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J. Allan Hobson, M.D.

TitleProfessor of Psychiatry , Emeritus
InstitutionHarvard Medical School
DepartmentEmeritus
Address138 High St.
Brookline MA 02445
Phone617/998-5033

 Bibliographic 
 selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Hobson JA. Wake up or dream on? Six questions for Turnbull and Solms. Cortex. 2007 Nov; 43(8):1113-5; discussion 1116-21.
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  2. Hobson JA. Sleep is of the brain, by the brain and for the brain. Nature. 2005 Oct 27; 437(7063):1254-6.
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  3. Quattrochi JJ, Bazalakova M, Hobson JA. From synapse to gene product: prolonged expression of c-fos induced by a single microinjection of carbachol in the pontomesencephalic tegmentum. Brain Res Mol Brain Res. 2005 May 20; 136(1-2):164-76.
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  4. Pace-Schott EF, Stickgold R, Muzur A, Wigren PE, Ward AS, Hart CL, Clarke D, Morgan A, Hobson JA. Sleep quality deteriorates over a binge--abstinence cycle in chronic smoked cocaine users. Psychopharmacology (Berl). 2005 Jun; 179(4):873-83.
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  5. Pace-Schott EF, Stickgold R, Muzur A, Wigren PE, Ward AS, Hart CL, Walker M, Edgar C, Hobson JA. Cognitive performance by humans during a smoked cocaine binge-abstinence cycle. Am J Drug Alcohol Abuse. 2005; 31(4):571-91.
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  6. Kahn D, Hobson JA. State-dependent thinking: a comparison of waking and dreaming thought. Conscious Cogn. 2005 Sep; 14(3):429-38.
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  7. Hobson JA. Michel Jouvet: a personal tribute. Arch Ital Biol. 2004 Jul; 142(4):347-52.
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  8. Hobson JA. Freud returns? Like a bad dream. Sci Am. 2004 May; 290(5):89.
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  9. Atienza M, Cantero JL, Stickgold R, Hobson JA. Eyelid movements measured by Nightcap predict slow eye movements during quiet wakefulness in humans. J Sleep Res. 2004 Mar; 13(1):25-9.
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  10. Fosse R, Stickgold R, Hobson JA. Thinking and hallucinating: reciprocal changes in sleep. Psychophysiology. 2004 Mar; 41(2):298-305.
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  11. Walker MP, Brakefield T, Hobson JA, Stickgold R. Dissociable stages of human memory consolidation and reconsolidation. Nature. 2003 Oct 9; 425(6958):616-20.
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  12. Walker MP, Brakefield T, Seidman J, Morgan A, Hobson JA, Stickgold R. Sleep and the time course of motor skill learning. Learn Mem. 2003 Jul-Aug; 10(4):275-84.
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  13. Fosse MJ, Fosse R, Hobson JA, Stickgold RJ. Dreaming and episodic memory: a functional dissociation? J Cogn Neurosci. 2003 Jan 1; 15(1):1-9.
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  14. Muzur A, Pace-Schott EF, Hobson JA. The prefrontal cortex in sleep. Trends Cogn Sci. 2002 Nov 1; 6(11):475-481.
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  15. Walker MP, Liston C, Hobson JA, Stickgold R. Cognitive flexibility across the sleep-wake cycle: REM-sleep enhancement of anagram problem solving. Brain Res Cogn Brain Res. 2002 Nov; 14(3):317-24.
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  16. Fosse R, Stickgold R, Hobson JA. Emotional experience during rapid-eye-movement sleep in narcolepsy. Sleep. 2002 Nov 1; 25(7):724-32.
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  17. Hobson JA, Pace-Schott EF. The cognitive neuroscience of sleep: neuronal systems, consciousness and learning. Nat Rev Neurosci. 2002 Sep; 3(9):679-93.
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  18. Pace-Schott EF, Hobson JA. The neurobiology of sleep: genetics, cellular physiology and subcortical networks. Nat Rev Neurosci. 2002 Aug; 3(8):591-605.
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  19. Walker MP, Brakefield T, Morgan A, Hobson JA, Stickgold R. Practice with sleep makes perfect: sleep-dependent motor skill learning. Neuron. 2002 Jul 3; 35(1):205-11.
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  20. Cantero JL, Atienza M, Stickgold R, Hobson JA. Nightcap: a reliable system for determining sleep onset latency. Sleep. 2002 Mar 15; 25(2):238-45.
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  21. Kahn D, Pace-Schott E, Hobson JA. Emotion and cognition: feeling and character identification in dreaming. Conscious Cogn. 2002 Mar; 11(1):34-50.
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  22. Fosse R, Stickgold R, Hobson JA. The mind in REM sleep: reports of emotional experience. Sleep. 2001 Dec 15; 24(8):947-55.
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  23. Stickgold R, Hobson JA, Fosse R, Fosse M. Sleep, learning, and dreams: off-line memory reprocessing. Science. 2001 Nov 2; 294(5544):1052-7.
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  24. Silvestri R, Pace-Schott EF, Gersh T, Stickgold R, Salzman C, Hobson JA. Effects of fluvoxamine and paroxetine on sleep structure in normal subjects: a home-based Nightcap evaluation during drug administration and withdrawal. J Clin Psychiatry. 2001 Aug; 62(8):642-52.
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  25. Pace-Schott EF, Gersh T, Silvestri R, Stickgold R, Salzman C, Hobson JA. SSRI treatment suppresses dream recall frequency but increases subjective dream intensity in normal subjects. J Sleep Res. 2001 Jun; 10(2):129-42.
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  26. Stickgold R, Malia A, Fosse R, Propper R, Hobson JA. Brain-mind states: I. Longitudinal field study of sleep/wake factors influencing mentation report length. Sleep. 2001 Mar 15; 24(2):171-9.
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  27. Fosse R, Stickgold R, Hobson JA. Brain-mind states: reciprocal variation in thoughts and hallucinations. Psychol Sci. 2001 Jan; 12(1):30-6.
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  28. Walker M, Hobson JA. Neuroimaging and the sleeping brain. Neuron. 2000 Dec; 28(3):629-31.
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  29. Datta S, Hobson JA. The rat as an experimental model for sleep neurophysiology. Behav Neurosci. 2000 Dec; 114(6):1239-44.
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  30. Kahn D, Stickgold R, Pace-Schott EF, Hobson JA. Dreaming and waking consciousness: a character recognition study. J Sleep Res. 2000 Dec; 9(4):317-25.
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  31. Hobson JA, Pace-Schott EF, Stickgold R. Dreaming and the brain: toward a cognitive neuroscience of conscious states. Behav Brain Sci. 2000 Dec; 23(6):793-842; discussion 904-1121.
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  32. Stickgold R, James L, Hobson JA. Visual discrimination learning requires sleep after training. Nat Neurosci. 2000 Dec; 3(12):1237-8.
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  33. Quattrochi JJ, Shapiro J, Verrier RL, Hobson JA. Transient cardiorespiratory events during NREM sleep: a feline model for human microarousals. J Sleep Res. 2000 Jun; 9(2):185-91.
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  34. Cacioppo JT, Ernst JM, Burleson MH, McClintock MK, Malarkey WB, Hawkley LC, Kowalewski RB, Paulsen A, Hobson JA, Hugdahl K, Spiegel D, Berntson GG. Lonely traits and concomitant physiological processes: the MacArthur social neuroscience studies. Int J Psychophysiol. 2000 Mar; 35(2-3):143-54.
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  35. Stickgold R, Whidbee D, Schirmer B, Patel V, Hobson JA. Visual discrimination task improvement: A multi-step process occurring during sleep. J Cogn Neurosci. 2000 Mar; 12(2):246-54.
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  36. Quattrochi JJ, Hobson JA. Carbachol microinjection into the caudal peribrachial area induces long-term enhancement of PGO wave activity but not REM sleep. J Sleep Res. 1999 Dec; 8(4):281-90.
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  37. Hobson JA. Arrest of firing of aminergic neurones during REM sleep: implications for dream theory. Brain Res Bull. 1999 Nov-Dec; 50(5-6):333-4.
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  38. Rowe K, Moreno R, Lau TR, Wallooppillai U, Nearing BD, Kocsis B, Quattrochi J, Hobson JA, Verrier RL. Heart rate surges during REM sleep are associated with theta rhythm and PGO activity in cats. Am J Physiol. 1999 Sep; 277(3 Pt 2):R843-9.
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  39. Stickgold R, Scott L, Rittenhouse C, Hobson JA. Sleep-induced changes in associative memory. J Cogn Neurosci. 1999 Mar; 11(2):182-93.
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  40. Hobson JA, Silvestri L. Parasomnias. Harv Ment Health Lett. 1999 Feb; 15(8):3-5.
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  41. Verrier RL, Lau TR, Wallooppillai U, Quattrochi J, Nearing BD, Moreno R, Hobson JA. Primary vagally mediated decelerations in heart rate during tonic rapid eye movement sleep in cats. Am J Physiol. 1998 Apr; 274(4 Pt 2):R1136-41.
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  42. Quattrochi J, Datta S, Hobson JA. Cholinergic and non-cholinergic afferents of the caudolateral parabrachial nucleus: a role in the long-term enhancement of rapid eye movement sleep. Neuroscience. 1998 Apr; 83(4):1123-36.
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  43. Hobson JA, Pace-Schott EF, Stickgold R, Kahn D. To dream or not to dream? Relevant data from new neuroimaging and electrophysiological studies. Curr Opin Neurobiol. 1998 Apr; 8(2):239-44.
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  44. Rowley JT, Stickgold R, Hobson JA. Eyelid movements and mental activity at sleep onset. Conscious Cogn. 1998 Mar; 7(1):67-84.
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  45. Hobson JA, Stickgold R, Pace-Schott EF. The neuropsychology of REM sleep dreaming. Neuroreport. 1998 Feb 16; 9(3):R1-14.
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  46. Hobson JA, Stickgold R, Pace-Schott EF, Leslie KR. Sleep and vestibular adaptation: implications for function in microgravity. J Vestib Res. 1998 Jan-Feb; 8(1):81-94.
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  47. Hobson JA. Dreaming as delirium: a mental status analysis of our nightly madness. Semin Neurol. 1997 Jun; 17(2):121-8.
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  48. Leslie KR, Stickgold R, Dizio P, Lackner JR, Hobson JA. The effect of optokinetic stimulation on daytime sleepiness. Arch Ital Biol. 1997 Jun; 135(3):219-28.
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  49. Kahn D, Pace-Schott EF, Hobson JA. Consciousness in waking and dreaming: the roles of neuronal oscillation and neuromodulation in determining similarities and differences. Neuroscience. 1997 May; 78(1):13-38.
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  50. Verrier RL, Muller JE, Hobson JA. Sleep, dreams, and sudden death: the case for sleep as an autonomic stress test for the heart. Cardiovasc Res. 1996 Feb; 31(2):181-211.
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  51. Datta S, Hobson JA. Suppression of ponto-geniculo-occipital waves by neurotoxic lesions of pontine caudo-lateral peribrachial cells. Neuroscience. 1995 Aug; 67(3):703-12.
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  52. Ajilore O, Stickgold R, Rittenhouse CD, Hobson JA. Nightcap: laboratory and home-based evaluation of a portable sleep monitor. Psychophysiology. 1995 Jan; 32(1):92-8.
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  53. Hobson JA, Stickgold R. Sleep. Sleep the beloved teacher? Curr Biol. 1995 Jan 1; 5(1):35-6.
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  54. Pace-Schott EF, Kaji J, Stickgold R, Hobson JA. Nightcap measurement of sleep quality in self-described good and poor sleepers. Sleep. 1994 Dec; 17(8):688-92.
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  55. Datta S, Hobson JA. Neuronal activity in the caudolateral peribrachial pons: relationship to PGO waves and rapid eye movements. J Neurophysiol. 1994 Jan; 71(1):95-109.
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  56. Stickgold R, Williams J, Datta S, Quattrochi J, Hobson JA. Suppression of eltoprazine-induced REM sleep rebound by scopolamine. Neuropharmacology. 1993 May; 32(5):447-53.
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  57. Hobson JA, Datta S, Calvo JM, Quattrochi J. Acetylcholine as a brain state modulator: triggering and long-term regulation of REM sleep. Prog Brain Res. 1993; 98:389-404.
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  58. Datta S, Quattrochi JJ, Hobson JA. Effect of specific muscarinic M2 receptor antagonist on carbachol induced long-term REM sleep. Sleep. 1993 Jan; 16(1):8-14.
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  59. Quattrochi JJ, Mamelak AN, Binder D, Williams J, Hobson JA. Dose-related suppression of REM sleep and PGO waves by the serotonin-1 agonist eltoprazine. Neuropsychopharmacology. 1993 Jan; 8(1):7-13.
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  60. Hobson JA. Sleep and dreaming: induction and mediation of REM sleep by cholinergic mechanisms. Curr Opin Neurobiol. 1992 Dec; 2(6):759-63.
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  61. Datta S, Calvo JM, Quattrochi J, Hobson JA. Cholinergic microstimulation of the peribrachial nucleus in the cat. I. Immediate and prolonged increases in ponto-geniculo-occipital waves. Arch Ital Biol. 1992 Oct; 130(4):263-84.
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  62. Calvo JM, Datta S, Quattrochi J, Hobson JA. Cholinergic microstimulation of the peribrachial nucleus in the cat. II. Delayed and prolonged increases in REM sleep. Arch Ital Biol. 1992 Oct; 130(4):285-301.
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  63. Quattrochi JJ, Mamelak A, Binder DK, Williams J, Rittenhouse C, Hobson JA. Dynamic suppression of REM sleep by parenteral administration of the serotonin-1 agonist eltoprazine. Sleep. 1992 Apr; 15(2):125-32.
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  64. Datta S, Calvo JM, Quattrochi JJ, Hobson JA. Long-term enhancement of REM sleep following cholinergic stimulation. Neuroreport. 1991 Oct; 2(10):619-22.
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  65. Mamelak AN, Quattrochi JJ, Hobson JA. Automated staging of sleep in cats using neural networks. Electroencephalogr Clin Neurophysiol. 1991 Jul; 79(1):52-61.
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  66. Hobson JA. Sleep and dreaming. J Neurosci. 1990 Feb; 10(2):371-82.
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  67. Yamamoto K, Mamelak AN, Quattrochi JJ, Hobson JA. A cholinoceptive desynchronized sleep induction zone in the anterodorsal pontine tegmentum: spontaneous and drug-induced neuronal activity. Neuroscience. 1990; 39(2):295-304.
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  68. Yamamoto K, Mamelak AN, Quattrochi JJ, Hobson JA. A cholinoceptive desynchronized sleep induction zone in the anterodorsal pontine tegmentum: locus of the sensitive region. Neuroscience. 1990; 39(2):279-93.
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  69. Quattrochi JJ, Mamelak AN, Madison RD, Macklis JD, Hobson JA. Mapping neuronal inputs to REM sleep induction sites with carbachol-fluorescent microspheres. Science. 1989 Sep 1; 245(4921):984-6.
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  70. Mamelak A, Hobson JA. Nightcap: a home-based sleep monitoring system. Sleep. 1989 Apr; 12(2):157-66.
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  71. Denlinger SL, Patarca R, Hobson JA. Differential enhancement of rapid eye movement sleep signs in the cat: a comparison of microinjection of the cholinergic agonist carbachol and the beta-adrenergic antagonist propranolol on pontogeniculo-occipital wave clusters. Brain Res. 1988 Nov 8; 473(1):116-26.
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  72. Mamelak A, Quattrochi JJ, Hobson JA. A microcomputer-based system for automated EEG collection and scoring of behavioral state in cats. Brain Res Bull. 1988 Nov; 21(5):843-9.
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  73. Hobson JA, Schmajuk NA. Brain state and plasticity: an integration of the reciprocal interaction model of sleep cycle oscillation with attentional models of hippocampal function. Arch Ital Biol. 1988 Oct; 126(4):209-24.
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  74. Baghdoyan HA, Lydic R, Callaway CW, Hobson JA. Increased ponto-geniculo-occipital (PGO) wave frequency following central administration of neostigmine. Neurosci Lett. 1987 Dec 4; 82(3):278-84.
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  75. Lydic R, McCarley RW, Hobson JA. Serotonin neurons and sleep. II. Time course of dorsal raphe discharge, PGO waves, and behavioral states. Arch Ital Biol. 1987 Dec; 126(1):1-28.
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  76. Lydic R, McCarley RW, Hobson JA. Serotonin neurons and sleep. I. Long term recordings of dorsal raphe discharge frequency and PGO waves. Arch Ital Biol. 1987 Oct; 125(4):317-43.
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  77. Baghdoyan HA, Rodrigo-Angulo ML, McCarley RW, Hobson JA. A neuroanatomical gradient in the pontine tegmentum for the cholinoceptive induction of desynchronized sleep signs. Brain Res. 1987 Jun 30; 414(2):245-61.
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  78. Callaway CW, Lydic R, Baghdoyan HA, Hobson JA. Pontogeniculooccipital waves: spontaneous visual system activity during rapid eye movement sleep. Cell Mol Neurobiol. 1987 Jun; 7(2):105-49.
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  79. Hobson JA, Hoffman SA, Helfand R, Kostner D. Dream bizarreness and the activation-synthesis hypothesis. Hum Neurobiol. 1987; 6(3):157-64.
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  80. Baghdoyan HA, Monaco AP, Rodrigo-Angulo ML, Assens F, McCarley RW, Hobson JA. Microinjection of neostigmine into the pontine reticular formation of cats enhances desynchronized sleep signs. J Pharmacol Exp Ther. 1984 Oct; 231(1):173-80.
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  81. Baghdoyan HA, Rodrigo-Angulo ML, McCarley RW, Hobson JA. Site-specific enhancement and suppression of desynchronized sleep signs following cholinergic stimulation of three brainstem regions. Brain Res. 1984 Jul 23; 306(1-2):39-52.
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  82. Lydic R, McCarley RW, Hobson JA. Forced activity alters sleep cycle periodicity and dorsal raphe discharge rhythm. Am J Physiol. 1984 Jul; 247(1 Pt 2):R135-45.
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  83. Nelson JP, McCarley RW, Hobson JA. REM sleep burst neurons, PGO waves, and eye movement information. J Neurophysiol. 1983 Oct; 50(4):784-97.
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  84. Hobson JA, McCarley RW, Nelson JP. Location and spike-train characteristics of cells in anterodorsal pons having selective decreases in firing rate during desynchronized sleep. J Neurophysiol. 1983 Oct; 50(4):770-83.
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  85. Lydic R, McCarley RW, Hobson JA. The time-course of dorsal raphe discharge, PGO waves, and muscle tone averaged across multiple sleep cycles. Brain Res. 1983 Sep 12; 274(2):365-70.
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  86. Lydic R, McCarley RW, Hobson JA. Enhancement of dorsal raphe discharge by medial pontine reticular formation stimulation depends on behavioral state. Neurosci Lett. 1983 Jul 15; 38(1):35-40.
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  87. Flicker C, McCarley RW, Hobson JA. Aminergic neurons: state control and plasticity in three model systems. Cell Mol Neurobiol. 1981 Jun; 1(2):123-66.
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  88. Silberman EK, Vivaldi E, Garfield J, McCarley RW, Hobson JA. Carbachol triggering of desynchronized sleep phenomena: enhancement via small volume infusions. Brain Res. 1980 Jun 2; 191(1):215-24.
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  89. McCarley RW, Nelson JP, Hobson JA. Ponto-geniculo-occipital (PGO) burst neurons: correlative evidence for neuronal generators of PGO waves. Science. 1978 Jul 21; 201(4352):269-72.
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  90. Wyzinski PW, McCarley RW, Hobson JA. Discharge properties of pontine reticulospinal neurons during sleep-waking cycle. J Neurophysiol. 1978 May; 41(3):821-34.
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  91. Hobson JA, McCarley RW. The brain as a dream state generator: an activation-synthesis hypothesis of the dream process. Am J Psychiatry. 1977 Dec; 134(12):1335-48.
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  92. McCarley RW, Hobson JA. The neurobiological origins of psychoanalytic dream theory. Am J Psychiatry. 1977 Nov; 134(11):1211-21.
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  93. Pivik RT, McCarley RW, Hobson JA. Eye movement-associated discharge in brain stem neurons during desynchronized sleep. Brain Res. 1977 Jan 31; 121(1):59-76.
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  94. Amatruda TT, Black DA, McKenna TM, McCarley RW, Hobson JA. Sleep cycle control and cholinergic mechanisms: differential effects of carbachol injections at pontine brain stem sites. Brain Res. 1975 Nov 21; 98(3):501-15.
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  95. McCarley RW, Hobson JA. Discharge patterns of cat pontine brain stem neurons during desynchronized sleep. J Neurophysiol. 1975 Jul; 38(4):751-66.
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  96. McCarley RW, Hobson JA. Neuronal excitability modulation over the sleep cycle: a structural and mathematical model. Science. 1975 Jun 4; 189(4196):58-60.
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  97. Hobson JA, McCarley RW, Wyzinski PW. Sleep cycle oscillation: reciprocal discharge by two brainstem neuronal groups. Science. 1975 Jun 4; 189(4196):55-8.
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  98. Hobson JA, McCarley RW, Freedman R, Pivik RT. Time course of discharge rate changes by cat pontine brain stem neurons during sleep cycle. J Neurophysiol. 1974 Nov; 37(6):1297-309.
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  99. Hobson JA, McCarley RW. Multiple firings by cat cerebellar Purkinje cells in sleep and waking. Exp Neurol. 1974 Jul; 44(1):41-8.
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  100. Hobson JA, McCarley RW, Pivik RT, Freedman R. Selective firing by cat pontine brain stem neurons in desynchronized sleep. J Neurophysiol. 1974 May; 37(3):497-511.
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  101. Hobson JA, McCarley RW. Spontaneous discharge rates of cat cerebellar Purkinje cells in sleep and waking. Electroencephalogr Clin Neurophysiol. 1972 Nov; 33(5):457-69.
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  102. McCarley RW, Hobson JA. Simple spike firing patterns of cat cerebellar Purkinje cells in sleep and waking. Electroencephalogr Clin Neurophysiol. 1972 Nov; 33(5):471-83.
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  103. McCarley RW, Hobson JA. Single neuron activity in cat gigantocellular tegmental field: selectivity of discharge in desynchronized sleep. Science. 1971 Dec 17; 174(4015):1250-2.
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  104. Hobson JA, McCarley RW. Cortical unit activity in sleep and waking. Electroencephalogr Clin Neurophysiol. 1971 Feb; 30(2):97-112.
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  105. McCarley RW, Hobson JA. Cortical unit activity in desynchronized sleep. Science. 1970 Feb 6; 167(3919):901-3.
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