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Rohit N. Kulkarni, PH.D., M.D.

TitleAssociate Professor of Medicine
InstitutionJoslin Diabetes Center
DepartmentMedicine
AddressJoslin Diabetes Center
One Joslin Place - Rm 602
Research 6th Floor
Boston MA 02215
Phone617/309-3460
Fax617/309-3476

 Research 
 research resources
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in the eagle-i Network. To update or add resource records, contact
eagle-i@hms.harvard.edu.
Specialized Assay Core (JDC) - Core services (6)

 Bibliographic 
 selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Winnay JN, Dirice E, Liew CW, Kulkarni RN, Kahn CR. p85a deficiency protects ß-cells from endoplasmic reticulum stress-induced apoptosis. Proc Natl Acad Sci U S A. 2014 Jan 21; 111(3):1192-7.
    View in: PubMed
  2. Dirice E, Kahraman S, Jiang W, El Ouaamari A, De Jesus DF, Teo AK, Hu J, Kawamori D, Gaglia JL, Mathis D, Kulkarni RN. Soluble Factors Secreted by T Cells Promote ß-Cell Proliferation. Diabetes. 2014 Jan; 63(1):188-202.
    View in: PubMed
  3. Ræder H, McAllister FE, Tjora E, Bhatt S, Haldorsen I, Hu J, Willems SM, Vesterhus M, El Ouaamari A, Liu M, Ræder MB, Immervoll H, Hoem D, Dimcevski G, Njølstad PR, Molven A, Gygi SP, Kulkarni RN. Carboxyl-ester lipase maturity-onset diabetes of the young is associated with development of pancreatic cysts and upregulated MAPK signaling in secretin-stimulated duodenal fluid. Diabetes. 2014 Jan; 63(1):259-69.
    View in: PubMed
  4. Teo AK, Wagers AJ, Kulkarni RN. New opportunities: harnessing induced pluripotency for discovery in diabetes and metabolism. Cell Metab. 2013 Dec 3; 18(6):775-91.
    View in: PubMed
  5. Negahdar M, Aukrust I, Molnes J, Solheim MH, Johansson BB, Sagen JV, Dahl-Jørgensen K, Kulkarni RN, Søvik O, Flatmark T, Njølstad PR, Bjørkhaug L. GCK-MODY diabetes as a protein misfolding disease: The mutation R275C promotes protein misfolding, self-association and cellular degradation. Mol Cell Endocrinol. 2014 Jan 25; 382(1):55-65.
    View in: PubMed
  6. Pockros PJ, Jensen D, Tsai N, Taylor R, Ramji A, Cooper C, Dickson R, Tice A, Kulkarni R, Vierling JM, Lou Munson M, Chen YC, Najera I, Thommes J. JUMP-C: A randomized trial of mericitabine plus pegylated interferon alpha-2a/ribavirin for 24 weeks in treatment-naïve HCV genotype 1/4 patients. Hepatology. 2013 Aug; 58(2):514-23.
    View in: PubMed
  7. Ræder H, Vesterhus M, El Ouaamari A, Paulo JA, McAllister FE, Liew CW, Hu J, Kawamori D, Molven A, Gygi SP, Njølstad PR, Kahn CR, Kulkarni RN. Absence of Diabetes and Pancreatic Exocrine Dysfunction in a Transgenic Model of Carboxyl-Ester Lipase-MODY (Maturity-Onset Diabetes of the Young). PLoS One. 2013; 8(4):e60229.
    View in: PubMed
  8. Akiyama M, Liew CW, Lu S, Hu J, Martinez R, Hambro B, Kennedy RT, Kulkarni RN. X-Box Binding Protein 1 Is Essential for Insulin Regulation of Pancreatic a-Cell Function. Diabetes. 2013 Jul; 62(7):2439-49.
    View in: PubMed
  9. El Ouaamari A, Kawamori D, Dirice E, Liew CW, Shadrach JL, Hu J, Katsuta H, Hollister-Lock J, Qian WJ, Wagers AJ, Kulkarni RN. Liver-Derived Systemic Factors Drive ß Cell Hyperplasia in Insulin-Resistant States. Cell Rep. 2013 Feb 21; 3(2):401-10.
    View in: PubMed
  10. Teo AK, Windmueller R, Johansson BB, Dirice E, Njolstad PR, Tjora E, Raeder H, Kulkarni RN. Derivation of human induced pluripotent stem cells from patients with maturity onset diabetes of the young. J Biol Chem. 2013 Feb 22; 288(8):5353-6.
    View in: PubMed
  11. Aukrust I, Bjørkhaug L, Negahdar M, Molnes J, Johansson BB, Müller Y, Haas W, Gygi SP, Søvik O, Flatmark T, Kulkarni RN, Njølstad PR. SUMOylation of Pancreatic Glucokinase Regulates Its Cellular Stability and Activity. J Biol Chem. 2013 Feb 22; 288(8):5951-62.
    View in: PubMed
  12. Liew CW, Boucher J, Cheong JK, Vernochet C, Koh HJ, Mallol C, Townsend K, Langin D, Kawamori D, Hu J, Tseng YH, Hellerstein MK, Farmer SR, Goodyear L, Doria A, Blüher M, Hsu SI, Kulkarni RN. Ablation of TRIP-Br2, a regulator of fat lipolysis, thermogenesis and oxidative metabolism, prevents diet-induced obesity and insulin resistance. Nat Med. 2013 Feb; 19(2):217-26.
    View in: PubMed
  13. Koh HJ, Toyoda T, Didesch MM, Lee MY, Sleeman MW, Kulkarni RN, Musi N, Hirshman MF, Goodyear LJ. Tribbles 3 mediates endoplasmic reticulum stress-induced insulin resistance in skeletal muscle. Nat Commun. 2013; 4:1871.
    View in: PubMed
  14. Su D, Shukla AK, Chen B, Kim JS, Nakayasu E, Qu Y, Aryal U, Weitz K, Clauss TR, Monroe ME, Camp Ii DG, Bigelow DJ, Smith RD, Kulkarni RN, Qian WJ. Quantitative site-specific reactivity profiling of S-nitrosylation in mouse skeletal muscle using cysteinyl peptide enrichment coupled with mass spectrometry. Free Radic Biol Med. 2013 Apr; 57:68-78.
    View in: PubMed
  15. Goldfine AB, Kulkarni RN. Modulation of ß-cell function: a translational journey from the bench to the bedside. Diabetes Obes Metab. 2012 Oct; 14 Suppl 3:152-60.
    View in: PubMed
  16. Teo AK, Kulkarni RN. Setting sail for glucose homeostasis with the AKAP150-PP2B-anchor. EMBO J. 2012 Oct 17; 31(20):3956-7.
    View in: PubMed
  17. Kulkarni RN. Identifying biomarkers of subclinical diabetes. Diabetes. 2012 Aug; 61(8):1925-6.
    View in: PubMed
  18. Negahdar M, Aukrust I, Johansson BB, Molnes J, Molven A, Matschinsky FM, Søvik O, Kulkarni RN, Flatmark T, Njølstad PR, Bjørkhaug L. GCK-MODY diabetes associated with protein misfolding, cellular self-association and degradation. Biochim Biophys Acta. 2012 Nov; 1822(11):1705-15.
    View in: PubMed
  19. Welters HJ, El Ouaamari A, Kawamori D, Meyer J, Hu J, Smith DM, Kulkarni RN. Rosiglitazone promotes PPAR?-dependent and -independent alterations in gene expression in mouse islets. Endocrinology. 2012 Oct; 153(10):4593-9.
    View in: PubMed
  20. Kulkarni RN, Mizrachi EB, Ocana AG, Stewart AF. Human ß-cell proliferation and intracellular signaling: driving in the dark without a road map. Diabetes. 2012 Sep; 61(9):2205-13.
    View in: PubMed
  21. Morioka T, Dishinger JF, Reid KR, Liew CW, Zhang T, Inaba M, Kennedy RT, Kulkarni RN. Enhanced GLP-1- and sulfonylurea-induced insulin secretion in islets lacking leptin signaling. Mol Endocrinol. 2012 Jun; 26(6):967-76.
    View in: PubMed
  22. Kim W, Lao Q, Shin YK, Carlson OD, Lee EK, Gorospe M, Kulkarni RN, Egan JM. Cannabinoids induce pancreatic ß-cell death by directly inhibiting insulin receptor activation. Sci Signal. 2012 Mar 20; 5(216):ra23.
    View in: PubMed
  23. Lee EK, Kim W, Tominaga K, Martindale JL, Yang X, Subaran SS, Carlson OD, Mercken EM, Kulkarni RN, Akamatsu W, Okano H, Perrone-Bizzozero NI, de Cabo R, Egan JM, Gorospe M. RNA-binding protein HuD controls insulin translation. Mol Cell. 2012 Mar 30; 45(6):826-35.
    View in: PubMed
  24. Halperin F, Lopez X, Manning R, Kahn CR, Kulkarni RN, Goldfine AB. Insulin augmentation of glucose-stimulated insulin secretion is impaired in insulin-resistant humans. Diabetes. 2012 Feb; 61(2):301-9.
    View in: PubMed
  25. Kebede M, Ferdaoussi M, Mancini A, Alquier T, Kulkarni RN, Walker MD, Poitout V. Glucose activates free fatty acid receptor 1 gene transcription via phosphatidylinositol-3-kinase-dependent O-GlcNAcylation of pancreas-duodenum homeobox-1. Proc Natl Acad Sci U S A. 2012 Feb 14; 109(7):2376-81.
    View in: PubMed
  26. Chu TW, Kulkarni R, Gane EJ, Roberts SK, Stedman C, Angus PW, Ritchie B, Lu XY, Ipe D, Lopatin U, Germer S, Iglesias VA, Elston R, Smith PF, Shulman NS. Effect of IL28B genotype on early viral kinetics during interferon-free treatment of patients with chronic hepatitis C. Gastroenterology. 2012 Apr; 142(4):790-5.
    View in: PubMed
  27. Galkina EV, Butcher M, Keller SR, Goff M, Bruce A, Pei H, Sarembock IJ, Sanders JM, Nagelin MH, Srinivasan S, Kulkarni RN, Hedrick CC, Lattanzio FA, Dobrian AD, Nadler JL, Ley K. Accelerated atherosclerosis in Apoe-/- mice heterozygous for the insulin receptor and the insulin receptor substrate-1. Arterioscler Thromb Vasc Biol. 2012 Feb; 32(2):247-56.
    View in: PubMed
  28. Folli F, Okada T, Perego C, Gunton J, Liew CW, Akiyama M, D'Amico A, La Rosa S, Placidi C, Lupi R, Marchetti P, Sesti G, Hellerstein M, Perego L, Kulkarni RN. Altered insulin receptor signalling and ß-cell cycle dynamics in type 2 diabetes mellitus. PLoS One. 2011; 6(11):e28050.
    View in: PubMed
  29. Kawamori D, Akiyama M, Hu J, Hambro B, Kulkarni RN. Growth factor signalling in the regulation of a-cell fate. Diabetes Obes Metab. 2011 Oct; 13 Suppl 1:21-30.
    View in: PubMed
  30. Lopez X, Cypess A, Manning R, O'Shea S, Kulkarni RN, Goldfine AB. Exogenous insulin enhances glucose-stimulated insulin response in healthy humans independent of changes in free fatty acids. J Clin Endocrinol Metab. 2011 Dec; 96(12):3811-21.
    View in: PubMed
  31. Rowland KJ, Trivedi S, Lee D, Wan K, Kulkarni RN, Holzenberger M, Brubaker PL. Loss of glucagon-like peptide-2-induced proliferation following intestinal epithelial insulin-like growth factor-1-receptor deletion. Gastroenterology. 2011 Dec; 141(6):2166-2175.e7.
    View in: PubMed
  32. Zhou JY, Dann GP, Liew CW, Smith RD, Kulkarni RN, Qian WJ. Unraveling pancreatic islet biology by quantitative proteomics. Expert Rev Proteomics. 2011 Aug; 8(4):495-504.
    View in: PubMed
  33. Lin W, Cao J, Liu J, Beshiri ML, Fujiwara Y, Francis J, Cherniack AD, Geisen C, Blair LP, Zou MR, Shen X, Kawamori D, Liu Z, Grisanzio C, Watanabe H, Minamishima YA, Zhang Q, Kulkarni RN, Signoretti S, Rodig SJ, Bronson RT, Orkin SH, Tuck DP, Benevolenskaya EV, Meyerson M, Kaelin WG, Yan Q. Loss of the retinoblastoma binding protein 2 (RBP2) histone demethylase suppresses tumorigenesis in mice lacking Rb1 or Men1. Proc Natl Acad Sci U S A. 2011 Aug 16; 108(33):13379-86.
    View in: PubMed
  34. Reiner T, Thurber G, Gaglia J, Vinegoni C, Liew CW, Upadhyay R, Kohler RH, Li L, Kulkarni RN, Benoist C, Mathis D, Weissleder R. Accurate measurement of pancreatic islet beta-cell mass using a second-generation fluorescent exendin-4 analog. Proc Natl Acad Sci U S A. 2011 Aug 2; 108(31):12815-20.
    View in: PubMed
  35. Hinault C, Kawamori D, Liew CW, Maier B, Hu J, Keller SR, Mirmira RG, Scrable H, Kulkarni RN. ?40 Isoform of p53 controls ß-cell proliferation and glucose homeostasis in mice. Diabetes. 2011 Apr; 60(4):1210-22.
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  36. Kim W, Doyle ME, Liu Z, Lao Q, Shin YK, Carlson OD, Kim HS, Thomas S, Napora JK, Lee EK, Moaddel R, Wang Y, Maudsley S, Martin B, Kulkarni RN, Egan JM. Cannabinoids inhibit insulin receptor signaling in pancreatic ß-cells. Diabetes. 2011 Apr; 60(4):1198-209.
    View in: PubMed
  37. Kaneko K, Ueki K, Takahashi N, Hashimoto S, Okamoto M, Awazawa M, Okazaki Y, Ohsugi M, Inabe K, Umehara T, Yoshida M, Kakei M, Kitamura T, Luo J, Kulkarni RN, Kahn CR, Kasai H, Cantley LC, Kadowaki T. Class IA phosphatidylinositol 3-kinase in pancreatic ß cells controls insulin secretion by multiple mechanisms. Cell Metab. 2010 Dec 1; 12(6):619-32.
    View in: PubMed
  38. Kulkarni RN. GIP: no longer the neglected incretin twin? Sci Transl Med. 2010 Sep 15; 2(49):49ps47.
    View in: PubMed
  39. Vesterhus M, Raeder H, Kurpad AJ, Kawamori D, Molven A, Kulkarni RN, Kahn CR, Njølstad PR. Pancreatic function in carboxyl-ester lipase knockout mice. Pancreatology. 2010; 10(4):467-76.
    View in: PubMed
  40. Reiner T, Kohler RH, Liew CW, Hill JA, Gaglia J, Kulkarni RN, Weissleder R. Near-infrared fluorescent probe for imaging of pancreatic beta cells. Bioconjug Chem. 2010 Jul 21; 21(7):1362-8.
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  41. Liew CW, Bochenski J, Kawamori D, Hu J, Leech CA, Wanic K, Malecki M, Warram JH, Qi L, Krolewski AS, Kulkarni RN. The pseudokinase tribbles homolog 3 interacts with ATF4 to negatively regulate insulin exocytosis in human and mouse beta cells. J Clin Invest. 2010 Aug; 120(8):2876-88.
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  42. Cheng K, Ho K, Stokes R, Scott C, Lau SM, Hawthorne WJ, O'Connell PJ, Loudovaris T, Kay TW, Kulkarni RN, Okada T, Wang XL, Yim SH, Shah Y, Grey ST, Biankin AV, Kench JG, Laybutt DR, Gonzalez FJ, Kahn CR, Gunton JE. Hypoxia-inducible factor-1alpha regulates beta cell function in mouse and human islets. J Clin Invest. 2010 Jun; 120(6):2171-83.
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  43. Bouche C, Lopez X, Fleischman A, Cypess AM, O'Shea S, Stefanovski D, Bergman RN, Rogatsky E, Stein DT, Kahn CR, Kulkarni RN, Goldfine AB. Insulin enhances glucose-stimulated insulin secretion in healthy humans. Proc Natl Acad Sci U S A. 2010 Mar 9; 107(10):4770-5.
    View in: PubMed
  44. Cornu M, Modi H, Kawamori D, Kulkarni RN, Joffraud M, Thorens B. Glucagon-like peptide-1 increases beta-cell glucose competence and proliferation by translational induction of insulin-like growth factor-1 receptor expression. J Biol Chem. 2010 Apr 2; 285(14):10538-45.
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  45. Georgia S, Hinault C, Kawamori D, Hu J, Meyer J, Kanji M, Bhushan A, Kulkarni RN. Cyclin D2 is essential for the compensatory beta-cell hyperplastic response to insulin resistance in rodents. Diabetes. 2010 Apr; 59(4):987-96.
    View in: PubMed
  46. Robertson S, Ishida-Takahashi R, Tawara I, Hu J, Patterson CM, Jones JC, Kulkarni RN, Myers MG. Insufficiency of Janus kinase 2-autonomous leptin receptor signals for most physiologic leptin actions. Diabetes. 2010 Apr; 59(4):782-90.
    View in: PubMed
  47. Kawamori D, Welters HJ, Kulkarni RN. Molecular pathways underlying the pathogenesis of pancreatic alpha-cell dysfunction. Adv Exp Med Biol. 2010; 654:421-45.
    View in: PubMed
  48. Zhang Z, Liew CW, Handy DE, Zhang Y, Leopold JA, Hu J, Guo L, Kulkarni RN, Loscalzo J, Stanton RC. High glucose inhibits glucose-6-phosphate dehydrogenase, leading to increased oxidative stress and beta-cell apoptosis. FASEB J. 2010 May; 24(5):1497-505.
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  49. Liu S, Okada T, Assmann A, Soto J, Liew CW, Bugger H, Shirihai OS, Abel ED, Kulkarni RN. Insulin signaling regulates mitochondrial function in pancreatic beta-cells. PLoS One. 2009; 4(11):e7983.
    View in: PubMed
  50. Zhou JY, Petritis BO, Petritis K, Norbeck AD, Weitz KK, Moore RJ, Camp DG, Kulkarni RN, Smith RD, Qian WJ. Mouse-specific tandem IgY7-SuperMix immunoaffinity separations for improved LC-MS/MS coverage of the plasma proteome. J Proteome Res. 2009 Nov; 8(11):5387-95.
    View in: PubMed
  51. Liew CW, Holman A, Kulkarni RN. The roles of telomeres and telomerase in beta-cell regeneration. Diabetes Obes Metab. 2009 Nov; 11 Suppl 4:21-9.
    View in: PubMed
  52. Kawamori D, Kulkarni RN. Insulin modulation of glucagon secretion: the role of insulin and other factors in the regulation of glucagon secretion. Islets. 2009 Nov-Dec; 1(3):276-9.
    View in: PubMed
  53. Borowiec M, Liew CW, Thompson R, Boonyasrisawat W, Hu J, Mlynarski WM, El Khattabi I, Kim SH, Marselli L, Rich SS, Krolewski AS, Bonner-Weir S, Sharma A, Sale M, Mychaleckyj JC, Kulkarni RN, Doria A. Mutations at the BLK locus linked to maturity onset diabetes of the young and beta-cell dysfunction. Proc Natl Acad Sci U S A. 2009 Aug 25; 106(34):14460-5.
    View in: PubMed
  54. Kulkarni RN. Uncoupling modifier genes from uncoupling protein 2 in pancreatic beta-cells. Endocrinology. 2009 Jul; 150(7):2994-6.
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  55. Kawamori D, Kurpad AJ, Hu J, Liew CW, Shih JL, Ford EL, Herrera PL, Polonsky KS, McGuinness OP, Kulkarni RN. Insulin signaling in alpha cells modulates glucagon secretion in vivo. Cell Metab. 2009 Apr; 9(4):350-61.
    View in: PubMed
  56. Assmann A, Ueki K, Winnay JN, Kadowaki T, Kulkarni RN. Glucose effects on beta-cell growth and survival require activation of insulin receptors and insulin receptor substrate 2. Mol Cell Biol. 2009 Jun; 29(11):3219-28.
    View in: PubMed
  57. Torii S, Saito N, Kawano A, Hou N, Ueki K, Kulkarni RN, Takeuchi T. Gene silencing of phogrin unveils its essential role in glucose-responsive pancreatic beta-cell growth. Diabetes. 2009 Mar; 58(3):682-92.
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  58. Hisanaga E, Nagasawa M, Ueki K, Kulkarni RN, Mori M, Kojima I. Regulation of calcium-permeable TRPV2 channel by insulin in pancreatic beta-cells. Diabetes. 2009 Jan; 58(1):174-84.
    View in: PubMed
  59. Hinault C, Hu J, Maier BF, Mirmira RG, Kulkarni RN. Differential expression of cell cycle proteins during ageing of pancreatic islet cells. Diabetes Obes Metab. 2008 Nov; 10 Suppl 4:136-46.
    View in: PubMed
  60. Welters HJ, Kulkarni RN. Wnt signaling: relevance to beta-cell biology and diabetes. Trends Endocrinol Metab. 2008 Dec; 19(10):349-55.
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  61. Assmann A, Hinault C, Kulkarni RN. Growth factor control of pancreatic islet regeneration and function. Pediatr Diabetes. 2009 Feb; 10(1):14-32.
    View in: PubMed
  62. Wang L, Huang J, Saha P, Kulkarni RN, Hu M, Kim Y, Park K, Chan L, Rajan AS, Lee I, Moore DD. Retraction. Orphan receptor small heterodimer partner is an important mediator of glucose homeostasis. Mol Endocrinol. 2008 Sep; 22(9):2203.
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  63. Tseng YH, Kokkotou E, Schulz TJ, Huang TL, Winnay JN, Taniguchi CM, Tran TT, Suzuki R, Espinoza DO, Yamamoto Y, Ahrens MJ, Dudley AT, Norris AW, Kulkarni RN, Kahn CR. New role of bone morphogenetic protein 7 in brown adipogenesis and energy expenditure. Nature. 2008 Aug 21; 454(7207):1000-4.
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  64. Petyuk VA, Qian WJ, Hinault C, Gritsenko MA, Singhal M, Monroe ME, Camp DG, Kulkarni RN, Smith RD. Characterization of the mouse pancreatic islet proteome and comparative analysis with other mouse tissues. J Proteome Res. 2008 Aug; 7(8):3114-26.
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  65. DeAngelis AM, Heinrich G, Dai T, Bowman TA, Patel PR, Lee SJ, Hong EG, Jung DY, Assmann A, Kulkarni RN, Kim JK, Najjar SM. Carcinoembryonic antigen-related cell adhesion molecule 1: a link between insulin and lipid metabolism. Diabetes. 2008 Sep; 57(9):2296-303.
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  66. Page KA, Dejardin S, Kahn CR, Kulkarni RN, Herold KC, Inzucchi SE. A patient with type B insulin resistance syndrome, responsive to immune therapy. Nat Clin Pract Endocrinol Metab. 2007 Dec; 3(12):835-40.
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  67. Handschin C, Choi CS, Chin S, Kim S, Kawamori D, Kurpad AJ, Neubauer N, Hu J, Mootha VK, Kim YB, Kulkarni RN, Shulman GI, Spiegelman BM. Abnormal glucose homeostasis in skeletal muscle-specific PGC-1alpha knockout mice reveals skeletal muscle-pancreatic beta cell crosstalk. J Clin Invest. 2007 Nov; 117(11):3463-74.
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  68. Morioka T, Asilmaz E, Hu J, Dishinger JF, Kurpad AJ, Elias CF, Li H, Elmquist JK, Kennedy RT, Kulkarni RN. Disruption of leptin receptor expression in the pancreas directly affects beta cell growth and function in mice. J Clin Invest. 2007 Oct; 117(10):2860-8.
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  69. Matsumura K, Chang BH, Fujimiya M, Chen W, Kulkarni RN, Eguchi Y, Kimura H, Kojima H, Chan L. Aquaporin 7 is a beta-cell protein and regulator of intraislet glycerol content and glycerol kinase activity, beta-cell mass, and insulin production and secretion. Mol Cell Biol. 2007 Sep; 27(17):6026-37.
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  70. Kulkarni RN, Kahn CR. Ephs and ephrins keep pancreatic Beta cells connected. Cell. 2007 Apr 20; 129(2):241-3.
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  71. Okada T, Liew CW, Hu J, Hinault C, Michael MD, Krtzfeldt J, Yin C, Holzenberger M, Stoffel M, Kulkarni RN. Insulin receptors in beta-cells are critical for islet compensatory growth response to insulin resistance. Proc Natl Acad Sci U S A. 2007 May 22; 104(21):8977-82.
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  72. Pissios P, Ozcan U, Kokkotou E, Okada T, Liew CW, Liu S, Peters JN, Dahlgren G, Karamchandani J, Kudva YC, Kurpad AJ, Kennedy RT, Maratos-Flier E, Kulkarni RN. Melanin concentrating hormone is a novel regulator of islet function and growth. Diabetes. 2007 Feb; 56(2):311-9.
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  73. Koh HJ, Arnolds DE, Fujii N, Tran TT, Rogers MJ, Jessen N, Li Y, Liew CW, Ho RC, Hirshman MF, Kulkarni RN, Kahn CR, Goodyear LJ. Skeletal muscle-selective knockout of LKB1 increases insulin sensitivity, improves glucose homeostasis, and decreases TRB3. Mol Cell Biol. 2006 Nov; 26(22):8217-27.
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  74. Wang L, Huang J, Saha P, Kulkarni RN, Hu M, Kim Y, Park K, Chan L, Rajan AS, Lee I, Moore DD. Orphan receptor small heterodimer partner is an important mediator of glucose homeostasis. Mol Endocrinol. 2006 Nov; 20(11):2671-81.
    View in: PubMed
  75. Qi L, Heredia JE, Altarejos JY, Screaton R, Goebel N, Niessen S, Macleod IX, Liew CW, Kulkarni RN, Bain J, Newgard C, Nelson M, Evans RM, Yates J, Montminy M. TRB3 links the E3 ubiquitin ligase COP1 to lipid metabolism. Science. 2006 Jun 23; 312(5781):1763-6.
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  76. Ueki K, Okada T, Hu J, Liew CW, Assmann A, Dahlgren GM, Peters JL, Shackman JG, Zhang M, Artner I, Satin LS, Stein R, Holzenberger M, Kennedy RT, Kahn CR, Kulkarni RN. Total insulin and IGF-I resistance in pancreatic beta cells causes overt diabetes. Nat Genet. 2006 May; 38(5):583-8.
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  77. He Z, Opland DM, Way KJ, Ueki K, Bodyak N, Kang PM, Izumo S, Kulkarni RN, Wang B, Liao R, Kahn CR, King GL. Regulation of vascular endothelial growth factor expression and vascularization in the myocardium by insulin receptor and PI3K/Akt pathways in insulin resistance and ischemia. Arterioscler Thromb Vasc Biol. 2006 Apr; 26(4):787-93.
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  78. Neubauer N, Kulkarni RN. Molecular approaches to study control of glucose homeostasis. ILAR J. 2006; 47(3):199-211.
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  79. Gunton JE, Kulkarni RN, Yim S, Okada T, Hawthorne WJ, Tseng YH, Roberson RS, Ricordi C, O'Connell PJ, Gonzalez FJ, Kahn CR. Loss of ARNT/HIF1beta mediates altered gene expression and pancreatic-islet dysfunction in human type 2 diabetes. Cell. 2005 Aug 12; 122(3):337-49.
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  80. Kulkarni RN. New insights into the roles of insulin/IGF-I in the development and maintenance of beta-cell mass. Rev Endocr Metab Disord. 2005 Aug; 6(3):199-210.
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  81. Hennige AM, Ozcan U, Okada T, Jhala US, Schubert M, White MF, Kulkarni RN. Alterations in growth and apoptosis of insulin receptor substrate-1-deficient beta-cells. Am J Physiol Endocrinol Metab. 2005 Aug; 289(2):E337-46.
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  82. Bates SH, Kulkarni RN, Seifert M, Myers MG. Roles for leptin receptor/STAT3-dependent and -independent signals in the regulation of glucose homeostasis. Cell Metab. 2005 Mar; 1(3):169-78.
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  83. Kulkarni RN, Jhala US, Winnay JN, Krajewski S, Montminy M, Kahn CR. PDX-1 haploinsufficiency limits the compensatory islet hyperplasia that occurs in response to insulin resistance. J Clin Invest. 2004 Sep; 114(6):828-36.
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  84. Kulkarni RN, Roper MG, Dahlgren G, Shih DQ, Kauri LM, Peters JL, Stoffel M, Kennedy RT. Islet secretory defect in insulin receptor substrate 1 null mice is linked with reduced calcium signaling and expression of sarco(endo)plasmic reticulum Ca2+-ATPase (SERCA)-2b and -3. Diabetes. 2004 Jun; 53(6):1517-25.
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  85. Koo SH, Satoh H, Herzig S, Lee CH, Hedrick S, Kulkarni R, Evans RM, Olefsky J, Montminy M. PGC-1 promotes insulin resistance in liver through PPAR-alpha-dependent induction of TRB-3. Nat Med. 2004 May; 10(5):530-4.
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  86. Goren HJ, Kulkarni RN, Kahn CR. Glucose homeostasis and tissue transcript content of insulin signaling intermediates in four inbred strains of mice: C57BL/6, C57BLKS/6, DBA/2, and 129X1. Endocrinology. 2004 Jul; 145(7):3307-23.
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  87. Kulkarni RN. The islet beta-cell. Int J Biochem Cell Biol. 2004 Mar; 36(3):365-71.
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  88. Kulkarni RN, Kahn CR. Molecular biology. HNFs--linking the liver and pancreatic islets in diabetes. Science. 2004 Feb 27; 303(5662):1311-2.
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  89. Hennige AM, Burks DJ, Ozcan U, Kulkarni RN, Ye J, Park S, Schubert M, Fisher TL, Dow MA, Leshan R, Zakaria M, Mossa-Basha M, White MF. Upregulation of insulin receptor substrate-2 in pancreatic beta cells prevents diabetes. J Clin Invest. 2003 Nov; 112(10):1521-32.
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  90. Rosen ED, Kulkarni RN, Sarraf P, Ozcan U, Okada T, Hsu CH, Eisenman D, Magnuson MA, Gonzalez FJ, Kahn CR, Spiegelman BM. Targeted elimination of peroxisome proliferator-activated receptor gamma in beta cells leads to abnormalities in islet mass without compromising glucose homeostasis. Mol Cell Biol. 2003 Oct; 23(20):7222-9.
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  91. Otani K, Kulkarni RN, Baldwin AC, Krutzfeldt J, Ueki K, Stoffel M, Kahn CR, Polonsky KS. Reduced beta-cell mass and altered glucose sensing impair insulin-secretory function in betaIRKO mice. Am J Physiol Endocrinol Metab. 2004 Jan; 286(1):E41-9.
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  92. Jhala US, Canettieri G, Screaton RA, Kulkarni RN, Krajewski S, Reed J, Walker J, Lin X, White M, Montminy M. cAMP promotes pancreatic beta-cell survival via CREB-mediated induction of IRS2. Genes Dev. 2003 Jul 1; 17(13):1575-80.
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  93. Du K, Herzig S, Kulkarni RN, Montminy M. TRB3: a tribbles homolog that inhibits Akt/PKB activation by insulin in liver. Science. 2003 Jun 6; 300(5625):1574-7.
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  94. Almind K, Kulkarni RN, Lannon SM, Kahn CR. Identification of interactive loci linked to insulin and leptin in mice with genetic insulin resistance. Diabetes. 2003 Jun; 52(6):1535-43.
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  95. Kulkarni RN, Almind K, Goren HJ, Winnay JN, Ueki K, Okada T, Kahn CR. Impact of genetic background on development of hyperinsulinemia and diabetes in insulin receptor/insulin receptor substrate-1 double heterozygous mice. Diabetes. 2003 Jun; 52(6):1528-34.
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  96. Jiang ZY, He Z, King BL, Kuroki T, Opland DM, Suzuma K, Suzuma I, Ueki K, Kulkarni RN, Kahn CR, King GL. Characterization of multiple signaling pathways of insulin in the regulation of vascular endothelial growth factor expression in vascular cells and angiogenesis. J Biol Chem. 2003 Aug 22; 278(34):31964-71.
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  97. Kulkarni RN, Zisman A. Lessons for human diabetes from experimental mouse models. Curr Diab Rep. 2003 Apr; 3(2):168-75.
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  98. Laustsen PG, Michael MD, Crute BE, Cohen SE, Ueki K, Kulkarni RN, Keller SR, Lienhard GE, Kahn CR. Lipoatrophic diabetes in Irs1(-/-)/Irs3(-/-) double knockout mice. Genes Dev. 2002 Dec 15; 16(24):3213-22.
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  99. Kulkarni RN, Okada T. Tissue-specific targeting of the insulin receptor gene. Endocrine. 2002 Dec; 19(3):257-66.
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  100. Mauvais-Jarvis F, Kulkarni RN, Kahn CR. Knockout models are useful tools to dissect the pathophysiology and genetics of insulin resistance. Clin Endocrinol (Oxf). 2002 Jul; 57(1):1-9.
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  101. Kulkarni RN, Holzenberger M, Shih DQ, Ozcan U, Stoffel M, Magnuson MA, Kahn CR. beta-cell-specific deletion of the Igf1 receptor leads to hyperinsulinemia and glucose intolerance but does not alter beta-cell mass. Nat Genet. 2002 May; 31(1):111-5.
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  102. Kulkarni RN. Receptors for insulin and insulin-like growth factor-1 and insulin receptor substrate-1 mediate pathways that regulate islet function. Biochem Soc Trans. 2002 Apr; 30(2):317-22.
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  103. Roper MG, Qian WJ, Zhang BB, Kulkarni RN, Kahn CR, Kennedy RT. Effect of the insulin mimetic L-783,281 on intracellular Ca2+ and insulin secretion from pancreatic beta-cells. Diabetes. 2002 Feb; 51 Suppl 1:S43-9.
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  104. Flier SN, Kulkarni RN, Kahn CR. Evidence for a circulating islet cell growth factor in insulin-resistant states. Proc Natl Acad Sci U S A. 2001 Jun 19; 98(13):7475-80.
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  105. Leibiger B, Leibiger IB, Moede T, Kemper S, Kulkarni RN, Kahn CR, de Vargas LM, Berggren PO. Selective insulin signaling through A and B insulin receptors regulates transcription of insulin and glucokinase genes in pancreatic beta cells. Mol Cell. 2001 Mar; 7(3):559-70.
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  106. Ludwig DS, Tritos NA, Mastaitis JW, Kulkarni R, Kokkotou E, Elmquist J, Lowell B, Flier JS, Maratos-Flier E. Melanin-concentrating hormone overexpression in transgenic mice leads to obesity and insulin resistance. J Clin Invest. 2001 Feb; 107(3):379-86.
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  107. Mauvais-Jarvis F, Virkamaki A, Michael MD, Winnay JN, Zisman A, Kulkarni RN, Kahn CR. A model to explore the interaction between muscle insulin resistance and beta-cell dysfunction in the development of type 2 diabetes. Diabetes. 2000 Dec; 49(12):2126-34.
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  108. Aspinwall CA, Qian WJ, Roper MG, Kulkarni RN, Kahn CR, Kennedy RT. Roles of insulin receptor substrate-1, phosphatidylinositol 3-kinase, and release of intracellular Ca2+ stores in insulin-stimulated insulin secretion in beta -cells. J Biol Chem. 2000 Jul 21; 275(29):22331-8.
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  109. Michael MD, Kulkarni RN, Postic C, Previs SF, Shulman GI, Magnuson MA, Kahn CR. Loss of insulin signaling in hepatocytes leads to severe insulin resistance and progressive hepatic dysfunction. Mol Cell. 2000 Jul; 6(1):87-97.
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  110. Kulkarni RN, Wang ZL, Wang RM, Smith DM, Ghatei MA, Bloom SR. Glibenclamide but not other sulphonylureas stimulates release of neuropeptide Y from perifused rat islets and hamster insulinoma cells. J Endocrinol. 2000 May; 165(2):509-18.
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  111. Kahn CR, Brüning JC, Michael MD, Kulkarni RN. Knockout mice challenge our concepts of glucose homeostasis and the pathogenesis of diabetes mellitus. J Pediatr Endocrinol Metab. 2000; 13 Suppl 6:1377-84.
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  112. Kulkarni RN, Winnay JN, Daniels M, Brüning JC, Flier SN, Hanahan D, Kahn CR. Altered function of insulin receptor substrate-1-deficient mouse islets and cultured beta-cell lines. J Clin Invest. 1999 Dec; 104(12):R69-75.
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  113. Kulkarni RN, Brüning JC, Winnay JN, Postic C, Magnuson MA, Kahn CR. Tissue-specific knockout of the insulin receptor in pancreatic beta cells creates an insulin secretory defect similar to that in type 2 diabetes. Cell. 1999 Feb 5; 96(3):329-39.
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  114. Morgan DG, Kulkarni RN, Hurley JD, Wang ZL, Wang RM, Ghatei MA, Karlsen AE, Bloom SR, Smith DM. Inhibition of glucose stimulated insulin secretion by neuropeptide Y is mediated via the Y1 receptor and inhibition of adenylyl cyclase in RIN 5AH rat insulinoma cells. Diabetologia. 1998 Dec; 41(12):1482-91.
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  115. Vaz M, Kulkarni RN, Shetty PS. Metabolic responses to repeated infusions of identical doses of norepinephrine in chronically energy deficient human subjects. Indian J Med Res. 1998 Feb; 107:103-8.
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  116. Kulkarni RN, Wang ZL, Wang RM, Hurley JD, Smith DM, Ghatei MA, Withers DJ, Gardiner JV, Bailey CJ, Bloom SR. Leptin rapidly suppresses insulin release from insulinoma cells, rat and human islets and, in vivo, in mice. J Clin Invest. 1997 Dec 1; 100(11):2729-36.
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  117. Wang ZL, Kulkarni RN, Wang RM, Smith DM, Ghatei MA, Byfield PG, Bennet WM, Bloom SR. Possible evidence for endogenous production of a novel galanin-like peptide. J Clin Invest. 1997 Jul 1; 100(1):189-96.
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  118. Kulkarni RN, Smith DM, Ghatei MA, Jones PM, Bloom SR. Investigation of the effects of antisense oligodeoxynucleotides to islet amyloid polypeptide mRNA on insulin release, content and expression. J Endocrinol. 1996 Dec; 151(3):341-8.
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  119. Kulkarni RN, Wang ZL, Akinsanya KO, Bennet WM, Wang RM, Smith DM, Ghatei MA, Byfield PG, Bloom SR. Pyroglutamyl-phenylalanyl-proline amide attenuates thyrotropin-releasing hormone-stimulated insulin secretion in perifused rat islets and insulin-secreting clonal beta-cell lines. Endocrinology. 1995 Nov; 136(11):5155-64.
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  120. Kulkarni RN, Smith DM, Ghatei MA, Bloom SR. A 67 kDa protein mediates pituitary adenylate cyclase-activating polypeptide and vasoactive intestinal peptide-stimulated insulin secretion in a hamster clonal beta-cell line. J Endocrinol. 1995 Oct; 147(1):121-30.
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  121. Olmos G, Kulkarni RN, Haque M, MacDermot J. Imidazolines stimulate release of insulin from RIN-5AH cells independently from I1- and I2-imidazoline receptors. Ann N Y Acad Sci. 1995 Jul 12; 763:374-6.
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  122. Piers LS, Soares MJ, Kulkarni RN, Shetty PS. Thermic effect of a meal. 3. Effect of dietary supplementation in chronically undernourished human subjects. Br J Nutr. 1992 Mar; 67(2):187-94.
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