metocurine with persistence after complete recovery in a burned patient. Anesth Analg. 1982 Jul; 61(7):614-7.
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  135. Martyn JA, Matteo RS, Greenblatt DJ, Lebowitz PW, Savarese JJ. Pharmacokinetics of d-tubocurarine in patients with thermal injury. Anesth Analg. 1982 Mar; 61(3):241-6.
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  136. Martyn JA, Snider MT, Farago LF, Burke JF. Thermodilution right ventricular volume: a novel and better predictor of volume replacement in acute thermal injury. J Trauma. 1981 Aug; 21(8):619-26.
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  137. Szyfelbein SK, Drop LJ, Martyn JA. Persistent ionized hypocalcemia in patients during resuscitation and recovery phases of body burns. Crit Care Med. 1981 Jun; 9(6):454-8.
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  138. Leibel WS, Martyn JA, Szyfelbein SK, Miller KW. Elevated plasma binding cannot account for the burn-related d-tubocurarine hyposensitivity. Anesthesiology. 1981 May; 54(5):378-82.
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  139. Morgan RJ, Martyn JA, Philbin DM, Coggins CH, Burke JF. Water metabolism and antidiuretic hormone (ADH) response following thermal injury. J Trauma. 1980 Jun; 20(6):468-72.
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  140. Martyn JA, Szyfelbein SK, Ali HH, Matteo RS, Savarese JJ. Increased d-tubocurarine requirement following major thermal injury. Anesthesiology. 1980 Apr; 52(4):352-5.
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  141. Martyn JA, Snider MT, Szyfelbein SK, Burke JF, Laver MB. Right ventricular dysfunction in acute thermal injury. Ann Surg. 1980 Mar; 191(3):330-5.
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  142. Martyn JA, Aikawa N, Wilson RS, Szyfelbein SK, Burke JF. Extrapulmonary factors influencing the ratio of arterial oxygen tension to inspired oxygen concentration in burn patients. Crit Care Med. 1979 Nov; 7(11):492-6.
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  143. Martyn JA, Burke JF. Is there a selective increase in pulmonary capillary permeability following cutaneous burns? Chest. 1979 Oct; 76(4):374-5.
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  144. Aikawa N, Martyn JA, Burke JF. Pulmonary artery catheterization and thermodilution cardiac output determination in the management of critically burned patients. Am J Surg. 1978 Jun; 135(6):811-7.
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