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Ana Carrizosa Anderson, PH.D.

TitleAssistant Professor of Neurology
InstitutionBrigham and Women's Hospital
DepartmentNeurology
AddressHarvard Medical School
BWH/Neurology, HIM 784
77 Avenue Louis Pasteur
Boston MA 02115
Phone617/525-5850
Fax617/525-5566

 Bibliographic 
 selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Jayaraman P, Sada-Ovalle I, Nishimura T, Anderson AC, Kuchroo VK, Remold HG, Behar SM. IL-1ß Promotes Antimicrobial Immunity in Macrophages by Regulating TNFR Signaling and Caspase-3 Activation. J Immunol. 2013 Apr 15; 190(8):4196-204.
    View in: PubMed
  2. Rangachari M, Zhu C, Sakuishi K, Xiao S, Karman J, Chen A, Angin M, Wakeham A, Greenfield EA, Sobel RA, Okada H, McKinnon PJ, Mak TW, Addo MM, Anderson AC, Kuchroo VK. Bat3 promotes T cell responses and autoimmunity by repressing Tim-3–mediated cell death and exhaustion. Nat Med. 2012 Sep; 18(9):1394-400.
    View in: PubMed
  3. Joller N, Peters A, Anderson AC, Kuchroo VK. Immune checkpoints in central nervous system autoimmunity. Immunol Rev. 2012 Jul; 248(1):122-39.
    View in: PubMed
  4. Veenstra RG, Taylor PA, Zhou Q, Panoskaltsis-Mortari A, Hirashima M, Flynn R, Liu D, Anderson AC, Strom TB, Kuchroo VK, Blazar BR. Contrasting acute graft-versus-host disease effects of Tim-3/galectin-9 pathway blockade dependent upon the presence of donor regulatory T cells. Blood. 2012 Jul 19; 120(3):682-90.
    View in: PubMed
  5. Anderson AC, Chandwaskar R, Lee DH, Sullivan JM, Solomon A, Rodriguez-Manzanet R, Greve B, Sobel RA, Kuchroo VK. A transgenic model of central nervous system autoimmunity mediated by CD4+ and CD8+ T and B cells. J Immunol. 2012 Mar 1; 188(5):2084-92.
    View in: PubMed
  6. Liu SM, Lee DH, Sullivan JM, Chung D, Jäger A, Shum BO, Sarvetnick NE, Anderson AC, Kuchroo VK. Differential IL-21 signaling in APCs leads to disparate Th17 differentiation in diabetes-susceptible NOD and diabetes-resistant NOD.Idd3 mice. J Clin Invest. 2011 Nov; 121(11):4303-10.
    View in: PubMed
  7. Sakuishi K, Jayaraman P, Behar SM, Anderson AC, Kuchroo VK. Emerging Tim-3 functions in antimicrobial and tumor immunity. Trends Immunol. 2011 Aug; 32(8):345-9.
    View in: PubMed
  8. Zhou Q, Munger ME, Veenstra RG, Weigel BJ, Hirashima M, Munn DH, Murphy WJ, Azuma M, Anderson AC, Kuchroo VK, Blazar BR. Coexpression of Tim-3 and PD-1 identifies a CD8+ T-cell exhaustion phenotype in mice with disseminated acute myelogenous leukemia. Blood. 2011 Apr 28; 117(17):4501-10.
    View in: PubMed
  9. Zhu C, Anderson AC, Kuchroo VK. TIM-3 and its regulatory role in immune responses. Curr Top Microbiol Immunol. 2011; 350:1-15.
    View in: PubMed
  10. Jayaraman P, Sada-Ovalle I, Beladi S, Anderson AC, Dardalhon V, Hotta C, Kuchroo VK, Behar SM. Tim3 binding to galectin-9 stimulates antimicrobial immunity. J Exp Med. 2010 Oct 25; 207(11):2343-54.
    View in: PubMed
  11. Sakuishi K, Apetoh L, Sullivan JM, Blazar BR, Kuchroo VK, Anderson AC. Targeting Tim-3 and PD-1 pathways to reverse T cell exhaustion and restore anti-tumor immunity. J Exp Med. 2010 Sep 27; 207(10):2187-94.
    View in: PubMed
  12. Jin HT, Anderson AC, Tan WG, West EE, Ha SJ, Araki K, Freeman GJ, Kuchroo VK, Ahmed R. Cooperation of Tim-3 and PD-1 in CD8 T-cell exhaustion during chronic viral infection. Proc Natl Acad Sci U S A. 2010 Aug 17; 107(33):14733-8.
    View in: PubMed
  13. Dardalhon V, Anderson AC, Karman J, Apetoh L, Chandwaskar R, Lee DH, Cornejo M, Nishi N, Yamauchi A, Quintana FJ, Sobel RA, Hirashima M, Kuchroo VK. Tim-3/galectin-9 pathway: regulation of Th1 immunity through promotion of CD11b+Ly-6G+ myeloid cells. J Immunol. 2010 Aug 1; 185(3):1383-92.
    View in: PubMed
  14. Rodriguez-Manzanet R, Sanjuan MA, Wu HY, Quintana FJ, Xiao S, Anderson AC, Weiner HL, Green DR, Kuchroo VK. T and B cell hyperactivity and autoimmunity associated with niche-specific defects in apoptotic body clearance in TIM-4-deficient mice. Proc Natl Acad Sci U S A. 2010 May 11; 107(19):8706-11.
    View in: PubMed
  15. Anderson AC, Lord GM, Dardalhon V, Lee DH, Sabatos-Peyton CA, Glimcher LH, Kuchroo VK. T-bet, a Th1 transcription factor regulates the expression of Tim-3. Eur J Immunol. 2010 Mar; 40(3):859-66.
    View in: PubMed
  16. Anderson AC, Chandwaskar R, Lee DH, Kuchroo VK. Cutting edge: the Idd3 genetic interval determines regulatory T cell function through CD11b+CD11c- APC. J Immunol. 2008 Dec 1; 181(11):7449-52.
    View in: PubMed
  17. Kuchroo VK, Dardalhon V, Xiao S, Anderson AC. New roles for TIM family members in immune regulation. Nat Rev Immunol. 2008 Aug; 8(8):577-80.
    View in: PubMed
  18. Dardalhon V, Korn T, Kuchroo VK, Anderson AC. Role of Th1 and Th17 cells in organ-specific autoimmunity. J Autoimmun. 2008 Nov; 31(3):252-6.
    View in: PubMed
  19. Rodriguez-Manzanet R, Meyers JH, Balasubramanian S, Slavik J, Kassam N, Dardalhon V, Greenfield EA, Anderson AC, Sobel RA, Hafler DA, Strom TB, Kuchroo VK. TIM-4 expressed on APCs induces T cell expansion and survival. J Immunol. 2008 Apr 1; 180(7):4706-13.
    View in: PubMed
  20. Anderson AC, Anderson DE, Bregoli L, Hastings WD, Kassam N, Lei C, Chandwaskar R, Karman J, Su EW, Hirashima M, Bruce JN, Kane LP, Kuchroo VK, Hafler DA. Promotion of tissue inflammation by the immune receptor Tim-3 expressed on innate immune cells. Science. 2007 Nov 16; 318(5853):1141-3.
    View in: PubMed
  21. Zhu B, Bando Y, Xiao S, Yang K, Anderson AC, Kuchroo VK, Khoury SJ. CD11b+Ly-6C(hi) suppressive monocytes in experimental autoimmune encephalomyelitis. J Immunol. 2007 Oct 15; 179(8):5228-37.
    View in: PubMed
  22. Korn T, Anderson AC, Bettelli E, Oukka M. The dynamics of effector T cells and Foxp3+ regulatory T cells in the promotion and regulation of autoimmune encephalomyelitis. J Neuroimmunol. 2007 Nov; 191(1-2):51-60.
    View in: PubMed
  23. Illés Z, Waldner H, Reddy J, Anderson AC, Sobel RA, Kuchroo VK. Modulation of CD4 co-receptor limits spontaneous autoimmunity when high-affinity transgenic TCR specific for self-antigen is expressed on a genetically resistant background. Int Immunol. 2007 Oct; 19(10):1235-48.
    View in: PubMed
  24. Xiao S, Najafian N, Reddy J, Albin M, Zhu C, Jensen E, Imitola J, Korn T, Anderson AC, Zhang Z, Gutierrez C, Moll T, Sobel RA, Umetsu DT, Yagita H, Akiba H, Strom T, Sayegh MH, DeKruyff RH, Khoury SJ, Kuchroo VK. Differential engagement of Tim-1 during activation can positively or negatively costimulate T cell expansion and effector function. J Exp Med. 2007 Jul 9; 204(7):1691-702.
    View in: PubMed
  25. Kostianovsky AM, Maier LM, Baecher-Allan C, Anderson AC, Anderson DE. Up-regulation of gene related to anergy in lymphocytes is associated with Notch-mediated human T cell suppression. J Immunol. 2007 May 15; 178(10):6158-63.
    View in: PubMed
  26. Anderson AC, Xiao S, Kuchroo VK. Tim protein structures reveal a unique face for ligand binding. Immunity. 2007 Mar; 26(3):273-5.
    View in: PubMed
  27. Anderson AC, Anderson DE. TIM-3 in autoimmunity. Curr Opin Immunol. 2006 Dec; 18(6):665-9.
    View in: PubMed
  28. Zhu C, Anderson AC, Schubart A, Xiong H, Imitola J, Khoury SJ, Zheng XX, Strom TB, Kuchroo VK. The Tim-3 ligand galectin-9 negatively regulates T helper type 1 immunity. Nat Immunol. 2005 Dec; 6(12):1245-52.
    View in: PubMed
  29. Manilay JO, Anderson AC, Kang C, Robey EA. Impairment of thymocyte development by dominant-negative Kuzbanian (ADAM-10) is rescued by the Notch ligand, delta-1. J Immunol. 2005 Jun 1; 174(11):6732-41.
    View in: PubMed
  30. Anderson AC, Kitchens EA, Chan SW, St Hill C, Jan YN, Zhong W, Robey EA. The Notch regulator Numb links the Notch and TCR signaling pathways. J Immunol. 2005 Jan 15; 174(2):890-7.
    View in: PubMed
  31. Anderson AC, Reddy J, Nazareno R, Sobel RA, Nicholson LB, Kuchroo VK. IL-10 plays an important role in the homeostatic regulation of the autoreactive repertoire in naive mice. J Immunol. 2004 Jul 15; 173(2):828-34.
    View in: PubMed
  32. Anderson AC, Kuchroo VK. Expression of self-antigen in the thymus: a little goes a long way. J Exp Med. 2003 Dec 1; 198(11):1627-9.
    View in: PubMed
  33. Kuchroo VK, Anderson AC, Waldner H, Munder M, Bettelli E, Nicholson LB. T cell response in experimental autoimmune encephalomyelitis (EAE): role of self and cross-reactive antigens in shaping, tuning, and regulating the autopathogenic T cell repertoire. Annu Rev Immunol. 2002; 20:101-23.
    View in: PubMed
  34. Anderson AC, Robey EA, Huang YH. Notch signaling in lymphocyte development. Curr Opin Genet Dev. 2001 Oct; 11(5):554-60.
    View in: PubMed
  35. Anderson AC, Nicholson LB, Kuchroo VK. The origin and regulation of autopathogenic T cells. J Clin Immunol. 2001 Mar; 21(2):74-80.
    View in: PubMed
  36. Anderson AC, Waldner H, Turchin V, Jabs C, Prabhu Das M, Kuchroo VK, Nicholson LB. Autoantigen-responsive T cell clones demonstrate unfocused TCR cross-reactivity toward multiple related ligands: implications for autoimmunity. Cell Immunol. 2000 Jun 15; 202(2):88-96.
    View in: PubMed
  37. Anderson AC, Nicholson LB, Legge KL, Turchin V, Zaghouani H, Kuchroo VK. High frequency of autoreactive myelin proteolipid protein-specific T cells in the periphery of naive mice: mechanisms of selection of the self-reactive repertoire. J Exp Med. 2000 Mar 6; 191(5):761-70.
    View in: PubMed
  38. Nicholson LB, Anderson AC, Kuchroo VK. Tuning T cell activation threshold and effector function with cross-reactive peptide ligands. Int Immunol. 2000 Feb; 12(2):205-13.
    View in: PubMed
  39. Flajnik MF, Ohta Y, Greenberg AS, Salter-Cid L, Carrizosa A, Du Pasquier L, Kasahara M. Two ancient allelic lineages at the single classical class I locus in the Xenopus MHC. J Immunol. 1999 Oct 1; 163(7):3826-33.
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  40. Windhagen A, Anderson DE, Carrizosa A, Balashov K, Weiner HL, Hafler DA. Cytokine secretion of myelin basic protein reactive T cells in patients with multiple sclerosis. J Neuroimmunol. 1998 Nov 2; 91(1-2):1-9.
    View in: PubMed
  41. Carrizosa AM, Nicholson LB, Farzan M, Southwood S, Sette A, Sobel RA, Kuchroo VK. Expansion by self antigen is necessary for the induction of experimental autoimmune encephalomyelitis by T cells primed with a cross-reactive environmental antigen. J Immunol. 1998 Oct 1; 161(7):3307-14.
    View in: PubMed
  42. Nicholson LB, Waldner H, Carrizosa AM, Sette A, Collins M, Kuchroo VK. Heteroclitic proliferative responses and changes in cytokine profile induced by altered peptides: implications for autoimmunity. Proc Natl Acad Sci U S A. 1998 Jan 6; 95(1):264-9.
    View in: PubMed
  43. Miller SD, Vanderlugt CL, Begolka WS, Pao W, Yauch RL, Neville KL, Katz-Levy Y, Carrizosa A, Kim BS. Persistent infection with Theiler's virus leads to CNS autoimmunity via epitope spreading. Nat Med. 1997 Oct; 3(10):1133-6.
    View in: PubMed
  44. Windhagen A, Anderson DE, Carrizosa A, Williams RE, Hafler DA. IL-12 induces human T cells secreting IL-10 with IFN-gamma. J Immunol. 1996 Aug 1; 157(3):1127-31.
    View in: PubMed
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