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Last Name
Institution

Sam Whan Lee, Ph.D.

TitleAssociate Professor of Dermatology
InstitutionMassachusetts General Hospital
DepartmentDermatology
AddressMassachusetts General Hospital
Cbrc
149 13th Street
Charlestown MA 02129
Phone617/726-6691
Fax617/643-2334

 Research 
 research resources
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eagle-i@hms.harvard.edu.
Sam W. Lee Laboratory - Mouse strains (2)

 Bibliographic 
 selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Namba T, Tian F, Chu K, Hwang SY, Yoon KW, Byun S, Hiraki M, Mandinova A, Lee SW. CDIP1-BAP31 Complex Transduces Apoptotic Signals from Endoplasmic Reticulum to Mitochondria under Endoplasmic Reticulum Stress. Cell Rep. 2013 Oct 31; 5(2):331-9.
    View in: PubMed
  2. Ide T, Brown-Endres L, Chu K, Ongusaha PP, Ohtsuka T, El-Deiry WS, Aaronson SA, Lee SW. Retraction notice to: GAMT, a p53-inducible modulator of apoptosis, is critical for the adaptive response to nutrient stress. Mol Cell. 2013 Aug 22; 51(4):552.
    View in: PubMed
  3. Kim HG, Tan L, Weisberg EL, Liu F, Canning P, Choi HG, Ezell SA, Wu H, Zhao Z, Wang J, Mandinova A, Griffin JD, Bullock AN, Liu Q, Lee SW, Gray NS. Discovery of a Potent and Selective DDR1 Receptor Tyrosine Kinase Inhibitor. ACS Chem Biol. 2013 Oct 18; 8(10):2145-50.
    View in: PubMed
  4. Gurkar AU, Chu K, Raj L, Bouley R, Lee SH, Kim YB, Dunn SE, Mandinova A, Lee SW. Identification of ROCK1 kinase as a critical regulator of Beclin1-mediated autophagy during metabolic stress. Nat Commun. 2013 Jul 23; 4:2189.
    View in: PubMed
  5. Huang H, Kong D, Byun KH, Ye C, Koda S, Lee DH, Oh BC, Lee SW, Lee B, Zabolotny JM, Kim MS, Bjørbæk C, Lowell BB, Kim YB. Rho-kinase regulates energy balance by targeting hypothalamic leptin receptor signaling. Nat Neurosci. 2012 Oct; 15(10):1391-8.
    View in: PubMed
  6. Matochko WL, Chu K, Jin B, Lee SW, Whitesides GM, Derda R. Deep sequencing analysis of phage libraries using Illumina platform. Methods. 2012 Sep; 58(1):47-55.
    View in: PubMed
  7. Brown-Endres L, Schoenfeld D, Tian F, Kim HG, Namba T, Muñoz-Fontela C, Mandinova A, Aaronson SA, Lee SW. Expression of the p53 target CDIP correlates with sensitivity to TNFa-induced apoptosis in cancer cells. Cancer Res. 2012 May 1; 72(9):2373-82.
    View in: PubMed
  8. Mungamuri SK, Benson EK, Wang S, Gu W, Lee SW, Aaronson SA. p53-mediated heterochromatin reorganization regulates its cell fate decisions. Nat Struct Mol Biol. 2012 May; 19(5):478-84, S1.
    View in: PubMed
  9. Chun KH, Araki K, Jee Y, Lee DH, Oh BC, Huang H, Park KS, Lee SW, Zabolotny JM, Kim YB. Regulation of glucose transport by ROCK1 differs from that of ROCK2 and is controlled by actin polymerization. Endocrinology. 2012 Apr; 153(4):1649-62.
    View in: PubMed
  10. Muñoz-Fontela C, Pazos M, Delgado I, Murk W, Mungamuri SK, Lee SW, García-Sastre A, Moran TM, Aaronson SA. p53 serves as a host antiviral factor that enhances innate and adaptive immune responses to influenza A virus. J Immunol. 2011 Dec 15; 187(12):6428-36.
    View in: PubMed
  11. Raj L, Ide T, Gurkar AU, Foley M, Schenone M, Li X, Tolliday NJ, Golub TR, Carr SA, Shamji AF, Stern AM, Mandinova A, Schreiber SL, Lee SW. Selective killing of cancer cells by a small molecule targeting the stress response to ROS. Nature. 2011 Jul 14; 475(7355):231-4.
    View in: PubMed
  12. Kim HG, Hwang SY, Aaronson SA, Mandinova A, Lee SW. DDR1 receptor tyrosine kinase promotes prosurvival pathway through Notch1 activation. J Biol Chem. 2011 May 20; 286(20):17672-81.
    View in: PubMed
  13. Nishi M, Akutsu H, Masui S, Kondo A, Nagashima Y, Kimura H, Perrem K, Shigeri Y, Toyoda M, Okayama A, Hirano H, Umezawa A, Yamamoto N, Lee SW, Ryo A. A distinct role for Pin1 in the induction and maintenance of pluripotency. J Biol Chem. 2011 Apr 1; 286(13):11593-603.
    View in: PubMed
  14. Mandinova A, Lee SW. The p53 pathway as a target in cancer therapeutics: obstacles and promise. Sci Transl Med. 2011 Jan 5; 3(64):64rv1.
    View in: PubMed
  15. Tian F, Lee SW. X-linked inhibitor of apoptosis protein as a therapeutic target in metastatic melanoma. J Invest Dermatol. 2010 Sep; 130(9):2169-72.
    View in: PubMed
  16. Benson EK, Lee SW, Aaronson SA. Role of progerin-induced telomere dysfunction in HGPS premature cellular senescence. J Cell Sci. 2010 Aug 1; 123(Pt 15):2605-12.
    View in: PubMed
  17. Ide T, Chu K, Aaronson SA, Lee SW. GAMT joins the p53 network: branching into metabolism. Cell Cycle. 2010 May; 9(9):1706-10.
    View in: PubMed
  18. Carrera S, de Verdier PJ, Khan Z, Zhao B, Mahale A, Bowman KJ, Zainol M, Jones GD, Lee SW, Aaronson SA, Macip S. Protection of cells in physiological oxygen tensions against DNA damage-induced apoptosis. J Biol Chem. 2010 Apr 30; 285(18):13658-65.
    View in: PubMed
  19. Ide T, Brown-Endres L, Chu K, Ongusaha PP, Ohtsuka T, El-Deiry WS, Aaronson SA, Lee SW. GAMT, a p53-inducible modulator of apoptosis, is critical for the adaptive response to nutrient stress. Mol Cell. 2009 Nov 13; 36(3):379-92.
    View in: PubMed
  20. Benson EK, Zhao B, Sassoon DA, Lee SW, Aaronson SA. Effects of p21 deletion in mouse models of premature aging. Cell Cycle. 2009 Jul 1; 8(13):2002-4.
    View in: PubMed
  21. Xia Y, Ongusaha P, Lee SW, Liou YC. Loss of Wip1 sensitizes cells to stress- and DNA damage-induced apoptosis. J Biol Chem. 2009 Jun 26; 284(26):17428-37.
    View in: PubMed
  22. Lee DH, Shi J, Jeoung NH, Kim MS, Zabolotny JM, Lee SW, White MF, Wei L, Kim YB. Targeted disruption of ROCK1 causes insulin resistance in vivo. J Biol Chem. 2009 May 1; 284(18):11776-80.
    View in: PubMed
  23. Ongusaha PP, Lee SW. Maximizing tumor cell invasion. Pigment Cell Melanoma Res. 2009 Apr; 22(2):148-9.
    View in: PubMed
  24. Stanton BZ, Peng LF, Maloof N, Nakai K, Wang X, Duffner JL, Taveras KM, Hyman JM, Lee SW, Koehler AN, Chen JK, Fox JL, Mandinova A, Schreiber SL. A small molecule that binds Hedgehog and blocks its signaling in human cells. Nat Chem Biol. 2009 Mar; 5(3):154-6.
    View in: PubMed
  25. Zhao B, Benson EK, Qiao R, Wang X, Kim S, Manfredi JJ, Lee SW, Aaronson SA. Cellular senescence and organismal ageing in the absence of p21(CIP1/WAF1) in ku80(-/-) mice. EMBO Rep. 2009 Jan; 10(1):71-8.
    View in: PubMed
  26. Ongusaha PP, Qi HH, Raj L, Kim YB, Aaronson SA, Davis RJ, Shi Y, Liao JK, Lee SW. Identification of ROCK1 as an upstream activator of the JIP-3 to JNK signaling axis in response to UVB damage. Sci Signal. 2008; 1(47):ra14.
    View in: PubMed
  27. Ohtsuka T, Mitsuno M, Kitajima Y, Ide T, Lee SW, Miyazaki K. Role of ASC in hypoxia-mediated cell death in pancreatic cancer. Mol Med Report. 2008 Nov-Dec; 1(6):827-31.
    View in: PubMed
  28. Qi HH, Ongusaha PP, Myllyharju J, Cheng D, Pakkanen O, Shi Y, Lee SW, Peng J, Shi Y. Prolyl 4-hydroxylation regulates Argonaute 2 stability. Nature. 2008 Sep 18; 455(7211):421-4.
    View in: PubMed
  29. Muñoz-Fontela C, Macip S, Martínez-Sobrido L, Brown L, Ashour J, García-Sastre A, Lee SW, Aaronson SA. Transcriptional role of p53 in interferon-mediated antiviral immunity. J Exp Med. 2008 Aug 4; 205(8):1929-38.
    View in: PubMed
  30. Hwang SO, Boswell SA, Seo JS, Lee SW. Novel oxidative stress-responsive gene ERS25 functions as a regulator of the heat-shock and cell death response. J Biol Chem. 2008 May 9; 283(19):13063-9.
    View in: PubMed
  31. Mahale AM, Khan ZA, Igarashi M, Nanjangud GJ, Qiao RF, Yao S, Lee SW, Aaronson SA. Clonal selection in malignant transformation of human fibroblasts transduced with defined cellular oncogenes. Cancer Res. 2008 Mar 1; 68(5):1417-26.
    View in: PubMed
  32. Das S, Boswell SA, Aaronson SA, Lee SW. P53 promoter selection: choosing between life and death. Cell Cycle. 2008 Jan 15; 7(2):154-7.
    View in: PubMed
  33. Ryo A, Hirai A, Nishi M, Liou YC, Perrem K, Lin SC, Hirano H, Lee SW, Aoki I. A suppressive role of the prolyl isomerase Pin1 in cellular apoptosis mediated by the death-associated protein Daxx. J Biol Chem. 2007 Dec 14; 282(50):36671-81.
    View in: PubMed
  34. Wang F, Sloss C, Zhang X, Lee SW, Cusack JC. Membrane-bound heparin-binding epidermal growth factor like growth factor regulates E-cadherin expression in pancreatic carcinoma cells. Cancer Res. 2007 Sep 15; 67(18):8486-93.
    View in: PubMed
  35. Das S, Raj L, Zhao B, Kimura Y, Bernstein A, Aaronson SA, Lee SW. Hzf Determines cell survival upon genotoxic stress by modulating p53 transactivation. Cell. 2007 Aug 24; 130(4):624-37.
    View in: PubMed
  36. Brown L, Ongusaha PP, Kim HG, Nuti S, Mandinova A, Lee JW, Khosravi-Far R, Aaronson SA, Lee SW. CDIP, a novel pro-apoptotic gene, regulates TNFalpha-mediated apoptosis in a p53-dependent manner. EMBO J. 2007 Jul 25; 26(14):3410-22.
    View in: PubMed
  37. He J, Zhou F, Shao K, Hang J, Wang H, Rayburn E, Xiao ZX, Lee SW, Xue Q, Feng XL, Shi SS, Zhang CY, Zhang S. Overexpression of Pin1 in non-small cell lung cancer (NSCLC) and its correlation with lymph node metastases. Lung Cancer. 2007 Apr; 56(1):51-8.
    View in: PubMed
  38. Brown L, Boswell S, Raj L, Lee SW. Transcriptional targets of p53 that regulate cellular proliferation. Crit Rev Eukaryot Gene Expr. 2007; 17(1):73-85.
    View in: PubMed
  39. Ongusaha PP, Kim HG, Boswell SA, Ridley AJ, Der CJ, Dotto GP, Kim YB, Aaronson SA, Lee SW. RhoE is a pro-survival p53 target gene that inhibits ROCK I-mediated apoptosis in response to genotoxic stress. Curr Biol. 2006 Dec 19; 16(24):2466-72.
    View in: PubMed
  40. Boswell SA, Ongusaha PP, Nghiem P, Lee SW. The protective role of a small GTPase RhoE against UVB-induced DNA damage in keratinocytes. J Biol Chem. 2007 Feb 16; 282(7):4850-8.
    View in: PubMed
  41. Lee J, Kosaras B, Aleyasin H, Han JA, Park DS, Ratan RR, Kowall NW, Ferrante RJ, Lee SW, Ryu H. Role of cyclooxygenase-2 induction by transcription factor Sp1 and Sp3 in neuronal oxidative and DNA damage response. FASEB J. 2006 Nov; 20(13):2375-7.
    View in: PubMed
  42. Glait C, Ravid D, Lee SW, Liscovitch M, Werner H. Caveolin-1 controls BRCA1 gene expression and cellular localization in human breast cancer cells. FEBS Lett. 2006 Oct 2; 580(22):5268-74.
    View in: PubMed
  43. Das S, Ongusaha PP, Yang YS, Park JM, Aaronson SA, Lee SW. Discoidin domain receptor 1 receptor tyrosine kinase induces cyclooxygenase-2 and promotes chemoresistance through nuclear factor-kappaB pathway activation. Cancer Res. 2006 Aug 15; 66(16):8123-30.
    View in: PubMed
  44. Zhang Y, Chen J, Gurumurthy CB, Kim J, Bhat I, Gao Q, Dimri G, Lee SW, Band H, Band V. The human orthologue of Drosophila ecdysoneless protein interacts with p53 and regulates its function. Cancer Res. 2006 Jul 15; 66(14):7167-75.
    View in: PubMed
  45. Aglipay JA, Martin SA, Tawara H, Lee SW, Ouchi T. ATM activation by ionizing radiation requires BRCA1-associated BAAT1. J Biol Chem. 2006 Apr 7; 281(14):9710-8.
    View in: PubMed
  46. Furukawa N, Ongusaha P, Jahng WJ, Araki K, Choi CS, Kim HJ, Lee YH, Kaibuchi K, Kahn BB, Masuzaki H, Kim JK, Lee SW, Kim YB. Role of Rho-kinase in regulation of insulin action and glucose homeostasis. Cell Metab. 2005 Aug; 2(2):119-29.
    View in: PubMed
  47. Choi EM, Kwak SJ, Kim YM, Ha KS, Kim JI, Lee SW, Han JA. COX-2 inhibits anoikis by activation of the PI-3K/Akt pathway in human bladder cancer cells. Exp Mol Med. 2005 Jun 30; 37(3):199-203.
    View in: PubMed
  48. Ongusaha PP, Kwak JC, Zwible AJ, Macip S, Higashiyama S, Taniguchi N, Fang L, Lee SW. HB-EGF is a potent inducer of tumor growth and angiogenesis. Cancer Res. 2004 Aug 1; 64(15):5283-90.
    View in: PubMed
  49. Kim KT, Ongusaha PP, Hong YK, Kurdistani SK, Nakamura M, Lu KP, Lee SW. Function of Drg1/Rit42 in p53-dependent mitotic spindle checkpoint. J Biol Chem. 2004 Sep 10; 279(37):38597-602.
    View in: PubMed
  50. Ohtsuka T, Jensen MR, Kim HG, Kim KT, Lee SW. The negative role of cyclin G in ATM-dependent p53 activation. Oncogene. 2004 Jul 8; 23(31):5405-8.
    View in: PubMed
  51. Ouchi M, Fujiuchi N, Sasai K, Katayama H, Minamishima YA, Ongusaha PP, Deng C, Sen S, Lee SW, Ouchi T. BRCA1 phosphorylation by Aurora-A in the regulation of G2 to M transition. J Biol Chem. 2004 May 7; 279(19):19643-8.
    View in: PubMed
  52. Fujiuchi N, Aglipay JA, Ohtsuka T, Maehara N, Sahin F, Su GH, Lee SW, Ouchi T. Requirement of IFI16 for the maximal activation of p53 induced by ionizing radiation. J Biol Chem. 2004 May 7; 279(19):20339-44.
    View in: PubMed
  53. Ohtsuka T, Ryu H, Minamishima YA, Macip S, Sagara J, Nakayama KI, Aaronson SA, Lee SW. ASC is a Bax adaptor and regulates the p53-Bax mitochondrial apoptosis pathway. Nat Cell Biol. 2004 Feb; 6(2):121-8.
    View in: PubMed
  54. Aglipay JA, Lee SW, Okada S, Fujiuchi N, Ohtsuka T, Kwak JC, Wang Y, Johnstone RW, Deng C, Qin J, Ouchi T. A member of the Pyrin family, IFI16, is a novel BRCA1-associated protein involved in the p53-mediated apoptosis pathway. Oncogene. 2003 Dec 4; 22(55):8931-8.
    View in: PubMed
  55. Macip S, Igarashi M, Berggren P, Yu J, Lee SW, Aaronson SA. Influence of induced reactive oxygen species in p53-mediated cell fate decisions. Mol Cell Biol. 2003 Dec; 23(23):8576-85.
    View in: PubMed
  56. Kwak JC, Ongusaha PP, Ouchi T, Lee SW. IFI16 as a negative regulator in the regulation of p53 and p21(Waf1). J Biol Chem. 2003 Oct 17; 278(42):40899-904.
    View in: PubMed
  57. Ongusaha PP, Ouchi T, Kim KT, Nytko E, Kwak JC, Duda RB, Deng CX, Lee SW. BRCA1 shifts p53-mediated cellular outcomes towards irreversible growth arrest. Oncogene. 2003 Jun 12; 22(24):3749-58.
    View in: PubMed
  58. Ohtsuka T, Ryu H, Minamishima YA, Ryo A, Lee SW. Modulation of p53 and p73 levels by cyclin G: implication of a negative feedback regulation. Oncogene. 2003 Mar 20; 22(11):1678-87.
    View in: PubMed
  59. Ongusaha PP, Kim JI, Fang L, Wong TW, Yancopoulos GD, Aaronson SA, Lee SW. p53 induction and activation of DDR1 kinase counteract p53-mediated apoptosis and influence p53 regulation through a positive feedback loop. EMBO J. 2003 Mar 17; 22(6):1289-301.
    View in: PubMed
  60. Han JA, Kim JI, Ongusaha PP, Hwang DH, Ballou LR, Mahale A, Aaronson SA, Lee SW. P53-mediated induction of Cox-2 counteracts p53- or genotoxic stress-induced apoptosis. EMBO J. 2002 Nov 1; 21(21):5635-44.
    View in: PubMed
  61. Wulf GM, Liou YC, Ryo A, Lee SW, Lu KP. Role of Pin1 in the regulation of p53 stability and p21 transactivation, and cell cycle checkpoints in response to DNA damage. J Biol Chem. 2002 Dec 13; 277(50):47976-9.
    View in: PubMed
  62. Ryo A, Liou YC, Wulf G, Nakamura M, Lee SW, Lu KP. PIN1 is an E2F target gene essential for Neu/Ras-induced transformation of mammary epithelial cells. Mol Cell Biol. 2002 Aug; 22(15):5281-95.
    View in: PubMed
  63. Macip S, Igarashi M, Fang L, Chen A, Pan ZQ, Lee SW, Aaronson SA. Inhibition of p21-mediated ROS accumulation can rescue p21-induced senescence. EMBO J. 2002 May 1; 21(9):2180-8.
    View in: PubMed
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