Paula Goodman Fraenkel, M.D.
|Title||Assistant Professor of Medicine|
|Institution||Beth Israel Deaconess Medical Center|
|Address||Beth Israel Deaconess Med Ctr|
Hematology/Oncology, SLD 423B
330 Brookline Ave
Boston MA 02215
Anemia is a common medical problem, particularly in the elderly, which is associated with cognitive impairment, frailty, and increased mortality. Anemia is frequently caused by impaired intestinal iron absorption or by inadequate release of iron from macrophage iron stores. On the other hand, iron overload affects numerous individuals with hereditary hemochromatosis, hemoglobin disorders, and chronic transfusions. The focus of my research is to improve our understanding of the genetic pathways that affect blood development and iron homeostasis and thus cause either anemia and iron overload disorders using zebrafish, mouse, and tissue culture models. To that end, we are identifying small molecules that increase expression of the iron regulatory hormone hepcidin that may lead to new therapies for iron overload disorders. Ongoing collaborations include the following: (1) inflammatory bowel disease models Dr. Efi Kokkotou (Division of Gastroenterology, BIDMC), (2) the effect of vitamin D deficiency on erythropoiesis with Dr. Gary Vanasse (Division of Hematology/Oncology, BWH), and (3) functional toxicology with Dr. Chris Vulpe (UC Berkeley). In addition to research, I teach and precept Harvard undergraduate students, medical students, residents, and fellows, and serve as an Attending Physician on the Hematology/Oncology Consult Service, the Hematologic Malignancy/Bone Marrow Transplant Service, and the Hematology Clinic at Beth Israel Deaconess Medical Center.
Available: 09/10/12, Expires: 09/09/13
Iron overload, as a result of frequent blood transfusion and increased nutritional iron uptake, often causes death and disability in individuals with hereditary forms of anemia. The current therapies are inconvenient and only partially effective. Using high throughput screening, our laboratory is identifying new candidate drugs to prevent iron overload. We are looking for a student who will work with us to test the effects of small molecules on preventing iron overload in mouse models of human diseases.
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