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Last Name
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Kenneth Daniel Bloch, M.D.

TitleWilliam Thomas Green Morton Professor of Anaesthesia
InstitutionMassachusetts General Hospital
DepartmentAnaesthesia
AddressMassachusetts General Hospital
Anesthesia Center for Critical Care Research
55 Fruit St
Boston MA 02114
Phone617/724-9540
Fax617/724-7768
Other Positions
TitleProfessor of Medicine
InstitutionMassachusetts General Hospital
DepartmentMedicine
DivisionCardiology


 Mentoring 
 current student opportunities
Available: 09/01/11, Expires: 08/30/13

There are a broad spectrum of projects underway in the laboratory related to how BMP signaling regulates endothelial and smooth muscle biology (in vitro and in vivo), as well as the contributions of abnormal BMP signaling to anemia, atherogenesis, and pulmonary hypertension. The student's role would depend on his or her interests, time commitment/availability, and prior experiences. It is anticipated that the student would lead a project and author a manuscript for publication.


 Bibliographic 
 selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Francis RC, Vaporidi K, Bloch KD, Ichinose F, Zapol WM. Protective and Detrimental Effects of Sodium Sulfide and Hydrogen Sulfide in Murine Ventilator-induced Lung Injury. Anesthesiology. 2011 Nov; 115(5):1012-21.
    View in: PubMed
  2. Petersen B, Austen KF, Bloch KD, Hotta Y, Ichinose F, Kanaoka Y, Zapol WM. Cysteinyl leukotrienes impair hypoxic pulmonary vasoconstriction in endotoxemic mice. Anesthesiology. 2011 Oct; 115(4):804-11.
    View in: PubMed
  3. Minamishima S, Kida K, Tokuda K, Wang H, Sips PY, Kosugi S, Mandeville JB, Buys ES, Brouckaert P, Liu PK, Liu CH, Bloch KD, Ichinose F. Inhaled nitric oxide improves outcomes after successful cardiopulmonary resuscitation in mice. Circulation. 2011 Oct 11; 124(15):1645-53.
    View in: PubMed
  4. Kurtz B, Thibault HB, Raher MJ, Popovich JR, Cawley S, Atochin DN, Hayton S, Shakartzi HR, Huang PL, Bloch KD, Buys E, Scherrer-Crosbie M. Nitric oxide synthase 3 deficiency limits adverse ventricular remodeling after pressure overload in insulin resistance. Am J Physiol Heart Circ Physiol. 2011 Nov; 301(5):H2093-101.
    View in: PubMed
  5. Steinbicker AU, Bartnikas TB, Lohmeyer LK, Leyton P, Mayeur C, Kao SM, Pappas AE, Peterson RT, Bloch DB, Yu PB, Fleming MD, Bloch KD. Perturbation of hepcidin expression by BMP type I receptor deletion induces iron overload in mice. Blood. 2011 Oct 13; 118(15):4224-30.
    View in: PubMed
  6. Steinbicker AU, Liu H, Jiramongkolchai K, Malhotra R, Choe EY, Busch CJ, Graveline AR, Kao SM, Nagasaka Y, Ichinose F, Buys ES, Brouckaert P, Zapol WM, Bloch KD. Nitric oxide regulates pulmonary vascular smooth muscle cell expression of the inducible cAMP early repressor gene. Nitric Oxide. 2011 Oct 30; 25(3):294-302.
    View in: PubMed
  7. Cawley SM, Kolodziej S, Ichinose F, Brouckaert P, Buys ES, Bloch KD. sGC{alpha}1 mediates the negative inotropic effects of NO in cardiac myocytes independent of changes in calcium handling. Am J Physiol Heart Circ Physiol. 2011 Jul; 301(1):H157-63.
    View in: PubMed
  8. Routray C, Liu C, Yaqoob U, Billadeau DD, Bloch KD, Kaibuchi K, Shah VH, Kang N. Protein kinase G signaling disrupts Rac1-dependent focal adhesion assembly in liver specific pericytes. Am J Physiol Cell Physiol. 2011 Jul; 301(1):C66-74.
    View in: PubMed
  9. Steinbicker AU, Sachidanandan C, Vonner AJ, Yusuf RZ, Deng DY, Lai CS, Rauwerdink KM, Winn JC, Saez B, Cook CM, Szekely BA, Roy CN, Seehra JS, Cuny GD, Scadden DT, Peterson RT, Bloch KD, Yu PB. Inhibition of bone morphogenetic protein signaling attenuates anemia associated with inflammation. Blood. 2011 May 5; 117(18):4915-23.
    View in: PubMed
  10. Lewis GD, Murphy RM, Shah RV, Pappagianopoulos PP, Malhotra R, Bloch KD, Systrom DM, Semigran MJ. Pulmonary vascular response patterns during exercise in left ventricular systolic dysfunction predict exercise capacity and outcomes. Circ Heart Fail. 2011 May; 4(3):276-85.
    View in: PubMed
  11. Nagasaka Y, Buys ES, Spagnolli E, Steinbicker AU, Hayton SR, Rauwerdink KM, Brouckaert P, Zapol WM, Bloch KD. Soluble guanylate cyclase-a1 is required for the cardioprotective effects of inhaled nitric oxide. Am J Physiol Heart Circ Physiol. 2011 Apr; 300(4):H1477-83.
    View in: PubMed
  12. Weng M, Raher MJ, Leyton P, Combs TP, Scherer PE, Bloch KD, Medoff BD. Adiponectin decreases pulmonary arterial remodeling in murine models of pulmonary hypertension. Am J Respir Cell Mol Biol. 2011 Aug; 45(2):340-7.
    View in: PubMed
  13. Kang N, Yaqoob U, Geng Z, Bloch K, Liu C, Gomez T, Billadeau D, Shah V. Focal adhesion assembly in myofibroblasts fosters a microenvironment that promotes tumor growth. Am J Pathol. 2010 Oct; 177(4):1888-900.
    View in: PubMed
  14. Atochin DN, Yuzawa I, Li Q, Rauwerdink KM, Malhotra R, Chang J, Brouckaert P, Ayata C, Moskowitz MA, Bloch KD, Huang PL, Buys ES. Soluble guanylate cyclase alpha1beta1 limits stroke size and attenuates neurological injury. Stroke. 2010 Aug; 41(8):1815-9.
    View in: PubMed
  15. Vaporidi K, Francis RC, Bloch KD, Zapol WM. Nitric oxide synthase 3 contributes to ventilator-induced lung injury. Am J Physiol Lung Cell Mol Physiol. 2010 Aug; 299(2):L150-9.
    View in: PubMed
  16. Yu B, Shahid M, Egorina EM, Sovershaev MA, Raher MJ, Lei C, Wu MX, Bloch KD, Zapol WM. Endothelial dysfunction enhances vasoconstriction due to scavenging of nitric oxide by a hemoglobin-based oxygen carrier. Anesthesiology. 2010 Mar; 112(3):586-94.
    View in: PubMed
  17. Thibault HB, Kurtz B, Raher MJ, Shaik RS, Waxman A, Derumeaux G, Halpern EF, Bloch KD, Scherrer-Crosbie M. Noninvasive assessment of murine pulmonary arterial pressure: validation and application to models of pulmonary hypertension. Circ Cardiovasc Imaging. 2010 Mar; 3(2):157-63.
    View in: PubMed
  18. Vermeersch P, Buys E, Sips P, Pokreisz P, Marsboom G, Gillijns H, Pellens M, Dewerchin M, Bloch KD, Brouckaert P, Janssens S. Gender-specific modulation of the response to arterial injury by soluble guanylate cyclase a1. Open Cardiovasc Med J. 2009; 3:98-104.
    View in: PubMed
  19. Minamishima S, Bougaki M, Sips PY, Yu JD, Minamishima YA, Elrod JW, Lefer DJ, Bloch KD, Ichinose F. Hydrogen sulfide improves survival after cardiac arrest and cardiopulmonary resuscitation via a nitric oxide synthase 3-dependent mechanism in mice. Circulation. 2009 Sep 8; 120(10):888-96.
    View in: PubMed
  20. Buys ES, Cauwels A, Raher MJ, Passeri JJ, Hobai I, Cawley SM, Rauwerdink KM, Thibault H, Sips PY, Thoonen R, Scherrer-Crosbie M, Ichinose F, Brouckaert P, Bloch KD. sGC(alpha)1(beta)1 attenuates cardiac dysfunction and mortality in murine inflammatory shock models. Am J Physiol Heart Circ Physiol. 2009 Aug; 297(2):H654-63.
    View in: PubMed
  21. Bloch KD. Careers in basic cardiovascular research. Circulation. 2009 May 12; 119(18):2526-30.
    View in: PubMed
  22. Beppu H, Malhotra R, Beppu Y, Lepore JJ, Parmacek MS, Bloch KD. BMP type II receptor regulates positioning of outflow tract and remodeling of atrioventricular cushion during cardiogenesis. Dev Biol. 2009 Jul 15; 331(2):167-75.
    View in: PubMed
  23. Yu B, Bloch KD, Zapol WM. Hemoglobin-based red blood cell substitutes and nitric oxide. Trends Cardiovasc Med. 2009 Apr; 19(3):103-7.
    View in: PubMed
  24. Newton-Cheh C, Larson MG, Vasan RS, Levy D, Bloch KD, Surti A, Guiducci C, Kathiresan S, Benjamin EJ, Struck J, Morgenthaler NG, Bergmann A, Blankenberg S, Kee F, Nilsson P, Yin X, Peltonen L, Vartiainen E, Salomaa V, Hirschhorn JN, Melander O, Wang TJ. Association of common variants in NPPA and NPPB with circulating natriuretic peptides and blood pressure. Nat Genet. 2009 Mar; 41(3):348-53.
    View in: PubMed
  25. Medoff BD, Okamoto Y, Leyton P, Weng M, Sandall BP, Raher MJ, Kihara S, Bloch KD, Libby P, Luster AD. Adiponectin deficiency increases allergic airway inflammation and pulmonary vascular remodeling. Am J Respir Cell Mol Biol. 2009 Oct; 41(4):397-406.
    View in: PubMed
  26. Pokreisz P, Vandenwijngaert S, Bito V, Van den Bergh A, Lenaerts I, Busch C, Marsboom G, Gheysens O, Vermeersch P, Biesmans L, Liu X, Gillijns H, Pellens M, Van Lommel A, Buys E, Schoonjans L, Vanhaecke J, Verbeken E, Sipido K, Herijgers P, Bloch KD, Janssens SP. Ventricular phosphodiesterase-5 expression is increased in patients with advanced heart failure and contributes to adverse ventricular remodeling after myocardial infarction in mice. Circulation. 2009 Jan 27; 119(3):408-16.
    View in: PubMed
  27. Yu B, Volpato GP, Chang K, Bloch KD, Zapol WM. Prevention of the pulmonary vasoconstrictor effects of HBOC-201 in awake lambs by continuously breathing nitric oxide. Anesthesiology. 2009 Jan; 110(1):113-22.
    View in: PubMed
  28. Nishida T, Yu JD, Minamishima S, Sips PY, Searles RJ, Buys ES, Janssens S, Brouckaert P, Bloch KD, Ichinose F. Protective effects of nitric oxide synthase 3 and soluble guanylate cyclase on the outcome of cardiac arrest and cardiopulmonary resuscitation in mice. Crit Care Med. 2009 Jan; 37(1):256-62.
    View in: PubMed
  29. Yu PB, Deng DY, Lai CS, Hong CC, Cuny GD, Bouxsein ML, Hong DW, McManus PM, Katagiri T, Sachidanandan C, Kamiya N, Fukuda T, Mishina Y, Peterson RT, Bloch KD. BMP type I receptor inhibition reduces heterotopic [corrected] ossification. Nat Med. 2008 Dec; 14(12):1363-9.
    View in: PubMed
  30. Raher MJ, Thibault HB, Buys ES, Kuruppu D, Shimizu N, Brownell AL, Blake SL, Rieusset J, Kaneki M, Derumeaux G, Picard MH, Bloch KD, Scherrer-Crosbie M. A short duration of high-fat diet induces insulin resistance and predisposes to adverse left ventricular remodeling after pressure overload. Am J Physiol Heart Circ Physiol. 2008 Dec; 295(6):H2495-502.
    View in: PubMed
  31. Nagasaka Y, Fernandez BO, Garcia-Saura MF, Petersen B, Ichinose F, Bloch KD, Feelisch M, Zapol WM. Brief periods of nitric oxide inhalation protect against myocardial ischemia-reperfusion injury. Anesthesiology. 2008 Oct; 109(4):675-82.
    View in: PubMed
  32. Derumeaux G, Ichinose F, Raher MJ, Morgan JG, Coman T, Lee C, Cuesta JM, Thibault H, Bloch KD, Picard MH, Scherrer-Crosbie M. Myocardial alterations in senescent mice and effect of exercise training: a strain rate imaging study. Circ Cardiovasc Imaging. 2008 Nov; 1(3):227-34.
    View in: PubMed
  33. Hong KH, Lee YJ, Lee E, Park SO, Han C, Beppu H, Li E, Raizada MK, Bloch KD, Oh SP. Genetic ablation of the BMPR2 gene in pulmonary endothelium is sufficient to predispose to pulmonary arterial hypertension. Circulation. 2008 Aug 12; 118(7):722-30.
    View in: PubMed
  34. Cuny GD, Yu PB, Laha JK, Xing X, Liu JF, Lai CS, Deng DY, Sachidanandan C, Bloch KD, Peterson RT. Structure-activity relationship study of bone morphogenetic protein (BMP) signaling inhibitors. Bioorg Med Chem Lett. 2008 Aug 1; 18(15):4388-92.
    View in: PubMed
  35. Yu B, Raher MJ, Volpato GP, Bloch KD, Ichinose F, Zapol WM. Inhaled nitric oxide enables artificial blood transfusion without hypertension. Circulation. 2008 Apr 15; 117(15):1982-90.
    View in: PubMed
  36. Volpato GP, Searles R, Yu B, Scherrer-Crosbie M, Bloch KD, Ichinose F, Zapol WM. Inhaled hydrogen sulfide: a rapidly reversible inhibitor of cardiac and metabolic function in the mouse. Anesthesiology. 2008 Apr; 108(4):659-68.
    View in: PubMed
  37. Buys ES, Sips P, Vermeersch P, Raher MJ, Rogge E, Ichinose F, Dewerchin M, Bloch KD, Janssens S, Brouckaert P. Gender-specific hypertension and responsiveness to nitric oxide in sGCalpha1 knockout mice. Cardiovasc Res. 2008 Jul 1; 79(1):179-86.
    View in: PubMed
  38. Petersen B, Bloch KD, Ichinose F, Shin HS, Shigematsu M, Bagchi A, Zapol WM, Hellman J. Activation of Toll-like receptor 2 impairs hypoxic pulmonary vasoconstriction in mice. Am J Physiol Lung Cell Mol Physiol. 2008 Feb; 294(2):L300-8.
    View in: PubMed
  39. Yu PB, Deng DY, Beppu H, Hong CC, Lai C, Hoyng SA, Kawai N, Bloch KD. Bone morphogenetic protein (BMP) type II receptor is required for BMP-mediated growth arrest and differentiation in pulmonary artery smooth muscle cells. J Biol Chem. 2008 Feb 15; 283(7):3877-88.
    View in: PubMed
  40. Yu PB, Hong CC, Sachidanandan C, Babitt JL, Deng DY, Hoyng SA, Lin HY, Bloch KD, Peterson RT. Dorsomorphin inhibits BMP signals required for embryogenesis and iron metabolism. Nat Chem Biol. 2008 Jan; 4(1):33-41.
    View in: PubMed
  41. Spöhr F, Busch CJ, Reich C, Motsch J, Gebhard MM, Kuebler WM, Bloch KD, Weimann J. 4-Aminopyridine restores impaired hypoxic pulmonary vasoconstriction in endotoxemic mice. Anesthesiology. 2007 Oct; 107(4):597-604.
    View in: PubMed
  42. Evgenov OV, Kohane DS, Bloch KD, Stasch JP, Volpato GP, Bellas E, Evgenov NV, Buys ES, Gnoth MJ, Graveline AR, Liu R, Hess DR, Langer R, Zapol WM. Inhaled agonists of soluble guanylate cyclase induce selective pulmonary vasodilation. Am J Respir Crit Care Med. 2007 Dec 1; 176(11):1138-45.
    View in: PubMed
  43. Lewis GD, Shah R, Shahzad K, Camuso JM, Pappagianopoulos PP, Hung J, Tawakol A, Gerszten RE, Systrom DM, Bloch KD, Semigran MJ. Sildenafil improves exercise capacity and quality of life in patients with systolic heart failure and secondary pulmonary hypertension. Circulation. 2007 Oct 2; 116(14):1555-62.
    View in: PubMed
  44. Liu R, Hotta Y, Graveline AR, Evgenov OV, Buys ES, Bloch KD, Ichinose F, Zapol WM. Congenital NOS2 deficiency prevents impairment of hypoxic pulmonary vasoconstriction in murine ventilator-induced lung injury. Am J Physiol Lung Cell Mol Physiol. 2007 Nov; 293(5):L1300-5.
    View in: PubMed
  45. Raher MJ, Thibault H, Poh KK, Liu R, Halpern EF, Derumeaux G, Ichinose F, Zapol WM, Bloch KD, Picard MH, Scherrer-Crosbie M. In vivo characterization of murine myocardial perfusion with myocardial contrast echocardiography: validation and application in nitric oxide synthase 3 deficient mice. Circulation. 2007 Sep 11; 116(11):1250-7.
    View in: PubMed
  46. Beppu H, Mwizerwa ON, Beppu Y, Dattwyler MP, Lauwers GY, Bloch KD, Goldstein AM. Stromal inactivation of BMPRII leads to colorectal epithelial overgrowth and polyp formation. Oncogene. 2008 Feb 14; 27(8):1063-70.
    View in: PubMed
  47. Liu X, Huang Y, Pokreisz P, Vermeersch P, Marsboom G, Swinnen M, Verbeken E, Santos J, Pellens M, Gillijns H, Van de Werf F, Bloch KD, Janssens S. Nitric oxide inhalation improves microvascular flow and decreases infarction size after myocardial ischemia and reperfusion. J Am Coll Cardiol. 2007 Aug 21; 50(8):808-17.
    View in: PubMed
  48. Vermeersch P, Buys E, Pokreisz P, Marsboom G, Ichinose F, Sips P, Pellens M, Gillijns H, Swinnen M, Graveline A, Collen D, Dewerchin M, Brouckaert P, Bloch KD, Janssens S. Soluble guanylate cyclase-alpha1 deficiency selectively inhibits the pulmonary vasodilator response to nitric oxide and increases the pulmonary vascular remodeling response to chronic hypoxia. Circulation. 2007 Aug 21; 116(8):936-43.
    View in: PubMed
  49. Neilan TG, Blake SL, Ichinose F, Raher MJ, Buys ES, Jassal DS, Furutani E, Perez-Sanz TM, Graveline A, Janssens SP, Picard MH, Scherrer-Crosbie M, Bloch KD. Disruption of nitric oxide synthase 3 protects against the cardiac injury, dysfunction, and mortality induced by doxorubicin. Circulation. 2007 Jul 31; 116(5):506-14.
    View in: PubMed
  50. Roberts JD, Chiche JD, Kolpa EM, Bloch DB, Bloch KD. cGMP-dependent protein kinase I interacts with TRIM39R, a novel Rpp21 domain-containing TRIM protein. Am J Physiol Lung Cell Mol Physiol. 2007 Oct; 293(4):L903-12.
    View in: PubMed
  51. Coggins MP, Bloch KD. Nitric oxide in the pulmonary vasculature. Arterioscler Thromb Vasc Biol. 2007 Sep; 27(9):1877-85.
    View in: PubMed
  52. Bloch KD, Ichinose F, Roberts JD, Zapol WM. Inhaled NO as a therapeutic agent. Cardiovasc Res. 2007 Jul 15; 75(2):339-48.
    View in: PubMed
  53. Xia Y, Yu PB, Sidis Y, Beppu H, Bloch KD, Schneyer AL, Lin HY. Repulsive guidance molecule RGMa alters utilization of bone morphogenetic protein (BMP) type II receptors by BMP2 and BMP4. J Biol Chem. 2007 Jun 22; 282(25):18129-40.
    View in: PubMed
  54. Buys ES, Raher MJ, Blake SL, Neilan TG, Graveline AR, Passeri JJ, Llano M, Perez-Sanz TM, Ichinose F, Janssens S, Zapol WM, Picard MH, Bloch KD, Scherrer-Crosbie M. Cardiomyocyte-restricted restoration of nitric oxide synthase 3 attenuates left ventricular remodeling after chronic pressure overload. Am J Physiol Heart Circ Physiol. 2007 Jul; 293(1):H620-7.
    View in: PubMed
  55. Mukherjee A, Sidis Y, Mahan A, Raher MJ, Xia Y, Rosen ED, Bloch KD, Thomas MK, Schneyer AL. FSTL3 deletion reveals roles for TGF-beta family ligands in glucose and fat homeostasis in adults. Proc Natl Acad Sci U S A. 2007 Jan 23; 104(4):1348-53.
    View in: PubMed
  56. Lewis GD, Lachmann J, Camuso J, Lepore JJ, Shin J, Martinovic ME, Systrom DM, Bloch KD, Semigran MJ. Sildenafil improves exercise hemodynamics and oxygen uptake in patients with systolic heart failure. Circulation. 2007 Jan 2; 115(1):59-66.
    View in: PubMed
  57. Ichinose F, Buys ES, Neilan TG, Furutani EM, Morgan JG, Jassal DS, Graveline AR, Searles RJ, Lim CC, Kaneki M, Picard MH, Scherrer-Crosbie M, Janssens S, Liao R, Bloch KD. Cardiomyocyte-specific overexpression of nitric oxide synthase 3 prevents myocardial dysfunction in murine models of septic shock. Circ Res. 2007 Jan 5; 100(1):130-9.
    View in: PubMed
  58. Schulze PC, Liu H, Choe E, Yoshioka J, Shalev A, Bloch KD, Lee RT. Nitric oxide-dependent suppression of thioredoxin-interacting protein expression enhances thioredoxin activity. Arterioscler Thromb Vasc Biol. 2006 Dec; 26(12):2666-72.
    View in: PubMed
  59. Neilan TG, Jassal DS, Perez-Sanz TM, Raher MJ, Pradhan AD, Buys ES, Ichinose F, Bayne DB, Halpern EF, Weyman AE, Derumeaux G, Bloch KD, Picard MH, Scherrer-Crosbie M. Tissue Doppler imaging predicts left ventricular dysfunction and mortality in a murine model of cardiac injury. Eur Heart J. 2006 Aug; 27(15):1868-75.
    View in: PubMed
  60. Bloch DB, Gulick T, Bloch KD, Yang WH. Processing body autoantibodies reconsidered. RNA. 2006 May; 12(5):707-9.
    View in: PubMed
  61. Zhu X, Zhao H, Graveline AR, Buys ES, Schmidt U, Bloch KD, Rosenzweig A, Chao W. MyD88 and NOS2 are essential for toll-like receptor 4-mediated survival effect in cardiomyocytes. Am J Physiol Heart Circ Physiol. 2006 Oct; 291(4):H1900-9.
    View in: PubMed
  62. Lewis GD, Witzke C, Colon-Hernandez P, Guerrero JL, Bloch KD, Semigran MJ. Sildenafil improves coronary artery patency in a canine model of platelet-mediated cyclic coronary occlusion after thrombolysis. J Am Coll Cardiol. 2006 Apr 4; 47(7):1471-7.
    View in: PubMed
  63. Hataishi R, Rodrigues AC, Morgan JG, Ichinose F, Derumeaux G, Bloch KD, Picard MH, Scherrer-Crosbie M. Nitric oxide synthase 2 and pressure-overload-induced left ventricular remodelling in mice. Exp Physiol. 2006 May; 91(3):633-9.
    View in: PubMed
  64. Yang WH, Yu JH, Gulick T, Bloch KD, Bloch DB. RNA-associated protein 55 (RAP55) localizes to mRNA processing bodies and stress granules. RNA. 2006 Apr; 12(4):547-54.
    View in: PubMed
  65. Hataishi R, Rodrigues AC, Neilan TG, Morgan JG, Buys E, Shiva S, Tambouret R, Jassal DS, Raher MJ, Furutani E, Ichinose F, Gladwin MT, Rosenzweig A, Zapol WM, Picard MH, Bloch KD, Scherrer-Crosbie M. Inhaled nitric oxide decreases infarction size and improves left ventricular function in a murine model of myocardial ischemia-reperfusion injury. Am J Physiol Heart Circ Physiol. 2006 Jul; 291(1):H379-84.
    View in: PubMed
  66. Yu JH, Yang WH, Gulick T, Bloch KD, Bloch DB. Ge-1 is a central component of the mammalian cytoplasmic mRNA processing body. RNA. 2005 Dec; 11(12):1795-802.
    View in: PubMed
  67. Hataishi R, Zapol WM, Bloch KD, Ichinose F. Inhaled nitric oxide does not reduce systemic vascular resistance in mice. Am J Physiol Heart Circ Physiol. 2006 May; 290(5):H1826-9.
    View in: PubMed
  68. Busch CJ, Liu H, Graveline AR, Bloch KD. Nitric oxide induces phosphodiesterase 4B expression in rat pulmonary artery smooth muscle cells. Am J Physiol Lung Cell Mol Physiol. 2006 Apr; 290(4):L747-L753.
    View in: PubMed
  69. Evgenov OV, Busch CJ, Evgenov NV, Liu R, Petersen B, Falkowski GE, Petho B, Vas A, Bloch KD, Zapol WM, Ichinose F. Inhibition of phosphodiesterase 1 augments the pulmonary vasodilator response to inhaled nitric oxide in awake lambs with acute pulmonary hypertension. Am J Physiol Lung Cell Mol Physiol. 2006 Apr; 290(4):L723-L729.
    View in: PubMed
  70. Bloch KD, Janssens S. Cardiomyocyte-specific overexpression of nitric oxide synthase 3: impact on left ventricular function and myocardial infarction. Trends Cardiovasc Med. 2005 Oct; 15(7):249-53.
    View in: PubMed
  71. Ling PD, Peng RS, Nakajima A, Yu JH, Tan J, Moses SM, Yang WH, Zhao B, Kieff E, Bloch KD, Bloch DB. Mediation of Epstein-Barr virus EBNA-LP transcriptional coactivation by Sp100. EMBO J. 2005 Oct 19; 24(20):3565-75.
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  72. Lepore JJ, Dec GW, Zapol WM, Bloch KD, Semigran MJ. Combined administration of intravenous dipyridamole and inhaled nitric oxide to assess reversibility of pulmonary arterial hypertension in potential cardiac transplant recipients. J Heart Lung Transplant. 2005 Nov; 24(11):1950-6.
    View in: PubMed
  73. Passeri J, Bloch KD. Nitric oxide and cardiac remodeling. Heart Fail Clin. 2005 Jul; 1(2):275-86.
    View in: PubMed
  74. Sebag IA, Handschumacher MD, Ichinose F, Morgan JG, Hataishi R, Rodrigues AC, Guerrero JL, Steudel W, Raher MJ, Halpern EF, Derumeaux G, Bloch KD, Picard MH, Scherrer-Crosbie M. Quantitative assessment of regional myocardial function in mice by tissue Doppler imaging: comparison with hemodynamics and sonomicrometry. Circulation. 2005 May 24; 111(20):2611-6.
    View in: PubMed
  75. Caironi P, Ichinose F, Liu R, Jones RC, Bloch KD, Zapol WM. 5-Lipoxygenase deficiency prevents respiratory failure during ventilator-induced lung injury. Am J Respir Crit Care Med. 2005 Aug 1; 172(3):334-43.
    View in: PubMed
  76. Yu PB, Beppu H, Kawai N, Li E, Bloch KD. Bone morphogenetic protein (BMP) type II receptor deletion reveals BMP ligand-specific gain of signaling in pulmonary artery smooth muscle cells. J Biol Chem. 2005 Jul 1; 280(26):24443-50.
    View in: PubMed
  77. Lepore JJ, Maroo A, Bigatello LM, Dec GW, Zapol WM, Bloch KD, Semigran MJ. Hemodynamic effects of sildenafil in patients with congestive heart failure and pulmonary hypertension: combined administration with inhaled nitric oxide. Chest. 2005 May; 127(5):1647-53.
    View in: PubMed
  78. Bloch DB, Yu JH, Yang WH, Graeme-Cook F, Lindor KD, Viswanathan A, Bloch KD, Nakajima A. The cytoplasmic dot staining pattern is detected in a subgroup of patients with primary biliary cirrhosis. J Rheumatol. 2005 Mar; 32(3):477-83.
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  79. Beppu H, Lei H, Bloch KD, Li E. Generation of a floxed allele of the mouse BMP type II receptor gene. Genesis. 2005 Mar; 41(3):133-7.
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  80. Weinberg EO, Scherrer-Crosbie M, Picard MH, Nasseri BA, MacGillivray C, Gannon J, Lian Q, Bloch KD, Lee RT. Rosuvastatin reduces experimental left ventricular infarct size after ischemia-reperfusion injury but not total coronary occlusion. Am J Physiol Heart Circ Physiol. 2005 Apr; 288(4):H1802-9.
    View in: PubMed
  81. Evgenov OV, Ichinose F, Evgenov NV, Gnoth MJ, Falkowski GE, Chang Y, Bloch KD, Zapol WM. Soluble guanylate cyclase activator reverses acute pulmonary hypertension and augments the pulmonary vasodilator response to inhaled nitric oxide in awake lambs. Circulation. 2004 Oct 12; 110(15):2253-9.
    View in: PubMed
  82. Rodrigues AC, Hataishi R, Ichinose F, Bloch KD, Derumeaux G, Picard MH, Scherrer-Crosbie M. Relationship of systolic dysfunction to area at risk and infarction size after ischemia-reperfusion in mice. J Am Soc Echocardiogr. 2004 Sep; 17(9):948-53.
    View in: PubMed
  83. Browner NC, Dey NB, Bloch KD, Lincoln TM. Regulation of cGMP-dependent protein kinase expression by soluble guanylyl cyclase in vascular smooth muscle cells. J Biol Chem. 2004 Nov 5; 279(45):46631-6.
    View in: PubMed
  84. Inglessis I, Shin JT, Lepore JJ, Palacios IF, Zapol WM, Bloch KD, Semigran MJ. Hemodynamic effects of inhaled nitric oxide in right ventricular myocardial infarction and cardiogenic shock. J Am Coll Cardiol. 2004 Aug 18; 44(4):793-8.
    View in: PubMed
  85. Bloch, Kenneth D.; Ichinose, Fumito; Zapol, Warren M. . Enhancing therapeutic effectiveness of nitric oxide inhalation. 2004.
  86. Beppu H, Ichinose F, Kawai N, Jones RC, Yu PB, Zapol WM, Miyazono K, Li E, Bloch KD. BMPR-II heterozygous mice have mild pulmonary hypertension and an impaired pulmonary vascular remodeling response to prolonged hypoxia. Am J Physiol Lung Cell Mol Physiol. 2004 Dec; 287(6):L1241-7.
    View in: PubMed
  87. Del Monte F, Dalal R, Tabchy A, Couget J, Bloch KD, Peterson R, Hajjar RJ. Transcriptional changes following restoration of SERCA2a levels in failing rat hearts. FASEB J. 2004 Sep; 18(12):1474-6.
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  88. Lewis GD, Bloch KD, Semigran MJ. Pulmonary thromboembolism superimposed on a congenital ventricular septal defect in a 50-year-old man inhaled nitric oxide and sildenafil to the rescue. Cardiol Rev. 2004 Jul-Aug; 12(4):188-90.
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  89. Janssens, Stefan; Bloch, Kenneth D., Collen; Desire. Method of inducing vasodilation and treating pulmonary hypertension using adenoviral-mediated transfer of the nitric oxide synthase gene. 2004.
  90. Janssens S, Pokreisz P, Schoonjans L, Pellens M, Vermeersch P, Tjwa M, Jans P, Scherrer-Crosbie M, Picard MH, Szelid Z, Gillijns H, Van de Werf F, Collen D, Bloch KD. Cardiomyocyte-specific overexpression of nitric oxide synthase 3 improves left ventricular performance and reduces compensatory hypertrophy after myocardial infarction. Circ Res. 2004 May 14; 94(9):1256-62.
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  91. Yu JH, Nakajima A, Nakajima H, Diller LR, Bloch KD, Bloch DB. Restoration of promyelocytic leukemia protein-nuclear bodies in neuroblastoma cells enhances retinoic acid responsiveness. Cancer Res. 2004 Feb 1; 64(3):928-33.
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  92. Hassoun PM, Filippov G, Fogel M, Donaldson C, Kayyali US, Shimoda LA, Bloch KD. Hypoxia decreases expression of soluble guanylate cyclase in cultured rat pulmonary artery smooth muscle cells. Am J Respir Cell Mol Biol. 2004 Jun; 30(6):908-13.
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  93. Zapol, Warren M.; Bloch, Kenneth D. Use of inhaled NO as anti-inflammatory agent. 2003.
  94. Ichinose F, Bloch KD, Wu JC, Hataishi R, Aretz HT, Picard MH, Scherrer-Crosbie M. Pressure overload-induced LV hypertrophy and dysfunction in mice are exacerbated by congenital NOS3 deficiency. Am J Physiol Heart Circ Physiol. 2004 Mar; 286(3):H1070-5.
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  95. Wu JC, Nasseri BA, Bloch KD, Picard MH, Scherrer-Crosbie M. Influence of sex on ventricular remodeling after myocardial infarction in mice. J Am Soc Echocardiogr. 2003 Nov; 16(11):1158-62.
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  96. Liu H, Nowak R, Chao W, Bloch KD. Nerve growth factor induces anti-apoptotic heme oxygenase-1 in rat pheochromocytoma PC12 cells. J Neurochem. 2003 Sep; 86(6):1553-63.
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  97. Ichinose F, Hataishi R, Wu JC, Kawai N, Rodrigues AC, Mallari C, Post JM, Parkinson JF, Picard MH, Bloch KD, Zapol WM. A selective inducible NOS dimerization inhibitor prevents systemic, cardiac, and pulmonary hemodynamic dysfunction in endotoxemic mice. Am J Physiol Heart Circ Physiol. 2003 Dec; 285(6):H2524-30.
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  98. de la Monte SM, Chiche J, von dem Bussche A, Sanyal S, Lahousse SA, Janssens SP, Bloch KD. Nitric oxide synthase-3 overexpression causes apoptosis and impairs neuronal mitochondrial function: relevance to Alzheimer's-type neurodegeneration. Lab Invest. 2003 Feb; 83(2):287-98.
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  99. Baboolal HA, Ichinose F, Ullrich R, Kawai N, Bloch KD, Zapol WM. Reactive oxygen species scavengers attenuate endotoxin-induced impairment of hypoxic pulmonary vasoconstriction in mice. Anesthesiology. 2002 Nov; 97(5):1227-33.
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  100. Lepore JJ, Maroo A, Pereira NL, Ginns LC, Dec GW, Zapol WM, Bloch KD, Semigran MJ. Effect of sildenafil on the acute pulmonary vasodilator response to inhaled nitric oxide in adults with primary pulmonary hypertension. Am J Cardiol. 2002 Sep 15; 90(6):677-80.
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  101. Sinnaeve P, Chiche JD, Gillijns H, Van Pelt N, Wirthlin D, Van De Werf F, Collen D, Bloch KD, Janssens S. Overexpression of a constitutively active protein kinase G mutant reduces neointima formation and in-stent restenosis. Circulation. 2002 Jun 18; 105(24):2911-6.
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  102. Ichinose F, Ullrich R, Sapirstein A, Jones RC, Bonventre JV, Serhan CN, Bloch KD, Zapol WM. Cytosolic phospholipase A(2) in hypoxic pulmonary vasoconstriction. J Clin Invest. 2002 Jun; 109(11):1493-500.
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  103. Raveh Y, Ichinose F, Orbach P, Bloch KD, Zapol WM. Radical scavengers protect murine lungs from endotoxin-induced hyporesponsiveness to inhaled nitric oxide. Anesthesiology. 2002 Apr; 96(4):926-33.
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  104. Scherrer-Crosbie M, Ullrich R, Bloch KD, Nakajima H, Nasseri B, Aretz HT, Lindsey ML, Vançon AC, Huang PL, Lee RT, Zapol WM, Picard MH. Endothelial nitric oxide synthase limits left ventricular remodeling after myocardial infarction in mice. Circulation. 2001 Sep 11; 104(11):1286-91.
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  105. Schmidt U, Han RO, DiSalvo TG, Guerrero JL, Gold HK, Zapol WM, Bloch KD, Semigran MJ. Cessation of platelet-mediated cyclic canine coronary occlusion after thrombolysis by combining nitric oxide inhalation with phosphodiesterase-5 inhibition. J Am Coll Cardiol. 2001 Jun 1; 37(7):1981-8.
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  106. Ichinose F, Erana-Garcia J, Hromi J, Raveh Y, Jones R, Krim L, Clark MW, Winkler JD, Bloch KD, Zapol WM. Nebulized sildenafil is a selective pulmonary vasodilator in lambs with acute pulmonary hypertension. Crit Care Med. 2001 May; 29(5):1000-5.
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  107. Bloch KD. Digestion of DNA with restriction endonucleases. Curr Protoc Protein Sci. 2001 May; Appendix 4:Appendix 4I.
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  108. Bloch KD. Mapping by multiple endonuclease digestions. Curr Protoc Mol Biol. 2001 May; Chapter 3:Unit3.2.
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  109. Bloch KD, Grossmann B. Digestion of DNA with restriction endonucleases. Curr Protoc Mol Biol. 2001 May; Chapter 3:Unit3.1.
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  110. Bloch KD. Digestion of DNA with restriction endonucleases. Curr Protoc Neurosci. 2001 May; Appendix 1:Appendix 1M.
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  111. Bloch KD. Digestion of DNA with restriction endonucleases. Curr Protoc Immunol. 2001 May; Chapter 10:Unit 10.8.
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  112. Bloch KD. Mapping by partial endonuclease digestions. Curr Protoc Mol Biol. 2001 May; Chapter 3:Unit3.3.
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  113. Ichinose F, Zapol WM, Sapirstein A, Ullrich R, Tager AM, Coggins K, Jones R, Bloch KD. Attenuation of hypoxic pulmonary vasoconstriction by endotoxemia requires 5-lipoxygenase in mice. Circ Res. 2001 Apr 27; 88(8):832-8.
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  114. Bloch, Donald B.; Bloch, Kenneth D. . Leukocyte-specific protein and gene, and methods of use thereof. 2001.
  115. Takata M, Filippov G, Liu H, Ichinose F, Janssens S, Bloch DB, Bloch KD. Cytokines decrease sGC in pulmonary artery smooth muscle cells via NO-dependent and NO-independent mechanisms. Am J Physiol Lung Cell Mol Physiol. 2001 Feb; 280(2):L272-8.
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  116. Sinnaeve P, Chiche JD, Nong Z, Varenne O, Van Pelt N, Gillijns H, Collen D, Bloch KD, Janssens S. Soluble guanylate cyclase alpha(1) and beta(1) gene transfer increases NO responsiveness and reduces neointima formation after balloon injury in rats via antiproliferative and antimigratory effects. Circ Res. 2001 Jan 19; 88(1):103-9.
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  117. Holzmann A, Manktelow C, Weimann J, Bloch KD, Zapol WM. Inhibition of lung phosphodiesterase improves responsiveness to inhaled nitric oxide in isolated-perfused lungs from rats challenged with endotoxin. Intensive Care Med. 2001 Jan; 27(1):251-7.
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  118. Kwon OJ, Brautbar C, Weintrob N, Sprecher E, Saphirman C, Bloch K, Pinhas-Hamiel O, Assah S, Vardi P, Israel S. Immunogenetics of HLA class II in Israeli Ashkenazi Jewish, Israeli non-Ashkenazi Jewish, and in Israeli Arab IDDM patients. Hum Immunol. 2001 Jan; 62(1):85-91.
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  119. Budts W, Pokreisz P, Nong Z, Van Pelt N, Gillijns H, Gerard R, Lyons R, Collen D, Bloch KD, Janssens S. Aerosol gene transfer with inducible nitric oxide synthase reduces hypoxic pulmonary hypertension and pulmonary vascular remodeling in rats. Circulation. 2000 Dec 5; 102(23):2880-5.
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  120. Ullrich R, Scherrer-Crosbie M, Bloch KD, Ichinose F, Nakajima H, Picard MH, Zapol WM, Quezado ZM. Congenital deficiency of nitric oxide synthase 2 protects against endotoxin-induced myocardial dysfunction in mice. Circulation. 2000 Sep 19; 102(12):1440-6.
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  121. Bloch DB, Nakajima A, Gulick T, Chiche JD, Orth D, de La Monte SM, Bloch KD. Sp110 localizes to the PML-Sp100 nuclear body and may function as a nuclear hormone receptor transcriptional coactivator. Mol Cell Biol. 2000 Aug; 20(16):6138-46.
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  122. Roberts JD, Chiche JD, Weimann J, Steudel W, Zapol WM, Bloch KD. Nitric oxide inhalation decreases pulmonary artery remodeling in the injured lungs of rat pups. Circ Res. 2000 Jul 21; 87(2):140-5.
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  123. Weimann J, Ullrich R, Hromi J, Fujino Y, Clark MW, Bloch KD, Zapol WM. Sildenafil is a pulmonary vasodilator in awake lambs with acute pulmonary hypertension. Anesthesiology. 2000 Jun; 92(6):1702-12.
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  124. Zapol, Warren M.; Bloch, Kenneth D. Treatment of vascular thrombosis and restenosis with inhaled nitric oxide . 2000.
  125. Bloch K, Vardi P. Therapeutic differentiation of tumor-derived insulin-producing cells selected for resistance to diabetogenic drugs. Int J Exp Diabetes Res. 2000; 1(3):233-7.
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  126. Weimann J, Bloch KD, Takata M, Steudel W, Zapol WM. Congenital NOS2 deficiency protects mice from LPS-induced hyporesponsiveness to inhaled nitric oxide. Anesthesiology. 1999 Dec; 91(6):1744-53.
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  127. Ullrich R, Bloch KD, Ichinose F, Steudel W, Zapol WM. Hypoxic pulmonary blood flow redistribution and arterial oxygenation in endotoxin-challenged NOS2-deficient mice. J Clin Invest. 1999 Nov; 104(10):1421-9.
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  128. Bloch KD. Regulation of endothelial NO synthase mRNA stability: RNA-binding proteins crowd on the 3'-untranslated region. Circ Res. 1999 Oct 1; 85(7):653-5.
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  129. Holzmann A, Manktelow C, Taut FJ, Bloch KD, Zapol WM. Inhibition of nitric oxide synthase prevents hyporesponsiveness to inhaled nitric oxide in lungs from endotoxin-challenged rats. Anesthesiology. 1999 Jul; 91(1):215-21.
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  130. Bloch DB, Chiche JD, Orth D, de la Monte SM, Rosenzweig A, Bloch KD. Structural and functional heterogeneity of nuclear bodies. Mol Cell Biol. 1999 Jun; 19(6):4423-30.
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  131. Zapol, Warren M.; Bloch, Kenneth D. Treatment of vascular thrombosis and restenosis with inhaled nitric oxide. 1999.
  132. Powel V, Moreira GA, O'Donnell DC, Filippov G, Bloch KD, Gordon JB. Maturational changes in ovine pulmonary vascular responses to inhaled nitric oxide. Pediatr Pulmonol. 1999 Mar; 27(3):157-66.
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  133. Tyler RC, Muramatsu M, Abman SH, Stelzner TJ, Rodman DM, Bloch KD, McMurtry IF. Variable expression of endothelial NO synthase in three forms of rat pulmonary hypertension. Am J Physiol. 1999 Feb; 276(2 Pt 1):L297-303.
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  134. Sohn YK, Ganju N, Bloch KD, Wands JR, de la Monte SM. Neuritic sprouting with aberrant expression of the nitric oxide synthase III gene in neurodegenerative diseases. J Neurol Sci. 1999 Jan 15; 162(2):133-51.
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  135. Koike G, Chiche JD, Shiozawa M, Simon JS, Szpirer J, Jacob HJ, Szpirer C, Bloch KD. Localization of rat genes in the nitric oxide signaling pathway: candidates for the pathogenesis of complex diseases. Mamm Genome. 1999 Jan; 10(1):71-3.
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  136. Lepore JJ, Bloch KD. Nitric oxide and pulmonary hyperntension. Nitric oxide and the cardiovascular system. Loscalzo J and Vita JA, eds. 1999; 247-272.
  137. Chiche JD, Schlutsmeyer SM, Bloch DB, de la Monte SM, Roberts JD, Filippov G, Janssens SP, Rosenzweig A, Bloch KD. Adenovirus-mediated gene transfer of cGMP-dependent protein kinase increases the sensitivity of cultured vascular smooth muscle cells to the antiproliferative and pro-apoptotic effects of nitric oxide/cGMP. J Biol Chem. 1998 Dec 18; 273(51):34263-71.
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  138. Kauschansky A, Frydman M, Assa S, Kwon OJ, Israel S, Lazard D, Sprecher E, Bloch K, Brautbar C, Vardi P. D-penicillamine-induced pancreatic islet autoantibody production is independent of the immunogenetic background: a lesson from patients with Wilson's disease. Clin Immunol Immunopathol. 1998 Dec; 89(3):279-83.
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  139. Weimann J, Bauer H, Bigatello L, Bloch KD, Martin E, Zapol WM. ABO blood group and inhaled nitric oxide in acute respiratory distress syndrome. Lancet. 1998 Jun 13; 351(9118):1786-7.
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  140. Steudel W, Scherrer-Crosbie M, Bloch KD, Weimann J, Huang PL, Jones RC, Picard MH, Zapol WM. Sustained pulmonary hypertension and right ventricular hypertrophy after chronic hypoxia in mice with congenital deficiency of nitric oxide synthase 3. J Clin Invest. 1998 Jun 1; 101(11):2468-77.
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  141. Ichinose F, Adrie C, Hurford WE, Bloch KD, Zapol WM. Selective pulmonary vasodilation induced by aerosolized zaprinast. Anesthesiology. 1998 Feb; 88(2):410-6.
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  142. Sanchez LS, de la Monte SM, Filippov G, Jones RC, Zapol WM, Bloch KD. Cyclic-GMP-binding, cyclic-GMP-specific phosphodiesterase (PDE5) gene expression is regulated during rat pulmonary development. Pediatr Res. 1998 Feb; 43(2):163-8.
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  143. Head CA, Brugnara C, Martinez-Ruiz R, Kacmarek RM, Bridges KR, Kuter D, Bloch KD, Zapol WM. Low concentrations of nitric oxide increase oxygen affinity of sickle erythrocytes in vitro and in vivo. J Clin Invest. 1997 Sep 1; 100(5):1193-8.
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  144. Filippov G, Bloch DB, Bloch KD. Nitric oxide decreases stability of mRNAs encoding soluble guanylate cyclase subunits in rat pulmonary artery smooth muscle cells. J Clin Invest. 1997 Aug 15; 100(4):942-8.
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  145. Liu HW, Anand A, Bloch K, Christiani D, Kradin R. Expression of inducible nitric oxide synthase by macrophages in rat lung. Am J Respir Crit Care Med. 1997 Jul; 156(1):223-8.
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  146. Bloch KD, Filippov G, Sanchez LS, Nakane M, de la Monte SM. Pulmonary soluble guanylate cyclase, a nitric oxide receptor, is increased during the perinatal period. Am J Physiol. 1997 Mar; 272(3 Pt 1):L400-6.
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  147. Liu H, Force T, Bloch KD. Nerve growth factor decreases soluble guanylate cyclase in rat pheochromocytoma PC12 cells. J Biol Chem. 1997 Feb 28; 272(9):6038-43.
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  148. de la Monte SM, Bloch KD. Aberrant expression of the constitutive endothelial nitric oxide synthase gene in Alzheimer disease. Mol Chem Neuropathol. 1997 Jan-Feb; 30(1-2):139-59.
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  149. Holzmann A, Bloch KD, Sanchez LS, Filippov G, Zapol WM. Hyporesponsiveness to inhaled nitric oxide in isolated, perfused lungs from endotoxin-challenged rats. Am J Physiol. 1996 Dec; 271(6 Pt 1):L981-6.
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  150. Bloch DB, de la Monte SM, Guigaouri P, Filippov A, Bloch KD. Identification and characterization of a leukocyte-specific component of the nuclear body. J Biol Chem. 1996 Nov 15; 271(46):29198-204.
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  151. Adrie C, Bloch KD, Moreno PR, Hurford WE, Guerrero JL, Holt R, Zapol WM, Gold HK, Semigran MJ. Inhaled nitric oxide increases coronary artery patency after thrombolysis. Circulation. 1996 Oct 15; 94(8):1919-26.
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  152. Janssens SP, Bloch KD, Nong Z, Gerard RD, Zoldhelyi P, Collen D. Adenoviral-mediated transfer of the human endothelial nitric oxide synthase gene reduces acute hypoxic pulmonary vasoconstriction in rats. J Clin Invest. 1996 Jul 15; 98(2):317-24.
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  153. Bloch K. Some biochemical thoughts on the RNA world. Chem Biol. 1996 May; 3(5):405-7.
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  154. Bloch K. The origins of intermediary metabolism at Columbia College of Physicians and Surgeons (P&S). FASEB J. 1996 May; 10(7):802-5.
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  155. Lee JS, Adrie C, Jacob HJ, Roberts JD, Zapol WM, Bloch KD. Chronic inhalation of nitric oxide inhibits neointimal formation after balloon-induced arterial injury. Circ Res. 1996 Feb; 78(2):337-42.
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  156. Lloyd-Jones DM, Bloch KD. The vascular biology of nitric oxide and its role in atherogenesis. Annu Rev Med. 1996; 47:365-75.
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  157. Zapol WM, Bloch KD. Nitric oxide and the lung. Lung biology in health and disease. Lenfant C, executive editor. 1996.
  158. Kurrek MM, Zapol WM, Holzmann A, Filippov G, Winkler M, Bloch KD. In vivo lipopolysaccharide pretreatment inhibits cGMP release from the isolated-perfused rat lung. Am J Physiol. 1995 Nov; 269(5 Pt 1):L618-24.
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  159. Kurrek MM, Castillo L, Bloch KD, Tannenbaum SR, Zapol WM. Inhaled nitric oxide does not alter endotoxin-induced nitric oxide synthase activity during rat lung perfusion. J Appl Physiol. 1995 Oct; 79(4):1088-92.
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  160. Huang PL, Huang Z, Mashimo H, Bloch KD, Moskowitz MA, Bevan JA, Fishman MC. Hypertension in mice lacking the gene for endothelial nitric oxide synthase. Nature. 1995 Sep 21; 377(6546):239-42.
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  161. Bloch DB, Rabkina D, Bloch KD. The cell proliferation-associated protein Ki-67 is a target of autoantibodies in the serum of MRL mice. Lab Invest. 1995 Sep; 73(3):366-71.
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  162. Bloch KD, Wolfram JR, Brown DM, Roberts JD, Zapol DG, Lepore JJ, Filippov G, Thomas JE, Jacob HJ, Bloch DB. Three members of the nitric oxide synthase II gene family (NOS2A, NOS2B, and NOS2C) colocalize to human chromosome 17. Genomics. 1995 Jun 10; 27(3):526-30.
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  163. Kawai N, Bloch DB, Filippov G, Rabkina D, Suen HC, Losty PD, Janssens SP, Zapol WM, de la Monte S, Bloch KD. Constitutive endothelial nitric oxide synthase gene expression is regulated during lung development. Am J Physiol. 1995 Apr; 268(4 Pt 1):L589-95.
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  164. Staples JF, Zapol WM, Bloch KD, Kawai N, Val VM, Hochachka PW. Nitric oxide responses of air-breathing and water-breathing fish. Am J Physiol. 1995 Mar; 268(3 Pt 2):R816-9.
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  165. de la Monte SM, Quertermous T, Hong CC, Bloch KD. Regional and maturation-associated expression of endothelin 2 in rat gastrointestinal tract. J Histochem Cytochem. 1995 Feb; 43(2):203-9.
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  166. Roberts JD, Roberts CT, Jones RC, Zapol WM, Bloch KD. Continuous nitric oxide inhalation reduces pulmonary arterial structural changes, right ventricular hypertrophy, and growth retardation in the hypoxic newborn rat. Circ Res. 1995 Feb; 76(2):215-22.
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  167. Bloch KD. The nitric oxide synthase gene family. Molecular Biology of the Kidney in Health and Disease. Schlondorff D and Bonventre JV, ed. 1995; 133-142.
  168. Bloch DB, Rabkina D, Quertermous T, Bloch KD. The immunoreactive region in a novel autoantigen contains a nuclear localization sequence. Clin Immunol Immunopathol. 1994 Sep; 72(3):380-9.
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  169. Horwitz MJ, Bloch KD, Kim NB, Amico JA. Expression of the endothelin-1 and oxytocin genes in the hypothalamus of the pregnant rat. Brain Res. 1994 Jun 13; 648(1):59-64.
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  170. Cicila GT, Rapp JP, Bloch KD, Kurtz TW, Pravenec M, Kren V, Hong CC, Quertermous T, Ng SC. Cosegregation of the endothelin-3 locus with blood pressure and relative heart weight in inbred Dahl rats. J Hypertens. 1994 Jun; 12(6):643-51.
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  171. Suen HC, Bloch KD, Donahoe PK. Antenatal glucocorticoid corrects pulmonary immaturity in experimentally induced congenital diaphragmatic hernia in rats. Pediatr Res. 1994 May; 35(5):523-9.
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  172. Rovira I, Chen TY, Winkler M, Kawai N, Bloch KD, Zapol WM. Effects of inhaled nitric oxide on pulmonary hemodynamics and gas exchange in an ovine model of ARDS. J Appl Physiol. 1994 Jan; 76(1):345-55.
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  173. Shimouchi A, Janssens SP, Bloch DB, Zapol WM, Bloch KD. cAMP regulates soluble guanylate cyclase beta 1-subunit gene expression in RFL-6 rat fetal lung fibroblasts. Am J Physiol. 1993 Nov; 265(5 Pt 1):L456-61.
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  174. Roberts JD, Chen TY, Kawai N, Wain J, Dupuy P, Shimouchi A, Bloch K, Polaner D, Zapol WM. Inhaled nitric oxide reverses pulmonary vasoconstriction in the hypoxic and acidotic newborn lamb. Circ Res. 1993 Feb; 72(2):246-54.
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  175. Janssens SP, Simouchi A, Quertermous T, Bloch DB, Bloch KD. Cloning and expression of a cDNA encoding human endothelium-derived relating factor/nitric oxide synthase. J Biol Chem. 1992 Nov 5; 267(31):22694.
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  176. Janssens SP, Shimouchi A, Quertermous T, Bloch DB, Bloch KD. Cloning and expression of a cDNA encoding human endothelium-derived relaxing factor/nitric oxide synthase. J Biol Chem. 1992 Jul 25; 267(21):14519-22.
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  177. Bloch KD, Hong CC, Eddy RL, Shows TB, Quertermous T. cDNA cloning and chromosomal assignment of the endothelin 2 gene: vasoactive intestinal contractor peptide is rat endothelin 2. Genomics. 1991 May; 10(1):236-42.
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  178. Lee ME, de la Monte SM, Ng SC, Bloch KD, Quertermous T. Expression of the potent vasoconstrictor endothelin in the human central nervous system. J Clin Invest. 1990 Jul; 86(1):141-7.
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  179. Lee ME, Bloch KD, Clifford JA, Quertermous T. Functional analysis of the endothelin-1 gene promoter. Evidence for an endothelial cell-specific cis-acting sequence. J Biol Chem. 1990 Jun 25; 265(18):10446-50.
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  180. Bloch KD, Eddy RL, Shows TB, Quertermous T. cDNA cloning and chromosomal assignment of the gene encoding endothelin 3. J Biol Chem. 1989 Oct 25; 264(30):18156-61.
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  181. Bloch KD, Friedrich SP, Lee ME, Eddy RL, Shows TB, Quertermous T. Structural organization and chromosomal assignment of the gene encoding endothelin. J Biol Chem. 1989 Jun 25; 264(18):10851-7.
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  182. Lee RT, Brock TA, Tolman C, Bloch KD, Seidman JG, Neer EJ. Subtype-specific increase in G-protein alpha-subunit mRNA by interleukin 1 beta. FEBS Lett. 1989 Jun 5; 249(2):139-42.
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  183. Bloch KD, Zamir N, Lichtstein D, Seidman CE, Seidman JG. Ouabain induces secretion of proatrial natriuretic factor by rat atrial cardiocytes. Am J Physiol. 1988 Sep; 255(3 Pt 1):E383-7.
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  184. Ladenson PW, Bloch KD, Seidman JG. Modulation of atrial natriuretic factor by thyroid hormone: messenger ribonucleic acid and peptide levels in hypothyroid, euthyroid, and hyperthyroid rat atria and ventricles. Endocrinology. 1988 Jul; 123(1):652-7.
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  185. Bloch DB, Bloch KD, Iannuzzi M, Collins FS, Neer EJ, Seidman JG, Morton CC. The gene for the alpha i1 subunit of human guanine nucleotide binding protein maps near the cystic fibrosis locus. Am J Hum Genet. 1988 Jun; 42(6):884-8.
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  186. Seidman CE, Wong DW, Jarcho JA, Bloch KD, Seidman JG. Cis-acting sequences that modulate atrial natriuretic factor gene expression. Proc Natl Acad Sci U S A. 1988 Jun; 85(11):4104-8.
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  187. Kim SY, Ang SL, Bloch DB, Bloch KD, Kawahara Y, Tolman C, Lee R, Seidman JG, Neer EJ. Identification of cDNA encoding an additional alpha subunit of a human GTP-binding protein: expression of three alpha i subtypes in human tissues and cell lines. Proc Natl Acad Sci U S A. 1988 Jun; 85(12):4153-7.
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  188. Lee RT, Bloch KD, Pfeffer JM, Pfeffer MA, Neer EJ, Seidman CE. Atrial natriuretic factor gene expression in ventricles of rats with spontaneous biventricular hypertrophy. J Clin Invest. 1988 Feb; 81(2):431-4.
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  189. Neer EJ, Kim SY, Ang SL, Bloch DB, Bloch KD, Kawahara Y, Tolman C, Lee R, Logothetis D, Kim D, et al. Functions of G-protein subunits. Cold Spring Harb Symp Quant Biol. 1988; 53 Pt 1:241-6.
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  190. Mendez RE, Pfeffer JM, Ortola FV, Bloch KD, Anderson S, Seidman JG, Brenner BM. Atrial natriuretic peptide transcription, storage, and release in rats with myocardial infarction. Am J Physiol. 1987 Dec; 253(6 Pt 2):H1449-55.
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  191. Seidman CE, Bloch KD. Molecular approaches to the study of atrial natriuretic factor. Am J Med Sci. 1987 Sep; 294(3):144-9.
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  192. Zeller R, Bloch KD, Williams BS, Arceci RJ, Seidman CE. Localized expression of the atrial natriuretic factor gene during cardiac embryogenesis. Genes Dev. 1987 Sep; 1(7):693-8.
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  193. Bloch KD, Jones SW, Preibisch G, Seipke G, Seidman CE, Seidman JG. Proatrial natriuretic factor is phosphorylated by rat cardiocytes in culture. J Biol Chem. 1987 Jul 25; 262(21):9956-61.
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  194. Bloch KD, Zisfein JB, Margolies MN, Homcy CJ, Seidman JG, Graham RM. A serum protease cleaves proANF into a 14-kilodalton peptide and ANF. Am J Physiol. 1987 Jan; 252(1 Pt 1):E147-51.
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  195. Bloch KD, Seidman JG, Naftilan JD, Fallon JT, Seidman CE. Neonatal atria and ventricles secrete atrial natriuretic factor via tissue-specific secretory pathways. Cell. 1986 Dec 5; 47(5):695-702.
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  196. Ballermann BJ, Bloch KD, Seidman JG, Brenner BM. Atrial natriuretic peptide transcription, secretion, and glomerular receptor activity during mineralocorticoid escape in the rat. J Clin Invest. 1986 Sep; 78(3):840-3.
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  197. Zisfein JB, Matsueda GR, Fallon JT, Bloch KD, Seidman CE, Seidman JG, Homcy CJ, Graham RM. Atrial natriuretic factor: assessment of its structure in atria and regulation of its biosynthesis with volume depletion. J Mol Cell Cardiol. 1986 Sep; 18(9):917-29.
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  198. Graham RM, Bloch KD, Delaney VB, Bourke E, Seidman JG. Bartter's syndrome and the atrial natriuretic factor gene. Hypertension. 1986 Jun; 8(6):549-51.
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  199. Bloch KD, Scott JA, Zisfein JB, Fallon JT, Margolies MN, Seidman CE, Matsueda GR, Homcy CJ, Graham RM, Seidman JG. Biosynthesis and secretion of proatrial natriuretic factor by cultured rat cardiocytes. Science. 1985 Dec 6; 230(4730):1168-71.
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  200. Seidman CE, Bloch KD, Zisfein J, Smith JA, Haber E, Homcy C, Duby AD, Choi E, Graham RM, Seidman JG. Molecular studies of the atrial natriuretic factor gene. Hypertension. 1985 May-Jun; 7(3 Pt 2):I31-4.
    View in: PubMed
  201. Seidman CE, Bloch KD, Klein KA, Smith JA, Seidman JG. Nucleotide sequences of the human and mouse atrial natriuretic factor genes. Science. 1984 Dec 7; 226(4679):1206-9.
    View in: PubMed
  202. Caras IW, Bloch K. Effects of a supernatant protein activator on microsomal squalene-2,3-oxide-lanosterol cyclase. J Biol Chem. 1979 Dec 10; 254(23):11816-21.
    View in: PubMed
  203. Bloch KD, Seidman JG, Seidman CE. Structure and expression of the atrial natriuretic factor gene. Atrial hormones and other natriuretic factors: Clinical Physiology Series. 1977; 7-18.
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