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Maristela Lika Onozato, Ph.D., M.D.

TitleResearch Fellow in Pathology (EXT)
InstitutionMassachusetts General Hospital
DepartmentPathology
AddressPathology Informatics
# 820
101 Merrimac St
Boston MA 02114
Phone617/643-5162
Fax617/643-7901

 Bibliographic 
 selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Sällström J, Peuckert C, Gao X, Larsson E, Nilsson A, Jensen BL, Onozato ML, Persson AE, Kullander K, Carlström M. Impaired EphA4 signaling leads to congenital hydronephrosis, renal injury, and hypertension. Am J Physiol Renal Physiol. 2013 Jul; 305(1):F71-9.
    View in: PubMed
  2. Onozato ML, Kovach AE, Yeap BY, Morales-Oyarvide V, Klepeis VE, Tammireddy S, Heist RS, Mark EJ, Dias-Santagata D, Iafrate AJ, Yagi Y, Mino-Kenudson M. Tumor Islands in Resected Early-stage Lung Adenocarcinomas are Associated With Unique Clinicopathologic and Molecular Characteristics and Worse Prognosis. Am J Surg Pathol. 2013 Feb; 37(2):287-94.
    View in: PubMed
  3. Lee RE, McClintock DS, Balis UJ, Baron JM, Becich MJ, Beckwith BA, Brodsky VB, Carter AB, Dighe AS, Haghighi M, Hipp JD, Henricks WH, Kim JY, Klepseis VE, Kuo FC, Lane WJ, Levy BP, Onozato ML, Park SL, Sinard JH, Tuthill MJ, Gilbertson JR. Pathology informatics fellowship retreats: The use of interactive scenarios and case studies as pathology informatics teaching tools. J Pathol Inform. 2012; 3:41.
    View in: PubMed
  4. McClintock DS, Levy BP, Lane WJ, Lee RE, Baron JM, Klepeis VE, Onozato ML, Kim J, Dighe AS, Beckwith BA, Kuo F, Black-Schaffer S, Gilbertson JR. A core curriculum for clinical fellowship training in pathology informatics. J Pathol Inform. 2012; 3:31.
    View in: PubMed
  5. Levy BP, McClintock DS, Lee RE, Lane WJ, Klepeis VE, Baron JM, Onozato ML, Kim J, Brodsky V, Beckwith B, Kuo F, Gilbertson JR. Different tracks for pathology informatics fellowship training: Experiences of and input from trainees in a large multisite fellowship program. J Pathol Inform. 2012; 3:30.
    View in: PubMed
  6. Lai EY, Luo Z, Onozato ML, Rudolph EH, Solis G, Jose PA, Wellstein A, Aslam S, Quinn MT, Griendling K, Le T, Li P, Palm F, Welch WJ, Wilcox CS. Effects of the antioxidant drug tempol on renal oxygenation in mice with reduced renal mass. Am J Physiol Renal Physiol. 2012 Jul 1; 303(1):F64-74.
    View in: PubMed
  7. Gilbertson JR, McClintock DS, Lee RE, Onozato M, Kuo FC, Beckwith BA, Yagi Y, Dighe AS, Gudewicz TM, Le LP, Wilbur DC, Kim JY, Brodsky VB, Black-Schaffer S. Clinical fellowship training in pathology informatics: A program description. J Pathol Inform. 2012; 3:11.
    View in: PubMed
  8. Onozato ML, Hammond S, Merren M, Yagi Y. Evaluation of a completely automated tissue-sectioning machine for paraffin blocks. Stud Health Technol Inform. 2012; 179:233-8.
    View in: PubMed
  9. Onozato ML, Klepeis VE, Yagi Y, Mino-Kenudson M. A role of three-dimensional (3D)-reconstruction in the classification of lung adenocarcinoma. Anal Cell Pathol (Amst). 2012; 35(2):79-84.
    View in: PubMed
  10. Yagi Y, Yoshioka S, Kyusojin H, Onozato M, Mizutani Y, Osato K, Yada H, Mark EJ, Frosch MP, Louis DN. An ultra-high speed whole slide image viewing system. Stud Health Technol Inform. 2012; 179:239-49.
    View in: PubMed
  11. Yagi Y, Yoshioka S, Kyusojin H, Onozato M, Mizutani Y, Osato K, Yada H, Mark EJ, Frosch MP, Louis DN. An ultra-high speed whole slide image viewing system. Anal Cell Pathol (Amst). 2012; 35(1):65-73.
    View in: PubMed
  12. Onozato ML, Klepeis VE, Yagi Y, Mino-Kenudson M. A Role of Three-Dimensional (3D) Reconstruction in the Classification of Lung Adenocarcinoma. Stud Health Technol Inform. 2012; 179:250-6.
    View in: PubMed
  13. Onozato ML, Hammond S, Merren M, Yagi Y. Evaluation of a completely automated tissue-sectioning machine for paraffin blocks. J Clin Pathol. 2013 Feb; 66(2):151-4.
    View in: PubMed
  14. Hariri LP, Mino-Kenudson M, Shea B, Digumarthy S, Onozato M, Yagi Y, Fraire AE, Matsubara O, Mark EJ. Distinct histopathology of acute onset or abrupt exacerbation of hypersensitivity pneumonitis. Hum Pathol. 2012 May; 43(5):660-8.
    View in: PubMed
  15. Wierwille J, Andrews PM, Onozato ML, Jiang J, Cable A, Chen Y. In vivo, label-free, three-dimensional quantitative imaging of kidney microcirculation using Doppler optical coherence tomography. Lab Invest. 2011 Nov; 91(11):1596-604.
    View in: PubMed
  16. Hanamura K, Tojo A, Kinugasa S, Asaba K, Onozato ML, Uozaki H, Fukayama M, Fujita T. Detection of myeloperoxidase in membranous nephropathy-like deposits in patients with anti-neutrophil cytoplasmic antibody-associated glomerulonephritis. Hum Pathol. 2011 May; 42(5):649-58.
    View in: PubMed
  17. Onozato ML, Andrews PM, Li Q, Jiang J, Cable A, Chen Y. Optical coherence tomography of human kidney. J Urol. 2010 May; 183(5):2090-4.
    View in: PubMed
  18. Lai EY, Onozato ML, Solis G, Aslam S, Welch WJ, Wilcox CS. Myogenic responses of mouse isolated perfused renal afferent arterioles: effects of salt intake and reduced renal mass. Hypertension. 2010 Apr; 55(4):983-9.
    View in: PubMed
  19. Palm F, Onozato M, Welch WJ, Wilcox CS. Blood pressure, blood flow, and oxygenation in the clipped kidney of chronic 2-kidney, 1-clip rats: effects of tempol and Angiotensin blockade. Hypertension. 2010 Feb; 55(2):298-304.
    View in: PubMed
  20. Li Q, Onozato ML, Andrews PM, Chen CW, Paek A, Naphas R, Yuan S, Jiang J, Cable A, Chen Y. Automated quantification of microstructural dimensions of the human kidney using optical coherence tomography (OCT). Opt Express. 2009 Aug 31; 17(18):16000-16.
    View in: PubMed
  21. Asaba K, Tojo A, Onozato ML, Kinugasa S, Miyazaki H, Miyashita K, Uehara Y, Hirata Y, Kimura K, Goto A, Omata M, Fujita T. Long-term renal prognosis of IgA nephropathy with therapeutic trend shifts. Intern Med. 2009; 48(11):883-90.
    View in: PubMed
  22. Li Q, Onozato M, Andrews PM, Paek A, Duttaroy A, Shirmahamoodi B, Jiang J, Cable A, Chen Y. Three-dimensional high-resolution optical coherence tomography (OCT) imaging of human kidney. Conf Proc IEEE Eng Med Biol Soc. 2009; 2009:5741-3.
    View in: PubMed
  23. Tojo A, Onozato ML, Kitiyakara C, Kinugasa S, Fukuda S, Sakai T, Fujita T. Glomerular albumin filtration through podocyte cell body in puromycin aminonucleoside nephrotic rat. Med Mol Morphol. 2008 Jun; 41(2):92-8.
    View in: PubMed
  24. Andrews PM, Chen Y, Onozato ML, Huang SW, Adler DC, Huber RA, Jiang J, Barry SE, Cable AE, Fujimoto JG. High-resolution optical coherence tomography imaging of the living kidney. Lab Invest. 2008 Apr; 88(4):441-9.
    View in: PubMed
  25. Kido M, Ando K, Onozato ML, Tojo A, Yoshikawa M, Ogita T, Fujita T. Protective effect of dietary potassium against vascular injury in salt-sensitive hypertension. Hypertension. 2008 Feb; 51(2):225-31.
    View in: PubMed
  26. Palm F, Onozato ML, Luo Z, Wilcox CS. Dimethylarginine dimethylaminohydrolase (DDAH): expression, regulation, and function in the cardiovascular and renal systems. Am J Physiol Heart Circ Physiol. 2007 Dec; 293(6):H3227-45.
    View in: PubMed
  27. Onozato ML, Tojo A, Leiper J, Fujita T, Palm F, Wilcox CS. Expression of NG,NG-dimethylarginine dimethylaminohydrolase and protein arginine N-methyltransferase isoforms in diabetic rat kidney: effects of angiotensin II receptor blockers. Diabetes. 2008 Jan; 57(1):172-80.
    View in: PubMed
  28. Wang D, Gill PS, Chabrashvili T, Onozato ML, Raggio J, Mendonca M, Dennehy K, Li M, Modlinger P, Leiper J, Vallance P, Adler O, Leone A, Tojo A, Welch WJ, Wilcox CS. Isoform-specific regulation by N(G),N(G)-dimethylarginine dimethylaminohydrolase of rat serum asymmetric dimethylarginine and vascular endothelium-derived relaxing factor/NO. Circ Res. 2007 Sep 14; 101(6):627-35.
    View in: PubMed
  29. Tojo A, Asaba K, Onozato ML. Suppressing renal NADPH oxidase to treat diabetic nephropathy. Expert Opin Ther Targets. 2007 Aug; 11(8):1011-8.
    View in: PubMed
  30. Onozato ML, Tojo A, Kobayashi N, Goto A, Matsuoka H, Fujita T. Dual blockade of aldosterone and angiotensin II additively suppresses TGF-beta and NADPH oxidase in the hypertensive kidney. Nephrol Dial Transplant. 2007 May; 22(5):1314-22.
    View in: PubMed
  31. Nilwarangkoon S, Anzai N, Shiraya K, Yu E, Islam R, Cha SH, Onozato ML, Miura D, Jutabha P, Tojo A, Kanai Y, Endou H. Role of mouse organic anion transporter 3 (mOat3) as a basolateral prostaglandin E2 transport pathway. J Pharmacol Sci. 2007 Jan; 103(1):48-55.
    View in: PubMed
  32. Asaba K, Tojo A, Onozato ML, Goto A, Fujita T. Double-edged action of SOD mimetic in diabetic nephropathy. J Cardiovasc Pharmacol. 2007 Jan; 49(1):13-9.
    View in: PubMed
  33. Nishi H, Tojo A, Onozato ML, Jimbo R, Nangaku M, Uozaki H, Hirano K, Isayama H, Omata M, Kaname S, Fujita T. Anti-carbonic anhydrase II antibody in autoimmune pancreatitis and tubulointerstitial nephritis. Nephrol Dial Transplant. 2007 Apr; 22(4):1273-5.
    View in: PubMed
  34. Tojo A, Onozato ML, Fujita T. Repeated subileus due to angioedema during renin-angiotensin system blockade. Am J Med Sci. 2006 Jul; 332(1):36-8.
    View in: PubMed
  35. Tojo A, Onozato ML, Asaba K, Fujita T. Spironolactone with ACE inhibitor is effective in gross hematuria caused by nephroptosis. Int J Urol. 2006 Jul; 13(7):990-2.
    View in: PubMed
  36. Tojo A, Onozato ML, Fujita T. Role of macula densa neuronal nitric oxide synthase in renal diseases. Med Mol Morphol. 2006 Mar; 39(1):2-7.
    View in: PubMed
  37. Asaba K, Tojo A, Onozato ML, Goto A, Quinn MT, Fujita T, Wilcox CS. Effects of NADPH oxidase inhibitor in diabetic nephropathy. Kidney Int. 2005 May; 67(5):1890-8.
    View in: PubMed
  38. Tagawa H, Kizuka Y, Ikeda T, Itoh S, Kawasaki N, Kurihara H, Onozato ML, Tojo A, Sakai T, Kawasaki T, Oka S. A non-sulfated form of the HNK-1 carbohydrate is expressed in mouse kidney. J Biol Chem. 2005 Jun 24; 280(25):23876-83.
    View in: PubMed
  39. Kobayashi N, Hara K, Tojo A, Onozato ML, Honda T, Yoshida K, Mita S, Nakano S, Tsubokou Y, Matsuoka H. Eplerenone shows renoprotective effect by reducing LOX-1-mediated adhesion molecule, PKCepsilon-MAPK-p90RSK, and Rho-kinase pathway. Hypertension. 2005 Apr; 45(4):538-44.
    View in: PubMed
  40. Tojo A, Onozato ML, Kobayashi N, Goto A, Matsuoka H, Fujita T. Antioxidative effect of p38 mitogen-activated protein kinase inhibitor in the kidney of hypertensive rat. J Hypertens. 2005 Jan; 23(1):165-74.
    View in: PubMed
  41. Tojo A, Onozato ML, Fukuda S, Asaba K, Kimura K, Fujita T. Nitric oxide generated by nNOS in the macula densa regulates the afferent arteriolar diameter in rat kidney. Med Electron Microsc. 2004 Dec; 37(4):236-41.
    View in: PubMed
  42. Hasannejad H, Takeda M, Narikawa S, Huang XL, Enomoto A, Taki K, Niwa T, Jung SH, Onozato ML, Tojo A, Endou H. Human organic cation transporter 3 mediates the transport of antiarrhythmic drugs. Eur J Pharmacol. 2004 Sep 19; 499(1-2):45-51.
    View in: PubMed
  43. Onozato ML, Tojo A, Goto A, Fujita T. Radical scavenging effect of gliclazide in diabetic rats fed with a high cholesterol diet. Kidney Int. 2004 Mar; 65(3):951-60.
    View in: PubMed
  44. Kawai J, Ando K, Tojo A, Shimosawa T, Takahashi K, Onozato ML, Yamasaki M, Ogita T, Nakaoka T, Fujita T. Endogenous adrenomedullin protects against vascular response to injury in mice. Circulation. 2004 Mar 9; 109(9):1147-53.
    View in: PubMed
  45. Takeda M, Noshiro R, Onozato ML, Tojo A, Hasannejad H, Huang XL, Narikawa S, Endou H. Evidence for a role of human organic anion transporters in the muscular side effects of HMG-CoA reductase inhibitors. Eur J Pharmacol. 2004 Jan 12; 483(2-3):133-8.
    View in: PubMed
  46. Asaba K, Tojo A, Onozato ML, Mimura N, Kido M, Goto A, Endo H, Fujita T. Fibrillary glomerulonephritis associated with essential thrombocytosis. Clin Exp Nephrol. 2003 Dec; 7(4):296-300.
    View in: PubMed
  47. Alebouyeh M, Takeda M, Onozato ML, Tojo A, Noshiro R, Hasannejad H, Inatomi J, Narikawa S, Huang XL, Khamdang S, Anzai N, Endou H. Expression of human organic anion transporters in the choroid plexus and their interactions with neurotransmitter metabolites. J Pharmacol Sci. 2003 Dec; 93(4):430-6.
    View in: PubMed
  48. Hasannejad H, Takeda M, Taki K, Shin HJ, Babu E, Jutabha P, Khamdang S, Aleboyeh M, Onozato ML, Tojo A, Enomoto A, Anzai N, Narikawa S, Huang XL, Niwa T, Endou H. Interactions of human organic anion transporters with diuretics. J Pharmacol Exp Ther. 2004 Mar; 308(3):1021-9.
    View in: PubMed
  49. Tojo A, Onozato ML, Kurihara H, Sakai T, Goto A, Fujita T. Angiotensin II blockade restores albumin reabsorption in the proximal tubules of diabetic rats. Hypertens Res. 2003 May; 26(5):413-9.
    View in: PubMed
  50. Khamdang S, Takeda M, Babu E, Noshiro R, Onozato ML, Tojo A, Enomoto A, Huang XL, Narikawa S, Anzai N, Piyachaturawat P, Endou H. Interaction of human and rat organic anion transporter 2 with various cephalosporin antibiotics. Eur J Pharmacol. 2003 Mar 28; 465(1-2):1-7.
    View in: PubMed
  51. Onozato ML, Tojo A, Goto A, Fujita T. Effect of combination therapy with dipyridamole and quinapril in diabetic nephropathy. Diabetes Res Clin Pract. 2003 Feb; 59(2):83-92.
    View in: PubMed
  52. Ueno T, Kaname S, Takaichi K, Nagase M, Tojo A, Onozato ML, Fujita T. LOX-1, an oxidized low-density lipoprotein receptor, was upregulated in the kidneys of chronic renal failure rats. Hypertens Res. 2003 Jan; 26(1):117-22.
    View in: PubMed
  53. Tojo A, Onozato ML, Kobayashi N, Goto A, Matsuoka H, Fujita T. Angiotensin II and oxidative stress in Dahl Salt-sensitive rat with heart failure. Hypertension. 2002 Dec; 40(6):834-9.
    View in: PubMed
  54. Chabrashvili T, Tojo A, Onozato ML, Kitiyakara C, Quinn MT, Fujita T, Welch WJ, Wilcox CS. Expression and cellular localization of classic NADPH oxidase subunits in the spontaneously hypertensive rat kidney. Hypertension. 2002 Feb; 39(2):269-74.
    View in: PubMed
  55. Onozato ML, Tojo A, Goto A, Fujita T, Wilcox CS. Oxidative stress and nitric oxide synthase in rat diabetic nephropathy: effects of ACEI and ARB. Kidney Int. 2002 Jan; 61(1):186-94.
    View in: PubMed
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