John M Asara, PH.D.
|Title||Assistant Professor of Medicine|
|Institution||Beth Israel Deaconess Medical Center|
|Address||Center for Life Science|
BIDMC - Rm 409
3 Blackfan Circle
Boston MA 02115
||10 out of 100 Top Scientific Discoveries|
||Young Investigator Award|
||Faculty of 1000, Biology, Signal Transduction|
||Outstanding Poster Award|
||Shared Instrumentation Grant Award|
Research activities in the Asara lab focusses on developing -omics (proteomics and metabolomics) approaches to personalized medicine by analyzing cancer cells and tumor samples in order help make appropriate therapeutic decisions with "smart" drugs. This is accomplished by understanding how cancer cells are signaling for growth and proliferation and how signaling talks to metabolic processes in order to develop mass spec quantitative assays. We are developing hypothesis directed proteomics and metabolomics strategies to understand the fundamental drivers of disease in cancers such as multiple myeloma, lung cancer and prostate cancer by performing protein-protein interaction studies, immunoprecipitation (IP)-tandem mass spectrometry (MS/MS), quantitative phosphoproteomics and metabolic flux analyses. Taken together, this information is vital in selecting the appropriate use of newly developed drugs. In addition to our internal research, we are involved in many collaborative projects that are coordinated through our state-of-the-art mass spectrometry technologies and services through our mass spectrometry facility. We were just awarded a NIH Shared Instrumentation Grant for a Thermo Velos Elite Orbitrap mass spectrometer to enhance the sensitivity and throughput of our personalized medicine approaches.
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