Contact, publication, and social network information about Harvard faculty and fellows. Harvard Catalyst Profiles
Keywords
Last Name
Institution

S. Alex Mitsialis, PH.D.

TitleAssistant Professor of Pediatrics
InstitutionChildren's Hospital Boston
DepartmentPediatrics
AddressChildren's Hospital
Newborn Medicine/Enders 971-320 Longwood Ave
300 Longwood Ave
Boston MA 02115
Phone617/355-7184
Fax617/730-0260

 Bibliographic 
 selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
List All   |   Timeline
  1. Lee C, Mitsialis SA, Aslam M, Vitali SH, Vergadi E, Konstantinou G, Sdrimas K, Fernandez-Gonzalez A, Kourembanas S. Exosomes mediate the cytoprotective action of mesenchymal stromal cells on hypoxia-induced pulmonary hypertension. Circulation. 2012 Nov 27; 126(22):2601-11.
    View in: PubMed
  2. Hansmann G, Fernandez-Gonzalez A, Aslam M, Vitali SH, Martin T, Mitsialis SA, Kourembanas S. Mesenchymal stem cell-mediated reversal of bronchopulmonary dysplasia and associated pulmonary hypertension. Pulm Circ. 2012 Apr; 2(2):170-81.
    View in: PubMed
  3. Christou H, Reslan OM, Mam V, Tanbe AF, Vitali SH, Touma M, Arons E, Mitsialis SA, Kourembanas S, Khalil RA. Improved pulmonary vascular reactivity and decreased hypertrophic remodeling during nonhypercapnic acidosis in experimental pulmonary hypertension. Am J Physiol Lung Cell Mol Physiol. 2012 May 1; 302(9):L875-90.
    View in: PubMed
  4. Vergadi E, Chang MS, Lee C, Liang OD, Liu X, Fernandez-Gonzalez A, Mitsialis SA, Kourembanas S. Early macrophage recruitment and alternative activation are critical for the later development of hypoxia-induced pulmonary hypertension. Circulation. 2011 May 10; 123(18):1986-95.
    View in: PubMed
  5. Liang OD, Mitsialis SA, Chang MS, Vergadi E, Lee C, Aslam M, Fernandez-Gonzalez A, Liu X, Baveja R, Kourembanas S. Mesenchymal stromal cells expressing heme oxygenase-1 reverse pulmonary hypertension. Stem Cells. 2011 Jan; 29(1):99-107.
    View in: PubMed
  6. Aslam M, Baveja R, Liang OD, Fernandez-Gonzalez A, Lee C, Mitsialis SA, Kourembanas S. Bone marrow stromal cells attenuate lung injury in a murine model of neonatal chronic lung disease. Am J Respir Crit Care Med. 2009 Dec 1; 180(11):1122-30.
    View in: PubMed
  7. Vitali SH, Mitsialis SA, Liang OD, Liu X, Fernandez-Gonzalez A, Christou H, Wu X, McGowan FX, Kourembanas S. Divergent cardiopulmonary actions of heme oxygenase enzymatic products in chronic hypoxia. PLoS One. 2009; 4(6):e5978.
    View in: PubMed
  8. Fernandez-Gonzalez A, Kourembanas S, Wyatt TA, Mitsialis SA. Mutation of murine adenylate kinase 7 underlies a primary ciliary dyskinesia phenotype. Am J Respir Cell Mol Biol. 2009 Mar; 40(3):305-13.
    View in: PubMed
  9. Fredenburgh LE, Liang OD, Macias AA, Polte TR, Liu X, Riascos DF, Chung SW, Schissel SL, Ingber DE, Mitsialis SA, Kourembanas S, Perrella MA. Absence of cyclooxygenase-2 exacerbates hypoxia-induced pulmonary hypertension and enhances contractility of vascular smooth muscle cells. Circulation. 2008 Apr 22; 117(16):2114-22.
    View in: PubMed
  10. Fredenburgh LE, Perrella MA, Mitsialis SA. The role of heme oxygenase-1 in pulmonary disease. Am J Respir Cell Mol Biol. 2007 Feb; 36(2):158-65.
    View in: PubMed
  11. Wu X, Chang MS, Mitsialis SA, Kourembanas S. Hypoxia regulates bone morphogenetic protein signaling through C-terminal-binding protein 1. Circ Res. 2006 Aug 4; 99(3):240-7.
    View in: PubMed
  12. Fernandez-Gonzalez A, Naghshineh S, Mitsialis SA, Kourembanas S. . Heme Oxygenase-1 (HO-1) overexpression prevents fibrosis and iron deposition in developmental lung injury. American Thoracic Society International Conference Proceedings. 2006; (3):A254.
  13. Liang OD, Mitsialis SA, Kourembanas S. Bone marrow derived mesenchymal stem cells expressing human heme oxygenase-1 (HO-1)reverse hypoxic pulmonary hypertension in HO-1 null mice. American Thoracic Society International Conference Proceedings. 2006; (3):A25.
  14. Fredenburgh LE, Liang OD, Macias AA, Mitsialis SA, Kourembanas S , Perrella MA. Exacerbation of hypoxia-induced pulmonary hypertension and vascular remodeling in COX-2 deficient mice. American Thoracic Society International Conference Proceedings. 2006; (3):A278.
  15. Vitali SH, Mitsialis SA, Christou H, Fernandez-Gonzalez A, Liu X, Kourembanas S. Mechanisms of heme oxygenase-1-mediated cardiac and pulmonary vascular protection in chronic hypoxia: roles of carbon monoxide and bilirubin. Chest. 2005 Dec; 128(6 Suppl):578S-579S.
    View in: PubMed
  16. Christou H, Bailey N, Kluger MS, Mitsialis SA, Kourembanas S. Extracellular acidosis induces heme oxygenase-1 expression in vascular smooth muscle cells. Am J Physiol Heart Circ Physiol. 2005 Jun; 288(6):H2647-52.
    View in: PubMed
  17. Vitali S, Mitsialis SA, Christou H, Kluger M, Liu X, Kourembanas S. HO-1 mediated cardiac protection in chronic hypoxia: Role of carbon monoxide and bilirubin. 2005.
  18. Fernandez-Gonzalez A, Naghshineh S, Mitsialis SA, Kourembanas S. . Heme Oxygenase-1 overexpression decreases alveolar remodeling and iron deposition in developmental lung injury. 2005.
  19. Liang O, Mitsialis SA, Kourembanas S. Bone-marrow derived mesenchymal stem cells expressing human HO-1 reverse hypoxic pulmonary hypertension in HO-1 null mice . 2005.
  20. Zampetaki A, Mitsialis SA, Pfeilschifter J, Kourembanas S. Hypoxia induces macrophage inflammatory protein-2 (MIP-2) gene expression in murine macrophages via NF-kappaB: the prominent role of p42/ p44 and PI3 kinase pathways. FASEB J. 2004 Jul; 18(10):1090-2.
    View in: PubMed
  21. Vitali, S., Mitsialis, S. A., Christou, H., Kourembanas, S. . Mechanisms of HO-1 cytopro-tection in hypoxic pulmonary hypertension. Pediatric Research. 2004; 55(4):A2638.
  22. Zampetaki A, Minamino T, Mitsialis SA, Kourembanas S. Effect of heme oxygenase-1 overexpression in two models of lung inflammation. Exp Biol Med (Maywood). 2003 May; 228(5):442-6.
    View in: PubMed
  23. Christou, H, Mitsialis, SA, Kourembanas, S. . Regulation of heme oxygenase-1 (HO-1) gene expression in vascular smooth muscle cells by extracellular acidosis. Pediatric Research. 2003; 53(4):A3220.
  24. Zampetaki A, Mitsialis, SA, Pfeilschifter, J, and Kourembanas, S. . Regulation of Macro-phage Inflammatory Protein – 2 (MIP-2) gene expression by hypoxia. Am. J. Respir. Crit. Care Med. 2002; A546.
  25. Kourembanas S, Minamino T, Christou H, Hsieh C-M, Liu Y, Dhawan V, Atwater L, Abraham NG, Perella MA and Mitsialis SA. . Targeted expression of heme oxygenase-1 and pulmonary responses to hypoxia. Heme Oxygenase in Biology and Medicine. 2002; 193-204.
  26. Minamino T, Christou H, Hsieh CM, Liu Y, Dhawan V, Abraham NG, Perrella MA, Mitsialis SA, Kourembanas S. Targeted expression of heme oxygenase-1 prevents the pulmonary inflammatory and vascular responses to hypoxia. Proc Natl Acad Sci U S A. 2001 Jul 17; 98(15):8798-803.
    View in: PubMed
  27. Minamino T, Mitsialis SA, Kourembanas S. Hypoxia extends the life span of vascular smooth muscle cells through telomerase activation. Mol Cell Biol. 2001 May; 21(10):3336-42.
    View in: PubMed
  28. Brodsky D, Mitsialis SA, Minamino T and Kourembanas S. Herbimycin and geldanamycin inhibit the hypoxic induction of the vascular endothelial growth factor (VEGF) in pulmonary artery endothelial cells. Pediatric Research 2000. 2000; 47(4):A380.
  29. Christou H, Minamino T, Hsie C-M, Liu Y, Lynch L, Mitsialis SA, Perella MA, and Kourembanas S. Transgenic mice overexpressing Heme Oxygenase - 1 (HO-1) in the lung are protected from development of hypoxia-induced pulmonary hypertension: Evidence of anti inflammatory effects of HO-1. Pediatric Research. 2000; 47(4):A385.
  30. Christou H, Minamino T, Mitsialis SA and Kourembanas S. Extracellular acidosis induces Heme Oxygenase - 1 (HO-1) gene expression in vascular smooth muscle cells. Pediatric Research. 2000; 47(4):A386.
  31. Kourembanas S, Minamino T, Christou H, Hsieh C-M, Liu Y, Dhawan V, Lynch L, Abra-ham NG, Perella MA and Mitsialis SA. . Heme Oxygenase and pulmonary responses to hypoxia. Acta Hematologica. 2000; (103(1)):A276.
  32. Kourembanas S, Morita, T, Christou, H., Liu, Y., Koike, H., Brodsky, D., Arthur, V. and S. A. Mitsialis. Hypoxic responses of vascular cells. Chest. 1998; 25S-28S.
  33. Morita T, Mitsialis SA, Koike H, Liu Y, Kourembanas S. Carbon monoxide controls the proliferation of hypoxic vascular smooth muscle cells. J Biol Chem. 1997 Dec 26; 272(52):32804-9.
    View in: PubMed
  34. Hatzivassiliou E, Cardot P, Zannis VI, Mitsialis SA. Ultraspiracle, a Drosophila retinoic X receptor alpha homologue, can mobilize the human thyroid hormone receptor to transactivate a human promoter. Biochemistry. 1997 Jul 29; 36(30):9221-31.
    View in: PubMed
  35. Cardoso WV, Mitsialis SA, Brody JS, Williams MC. Retinoic acid alters the expression of pattern-related genes in the developing rat lung. Dev Dyn. 1996 Sep; 207(1):47-59.
    View in: PubMed
  36. Cardoso WV, Williams MC, Mitsialis SA, Joyce-Brady M, Rishi AK, Brody JS. Retinoic acid induces changes in the pattern of airway branching and alters epithelial cell differentiation in the developing lung in vitro. Am J Respir Cell Mol Biol. 1995 May; 12(5):464-76.
    View in: PubMed
  37. Itoh A, Levinson SF, Morita T, Kourembanas S, Brody JS, Mitsialis SA. Structural characterization and specificity of expression of E2F-5: a new member of the E2F family of transcription factors. Cell Mol Biol Res. 1995; 41(3):147-54.
    View in: PubMed
  38. Goud HD, Oza NB, Mitsialis SA, Levinsky NG. Regulation of renal rK1-kallikrein in spontaneously hypertensive rats. Ren Physiol Biochem. 1993 May-Jun; 16(3):125-30.
    View in: PubMed
  39. Christianson AM, King DL, Hatzivassiliou E, Casas JE, Hallenbeck PL, Nikodem VM, Mitsialis SA, Kafatos FC. DNA binding and heteromerization of the Drosophila transcription factor chorion factor 1/ultraspiracle. Proc Natl Acad Sci U S A. 1992 Dec 1; 89(23):11503-7.
    View in: PubMed
  40. Mitsialis SA, Veletza S, Kafatos FC. Transgenic regulation of moth chorion gene promoters in Drosophila: tissue, temporal, and quantitative control of four bidirectional promoters. J Mol Evol. 1989 Dec; 29(6):486-95.
    View in: PubMed
  41. Mavrothalassitis G, Tzimagiorgis G, Mitsialis A, Zannis V, Plaitakis A, Papamatheakis J, Moschonas N. Isolation and characterization of cDNA clones encoding human liver glutamate dehydrogenase: evidence for a small gene family. Proc Natl Acad Sci U S A. 1988 May; 85(10):3494-8.
    View in: PubMed
  42. Mitsialis SA, Spoerel N, Leviten M, Kafatos FC. A short 5'-flanking DNA region is sufficient for developmentally correct expression of moth chorion genes in Drosophila. Proc Natl Acad Sci U S A. 1987 Nov; 84(22):7987-91.
    View in: PubMed
  43. Kafatos FC, Spoerel N, Mitsialis SA, Nguyen HT, Romano C, Lingappa JR, Mariani BD, Rodakis GC, Lecanidou R, Tsitilou SG. Developmental control and evolution in the chorion gene families of insects. Adv Genet. 1987; 24:223-42.
    View in: PubMed
  44. Kafatos, F.C., N. Spoerel, S.A. Mitsialis, H.T. Nguyen, C. Romano, J.R. Lingappa, B.D. Mariani, G.C. Rodakis, R. Lecanidou and S.G. Tsitilou. Developmental control and evolution in the chorion gene families of insects. Advances in Genetics, J.G. Scandalios, ed. 1987; 223-242.
  45. Kafatos, F.C., S.A. Mitsialis, H.T. Nguyen, N. Spoerel, S.G. Tsitilou and G.D. Mazur. . Evolution of Structural Genes and Regulatory Elements for the Insect Chorion. In: () 1987; Vol. 8, pp. Development as an Evolutionary Process, R. Raff and E.C. Raff, eds. 1987; 161-178.
  46. Mitsialis SA, Kafatos FC. Regulatory elements controlling chorion gene expression are conserved between flies and moths. Nature. 1985 Oct 3-9; 317(6036):453-6.
    View in: PubMed
  47. Kafatos FC, Mitsialis SA, Spoerel N, Mariani B, Lingappa JR, Delidakis C. Studies on the developmentally regulated expression and amplification of insect chorion genes. Cold Spring Harb Symp Quant Biol. 1985; 50:537-47.
    View in: PubMed
  48. Mitsialis SA, Caplan S, Guntaka RV. An upstream regulatory domain of avian tumor virus long terminal repeat is required for the expression of a procaryotic neomycin gene in eucaryotic cells. Mol Cell Biol. 1983 Nov; 3(11):1975-84.
    View in: PubMed
  49. Mitsialis SA, Katz RA, Svoboda J, Guntaka RV. Studies on the structure and organization of avian sarcoma proviruses in the rat XC cell line. J Gen Virol. 1983 Sep; 64 (Pt 9):1885-93.
    View in: PubMed
  50. Mitsialis SA, Manley JL, Guntaka RV. Localization of active promoters for eucaryotic RNA polymerase II in the long terminal repeat of avian sarcoma virus DNA. Mol Cell Biol. 1983 May; 3(5):811-8.
    View in: PubMed
  51. Katz RA, Mitsialis SA, Guntaka RV. Studies on the methylation of avian sarcoma proviruses in permissive and non-permissive cells. J Gen Virol. 1983 Feb; 64 (Pt 2):429-35.
    View in: PubMed
  52. S. Alex Mitsialis. Studies on transcriptional control elements within the retroviral long terminal repeat. 1983.
  53. Katz RA, Omer CA, Weis JH, Mitsialis SA, Faras AJ, Guntaka RV. Restriction endonuclease and nucleotide sequence analyses of molecularly cloned unintegrated avian tumor virus DNA: structure of large terminal repeats in circle junctions. J Virol. 1982 Apr; 42(1):346-51.
    View in: PubMed
  54. Mitsialis SA, Young JF, Palese P, Guntaka RV. An avian tumor virus promoter directs expression of plasmid genes in Escherichia coli. Gene. 1981 Dec; 16(1-3):217-25.
    View in: PubMed
  55. Guntaka RV, Mitsialis SA. Cloning of avian tumor virus DNA fragments in plasmid pBR322: evidence for efficient transcription in E. coli from a virus-coded promoter. Gene. 1980 Dec; 12(1-2):113-21.
    View in: PubMed
  56. Guntaka RV, Rao PY, Katz RA, Mitsialis SA. Binding of Escherichia coli RNA polymerase to a specific site located near the 3'-end of the avaian sarcoma virus genome. Biochim Biophys Acta. 1980 May 30; 607(3):457-69.
    View in: PubMed
  57. Guntaka RV, Rao PY, Mitsialis SA, Katz R. Modification of avian sarcoma proviral DNA sequences in nonpermissive XC cells but not in permissive chicken cells. J Virol. 1980 May; 34(2):569-72.
    View in: PubMed
Local representatives can answer questions about the Profiles website or help with editing a profile or issues with profile data. For assistance with this profile: HMS/HSDM faculty should contact Human Resources at faculty_serviceshms.harvard.edu.
Mitsialis's Networks
Click the "See All" links for more information and interactive visualizations!
Concepts
See all (263) concept(s)
_
Co-Authors
See all (17) people
_
Similar People
See all (60) people
_
Same Department
Search Department
Physical Neighbors
_