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Edda Fiebiger, PH.D.

TitleAssistant Professor of Pediatrics
InstitutionChildren's Hospital Boston
DepartmentPediatrics
AddressChildrens Hospital
GI, Enders 705
300 Longwood Ave
Boston MA 02115
Phone617/919-2458
Fax617/730-0498

 Bibliographic 
 selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Lexmond WS, Pardo M, Rooney K, Goettel JA, Snapper SB, Yen EH, Dehlink E, Nurko S, Fiebiger E. Elevated levels of leukotriene C4 synthase mRNA distinguish a subpopulation of eosinophilic oesophagitis patients. Clin Exp Allergy. 2013 Aug; 43(8):902-13.
    View in: PubMed
  2. Cho JA, Lee AH, Platzer B, Cross BC, Gardner BM, De Luca H, Luong P, Harding HP, Glimcher LH, Walter P, Fiebiger E, Ron D, Kagan JC, Lencer WI. The Unfolded Protein Response Element IRE1a Senses Bacterial Proteins Invading the ER to Activate RIG-I and Innate Immune Signaling. Cell Host Microbe. 2013 May 15; 13(5):558-69.
    View in: PubMed
  3. D'Angelo JA, Mattox ML, Fiebiger E, Dickinson BL. The cystine/glutamate antiporter regulates the functional expression of indoleamine 2,3-dioxygenase in human dendritic cells. Scand J Immunol. 2012 Oct; 76(4):448-9.
    View in: PubMed
  4. Rath T, Kuo TT, Baker K, Qiao SW, Kobayashi K, Yoshida M, Roopenian D, Fiebiger E, Lencer WI, Blumberg RS. The immunologic functions of the neonatal fc receptor for IgG. J Clin Immunol. 2013 Jan; 33 Suppl 1:9-17.
    View in: PubMed
  5. Baker K, Rath T, Lencer WI, Fiebiger E, Blumberg RS. Cross-presentation of IgG-containing immune complexes. Cell Mol Life Sci. 2013 Apr; 70(8):1319-34.
    View in: PubMed
  6. Bannert C, Bidmon-Fliegenschnee B, Stary G, Hotzy F, Stift J, Nurko S, Szépfalusi Z, Fiebiger E, Dehlink E. Fc-epsilon-RI, the high affinity IgE-receptor, is robustly expressed in the upper gastrointestinal tract and modulated by mucosal inflammation. PLoS One. 2012; 7(7):e42066.
    View in: PubMed
  7. Nguyen DD, Wurbel MA, Goettel JA, Eston MA, Ahmed OS, Marin R, Boden EK, Villablanca EJ, Paidassi H, Ahuja V, Reinecker HC, Fiebiger E, Lacy-Hulbert A, Horwitz BH, Mora JR, Snapper SB. Wiskott-Aldrich syndrome protein deficiency in innate immune cells leads to mucosal immune dysregulation and colitis in mice. Gastroenterology. 2012 Sep; 143(3):719-29.e1-2.
    View in: PubMed
  8. Platzer B, Dehlink E, Turley SJ, Fiebiger E. How to connect an IgE-driven response with CTL activity? Cancer Immunol Immunother. 2012 Sep; 61(9):1521-5.
    View in: PubMed
  9. Platzer B, Ruiter F, van der Mee J, Fiebiger E. Soluble IgE receptors--elements of the IgE network. Immunol Lett. 2011 Dec 30; 141(1):36-44.
    View in: PubMed
  10. Lexmond W, der Mee Jv, Ruiter F, Platzer B, Stary G, Yen EH, Dehlink E, Nurko S, Fiebiger E. Development and validation of a standardized ELISA for the detection of soluble Fc-epsilon-RI in human serum. J Immunol Methods. 2011 Oct 28; 373(1-2):192-9.
    View in: PubMed
  11. Baker K, Qiao SW, Kuo TT, Aveson VG, Platzer B, Andersen JT, Sandlie I, Chen Z, de Haar C, Lencer WI, Fiebiger E, Blumberg RS. Neonatal Fc receptor for IgG (FcRn) regulates cross-presentation of IgG immune complexes by CD8-CD11b+ dendritic cells. Proc Natl Acad Sci U S A. 2011 Jun 14; 108(24):9927-32.
    View in: PubMed
  12. Sallmann E, Reininger B, Brandt S, Duschek N, Hoflehner E, Garner-Spitzer E, Platzer B, Dehlink E, Hammer M, Holcmann M, Oettgen HC, Wiedermann U, Sibilia M, Fiebiger E, Rot A, Maurer D. High-affinity IgE receptors on dendritic cells exacerbate Th2-dependent inflammation. J Immunol. 2011 Jul 1; 187(1):164-71.
    View in: PubMed
  13. Dehlink E, Platzer B, Baker AH, Larosa J, Pardo M, Dwyer P, Yen EH, Szépfalusi Z, Nurko S, Fiebiger E. A soluble form of the high affinity IgE receptor, Fc-epsilon-RI, circulates in human serum. PLoS One. 2011; 6(4):e19098.
    View in: PubMed
  14. Wurbel MA, McIntire MG, Dwyer P, Fiebiger E. CCL25/CCR9 interactions regulate large intestinal inflammation in a murine model of acute colitis. PLoS One. 2011; 6(1):e16442.
    View in: PubMed
  15. Yen EH, Hornick JL, Dehlink E, Dokter M, Baker A, Fiebiger E, Nurko S. Comparative analysis of FceRI expression patterns in patients with eosinophilic and reflux esophagitis. J Pediatr Gastroenterol Nutr. 2010 Nov; 51(5):584-92.
    View in: PubMed
  16. D'Angelo JA, Dehlink E, Platzer B, Dwyer P, Circu ML, Garay J, Aw TY, Fiebiger E, Dickinson BL. The cystine/glutamate antiporter regulates dendritic cell differentiation and antigen presentation. J Immunol. 2010 Sep 15; 185(6):3217-26.
    View in: PubMed
  17. Garay J, D'Angelo JA, Park Y, Summa CM, Aiken ML, Morales E, Badizadegan K, Fiebiger E, Dickinson BL. Crosstalk between PKA and Epac regulates the phenotypic maturation and function of human dendritic cells. J Immunol. 2010 Sep 15; 185(6):3227-38.
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  18. Dehlink E, Baker AH, Yen E, Nurko S, Fiebiger E. Relationships between levels of serum IgE, cell-bound IgE, and IgE-receptors on peripheral blood cells in a pediatric population. PLoS One. 2010; 5(8):e12204.
    View in: PubMed
  19. Eleonora Dehlink, M.D. Ph.D. and Edda Fiebiger, Ph.D. . In search of a more comprehensive allergy diagnostic: assessment of the total-body IgE pool. 2010.
  20. Platzer B, Fiebiger E. The signal peptide of the IgE receptor alpha-chain prevents surface expression of an immunoreceptor tyrosine-based activation motif-free receptor pool. J Biol Chem. 2010 May 14; 285(20):15314-23.
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  21. Paulitschke V, Schicher N, Szekeres T, Jäger W, Elbling L, Riemer AB, Scheiner O, Trimurtulu G, Venkateswarlu S, Mikula M, Swoboda A, Fiebiger E, Gerner C, Pehamberger H, Kunstfeld R. 3,3',4,4',5,5'-hexahydroxystilbene impairs melanoma progression in a metastatic mouse model. J Invest Dermatol. 2010 Jun; 130(6):1668-79.
    View in: PubMed
  22. Singleton TE, Platzer B, Dehlink E, Fiebiger E. The first transmembrane region of the beta-chain stabilizes the tetrameric Fc epsilon RI complex. Mol Immunol. 2009 Jul; 46(11-12):2333-9.
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  23. Edelmann MJ, Iphöfer A, Akutsu M, Altun M, di Gleria K, Kramer HB, Fiebiger E, Dhe-Paganon S, Kessler BM. Structural basis and specificity of human otubain 1-mediated deubiquitination. Biochem J. 2009 Mar 1; 418(2):379-90.
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  24. Dehlink E, Fiebiger E. The role of the high-affinity IgE receptor, FcepsilonRI, in eosinophilic gastrointestinal diseases. Immunol Allergy Clin North Am. 2009 Feb; 29(1):159-70, xii.
    View in: PubMed
  25. Dehlink E, Yen E, Leichtner AM, Hait EJ, Fiebiger E. First evidence of a possible association between gastric acid suppression during pregnancy and childhood asthma: a population-based register study. Clin Exp Allergy. 2009 Feb; 39(2):246-53.
    View in: PubMed
  26. Catic A, Fiebiger E, Korbel GA, Blom D, Galardy PJ, Ploegh HL. Screen for ISG15-crossreactive deubiquitinases. PLoS One. 2007; 2(7):e679.
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  27. Majewski M, Bose TO, Sillé FC, Pollington AM, Fiebiger E, Boes M. Protein kinase C delta stimulates antigen presentation by Class II MHC in murine dendritic cells. Int Immunol. 2007 Jun; 19(6):719-32.
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  28. Berkers CR, Verdoes M, Lichtman E, Fiebiger E, Kessler BM, Anderson KC, Ploegh HL, Ovaa H, Galardy PJ. Activity probe for in vivo profiling of the specificity of proteasome inhibitor bortezomib. Nat Methods. 2005 May; 2(5):357-62.
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  29. Fiebiger E, Tortorella D, Jouvin MH, Kinet JP, Ploegh HL. Cotranslational endoplasmic reticulum assembly of FcepsilonRI controls the formation of functional IgE-binding receptors. J Exp Med. 2005 Jan 17; 201(2):267-77.
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  30. Jaksits S, Bauer W, Kriehuber E, Zeyda M, Stulnig TM, Stingl G, Fiebiger E, Maurer D. Lipid raft-associated GTPase signaling controls morphology and CD8+ T cell stimulatory capacity of human dendritic cells. J Immunol. 2004 Aug 1; 173(3):1628-39.
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  31. Kunstfeld R, Hirakawa S, Hong YK, Schacht V, Lange-Asschenfeldt B, Velasco P, Lin C, Fiebiger E, Wei X, Wu Y, Hicklin D, Bohlen P, Detmar M. Induction of cutaneous delayed-type hypersensitivity reactions in VEGF-A transgenic mice results in chronic skin inflammation associated with persistent lymphatic hyperplasia. Blood. 2004 Aug 15; 104(4):1048-57.
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  32. Fiebiger E, Hirsch C, Vyas JM, Gordon E, Ploegh HL, Tortorella D. Dissection of the dislocation pathway for type I membrane proteins with a new small molecule inhibitor, eeyarestatin. Mol Biol Cell. 2004 Apr; 15(4):1635-46.
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  33. Bertho N, Cerny J, Kim YM, Fiebiger E, Ploegh H, Boes M. Requirements for T cell-polarized tubulation of class II+ compartments in dendritic cells. J Immunol. 2003 Dec 1; 171(11):5689-96.
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  34. Winter D, Fiebiger E, Meraner P, Auer H, Brna C, Strohal R, Trautinger F, Knobler R, Fischer GF, Stingl G, Maurer D. Definition of TCR epitopes for CTL-mediated attack of cutaneous T cell lymphoma. J Immunol. 2003 Sep 1; 171(5):2714-24.
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  35. Ovaa H, van Swieten PF, Kessler BM, Leeuwenburgh MA, Fiebiger E, van den Nieuwendijk AM, Galardy PJ, van der Marel GA, Ploegh HL, Overkleeft HS. Chemistry in living cells: detection of active proteasomes by a two-step labeling strategy. Angew Chem Int Ed Engl. 2003 Aug 11; 42(31):3626-9.
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  36. Fiebiger E, Maehr R, Villadangos J, Weber E, Erickson A, Bikoff E, Ploegh HL, Lennon-Duménil AM. Invariant chain controls the activity of extracellular cathepsin L. J Exp Med. 2002 Nov 4; 196(9):1263-9.
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  37. Sabroe RA, Fiebiger E, Francis DM, Maurer D, Seed PT, Grattan CE, Black AK, Stingl G, Greaves MW, Barr RM. Classification of anti-FcepsilonRI and anti-IgE autoantibodies in chronic idiopathic urticaria and correlation with disease severity. J Allergy Clin Immunol. 2002 Sep; 110(3):492-9.
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  38. Lennon-Duménil AM, Bakker AH, Maehr R, Fiebiger E, Overkleeft HS, Rosemblatt M, Ploegh HL, Lagaudrière-Gesbert C. Analysis of protease activity in live antigen-presenting cells shows regulation of the phagosomal proteolytic contents during dendritic cell activation. J Exp Med. 2002 Aug 19; 196(4):529-40.
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  39. Fiebiger E, Story C, Ploegh HL, Tortorella D. Visualization of the ER-to-cytosol dislocation reaction of a type I membrane protein. EMBO J. 2002 Mar 1; 21(5):1041-53.
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  40. Bryant PW, Lennon-Dumenil AM, Fiebiger E, Lagaudriere-Gesbert C, Ploegh HL. Proteolysis and antigen presentation by MHC class II molecules. Adv Immunol. 2002;80:71-114. 2002.
  41. Bryant PW, Lennon-Duménil AM, Fiebiger E, Lagaudrière-Gesbert C, Ploegh HL. Proteolysis and antigen presentation by MHC class II molecules. Adv Immunol. 2002; 80:71-114.
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  42. Kessler BM, Tortorella D, Altun M, Kisselev AF, Fiebiger E, Hekking BG, Ploegh HL, Overkleeft HS. Extended peptide-based inhibitors efficiently target the proteasome and reveal overlapping specificities of the catalytic beta-subunits. Chem Biol. 2001 Sep; 8(9):913-29.
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  43. Fiebiger E, Meraner P, Weber E, Fang IF, Stingl G, Ploegh H, Maurer D. Cytokines regulate proteolysis in major histocompatibility complex class II-dependent antigen presentation by dendritic cells. J Exp Med. 2001 Apr 16; 193(8):881-92.
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  44. Zuberbier T, Henz BM, Fiebiger E, Maurer D, Stingl G. Anti-FcepsilonRIalpha serum autoantibodies in different subtypes of urticaria. Allergy. 2000 Oct; 55(10):951-4.
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  45. Elbe-Bürger A, Mommaas AM, Prieschl EE, Fiebiger E, Baumruker T, Stingl G. Major histocompatibility complex class II- fetal skin dendritic cells are potent accessory cells of polyclonal T-cell responses. Immunology. 2000 Oct; 101(2):242-53.
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  46. Maurer D, Fiebiger E, Reininger B, Ebner C, Petzelbauer P, Shi GP, Chapman HA, Stingl G. Fc epsilon receptor I on dendritic cells delivers IgE-bound multivalent antigens into a cathepsin S-dependent pathway of MHC class II presentation. J Immunol. 1998 Sep 15; 161(6):2731-9.
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  47. Fiebiger E, Hammerschmid F, Stingl G, Maurer D. Anti-FcepsilonRIalpha autoantibodies in autoimmune-mediated disorders. Identification of a structure-function relationship. J Clin Invest. 1998 Jan 1; 101(1):243-51.
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  48. Fuerst J, Fiebiger E, Jungwirth A, Mack D, Talwar PG, Frick J, Rovan E. Effect of active immunization against luteinizing hormone-releasing hormone on the androgen-sensitive Dunning R3327-PAP and androgen-independent Dunning R3327-AT2.1 prostate cancer sublines. Prostate. 1997 Jul 1; 32(2):77-84.
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  49. Maurer D, Ebner C, Reininger B, Petzelbauer P, Fiebiger E, Stingl G. Mechanisms of Fc epsilon RI-IgE-facilitated allergen presentation by dendritic cells. Adv Exp Med Biol. 1997; 417:175-8.
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  50. Maurer, D., Ebener C., Reininger B., Petzelbauer P., Fiebiger E., and Stingl G. . Mechanisms of FceRI-IgE-facilitated allergen presentation by dendritic cells. Dendritic Cells in Fundamental and Clinical Immunology, Plenum Press, New York, pp. 175. 1997.
  51. Maurer D, Ebner C, Reininger B, Petzelbauer P, Fiebiger E, Stingl G. . Mechanisms of Fc epsilon RI-IgE-facilitated allergen presentation by dendritic cells. Adv Exp Med Biol. 1997;417:175-8. 1997.
  52. Fiebiger E, Stingl G, Maurer D. Anti-IgE and anti-Fc epsilon RI autoantibodies in clinical allergy. Curr Opin Immunol. 1996 Dec; 8(6):784-9.
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  53. Grabbe J, Welker P, Rosenbach T, Nürnberg W, Krüger-Krasagakes S, Artuc M, Fiebiger E, Henz BM. Release of stem cell factor from a human keratinocyte line, HaCaT, is increased in differentiating versus proliferating cells. J Invest Dermatol. 1996 Aug; 107(2):219-24.
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  54. Gröger M, Sarmay G, Fiebiger E, Wolff K, Petzelbauer P. Dermal microvascular endothelial cells express CD32 receptors in vivo and in vitro. J Immunol. 1996 Feb 15; 156(4):1549-56.
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  55. Fiebiger E, Stingl G, Maurer D. . Anti-IgE and anti-Fc epsilon RI autoantibodies in clinical allergy. Curr Opin Immunol. 1996 Dec;8(6):784-9. 1996.
  56. Fiebiger E, Maurer D, Holub H, Reininger B, Hartmann G, Woisetschläger M, Kinet JP, Stingl G. Serum IgG autoantibodies directed against the alpha chain of Fc epsilon RI: a selective marker and pathogenetic factor for a distinct subset of chronic urticaria patients? J Clin Invest. 1995 Dec; 96(6):2606-12.
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  57. Kramer G, Steiner G, Födinger D, Fiebiger E, Rappersberger C, Binder S, Hofbauer J, Marberger M. High expression of a CD38-like molecule in normal prostatic epithelium and its differential loss in benign and malignant disease. J Urol. 1995 Nov; 154(5):1636-41.
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  58. Maurer D, Ebner C, Reininger B, Fiebiger E, Kraft D, Kinet JP, Stingl G. The high affinity IgE receptor (Fc epsilon RI) mediates IgE-dependent allergen presentation. J Immunol. 1995 Jun 15; 154(12):6285-90.
    View in: PubMed
  59. Maurer, D., Fiebiger E., Reininger B., Stingl G. 1995. FceRI: Structure, cellular distribution, and function. Symposium in Immunology IV, Springer-Verlag Berlin, Heidelberg, pp 59. 1995.
  60. Maurer D, Fiebiger E, Reininger B, Wolff-Winiski B, Jouvin MH, Kilgus O, Kinet JP, Stingl G. Expression of functional high affinity immunoglobulin E receptors (Fc epsilon RI) on monocytes of atopic individuals. J Exp Med. 1994 Feb 1; 179(2):745-50.
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  61. Fürst J, Fiebiger E, Mack D, Frick J, Rovan E. The effect of active immunization against gonadotropin-releasing hormone on the ultrastructure of the rat ventral prostate. Urol Res. 1994; 22(2):107-13.
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  62. Stöckl J, Majdic O, Rosenkranz A, Fiebiger E, Kniep B, Stockinger H, Knapp W. Monoclonal antibodies to the carbohydrate structure Lewis(x) stimulate the adhesive activity of leukocyte integrin CD11b/CD18 (CR3, Mac-1, alpha m beta 2) on human granulocytes. J Leukoc Biol. 1993 May; 53(5):541-9.
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  63. Kasinrerk W, Fiebiger E, Stefanová I, Baumruker T, Knapp W, Stockinger H. Human leukocyte activation antigen M6, a member of the Ig superfamily, is the species homologue of rat OX-47, mouse basigin, and chicken HT7 molecule. J Immunol. 1992 Aug 1; 149(3):847-54.
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  64. Rovan E, Fiebiger E, Kalla NR, Talwar GP, Aulitzky W, Frick J. Effect of active immunization to luteinizing-hormone-releasing hormone on the fertility and histoarchitecture of the reproductive organs of male rat. Urol Res. 1992; 20(5):323-34.
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  65. Heidrich HJ, Fiebiger E. [Research on corynebacterium pyogenes mastitis of cattle with special reference to enzyme therapy. IV. Therapy with antibiotics and varidase cyanamide]. Berl Munch Tierarztl Wochenschr. 1965 Oct 15; 78(20):389-90.
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  66. Heidrich HJ, Fiebiger E. [Research on bovine pyogenes mastitis with special reference to enzymatic therapy. 3. Therapy with antibiotics and Fibrolan-Parke Davis]. Berl Munch Tierarztl Wochenschr. 1965 Sep 15; 78(18):341-2.
    View in: PubMed
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