Contact, publication, and social network information about Harvard faculty and fellows. Harvard Catalyst Profiles
Keywords
Last Name
Institution

Robert Joseph Thomas, M.D.

TitleAssociate Professor of Medicine
InstitutionBeth Israel Deaconess Medical Center
DepartmentMedicine
AddressBeth Israel Deaconess Med Ctr
Kb 023
330 Brookline Ave
Boston MA 02215
Phone617/667-5864

 Mentoring 
 current student opportunities
Available: 09/01/11, Expires: 08/31/16

There is an opportunity to join and contribute to a long-range effort in a new approach to sleep physiology and pathology, called "sleep effectiveness". This approach to sleep is totally different from the conventional stages, yet is complementary. The base signal is the electrocardiogram (ECG), from which mapping of coupled oscillations during sleep provides a unique biological map. The technique is being applied to large (> 5000) and small datasets across the age spectrum, including epidemiological studies such as the Framingham Heart Study and the Korean Genome and Epidemiology study. The student will have a choice from a wide variety of options, based on interest, prior background and time. The student will learn significant amounts of sleep science across the basic, clinical and laboratory spectrum. Specific student type project include: 1. The genetic determinants of effective sleep. 2. Hemodynamics of sleep states. 3. Glucose metabolism in relation to sleep effectiveness. 4. Long range dynamics of sleep effectiveness in healthy and diseased populations.


 Bibliographic 
 selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
List All   |   Timeline
  1. Thomas RJ. Multimodality therapy for sleep apnea syndromes. J Clin Sleep Med. 2012; 8(5):565-7.
    View in: PubMed
  2. Thomas RJ. Single vs. multi-modality treatment of central apnea syndromes. Sleep. 2012 Sep; 35(9):1197-8; author reply 1199.
    View in: PubMed
  3. Bianchi MT, Thomas RJ, Ellenbogen JM. Hypnotics and mortality risk. J Clin Sleep Med. 2012; 8(4):351-2.
    View in: PubMed
  4. Lee SH, Choi JH, Park IH, Lee SH, Kim TH, Lee HM, Park HK, Thomas RJ, Shin C, Yun CH. Measuring sleep quality after adenotonsillectomy in pediatric sleep apnea. Laryngoscope. 2012 Sep; 122(9):2115-21.
    View in: PubMed
  5. Schramm PJ, Thomas RJ. Assessment of therapeutic options for mild obstructive sleep apnea using cardiopulmonary coupling measures. J Clin Sleep Med. 2012 Jun 15; 8(3):315-20.
    View in: PubMed
  6. Kim SJ, Lee SK, Kim SH, Yun CH, Kim JH, Thomas RJ, Shin C. Genetic association of short sleep duration with hypertension incidence--a 6-year follow-up in the Korean genome and epidemiology study. Circ J. 2012; 76(4):907-13.
    View in: PubMed
  7. Thomas RJ. Seeking useful biomarkers for the quality and effectiveness of sleep. Sleep. 2012 Feb; 35(2):173-4.
    View in: PubMed
  8. Pogach MS, Punjabi NM, Thomas N, Thomas RJ. Electrocardiogram-based sleep spectrogram measures of sleep stability and glucose disposal in sleep disordered breathing. Sleep. 2012 Jan; 35(1):139-48.
    View in: PubMed
  9. Thomas RJ. Sleep as a window into the world of fibromyalgia syndrome. J Rheumatol. 2011 Dec; 38(12):2499-500.
    View in: PubMed
  10. Bianchi MT, Eiseman NA, Cash SS, Mietus J, Peng CK, Thomas RJ. Probabilistic sleep architecture models in patients with and without sleep apnea. J Sleep Res. 2012 Jun; 21(3):330-41.
    View in: PubMed
  11. Eiseman NA, Westover MB, Mietus JE, Thomas RJ, Bianchi MT. Classification algorithms for predicting sleepiness and sleep apnea severity. J Sleep Res. 2012 Feb; 21(1):101-12.
    View in: PubMed
  12. Thomas RJ. The chemoreflex and sleep-disordered breathing: man and machine vs. the beast. Sleep Med. 2011 Jun; 12(6):533-5.
    View in: PubMed
  13. Guo D, Peng CK, Wu HL, Mietus JE, Liu Y, Sun RS, Thomas RJ. ECG-derived cardiopulmonary analysis of pediatric sleep-disordered breathing. Sleep Med. 2011 Apr; 12(4):384-9.
    View in: PubMed
  14. Thomas RJ, Mietus JE. Mapping sleep using coupled biological oscillations. Conf Proc IEEE Eng Med Biol Soc. 2011; 2011:1479-82.
    View in: PubMed
  15. Gilmartin G, McGeehan B, Vigneault K, Daly RW, Manento M, Weiss JW, Thomas RJ. Treatment of positive airway pressure treatment-associated respiratory instability with enhanced expiratory rebreathing space (EERS). J Clin Sleep Med. 2010 Dec 15; 6(6):529-38.
    View in: PubMed
  16. Ibrahim LH, Jacono FJ, Patel SR, Thomas RJ, Larkin EK, Mietus JE, Peng CK, Goldberger AL, Redline S. Heritability of abnormalities in cardiopulmonary coupling in sleep apnea: use of an electrocardiogram-based technique. Sleep. 2010 May; 33(5):643-6.
    View in: PubMed
  17. Thomas RJ, Mietus JE, Peng CK, Goldberger AL, Crofford LJ, Chervin RD. Impaired sleep quality in fibromyalgia: Detection and quantification with ECG-based cardiopulmonary coupling spectrograms. Sleep Med. 2010 May; 11(5):497-8.
    View in: PubMed
  18. Thomas RJ, Weiss MD, Mietus JE, Peng CK, Goldberger AL, Gottlieb DJ. Prevalent hypertension and stroke in the Sleep Heart Health Study: association with an ECG-derived spectrographic marker of cardiopulmonary coupling. Sleep. 2009 Jul; 32(7):897-904.
    View in: PubMed
  19. Thomas RJ. Strong chemoreflex modulation of sleep-breathing: some answers but even more questions. J Clin Sleep Med. 2009 Jun 15; 5(3):212-4.
    View in: PubMed
  20. Weiss MD, Tamisier R, Boucher J, Lynch M, Gilmartin G, Weiss JW, Thomas RJ. A pilot study of sleep, cognition, and respiration under 4 weeks of intermittent nocturnal hypoxia in adult humans. Sleep Med. 2009 Aug; 10(7):739-45.
    View in: PubMed
  21. Joseph E. Mietus Chung-Kang Peng Robert J. Thomas Ary L. Goldberger. Assessment of sleep quality and sleep disordered breathing based on cardiopulmonary coupling. 2008.
  22. Thomas RJ, Mietus JE, Peng CK, Gilmartin G, Daly RW, Goldberger AL, Gottlieb DJ. Differentiating obstructive from central and complex sleep apnea using an automated electrocardiogram-based method. Sleep. 2007 Dec; 30(12):1756-69.
    View in: PubMed
  23. Thomas RJ, Tamisier R, Boucher J, Kotlar Y, Vigneault K, Weiss JW, Gilmartin G. Nocturnal hypoxia exposure with simulated altitude for 14 days does not significantly alter working memory or vigilance in humans. Sleep. 2007 Sep; 30(9):1195-203.
    View in: PubMed
  24. Yeh GY, Mietus JE, Peng CK, Phillips RS, Davis RB, Wayne PM, Goldberger AL, Thomas RJ. Enhancement of sleep stability with Tai Chi exercise in chronic heart failure: preliminary findings using an ECG-based spectrogram method. Sleep Med. 2008 Jul; 9(5):527-36.
    View in: PubMed
  25. Thomas RJ. Cyclic alternating pattern in the electroencephalogram: what is its clinical utility? Sleep. 2007 May; 30(5):553-5.
    View in: PubMed
  26. Thomas RJ, Kwong K. Modafinil activates cortical and subcortical sites in the sleep-deprived state. Sleep. 2006 Nov; 29(11):1471-81.
    View in: PubMed
  27. Thomas RJ. Sleep fragmentation and arousals from sleep-time scales, associations, and implications. Clin Neurophysiol. 2006 Apr; 117(4):707-11.
    View in: PubMed
  28. Surman CB, Thomas RJ, Aleardi M, Pagano C, Biederman J. Adults with ADHD and sleep complaints: a pilot study identifying sleep-disordered breathing using polysomnography and sleep quality assessment. J Atten Disord. 2006 Feb; 9(3):550-5.
    View in: PubMed
  29. Deldin PJ, Phillips LK, Thomas RJ. A preliminary study of sleep-disordered breathing in major depressive disorder. Sleep Med. 2006 Mar; 7(2):131-9.
    View in: PubMed
  30. Gilmartin GS, Daly RW, Thomas RJ. Recognition and management of complex sleep-disordered breathing. Curr Opin Pulm Med. 2005 Nov; 11(6):485-93.
    View in: PubMed
  31. Thomas RJ. Fatigue in the executive cortical network demonstrated in narcoleptics using functional magnetic resonance imaging--a preliminary study. Sleep Med. 2005 Sep; 6(5):399-406.
    View in: PubMed
  32. Thomas RJ, Mietus JE, Peng CK, Goldberger AL. An electrocardiogram-based technique to assess cardiopulmonary coupling during sleep. Sleep. 2005 Sep; 28(9):1151-61.
    View in: PubMed
  33. Parrino L, Thomas RJ, Smerieri A, Spaggiari MC, Del Felice A, Terzano MG. Reorganization of sleep patterns in severe OSAS under prolonged CPAP treatment. Clin Neurophysiol. 2005 Sep; 116(9):2228-39.
    View in: PubMed
  34. Thomas RJ, Rosen BR, Stern CE, Weiss JW, Kwong KK. Functional imaging of working memory in obstructive sleep-disordered breathing. J Appl Physiol. 2005 Jun; 98(6):2226-34.
    View in: PubMed
  35. Thomas RJ. Effect of added dead space to positive airway pressure for treatment of complex sleep-disordered breathing. Sleep Med. 2005 Mar; 6(2):177-8.
    View in: PubMed
  36. Thomas RJ, Daly RW, Weiss JW. Low-concentration carbon dioxide is an effective adjunct to positive airway pressure in the treatment of refractory mixed central and obstructive sleep-disordered breathing. Sleep. 2005 Jan; 28(1):69-77.
    View in: PubMed
  37. Gilmartin GS, Thomas RJ. Mechanisms of arousal from sleep and their consequences. Curr Opin Pulm Med. 2004 Nov; 10(6):468-74.
    View in: PubMed
  38. Thomas RJ, Terzano MG, Parrino L, Weiss JW. Obstructive sleep-disordered breathing with a dominant cyclic alternating pattern--a recognizable polysomnographic variant with practical clinical implications. Sleep. 2004 Mar 15; 27(2):229-34.
    View in: PubMed
  39. Thomas RJ. Arousals in sleep-disordered breathing: patterns and implications. Sleep. 2003 Dec 15; 26(8):1042-7.
    View in: PubMed
  40. Thomas RJ, Kwong K. Computational neuroanatomy in sleep-disordered breathing and related disorders. Sleep Med. 2003 Sep; 4(5):379-80.
    View in: PubMed
  41. Thomas RJ. Cyclic alternating pattern and positive airway pressure titration. Sleep Med. 2002 Jul; 3(4):315-22.
    View in: PubMed
  42. Thomas RJ. Seizures and epilepsy in the elderly. Arch Intern Med. 1997 Mar 24; 157(6):605-17.
    View in: PubMed
  43. Thomas RJ, Reagan DR. Association of a Tourette-like syndrome with ofloxacin. Ann Pharmacother. 1996 Feb; 30(2):138-41.
    View in: PubMed
  44. Thomas RJ. Excitatory amino acids in health and disease. J Am Geriatr Soc. 1995 Nov; 43(11):1279-89.
    View in: PubMed
  45. Thomas RJ. Neurotoxicity of antibacterial therapy. South Med J. 1994 Sep; 87(9):869-74.
    View in: PubMed
  46. Thomas RJ. Blinking and the release reflexes: are they clinically useful? J Am Geriatr Soc. 1994 Jun; 42(6):609-13.
    View in: PubMed
  47. Bambery P, Thomas RJ, Malhotra HS, Kaur U, Bhusnurmath SR, Deodhar SD. Adult onset Still's disease: clinical experience with 18 patients over 15 years in northern India. Ann Rheum Dis. 1992 Apr; 51(4):529-32.
    View in: PubMed
Local representatives can answer questions about the Profiles website or help with editing a profile or issues with profile data. For assistance with this profile: HMS/HSDM faculty should contact Human Resources at faculty_serviceshms.harvard.edu.
Thomas's Networks
Click the "See All" links for more information and interactive visualizations!
Concepts
See all (195) concept(s)
_
Co-Authors
See all (20) people
_
Similar People
See all (60) people
_
Same Department
Search Department
Physical Neighbors
_