Da-Zhi Wang, PH.D.
|Title||Associate Professor of Pediatrics|
|Institution||Children's Hospital Boston|
Cardiology - Enders 1260
300 Longwood Ave
Boston MA 02115
||Basil O’Connor Scholar|
||Established Investigator Award|
Our lab is interested in the molecular events that control gene expression during animal development. Using muscle (cardiac, skeletal and smooth) as model systems, we study transcriptional, epigenetic and microRNA (miRNA)-mediated post-transcriptional regulation of gene expression. We apply a variety of developmental, molecular, cellular, biochemical, genetic and physiological approaches, including transgenic and knockout mouse models in our lab.
The heart is the “heart” of life. Heart disease is the number one cause of mortality and morbidity world wide. Congenital heart disease occurs in one of every one hundred live births and is the most common human birth defect. Discovery of the genetic control and molecular mechanisms of heart development is an important prerequisite to develop novel therapies for human cardiovascular disease.
Available: 11/01/12, Expires: 10/31/13
Congenital heart disease (CHD) affects nearly 1% of all newborns and is the most common human birth defect. Heart disease is the number one killer on both sides of the age spectrum, resulting in significant mortality and morbidity in children and adults. The lab focuses on the molecular pathways, in particular small non-coding miRNAs, in heart development, cardiac function and cardiovascular.
You are expected to apply a variety of state-of-art approaches, including that of molecular, cellular, biochemistry and genetic technologies as well as animal models in your projects.
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