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Akio Ohta, Ph.D.

TitleResearch Associate in Medicine
InstitutionDana-Farber Cancer Institute
DepartmentMedicine
AddressDana-Farber Cancer Institute
Medical Oncology - HIM 418
44 Binney St
Boston MA 02115
Phone617/632-3326
Fax617/632-3351

 Bibliographic 
 selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Georgiev P, Belikoff BG, Hatfield S, Ohta A, Sitkovsky MV, Lukashev D. Genetic deletion of the HIF-1a isoform I.1 in T cells enhances antibacterial immunity and improves survival in a murine peritonitis model. Eur J Immunol. 2013 Mar; 43(3):655-66.
    View in: PubMed
  2. Sitkovsky M, Ohta A. Targeting the hypoxia-adenosinergic signaling pathway to improve the adoptive immunotherapy of cancer. J Mol Med (Berl). 2013 Feb; 91(2):147-55.
    View in: PubMed
  3. Asakawa T, Ozawa T, Ohta A. Generation of fluorocarbon and hydrocarbon hybrid gemini surfactants controlled by micellar miscibility. J Oleo Sci. 2013; 62(1):17-20.
    View in: PubMed
  4. Choukèr A, Ohta A, Martignoni A, Lukashev D, Zacharia LC, Jackson EK, Schnermann J, Ward JM, Kaufmann I, Klaunberg B, Sitkovsky MV, Thiel M. In vivo hypoxic preconditioning protects from warm liver ischemia-reperfusion injury through the adenosine A2B receptor. Transplantation. 2012 Nov 15; 94(9):894-902.
    View in: PubMed
  5. Ohta A, Arai K, Nishine A, Sada Y, Kato H, Fukuda H, Asai S, Nagai Y, Katabami T, Tanaka Y. Comparison of daily glucose excursion by continuous glucose monitoring between type 2 diabetic patients receiving preprandial insulin aspart or postprandial insulin glulisine. Endocr J. 2013 Feb 28; 60(2):173-7.
    View in: PubMed
  6. Ohta A, Kini R, Ohta A, Subramanian M, Madasu M, Sitkovsky M. The development and immunosuppressive functions of CD4(+) CD25(+) FoxP3(+) regulatory T cells are under influence of the adenosine-A2A adenosine receptor pathway. Front Immunol. 2012; 3:190.
    View in: PubMed
  7. Waly MI, Hornig M, Trivedi M, Hodgson N, Kini R, Ohta A, Deth R. Prenatal and Postnatal Epigenetic Programming: Implications for GI, Immune, and Neuronal Function in Autism. Autism Res Treat. 2012; 2012:190930.
    View in: PubMed
  8. Kato H, Ohta A, Kobayashi S, Ishii S, Sada Y, Kobayashi H, Ohmori S, Kondo A, Katabami T, Fuse J, Fukuda H, Nagai Y, Tanaka Y. Effect of the a-glucosidase inhibitor miglitol on the glucose profile in Japanese type 2 diabetic patients receiving multiple daily insulin injections. Endocr J. 2012; 59(4):345-52.
    View in: PubMed
  9. Numata M, Kinoshita D, Taniguchi N, Tamiaki H, Ohta A. Self-assembly of amphiphilic molecules in droplet compartments: an approach toward discrete submicrometer-sized one-dimensional structures. Angew Chem Int Ed Engl. 2012 Feb 20; 51(8):1844-8.
    View in: PubMed
  10. Ohta A, Diwanji R, Kini R, Subramanian M, Ohta A, Sitkovsky M. In vivo T Cell Activation in Lymphoid Tissues is Inhibited in the Oxygen-Poor Microenvironment. Front Immunol. 2011; 2:27.
    View in: PubMed
  11. Yasuhara K, Miki S, Nakazono H, Ohta A, Kikuchi J. Synthesis of organic-inorganic hybrid bicelles-lipid bilayer nanodiscs encompassed by siloxane surfaces. Chem Commun (Camb). 2011 Apr 28; 47(16):4691-3.
    View in: PubMed
  12. Belikoff BG, Hatfield S, Georgiev P, Ohta A, Lukashev D, Buras JA, Remick DG, Sitkovsky M. A2B adenosine receptor blockade enhances macrophage-mediated bacterial phagocytosis and improves polymicrobial sepsis survival in mice. J Immunol. 2011 Feb 15; 186(4):2444-53.
    View in: PubMed
  13. Ohta A, Sitkovsky M. Methylxanthines, inflammation, and cancer: fundamental mechanisms. Handb Exp Pharmacol. 2011; (200):469-81.
    View in: PubMed
  14. Asakawa T, Mochizuki S, Ohta A. Aqueous solution behavior of cationic surfactants containing sulfide linked alkyl chain. J Oleo Sci. 2011; 60(4):165-70.
    View in: PubMed
  15. Asakawa T, Ozawa T, Ohta A. Aqueous solution properties of disulfide-linked fluorinated gemini and cleaved monomeric thiol surfactants. J Oleo Sci. 2011; 60(9):469-74.
    View in: PubMed
  16. Katabami T, Kato H, Asahina T, Hinohara S, Shin T, Kawata T, Ohta A, Iwamoto T, Tanaka Y. Serum free testosterone and metabolic syndrome in Japanese men. Endocr J. 2010; 57(6):533-9.
    View in: PubMed
  17. Nowak M, Lynch L, Yue S, Ohta A, Sitkovsky M, Balk SP, Exley MA. The A2aR adenosine receptor controls cytokine production in iNKT cells. Eur J Immunol. 2010 Mar; 40(3):682-7.
    View in: PubMed
  18. Asakawa T, Tango H, Ozawa T, Ohta A. Dissymmetric gemini surfactants generated by disulfide exchange in mixed micelles. J Oleo Sci. 2010; 59(2):95-100.
    View in: PubMed
  19. Suwa T, Ohta A, Matsui T, Koganei R, Kato H, Kawata T, Sada Y, Ishii S, Kondo A, Murakami K, Katabami T, Tanaka Y. Relationship between clinical markers of glycemia and glucose excursion evaluated by continuous glucose monitoring (CGM). Endocr J. 2010; 57(2):135-40.
    View in: PubMed
  20. Ohta A, Ohta A, Madasu M, Kini R, Subramanian M, Goel N, Sitkovsky M. A2A adenosine receptor may allow expansion of T cells lacking effector functions in extracellular adenosine-rich microenvironments. J Immunol. 2009 Nov 1; 183(9):5487-93.
    View in: PubMed
  21. Hatfield S, Belikoff B, Lukashev D, Sitkovsky M, Ohta A. The antihypoxia-adenosinergic pathogenesis as a result of collateral damage by overactive immune cells. J Leukoc Biol. 2009 Sep; 86(3):545-8.
    View in: PubMed
  22. Ohta A, Sitkovsky M. The adenosinergic immunomodulatory drugs. Curr Opin Pharmacol. 2009 Aug; 9(4):501-6.
    View in: PubMed
  23. Ohta A, Miyazato Y, Sasaki H, Yasuhara K, Asakawa T. Effect of functional groups on incorporation behavior of amino acid-type surfactant into phospholipid vesicle membrane. J Oleo Sci. 2009; 58(12):607-15.
    View in: PubMed
  24. Ohta A, Kjaergaard J, Sharma S, Mohsin M, Goel N, Madasu M, Fradkov E, Ohta A, Sitkovsky M. In vitro induction of T cells that are resistant to A2 adenosine receptor-mediated immunosuppression. Br J Pharmacol. 2009 Jan; 156(2):297-306.
    View in: PubMed
  25. Asai S, Katabami T, Obi N, Matsui T, Kato H, Obi R, Ogawa Y, Kawata T, Takama H, Ohta A, Tanaka Y. No ghrelin response to oral glucose in diabetes mellitus with gastroparesis. Endocr J. 2009; 56(1):79-87.
    View in: PubMed
  26. Sitkovsky MV, Kjaergaard J, Lukashev D, Ohta A. Hypoxia-adenosinergic immunosuppression: tumor protection by T regulatory cells and cancerous tissue hypoxia. Clin Cancer Res. 2008 Oct 1; 14(19):5947-52.
    View in: PubMed
  27. Choukèr A, Thiel M, Lukashev D, Ward JM, Kaufmann I, Apasov S, Sitkovsky MV, Ohta A. Critical role of hypoxia and A2A adenosine receptors in liver tissue-protecting physiological anti-inflammatory pathway. Mol Med. 2008 Mar-Apr; 14(3-4):116-23.
    View in: PubMed
  28. Choukèr A, Lizak M, Schimel D, Helmberger T, Ward JM, Despres D, Kaufmann I, Bruns C, Löhe F, Ohta A, Sitkovsky MV, Klaunberg B, Thiel M. Comparison of Fenestra VC Contrast-enhanced computed tomography imaging with gadopentetate dimeglumine and ferucarbotran magnetic resonance imaging for the in vivo evaluation of murine liver damage after ischemia and reperfusion. Invest Radiol. 2008 Feb; 43(2):77-91.
    View in: PubMed
  29. Asakawa T, Shimizu Y, Ozawa T, Ohta A, Miyagishi S. Aqueous solution properties of disulfide linked gemini and cleaved monomeric thiol surfactants. J Oleo Sci. 2008; 57(4):243-9.
    View in: PubMed
  30. Ohta A, Shirai M, Asakawa T, Miyagishi S. Effect of stereochemistry on the molecular aggregation of phenylalanine dipeptide-type surfactants. J Oleo Sci. 2008; 57(12):659-67.
    View in: PubMed
  31. Ohta A, Lukashev D, Jackson EK, Fredholm BB, Sitkovsky M. 1,3,7-trimethylxanthine (caffeine) may exacerbate acute inflammatory liver injury by weakening the physiological immunosuppressive mechanism. J Immunol. 2007 Dec 1; 179(11):7431-8.
    View in: PubMed
  32. Thiel M, Caldwell CC, Kreth S, Kuboki S, Chen P, Smith P, Ohta A, Lentsch AB, Lukashev D, Sitkovsky MV. Targeted deletion of HIF-1alpha gene in T cells prevents their inhibition in hypoxic inflamed tissues and improves septic mice survival. PLoS One. 2007; 2(9):e853.
    View in: PubMed
  33. Ohta A, Ohomori S, Mizukami T, Obi R, Tanaka Y. Penile necrosis by calciphylaxis in a diabetic patient with chronic renal failure. Intern Med. 2007; 46(13):985-90.
    View in: PubMed
  34. Sugai M, Ohta A, Ogata Y, Nakanishi M, Ueno S, Kawata T, Saito N, Tanaka Y. Asymmetric dimethylarginine (ADMA) in the aqueous humor of diabetic patients. Endocr J. 2007 Apr; 54(2):303-9.
    View in: PubMed
  35. Lukashev D, Sitkovsky M, Ohta A. From "Hellstrom Paradox" to anti-adenosinergic cancer immunotherapy. Purinergic Signal. 2007 Mar; 3(1-2):129-34.
    View in: PubMed
  36. Aratono M, Onimaru N, Yoshikai Y, Shigehisa M, Koga I, Wongwailikhit K, Ohta A, Takiue T, Lhoussaine B, Strey R, Takata Y, Villeneuve M, Matsubara H. Spontaneous vesicle formation of single chain and double chain cationic surfactant mixtures. J Phys Chem B. 2007 Jan 11; 111(1):107-15.
    View in: PubMed
  37. Ozawa T, Asakawa T, Ohta A, Miyagishi S. New fluorescent probes applicable to aggregates of fluorocarbon surfactants. J Oleo Sci. 2007; 56(11):587-93.
    View in: PubMed
  38. Lukashev D, Klebanov B, Kojima H, Grinberg A, Ohta A, Berenfeld L, Wenger RH, Ohta A, Sitkovsky M. Cutting edge: hypoxia-inducible factor 1alpha and its activation-inducible short isoform I.1 negatively regulate functions of CD4+ and CD8+ T lymphocytes. J Immunol. 2006 Oct 15; 177(8):4962-5.
    View in: PubMed
  39. Ohta A, Danev R, Nagayama K, Mita T, Asakawa T, Miyagishi S. Transition from nanotubes to micelles with increasing concentration in dilute aqueous solution of potassium N-acyl phenylalaninate. Langmuir. 2006 Sep 26; 22(20):8472-7.
    View in: PubMed
  40. Ohta A, Gorelik E, Prasad SJ, Ronchese F, Lukashev D, Wong MK, Huang X, Caldwell S, Liu K, Smith P, Chen JF, Jackson EK, Apasov S, Abrams S, Sitkovsky M. A2A adenosine receptor protects tumors from antitumor T cells. Proc Natl Acad Sci U S A. 2006 Aug 29; 103(35):13132-7.
    View in: PubMed
  41. Asakawa T, Okada T, Hayasaka T, Kuwamoto K, Ohta A, Miyagishi S. The unusual micelle micropolarity of partially fluorinated gemini surfactants sensed by pyrene fluorescence. Langmuir. 2006 Jul 4; 22(14):6053-5.
    View in: PubMed
  42. Kuwamoto K, Asakawa T, Ohta A, Miyagishi S. Degree of micelle ionization and micellar growth for gemini surfactants detected by 6-methoxy-N-(3-sulfopropyl)quinolinium fluorescence quenching. Langmuir. 2005 Aug 16; 21(17):7691-5.
    View in: PubMed
  43. Sitkovsky MV, Ohta A. The 'danger' sensors that STOP the immune response: the A2 adenosine receptors? Trends Immunol. 2005 Jun; 26(6):299-304.
    View in: PubMed
  44. Thiel M, Chouker A, Ohta A, Jackson E, Caldwell C, Smith P, Lukashev D, Bittmann I, Sitkovsky MV. Oxygenation inhibits the physiological tissue-protecting mechanism and thereby exacerbates acute inflammatory lung injury. PLoS Biol. 2005 Jun; 3(6):e174.
    View in: PubMed
  45. Asakawa T, Ishino S, Hansson P, Almgren M, Ohta A, Miyagishi S. Appearance of pure fluorocarbon micelles surveyed by fluorescence quenching of amphiphilic quinoline derivatives in fluorocarbon and hydrocarbon surfactant mixtures. Langmuir. 2004 Aug 17; 20(17):6998-7003.
    View in: PubMed
  46. Lukashev D, Ohta A, Apasov S, Chen JF, Sitkovsky M. Cutting edge: Physiologic attenuation of proinflammatory transcription by the Gs protein-coupled A2A adenosine receptor in vivo. J Immunol. 2004 Jul 1; 173(1):21-4.
    View in: PubMed
  47. Lukashev D, Ohta A, Sitkovsky M. Targeting hypoxia--A(2A) adenosine receptor-mediated mechanisms of tissue protection. Drug Discov Today. 2004 May 1; 9(9):403-9.
    View in: PubMed
  48. Murakami R, Takata Y, Ohta A, Takiue T, Aratono M. Aggregate formation in oil and adsorption at oil/water interface: thermodynamics and its application to the oleyl alcohol system. J Colloid Interface Sci. 2004 Feb 15; 270(2):262-9.
    View in: PubMed
  49. Sitkovsky MV, Lukashev D, Apasov S, Kojima H, Koshiba M, Caldwell C, Ohta A, Thiel M. Physiological control of immune response and inflammatory tissue damage by hypoxia-inducible factors and adenosine A2A receptors. Annu Rev Immunol. 2004; 22:657-82.
    View in: PubMed
  50. Lukashev DE, Smith PT, Caldwell CC, Ohta A, Apasov SG, Sitkovsky MV. Analysis of A2a receptor-deficient mice reveals no significant compensatory increases in the expression of A2b, A1, and A3 adenosine receptors in lymphoid organs. Biochem Pharmacol. 2003 Jun 15; 65(12):2081-90.
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  51. Miyagishi S, Takagi M, Kadono S, Ohta A, Asakawa T. Effect of amino acid surfactants on phase transition of poly(N-isopropylacrylamide) gel. J Colloid Interface Sci. 2003 May 1; 261(1):191-6.
    View in: PubMed
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