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Patricia Challender Come, M.D.

TitleAssociate Professor of Medicine
InstitutionHarvard Pilgrim Healthcare
DepartmentMedicine
AddressHvma
6th Fl-Cardiology
133 Brookline Ave
Boston MA 02215
Phone617/421-6050
Fax617/421-6083

 Bibliographic 
 selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Reimold SC, Orav EJ, Come PC, Caguioa ES, Lee RT. Progressive enlargement of the regurgitant orifice in patients with chronic aortic regurgitation. J Am Soc Echocardiogr. 1998 Mar; 11(3):259-65.
    View in: PubMed
  2. Fleischmann KE, Lee RT, Come PC, Goldman L, Kuntz KM, Johnson PA, Weissman MA, Lee TH. Clinical and echocardiographic correlates of health status in patients with acute chest pain. J Gen Intern Med. 1997 Dec; 12(12):751-6.
    View in: PubMed
  3. Fleischmann KE, Lee RT, Come PC, Goldman L, Cook EF, Weissman MA, Johnson PA, Lee TH. Impact of valvular regurgitation and ventricular dysfunction on long-term survival in patients with chest pain. Am J Cardiol. 1997 Nov 15; 80(10):1266-72.
    View in: PubMed
  4. Fleischmann KE, Lee TH, Come PC, Goldman L, Cook EF, Caguoia E, Johnson PA, Albano MP, Lee RT. Echocardiographic prediction of complications in patients with chest pain. Am J Cardiol. 1997 Feb 1; 79(3):292-8.
    View in: PubMed
  5. McConnell MV, Solomon SD, Rayan ME, Come PC, Goldhaber SZ, Lee RT. Regional right ventricular dysfunction detected by echocardiography in acute pulmonary embolism. Am J Cardiol. 1996 Aug 15; 78(4):469-73.
    View in: PubMed
  6. Manning WJ, Silverman DI, Katz SE, Riley MF, Come PC, Doherty RM, Munson JT, Douglas PS. Impaired left atrial mechanical function after cardioversion: relation to the duration of atrial fibrillation. J Am Coll Cardiol. 1994 Jun; 23(7):1535-40.
    View in: PubMed
  7. Wolfe MW, Lee RT, Feldstein ML, Parker JA, Come PC, Goldhaber SZ. Prognostic significance of right ventricular hypokinesis and perfusion lung scan defects in pulmonary embolism. Am Heart J. 1994 May; 127(5):1371-5.
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  8. Solomon SD, Wolff S, Watkins H, Ridker PM, Come P, McKenna WJ, Seidman CE, Lee RT. Left ventricular hypertrophy and morphology in familial hypertrophic cardiomyopathy associated with mutations of the beta-myosin heavy chain gene. J Am Coll Cardiol. 1993 Aug; 22(2):498-505.
    View in: PubMed
  9. Goldhaber SZ, Haire WD, Feldstein ML, Miller M, Toltzis R, Smith JL, Taveira da Silva AM, Come PC, Lee RT, Parker JA, et al. Alteplase versus heparin in acute pulmonary embolism: randomised trial assessing right-ventricular function and pulmonary perfusion. Lancet. 1993 Feb 27; 341(8844):507-11.
    View in: PubMed
  10. Gordon SP, Douglas PS, Come PC, Manning WJ. Two-dimensional and Doppler echocardiographic determinants of the natural history of mitral valve narrowing in patients with rheumatic mitral stenosis: implications for follow-up. J Am Coll Cardiol. 1992 Apr; 19(5):968-73.
    View in: PubMed
  11. Come PC. Echocardiographic evaluation of pulmonary embolism and its response to therapeutic interventions. Chest. 1992 Apr; 101(4 Suppl):151S-162S.
    View in: PubMed
  12. Gwathmey JK, Nakao S, Come PC, Goad ME, Serur JR, Als AV, Abelmann WH. An experimental model of acute and subacute viral myocarditis in the pig. J Am Coll Cardiol. 1992 Mar 15; 19(4):864-9.
    View in: PubMed
  13. Manning WJ, Shannon RP, Santinga JA, Parker JA, Gervino EV, Come PC, Wei JY. Reversal of changes in left ventricular diastolic filling associated with normal aging using diltiazem. Am J Cardiol. 1991 Apr 15; 67(9):894-6.
    View in: PubMed
  14. Manning WJ, Riley MF, Come PC. Effect of balloon aortic valvuloplasty on Doppler indexes of left ventricular diastolic filling. Am J Cardiol. 1991 Mar 1; 67(6):544-6.
    View in: PubMed
  15. Levine MJ, Lorell BH, Diver DJ, Come PC. Implications of echocardiographically assisted diagnosis of pericardial tamponade in contemporary medical patients: detection before hemodynamic embarrassment. J Am Coll Cardiol. 1991 Jan; 17(1):59-65.
    View in: PubMed
  16. Come PC, Riley MF, Berman AD, Safian RD, Wakmonski CA, McKay RG. Serial assessment of mitral regurgitation by pulsed Doppler echocardiography in patients undergoing balloon aortic valvuloplasty. J Am Coll Cardiol. 1989 Sep; 14(3):677-82.
    View in: PubMed
  17. Hirsch AT, Gervino EV, Nakao S, Come PC, Silverman KJ, Grossman W. The effect of caffeine on exercise tolerance and left ventricular function in patients with coronary artery disease. Ann Intern Med. 1989 Apr 15; 110(8):593-8.
    View in: PubMed
  18. Manning WJ, Leeman DE, Gotch PJ, Come PC. Pulsed Doppler evaluation of atrial mechanical function after electrical cardioversion of atrial fibrillation. J Am Coll Cardiol. 1989 Mar 1; 13(3):617-23.
    View in: PubMed
  19. Gwathmey JK, Nakao S, Come PC, Abelmann WH. Echocardiographic assessment of cardiac chamber size and functional performance in swine. Am J Vet Res. 1989 Feb; 50(2):192-7.
    View in: PubMed
  20. Ferguson JJ, Manning WJ, Come PC. Pulsed Doppler echocardiographic determination of the time course of left ventricular filling: validation with cineangiography. Am Heart J. 1989 Jan; 117(1):127-32.
    View in: PubMed
  21. Goldhaber SZ, Kessler CM, Heit J, Markis JE, Sharma GV, Dawley DL, Meyerovitz MF, Vaughan DE, Parker JA, Come PC, et al. Tissue plasminogen activator and acute pulmonary embolism. J Cell Biochem. 1988 Dec; 38(4):303-12.
    View in: PubMed
  22. Safian RD, Warren SE, Berman AD, Diver DJ, McKay LL, Come PC, Grossman W, McKay RG. Improvement in symptoms and left ventricular performance after balloon aortic valvuloplasty in patients with aortic stenosis and depressed left ventricular ejection fraction. Circulation. 1988 Nov; 78(5 Pt 1):1181-91.
    View in: PubMed
  23. Come PC, Riley MF, Carl LV, Lorell B. Doppler evidence that true left ventricular-to-aortic pressure gradients exist in hypertrophic cardiomyopathy. Am Heart J. 1988 Nov; 116(5 Pt 1):1253-61.
    View in: PubMed
  24. Safian RD, Berman AD, Diver DJ, McKay LL, Come PC, Riley MF, Warren SE, Cunningham MJ, Wyman RM, Weinstein JS, et al. Balloon aortic valvuloplasty in 170 consecutive patients. N Engl J Med. 1988 Jul 21; 319(3):125-30.
    View in: PubMed
  25. Come PC, Riley MF, Ferguson JF, Morgan JP, McKay RG. Prediction of severity of aortic stenosis: accuracy of multiple noninvasive parameters. Am J Med. 1988 Jul; 85(1):29-37.
    View in: PubMed
  26. Come PC, Riley MF, Safian RD, Ferguson JF, Diver DD, McKay RG. Usefulness of noninvasive assessment of aortic stenosis before and after percutaneous aortic valvuloplasty. Am J Cardiol. 1988 Jun 1; 61(15):1300-6.
    View in: PubMed
  27. Miklozek CL, Crumpacker CS, Royal HD, Come PC, Sullivan JL, Abelmann WH. Myocarditis presenting as acute myocardial infarction. Am Heart J. 1988 Apr; 115(4):768-76.
    View in: PubMed
  28. Come PC, Riley MF, Diver DJ, Morgan JP, Safian RD, McKay RG. Noninvasive assessment of mitral stenosis before and after percutaneous balloon mitral valvuloplasty. Am J Cardiol. 1988 Apr 1; 61(10):817-25.
    View in: PubMed
  29. Come PC. Echocardiographic recognition of pulmonary arterial disease and determination of its cause. Am J Med. 1988 Mar; 84(3 Pt 1):384-94.
    View in: PubMed
  30. Leeman DE, Levine MJ, Come PC. Doppler echocardiography in cardiac tamponade: exaggerated respiratory variation in transvalvular blood flow velocity integrals. J Am Coll Cardiol. 1988 Mar; 11(3):572-8.
    View in: PubMed
  31. Safian RD, Berman AD, Sachs B, Diver DJ, Come PC, Baim DS, McKay L, Grossman W, McKay RG. Percutaneous balloon mitral valvuloplasty in a pregnant woman with mitral stenosis. Cathet Cardiovasc Diagn. 1988; 15(2):103-8.
    View in: PubMed
  32. Reis GJ, Hirsch AT, Come PC. Detection and treatment of high-output cardiac failure resulting from a large hemodialysis fistula. Cathet Cardiovasc Diagn. 1988; 14(4):263-5.
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  33. Cunningham MJ, Safian RD, Come PC, Lorell BH. Absence of pulsus paradoxus in a patient with cardiac tamponade and coexisting pulmonary artery obstruction. Am J Med. 1987 Nov; 83(5):973-6.
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  34. Come PC, Kim D, Parker JA, Goldhaber SZ, Braunwald E, Markis JE. Early reversal of right ventricular dysfunction in patients with acute pulmonary embolism after treatment with intravenous tissue plasminogen activator. J Am Coll Cardiol. 1987 Nov; 10(5):971-8.
    View in: PubMed
  35. Come PC, Riley MF, McKay RG, Safian R. Echocardiographic assessment of aortic valve area in elderly patients with aortic stenosis and of changes in valve area after percutaneous balloon valvuloplasty. J Am Coll Cardiol. 1987 Jul; 10(1):115-24.
    View in: PubMed
  36. Come PC. Echocardiography in infective endocarditis. Am Heart J. 1987 Jun; 113(6):1538-9.
    View in: PubMed
  37. Come PC. Pitfalls in the diagnosis of periprosthetic valvular regurgitation by pulsed Doppler echocardiography. J Am Coll Cardiol. 1987 May; 9(5):1176-9.
    View in: PubMed
  38. Come PC, Riley MF, Weintraub RM, Wei JY, Markis JE, Lorell BH, Grossman W. Dynamic left ventricular outflow tract obstruction when the anterior leaflet is retained at prosthetic mitral valve replacement. Ann Thorac Surg. 1987 May; 43(5):561-3.
    View in: PubMed
  39. Come PC, Carl LV, Leeman D, Abelmann WH, Weintraub RM. Partial dehiscence of a porcine prosthesis in association with aortic annular separation producing a false aneurysm of the ascending aorta. Cathet Cardiovasc Diagn. 1987 May-Jun; 13(3):178-80.
    View in: PubMed
  40. McKay RG, Lock JE, Safian RD, Come PC, Diver DJ, Baim DS, Berman AD, Warren SE, Mandell VE, Royal HD, et al. Balloon dilation of mitral stenosis in adult patients: postmortem and percutaneous mitral valvuloplasty studies. J Am Coll Cardiol. 1987 Apr; 9(4):723-31.
    View in: PubMed
  41. McKay RG, Safian RD, Lock JE, Diver DJ, Berman AD, Warren SE, Come PC, Baim DS, Mandell VE, Royal HD, et al. Assessment of left ventricular and aortic valve function after aortic balloon valvuloplasty in adult patients with critical aortic stenosis. Circulation. 1987 Jan; 75(1):192-203.
    View in: PubMed
  42. Nakao S, Come PC, McKay RG, Ransil BJ. Effects of positional changes on inferior vena caval size and dynamics and correlations with right-sided cardiac pressure. Am J Cardiol. 1987 Jan 1; 59(1):125-32.
    View in: PubMed
  43. Berman AD, Come PC, Riley MF, Weintraub RM, Johnson RG, Aroesty JM. Two-dimensional and Doppler echocardiographic diagnosis of an aortic to right atrial fistula complicating aortic dissection. J Am Coll Cardiol. 1987 Jan; 9(1):228-30.
    View in: PubMed
  44. Come PC, Riley MF, Carl LV, Nakao S. Pulsed Doppler echocardiographic evaluation of valvular regurgitation in patients with mitral valve prolapse: comparison with normal subjects. J Am Coll Cardiol. 1986 Dec; 8(6):1355-64.
    View in: PubMed
  45. Come PC, Riley MF, Kaufman H, Parker JA, Morgan JP, Lorell B, Thurer R, Weintraub R, Axelrod P. Aortic false aneurysm: recognition by noninvasive techniques four years after mitral valve replacement. Am J Cardiol. 1986 Nov 15; 58(11):1137-9.
    View in: PubMed
  46. McKay RG, Pfeffer MA, Pasternak RC, Markis JE, Come PC, Nakao S, Alderman JD, Ferguson JJ, Safian RD, Grossman W. Left ventricular remodeling after myocardial infarction: a corollary to infarct expansion. Circulation. 1986 Oct; 74(4):693-702.
    View in: PubMed
  47. Miklozek CL, Kingsley EM, Crumpaker CS, Modlin JF, Royal HD, Come PC, Mark R, Abelmann WH. Serial cardiac function tests in myocarditis. Postgrad Med J. 1986 Jun; 62(728):577-9.
    View in: PubMed
  48. Miller MJ, McKay RG, Ferguson JJ, Sahagian P, Nakao S, Come PC, Grossman W. Right atrial pressure-volume relationships in tricuspid regurgitation. Circulation. 1986 Apr; 73(4):799-808.
    View in: PubMed
  49. Come PC. The optimal Doppler examination: pulsed, continuous wave or both? J Am Coll Cardiol. 1986 Apr; 7(4):886-8.
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  50. Nakao S, Come PC, Miller MJ, Momomura S, Sahagian P, Ransil BJ, Grossman W. Effects of supine and lateral positions on cardiac output and intracardiac pressures: an experimental study. Circulation. 1986 Mar; 73(3):579-85.
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  51. Come PC, Riley MF, Weintraub R, Morgan JP, Nakao S. Echocardiographic detection of complete and partial papillary muscle rupture during acute myocardial infarction. Am J Cardiol. 1985 Nov 1; 56(12):787-9.
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  52. Come PC. Doppler evaluation of aortic coarctation. Am Heart J. 1985 Jul; 110(1 Pt 1):178-80.
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  53. Come PC, Miklozek CL, Riley MF, Carl LV, Morgan JP. Echocardiographic changes in rapidly developing pericardial constriction. Am Heart J. 1985 Jun; 109(6):1385-7.
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  54. Borow KM, Come PC, Neumann A, Baim DS, Braunwald E, Grossman W. Physiologic assessment of the inotropic, vasodilator and afterload reducing effects of milrinone in subjects without cardiac disease. Am J Cardiol. 1985 Apr 15; 55(9):1204-9.
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  55. Come PC. Doppler detection of acquired ventricular septal defect. Am J Cardiol. 1985 Feb 15; 55(5):586-8.
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  56. Come PC, Riley MF. Tricuspid anular dilatation and failure of tricuspid leaflet coaptation in tricuspid regurgitation. Am J Cardiol. 1985 Feb 15; 55(5):599-601.
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  57. Come PC, Come SE, Riley MF, Carl LV, Nakao S. Reversible right ventricular outflow tract compression by immunoblastic sarcoma. Am J Cardiol. 1985 Jan 1; 55(1):239-40.
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  58. Heller GV, Aroesty JM, McKay RG, Parker JA, Silverman KJ, Come PC, Grossman W. The pacing stress test: a reexamination of the relation between coronary artery disease and pacing-induced electrocardiographic changes. Am J Cardiol. 1984 Jul 1; 54(1):50-5.
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  59. Come PC, Riley MF. Echographic recognition of perivalvular infection complicating aortic bacterial endocarditis. Am Heart J. 1984 Jul; 108(1):166-8.
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  60. McKay RG, Aroesty JM, Heller GV, Silverman KJ, Parker JA, Als AV, Come PC, Kolodny GM, Grossman W. The pacing stress test reexamined: correlation of pacing-induced hemodynamic changes with the amount of myocardium at risk. J Am Coll Cardiol. 1984 Jun; 3(6):1469-81.
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  61. Come PC, Riley MF, Miklozek CL. Echocardiographic evidence of increased obstruction following long cycle lengths in atrial fibrillation in patients with hypertrophic cardiomyopathy. J Clin Ultrasound. 1984 May; 12(4):241-3.
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  62. Heller GV, Aroesty JM, Parker JA, McKay RG, Silverman KJ, Als AV, Come PC, Kolodny GM, Grossman W. The pacing stress test: thallium-201 myocardial imaging after atrial pacing. Diagnostic value in detecting coronary artery disease compared with exercise testing. J Am Coll Cardiol. 1984 May; 3(5):1197-204.
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  63. Come PC, Bivas NK, Sacks B, Thurer RL, Weintraub RM, Axelrod P. Unusual echographic findings in aortic dissection: diastolic prolapse of intimal flap into left ventricle. Am Heart J. 1984 Apr; 107(4):790-2.
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  64. Strahan NV, Murphy EA, Fortuin NJ, Come PC, Humphries JO. Inheritance of the mitral valve prolapse syndrome. Discussion of a three-dimensional penetrance model. Am J Med. 1983 Jun; 74(6):967-72.
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  65. Come PC, Riley MF, Bivas NK. Roles of echocardiography and arrhythmia monitoring in the evaluation of patients with suspected systemic embolism. Ann Neurol. 1983 May; 13(5):527-31.
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  66. Bubley G, Come P, MacDougall D, Thurer R, Goldberg J. Pericardial tamponade associated with myeloid metaplasia. Am J Hematol. 1983 Apr; 14(2):185-8.
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  67. Come PC. Transient right atrial thrombus during acute myocardial infarction: diagnosis by echocardiography. Am J Cardiol. 1983 Apr; 51(7):1228-9.
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  68. Come PC. Production of abnormal systolic sounds by vibration of torn leaflet of porcine xenograft. Arch Intern Med. 1983 Apr; 143(4):801-3.
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  69. Come PC. Improved cross-sectional echocardiographic technique for visualization of the retrocardiac descending aorta in its long axis. Normal findings and abnormalities in saccular and/or dissecting aneurysms. Am J Cardiol. 1983 Mar 15; 51(6):1029-32.
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  70. Jones HR, Caplan LR, Come PC, Swinton NW, Breslin DJ. Cerebral emboli of paradoxical origin. Ann Neurol. 1983 Mar; 13(3):314-9.
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  71. Come PC, Fortuin NJ, White RI, McKusick VA. Echocardiographic assessment of cardiovascular abnormalities in the Marfan syndrome. Comparison with clinical findings and with roentgenographic estimation of aortic root size. Am J Med. 1983 Mar; 74(3):465-74.
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  72. Come PC, Riley MF. Hypertrophic cardiomyopathy. Disappearance of auscultatory, carotid pulse, and echocardiographic manifestations of obstruction following myocardial infarction. Chest. 1982 Oct; 82(4):451-4.
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  73. Come PC. Infective endocarditis: current perspectives. Compr Ther. 1982 Jul; 8(7):57-70.
    View in: PubMed
  74. Come PC, Come SE, Hawley CR, Gwon N, Riley MF. Echocardiographic manifestations of carcinoid heart disease. J Clin Ultrasound. 1982 May-Jun; 10(5):233-7.
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  75. Come PC, Isaacs RE, Riley MF. Diagnostic accuracy of M-mode echocardiography in active infective endocarditis and prognostic implications of ultrasound-detectable vegetations. Am Heart J. 1982 May; 103(5):839-47.
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  76. Come PC, Riley MF. M mode and cross-sectional echocardiographic recognition of fibrosis and calcification of the mitral valve chordae and left ventricular papillary muscles. Am J Cardiol. 1982 Feb 1; 49(2):461-6.
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  77. Come PC. Coronary arterial spasm. J Fam Pract. 1982 Jan; 14(1):119-9.
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  78. Come PC, Riley MF, Markis JE, Malagold M. Limitations of echocardiographic techniques in evaluation of left atrial masses. Am J Cardiol. 1981 Nov; 48(5):947-53.
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  79. Come PC, Flaherty JT, Becker LC, Weisfeldt ML, Greene HL, Weiss JL, Pitt B. Combined administration of nitroglycerin and propranolol to patients with acute myocardial infarction. Chest. 1981 Oct; 80(4):416-24.
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  80. Schulman P, Come PC, Isaacs R, Radvany P. Left ventricular outflow obstruction induced by tamponade in hypertrophic cardiomyopathy. Chest. 1981 Jul; 80(1):110-3.
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  81. Come PC, Sacks B, Vine H, McArdle C, Koretsky S, Weintraub R. Ultrasonic visualization of the posterior thoracic aorta in long axis: diagnosis of a saccular mycotic aneurysm. Chest. 1981 Apr; 79(4):470-2.
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  82. Come PC. Mitral valve prolapse: clinical features, laboratory abnormalities, complications, and prognosis. J Fam Pract. 1981 Mar; 12(3):435-46.
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  83. Come PC, Riley MF, Fortuin NJ. Echocardiographic mimicry of pericardial effusion. Am J Cardiol. 1981 Feb; 47(2):365-70.
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  84. Come PC, Markis JE, Vine HS, Sacks B, McArdle C, Ramirez A. Echocardiographic diagnosis of left ventricular thrombi. Am Heart J. 1980 Oct; 100(4):523-30.
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  85. Come PC. Echocardiography in diagnosis and management of cardiovascular disease. Compr Ther. 1980 Jun; 6(6):7-17.
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  86. Come PC. Echocardiography in diagnosis and management of cardiovascular disease. Part I. Study of the left ventricle and pericardium and recognition of intracardiac mass lesions. Compr Ther. 1980 May; 6(5):56-64.
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  87. Come PC, Kurland GS, Vine HS. Two dimensional echocardiography in differentiating right atrial and tricuspid valve mass lesions. Am J Cardiol. 1979 Nov; 44(6):1207-12.
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  88. Gerber SD, Levy BS, Come P, Komaroff AL. A diagnostic strategy for myocardial infarction. J Fam Pract. 1979 Aug; 9(2):207-18.
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  89. Angoff GH, Wistran D, Sloss LJ, Markis JE, Come PC, Zoll PM, Cohn PF. Value of a noninvasively induced ventricular extrasystole during echocardiographic and phonocardiographic assessment of patients with idiopathic hypertrophic subaortic stenosis. Am J Cardiol. 1978 Dec; 42(6):919-24.
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  90. Come PC, Bulkley BH, McKusick VA, Fortuin NJ. Echocardiographic recognition of silent aortic root dilatation in Marfan's syndrome. Chest. 1977 Dec; 72(6):789-92.
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  91. Bailey IK, Come PC, Kelly DT, Burow RD, Griffith LS, Strauss HW, Pitt B. Thallium-201 myocardial perfusion imaging in aortic valve stenosis. Am J Cardiol. 1977 Dec; 40(6):889-99.
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  92. Dashkoff N, Karacuschansky M, Come PC, Fortuin NJ. Echocardiographic features of mitral annulus calcification. Am Heart J. 1977 Nov; 94(5):585-92.
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  93. Come PC, Bulkley BH, Goodman ZD, Hutchins GM, Pitt B, Fortuin NJ. Hypercontractile cardiac states simulating hypertrophic cardiomyopathy. Circulation. 1977 Jun; 55(6):901-8.
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  94. Come PC, Pitt B. Nitroglycerin-induced severe hypotension and bradycardia in patients with acute myocardial infarction. Circulation. 1976 Oct; 54(4):624-8.
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  95. Flaherty JT, Come PC, Baird MG, Rouleau J, Taylor DR, Weisteldt ML, Greene HL, Becker LC, Pitt B. Effects of intravenous nitroglycerin on left ventricular function and ST segment changes in acute myocardial infarction. Br Heart J. 1976 Jun; 38(6):612-21.
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  96. Come PC, Flaherty JT, Baird MG, Rouleau JR, Weisfeldt ML, Greene HL, Becker L, Pitt B. Reversal by phenylephrine of the beneficial effects of intravenous nitroglycerin in patients with acute myocardial infarction. N Engl J Med. 1975 Nov 13; 293(20):1003-7.
    View in: PubMed
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