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Last Name
Institution

Uwe Rudolph, Dr.Med.

TitleProfessor of Psychiatry
InstitutionMcLean Hospital
DepartmentPsychiatry
AddressMcLean Hospital
Lab of Genetic Neuropharmacology
115 Mill St
Belmont MA 02478
Phone6178552088
Fax6178552012

 Bibliographic 
 selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Benham RS, Engin E, Rudolph U. Diversity of neuronal inhibition: a path to novel treatments for neuropsychiatric disorders. JAMA Psychiatry. 2014 Jan 1; 71(1):91-3.
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  2. Licata SC, Shinday NM, Huizenga MN, Darnell SB, Sangrey GR, Rudolph U, Rowlett JK, Sadri-Vakili G. Alterations in brain-derived neurotrophic factor in the mouse hippocampus following acute but not repeated benzodiazepine treatment. PLoS One. 2013; 8(12):e84806.
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  3. Rudolph U, Möhler H. GABAA Receptor Subtypes: Therapeutic Potential in Down Syndrome, Affective Disorders, Schizophrenia, and Autism. Annu Rev Pharmacol Toxicol. 2014 Jan 6; 54:483-507.
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  4. Paul J, Yévenes GE, Benke D, Lio AD, Ralvenius WT, Witschi R, Scheurer L, Cook JM, Rudolph U, Fritschy JM, Zeilhofer HU. Antihyperalgesia by a2-GABAA Receptors Occurs Via a Genuine Spinal Action and Does Not Involve Supraspinal Sites. Neuropsychopharmacology. 2014 Jan; 39(2):477-87.
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  5. Christian CA, Herbert AG, Holt RL, Peng K, Sherwood KD, Pangratz-Fuehrer S, Rudolph U, Huguenard JR. Endogenous Positive Allosteric Modulation of GABAA Receptors by Diazepam binding inhibitor. Neuron. 2013 Jun 19; 78(6):1063-74.
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  6. Straub CJ, Lau HM, Parlato R, Schuetz G, Fritschy JM, Rudolph U. Bidirectional regulation of intravenous general anesthetic actions by a3-containing ?-aminobutyric acid A receptors. Anesthesiology. 2013 Mar; 118(3):562-76.
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  7. Van't Veer A, Bechtholt AJ, Onvani S, Potter D, Wang Y, Liu-Chen LY, Schütz G, Chartoff EH, Rudolph U, Cohen BM, Carlezon WA. Ablation of Kappa-Opioid Receptors from Brain Dopamine Neurons has Anxiolytic-Like Effects and Enhances Cocaine-Induced Plasticity. Neuropsychopharmacology. 2013 Jul; 38(8):1585-97.
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  8. Ohtsuka N, Badurek S, Busslinger M, Benes FM, Minichiello L, Rudolph U. GABAergic neurons regulate lateral ventricular development via transcription factor Pax5. Genesis. 2013 Apr; 51(4):234-45.
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  9. Drexler B, Zinser S, Huang S, Poe MM, Rudolph U, Cook JM, Antkowiak B. Enhancing the function of alpha5-subunit-containing GABAA receptors promotes action potential firing of neocortical neurons during up-states. Eur J Pharmacol. 2013 Mar 5; 703(1-3):18-24.
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  10. Blednov YA, Benavidez JM, Black M, Chandra D, Homanics GE, Rudolph U, Harris RA. Linking GABA(A) receptor subunits to alcohol-induced conditioned taste aversion and recovery from acute alcohol intoxication. Neuropharmacology. 2013 Apr; 67:46-56.
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  11. Koester C, Rudolph U, Haenggi T, Papilloud A, Fritschy JM, Crestani F. Dissecting the role of diazepam-sensitive ?-aminobutyric acid type A receptors in defensive behavioral reactivity to mild threat. Pharmacol Biochem Behav. 2013 Jan; 103(3):541-9.
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  12. Engin E, Liu J, Rudolph U. a2-containing GABA(A) receptors: a target for the development of novel treatment strategies for CNS disorders. Pharmacol Ther. 2012 Nov; 136(2):142-52.
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  13. Reynolds LM, Engin E, Tantillo G, Lau HM, Muschamp JW, Carlezon WA, Rudolph U. Differential roles of GABA(A) receptor subtypes in benzodiazepine-induced enhancement of brain-stimulation reward. Neuropsychopharmacology. 2012 Oct; 37(11):2531-40.
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  14. Pallotto M, Nissant A, Fritschy JM, Rudolph U, Sassoè-Pognetto M, Panzanelli P, Lledo PM. Early formation of GABAergic synapses governs the development of adult-born neurons in the olfactory bulb. J Neurosci. 2012 Jun 27; 32(26):9103-15.
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  15. Marowsky A, Rudolph U, Fritschy JM, Arand M. Tonic inhibition in principal cells of the amygdala: a central role for a3 subunit-containing GABAA receptors. J Neurosci. 2012 Jun 20; 32(25):8611-9.
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  16. Auferkorte ON, Baden T, Kaushalya SK, Zabouri N, Rudolph U, Haverkamp S, Euler T. GABA(A) receptors containing the a2 subunit are critical for direction-selective inhibition in the retina. PLoS One. 2012; 7(4):e35109.
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  17. Smith KS, Engin E, Meloni EG, Rudolph U. Benzodiazepine-induced anxiolysis and reduction of conditioned fear are mediated by distinct GABAA receptor subtypes in mice. Neuropharmacology. 2012 Aug; 63(2):250-8.
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  18. Lalive AL, Rudolph U, Lüscher C, Tan KR. Is there a way to curb benzodiazepine addiction? Swiss Med Wkly. 2011; 141:w13277.
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  19. Panzanelli P, Gunn BG, Schlatter MC, Benke D, Tyagarajan SK, Scheiffele P, Belelli D, Lambert JJ, Rudolph U, Fritschy JM. Distinct mechanisms regulate GABAA receptor and gephyrin clustering at perisomatic and axo-axonic synapses on CA1 pyramidal cells. J Physiol. 2011 Oct 15; 589(Pt 20):4959-80.
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  20. Rudolph U, Knoflach F. Beyond classical benzodiazepines: novel therapeutic potential of GABAA receptor subtypes. Nat Rev Drug Discov. 2011 Sep; 10(9):685-97.
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  21. Smith KS, Rudolph U. Anxiety and depression: mouse genetics and pharmacological approaches to the role of GABA(A) receptor subtypes. Neuropharmacology. 2012 Jan; 62(1):54-62.
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  22. Bähner F, Weiss EK, Birke G, Maier N, Schmitz D, Rudolph U, Frotscher M, Traub RD, Both M, Draguhn A. Cellular correlate of assembly formation in oscillating hippocampal networks in vitro. Proc Natl Acad Sci U S A. 2011 Aug 30; 108(35):E607-16.
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  23. Yanovsky Y, Schubring S, Fleischer W, Gisselmann G, Zhu XR, Lübbert H, Hatt H, Rudolph U, Haas HL, Sergeeva OA. GABAA receptors involved in sleep and anaesthesia: ß1- versus ß3-containing assemblies. Pflugers Arch. 2012 Jan; 463(1):187-99.
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  24. Duveau V, Laustela S, Barth L, Gianolini F, Vogt KE, Keist R, Chandra D, Homanics GE, Rudolph U, Fritschy JM. Spatiotemporal specificity of GABAA receptor-mediated regulation of adult hippocampal neurogenesis. Eur J Neurosci. 2011 Aug; 34(3):362-73.
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  25. Witschi R, Punnakkal P, Paul J, Walczak JS, Cervero F, Fritschy JM, Kuner R, Keist R, Rudolph U, Zeilhofer HU. Presynaptic alpha2-GABAA receptors in primary afferent depolarization and spinal pain control. J Neurosci. 2011 Jun 1; 31(22):8134-42.
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  26. Tan KR, Rudolph U, Lüscher C. Hooked on benzodiazepines: GABAA receptor subtypes and addiction. Trends Neurosci. 2011 Apr; 34(4):188-97.
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  27. Drexler B, Antkowiak B, Engin E, Rudolph U. Identification and characterization of anesthetic targets by mouse molecular genetics approaches. Can J Anaesth. 2011 Feb; 58(2):178-90.
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  28. Vollenweider I, Smith KS, Keist R, Rudolph U. Antidepressant-like properties of a2-containing GABA(A) receptors. Behav Brain Res. 2011 Feb 2; 217(1):77-80.
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  29. Smith KS, Meloni EG, Myers KM, Van't Veer A, Carlezon WA, Rudolph U. Reduction of fear-potentiated startle by benzodiazepines in C57BL/6J mice. Psychopharmacology (Berl). 2011 Feb; 213(4):697-706.
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  30. Butovas S, Rudolph U, Jurd R, Schwarz C, Antkowiak B. Activity patterns in the prefrontal cortex and hippocampus during and after awakening from etomidate anesthesia. Anesthesiology. 2010 Jul; 113(1):48-57.
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  31. Tan KR, Brown M, Labouèbe G, Yvon C, Creton C, Fritschy JM, Rudolph U, Lüscher C. Neural bases for addictive properties of benzodiazepines. Nature. 2010 Feb 11; 463(7282):769-74.
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  32. Straub CJ, Carlezon WA, Rudolph U. Diazepam and cocaine potentiate brain stimulation reward in C57BL/6J mice. Behav Brain Res. 2010 Jan 5; 206(1):17-20.
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  33. Li P, Rudolph U, Huntsman MM. Long-term sensory deprivation selectively rearranges functional inhibitory circuits in mouse barrel cortex. Proc Natl Acad Sci U S A. 2009 Jul 21; 106(29):12156-61.
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  34. Drexler B, Jurd R, Rudolph U, Antkowiak B. Distinct actions of etomidate and propofol at beta3-containing gamma-aminobutyric acid type A receptors. Neuropharmacology. 2009 Sep; 57(4):446-55.
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  35. Riccio A, Li Y, Moon J, Kim KS, Smith KS, Rudolph U, Gapon S, Yao GL, Tsvetkov E, Rodig SJ, Van't Veer A, Meloni EG, Carlezon WA, Bolshakov VY, Clapham DE. Essential role for TRPC5 in amygdala function and fear-related behavior. Cell. 2009 May 15; 137(4):761-72.
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  36. Balic E, Rudolph U, Fritschy JM, Mohler H, Benke D. The alpha5(H105R) mutation impairs alpha5 selective binding properties by altered positioning of the alpha5 subunit in GABAA receptors containing two distinct types of alpha subunits. J Neurochem. 2009 Jul; 110(1):244-54.
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  37. Schofield CM, Kleiman-Weiner M, Rudolph U, Huguenard JR. A gain in GABAA receptor synaptic strength in thalamus reduces oscillatory activity and absence seizures. Proc Natl Acad Sci U S A. 2009 May 5; 106(18):7630-5.
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  38. Zecharia AY, Nelson LE, Gent TC, Schumacher M, Jurd R, Rudolph U, Brickley SG, Maze M, Franks NP. The involvement of hypothalamic sleep pathways in general anesthesia: testing the hypothesis using the GABAA receptor beta3N265M knock-in mouse. J Neurosci. 2009 Feb 18; 29(7):2177-87.
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  39. Knabl J, Zeilhofer UB, Crestani F, Rudolph U, Zeilhofer HU. Genuine antihyperalgesia by systemic diazepam revealed by experiments in GABAA receptor point-mutated mice. Pain. 2009 Feb; 141(3):233-8.
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  40. Zarnowska ED, Keist R, Rudolph U, Pearce RA. GABAA receptor alpha5 subunits contribute to GABAA,slow synaptic inhibition in mouse hippocampus. J Neurophysiol. 2009 Mar; 101(3):1179-91.
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  41. Fiorelli R, Rudolph U, Straub CJ, Feldon J, Yee BK. Affective and cognitive effects of global deletion of alpha3-containing gamma-aminobutyric acid-A receptors. Behav Pharmacol. 2008 Sep; 19(5-6):582-96.
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  42. Benke D, Barberis A, Kopp S, Altmann KH, Schubiger M, Vogt KE, Rudolph U, Möhler H. GABA A receptors as in vivo substrate for the anxiolytic action of valerenic acid, a major constituent of valerian root extracts. Neuropharmacology. 2009 Jan; 56(1):174-81.
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  43. Winsky-Sommerer R, Knapman A, Fedele DE, Schofield CM, Vyazovskiy VV, Rudolph U, Huguenard JR, Fritschy JM, Tobler I. Normal sleep homeostasis and lack of epilepsy phenotype in GABA A receptor alpha3 subunit-knockout mice. Neuroscience. 2008 Jun 23; 154(2):595-605.
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  44. Möhler H, Rudolph U, Boison D, Singer P, Feldon J, Yee BK. Regulation of cognition and symptoms of psychosis: focus on GABA(A) receptors and glycine transporter 1. Pharmacol Biochem Behav. 2008 Jul; 90(1):58-64.
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  45. Knabl J, Witschi R, Hösl K, Reinold H, Zeilhofer UB, Ahmadi S, Brockhaus J, Sergejeva M, Hess A, Brune K, Fritschy JM, Rudolph U, Möhler H, Zeilhofer HU. Reversal of pathological pain through specific spinal GABAA receptor subtypes. Nature. 2008 Jan 17; 451(7176):330-4.
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  46. Zeller A, Jurd R, Lambert S, Arras M, Drexler B, Grashoff C, Antkowiak B, Rudolph U. Inhibitory ligand-gated ion channels as substrates for general anesthetic actions. Handb Exp Pharmacol. 2008; (182):31-51.
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  47. Zeller A, Crestani F, Camenisch I, Iwasato T, Itohara S, Fritschy JM, Rudolph U. Cortical glutamatergic neurons mediate the motor sedative action of diazepam. Mol Pharmacol. 2008 Feb; 73(2):282-91.
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  48. Gerdjikov TV, Rudolph U, Keist R, Möhler H, Feldon J, Yee BK. Hippocampal alpha 5 subunit-containing GABA A receptors are involved in the development of the latent inhibition effect. Neurobiol Learn Mem. 2008 Feb; 89(2):87-94.
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  49. Grasshoff C, Jurd R, Rudolph U, Antkowiak B. Modulation of presynaptic beta3-containing GABAA receptors limits the immobilizing actions of GABAergic anesthetics. Mol Pharmacol. 2007 Sep; 72(3):780-7.
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  50. Zeller A, Arras M, Jurd R, Rudolph U. Mapping the contribution of beta3-containing GABAA receptors to volatile and intravenous general anesthetic actions. BMC Pharmacol. 2007; 7:2.
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  51. Sanchis-Segura C, Cline B, Jurd R, Rudolph U, Spanagel R. Etomidate and propofol-hyposensitive GABAA receptor beta3(N265M) mice show little changes in acute alcohol sensitivity but enhanced tolerance and withdrawal. Neurosci Lett. 2007 Apr 18; 416(3):275-8.
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  52. Pangratz-Fuehrer S, Rudolph U, Huguenard JR. Giant spontaneous depolarizing potentials in the developing thalamic reticular nucleus. J Neurophysiol. 2007 Mar; 97(3):2364-72.
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  53. Zeller A, Arras M, Jurd R, Rudolph U. Identification of a molecular target mediating the general anesthetic actions of pentobarbital. Mol Pharmacol. 2007 Mar; 71(3):852-9.
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  54. Studer R, von Boehmer L, Haenggi T, Schweizer C, Benke D, Rudolph U, Fritschy JM. Alteration of GABAergic synapses and gephyrin clusters in the thalamic reticular nucleus of GABAA receptor alpha3 subunit-null mice. Eur J Neurosci. 2006 Sep; 24(5):1307-15.
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  55. Prenosil GA, Schneider Gasser EM, Rudolph U, Keist R, Fritschy JM, Vogt KE. Specific subtypes of GABAA receptors mediate phasic and tonic forms of inhibition in hippocampal pyramidal neurons. J Neurophysiol. 2006 Aug; 96(2):846-57.
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  56. Merrill AW, Barter LS, Rudolph U, Eger EI, Antognini JF, Carstens MI, Carstens E. Propofol's effects on nociceptive behavior and spinal c-fos expression after intraplantar formalin injection in mice with a mutation in the gamma-aminobutyric acid-type(A) receptor beta3 subunit. Anesth Analg. 2006 Aug; 103(2):478-83, table of contents.
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  57. Drexler B, Jurd R, Rudolph U, Antkowiak B. Dual actions of enflurane on postsynaptic currents abolished by the gamma-aminobutyric acid type A receptor beta3(N265M) point mutation. Anesthesiology. 2006 Aug; 105(2):297-304.
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  58. Sohal VS, Pangratz-Fuehrer S, Rudolph U, Huguenard JR. Intrinsic and synaptic dynamics interact to generate emergent patterns of rhythmic bursting in thalamocortical neurons. J Neurosci. 2006 Apr 19; 26(16):4247-55.
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  59. Drexler B, Grasshoff C, Rudolph U, Unertl K, Antkowiak B. [The GABA(A) receptor family: possibilities for the development of better anesthetics]. Anaesthesist. 2006 Mar; 55(3):287-95.
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  60. Grasshoff C, Drexler B, Rudolph U, Antkowiak B. Anaesthetic drugs: linking molecular actions to clinical effects. Curr Pharm Des. 2006; 12(28):3665-79.
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  61. Rudolph U, Möhler H. GABA-based therapeutic approaches: GABAA receptor subtype functions. Curr Opin Pharmacol. 2006 Feb; 6(1):18-23.
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  62. Yee BK, Keist R, von Boehmer L, Studer R, Benke D, Hagenbuch N, Dong Y, Malenka RC, Fritschy JM, Bluethmann H, Feldon J, Möhler H, Rudolph U. A schizophrenia-related sensorimotor deficit links alpha 3-containing GABAA receptors to a dopamine hyperfunction. Proc Natl Acad Sci U S A. 2005 Nov 22; 102(47):17154-9.
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  63. Liao M, Sonner JM, Jurd R, Rudolph U, Borghese CM, Harris RA, Laster MJ, Eger EI. Beta3-containing gamma-aminobutyric acidA receptors are not major targets for the amnesic and immobilizing actions of isoflurane. Anesth Analg. 2005 Aug; 101(2):412-8, table of contents.
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  64. Grasshoff C, Rudolph U, Antkowiak B. Molecular and systemic mechanisms of general anaesthesia: the 'multi-site and multiple mechanisms' concept. Curr Opin Anaesthesiol. 2005 Aug; 18(4):386-91.
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  65. Zeller A, Arras M, Lazaris A, Jurd R, Rudolph U. Distinct molecular targets for the central respiratory and cardiac actions of the general anesthetics etomidate and propofol. FASEB J. 2005 Oct; 19(12):1677-9.
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  66. Liao M, Sonner JM, Husain SS, Miller KW, Jurd R, Rudolph U, Eger EI. R (+) etomidate and the photoactivable R (+) azietomidate have comparable anesthetic activity in wild-type mice and comparably decreased activity in mice with a N265M point mutation in the gamma-aminobutyric acid receptor beta3 subunit. Anesth Analg. 2005 Jul; 101(1):131-5, table of contents.
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  67. Lambert S, Arras M, Vogt KE, Rudolph U. Isoflurane-induced surgical tolerance mediated only in part by beta3-containing GABA(A) receptors. Eur J Pharmacol. 2005 May 23; 516(1):23-7.
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  68. Hauser J, Rudolph U, Keist R, Möhler H, Feldon J, Yee BK. Hippocampal alpha5 subunit-containing GABAA receptors modulate the expression of prepulse inhibition. Mol Psychiatry. 2005 Feb; 10(2):201-7.
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  69. Drexler B, Roether CL, Jurd R, Rudolph U, Antkowiak B. Opposing actions of etomidate on cortical theta oscillations are mediated by different gamma-aminobutyric acid type A receptor subtypes. Anesthesiology. 2005 Feb; 102(2):346-52.
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  70. Möhler H, Fritschy JM, Vogt K, Crestani F, Rudolph U. Pathophysiology and pharmacology of GABA(A) receptors. Handb Exp Pharmacol. 2005; (169):225-47.
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  71. Möhler H, Fritschy JM, Crestani F, Hensch T, Rudolph U. Specific GABA(A) circuits in brain development and therapy. Biochem Pharmacol. 2004 Oct 15; 68(8):1685-90.
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  72. Kopp C, Rudolph U, Tobler I. Sleep EEG changes after zolpidem in mice. Neuroreport. 2004 Oct 5; 15(14):2299-302.
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  73. Yee BK, Hauser J, Dolgov VV, Keist R, Möhler H, Rudolph U, Feldon J. GABA receptors containing the alpha5 subunit mediate the trace effect in aversive and appetitive conditioning and extinction of conditioned fear. Eur J Neurosci. 2004 Oct; 20(7):1928-36.
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  74. Rudolph U, Antkowiak B. Molecular and neuronal substrates for general anaesthetics. Nat Rev Neurosci. 2004 Sep; 5(9):709-20.
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  75. Benke D, Fakitsas P, Roggenmoser C, Michel C, Rudolph U, Mohler H. Analysis of the presence and abundance of GABAA receptors containing two different types of alpha subunits in murine brain using point-mutated alpha subunits. J Biol Chem. 2004 Oct 15; 279(42):43654-60.
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  76. van Rijnsoever C, Täuber M, Choulli MK, Keist R, Rudolph U, Mohler H, Fritschy JM, Crestani F. Requirement of alpha5-GABAA receptors for the development of tolerance to the sedative action of diazepam in mice. J Neurosci. 2004 Jul 28; 24(30):6785-90.
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  77. Fagiolini M, Fritschy JM, Löw K, Möhler H, Rudolph U, Hensch TK. Specific GABAA circuits for visual cortical plasticity. Science. 2004 Mar 12; 303(5664):1681-3.
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  78. Huopaniemi L, Keist R, Randolph A, Certa U, Rudolph U. Diazepam-induced adaptive plasticity revealed by alpha1 GABAA receptor-specific expression profiling. J Neurochem. 2004 Mar; 88(5):1059-67.
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  79. Kopp C, Rudolph U, Löw K, Tobler I. Modulation of rhythmic brain activity by diazepam: GABA(A) receptor subtype and state specificity. Proc Natl Acad Sci U S A. 2004 Mar 9; 101(10):3674-9.
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  80. Kosel M, Rudolph U, Wielepp P, Luginbühl M, Schmitt W, Fisch HU, Schlaepfer TE. Diminished GABA(A) receptor-binding capacity and a DNA base substitution in a patient with treatment-resistant depression and anxiety. Neuropsychopharmacology. 2004 Feb; 29(2):347-50.
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  81. Rudolph U, Möhler H. Analysis of GABAA receptor function and dissection of the pharmacology of benzodiazepines and general anesthetics through mouse genetics. Annu Rev Pharmacol Toxicol. 2004; 44:475-98.
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  82. Siegwart R, Krähenbühl K, Lambert S, Rudolph U. Mutational analysis of molecular requirements for the actions of general anaesthetics at the gamma-aminobutyric acidA receptor subtype, alpha1beta2gamma2. BMC Pharmacol. 2003 Nov 12; 3:13.
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  83. Täuber M, Calame-Droz E, Prut L, Rudolph U, Crestani F. alpha2-gamma-Aminobutyric acid (GABA)A receptors are the molecular substrates mediating precipitation of narcosis but not of sedation by the combined use of diazepam and alcohol in vivo. Eur J Neurosci. 2003 Nov; 18(9):2599-604.
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  84. Bacci A, Rudolph U, Huguenard JR, Prince DA. Major differences in inhibitory synaptic transmission onto two neocortical interneuron subclasses. J Neurosci. 2003 Oct 22; 23(29):9664-74.
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  85. Wieser HG, Rudolph U, Blau N, Boison D, Imhof HG, Bernays R, Yonekawa Y. Amino acid composition of brain cysts: levels of excitatory amino acids in cyst fluid fail to predict seizures. Epilepsy Res. 2003 Aug; 55(3):191-9.
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  86. Kopp C, Rudolph U, Keist R, Tobler I. Diazepam-induced changes on sleep and the EEG spectrum in mice: role of the alpha3-GABA(A) receptor subtype. Eur J Neurosci. 2003 May; 17(10):2226-30.
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  87. Sohal VS, Keist R, Rudolph U, Huguenard JR. Dynamic GABA(A) receptor subtype-specific modulation of the synchrony and duration of thalamic oscillations. J Neurosci. 2003 May 1; 23(9):3649-57.
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  88. Jurd R, Arras M, Lambert S, Drexler B, Siegwart R, Crestani F, Zaugg M, Vogt KE, Ledermann B, Antkowiak B, Rudolph U. General anesthetic actions in vivo strongly attenuated by a point mutation in the GABA(A) receptor beta3 subunit. FASEB J. 2003 Feb; 17(2):250-2.
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  89. Crestani F, Assandri R, Täuber M, Martin JR, Rudolph U. Contribution of the alpha1-GABA(A) receptor subtype to the pharmacological actions of benzodiazepine site inverse agonists. Neuropharmacology. 2002 Sep; 43(4):679-84.
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  90. Ohman L, Franzén L, Rudolph U, Birnbaumer L, Hörnquist EH. Regression of Peyer's patches in G alpha i2 deficient mice prior to colitis is associated with reduced expression of Bcl-2 and increased apoptosis. Gut. 2002 Sep; 51(3):392-7.
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  91. Crestani F, Keist R, Fritschy JM, Benke D, Vogt K, Prut L, Blüthmann H, Möhler H, Rudolph U. Trace fear conditioning involves hippocampal alpha5 GABA(A) receptors. Proc Natl Acad Sci U S A. 2002 Jun 25; 99(13):8980-5.
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  92. Jiang M, Spicher K, Boulay G, Martín-Requero A, Dye CA, Rudolph U, Birnbaumer L. Mouse gene knockout and knockin strategies in application to alpha subunits of Gi/Go family of G proteins. Methods Enzymol. 2002; 344:277-98.
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  93. Siegwart R, Jurd R, Rudolph U. Molecular determinants for the action of general anesthetics at recombinant alpha(2)beta(3)gamma(2)gamma-aminobutyric acid(A) receptors. J Neurochem. 2002 Jan; 80(1):140-8.
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  94. Möhler H, Fritschy JM, Rudolph U. A new benzodiazepine pharmacology. J Pharmacol Exp Ther. 2002 Jan; 300(1):2-8.
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  95. Uhlig HH, Hultgren Hörnquist E, Ohman Bache L, Rudolph U, Birnbaumer L, Mothes T. Antibody response to dietary and autoantigens in G alpha i2-deficient mice. Eur J Gastroenterol Hepatol. 2001 Dec; 13(12):1421-9.
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  96. Tobler I, Kopp C, Deboer T, Rudolph U. Diazepam-induced changes in sleep: role of the alpha 1 GABA(A) receptor subtype. Proc Natl Acad Sci U S A. 2001 May 22; 98(11):6464-9.
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  97. Rudolph U. Identification of molecular substrate for the attenuation of anxiety: a step toward the development of better anti-anxiety drugs. ScientificWorldJournal. 2001 May 1; 1:192-3.
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  98. Rudolph U, Crestani F, Möhler H. GABA(A) receptor subtypes: dissecting their pharmacological functions. Trends Pharmacol Sci. 2001 Apr; 22(4):188-94.
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  99. Crestani F, Löw K, Keist R, Mandelli M, Möhler H, Rudolph U. Molecular targets for the myorelaxant action of diazepam. Mol Pharmacol. 2001 Mar; 59(3):442-5.
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  100. Möhler H, Crestani F, Rudolph U. GABA(A)-receptor subtypes: a new pharmacology. Curr Opin Pharmacol. 2001 Feb; 1(1):22-5.
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  101. Crestani F, Martin JR, Möhler H, Rudolph U. Mechanism of action of the hypnotic zolpidem in vivo. Br J Pharmacol. 2000 Dec; 131(7):1251-4.
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  102. Crestani F, Martin JR, Möhler H, Rudolph U. Resolving differences in GABAA receptor mutant mouse studies. Nat Neurosci. 2000 Nov; 3(11):1059.
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  103. Löw K, Crestani F, Keist R, Benke D, Brünig I, Benson JA, Fritschy JM, Rülicke T, Bluethmann H, Möhler H, Rudolph U. Molecular and neuronal substrate for the selective attenuation of anxiety. Science. 2000 Oct 6; 290(5489):131-4.
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  104. Ohman L, Franzén L, Rudolph U, Harriman GR, Hultgren Hörnquist E. Immune activation in the intestinal mucosa before the onset of colitis in Galphai2-deficient mice. Scand J Immunol. 2000 Jul; 52(1):80-90.
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  105. Rudolph U, Crestani F, Benke D, Brünig I, Benson JA, Fritschy JM, Martin JR, Bluethmann H, Möhler H. Benzodiazepine actions mediated by specific gamma-aminobutyric acid(A) receptor subtypes. Nature. 1999 Oct 21; 401(6755):796-800.
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  106. Rudolph U, Möhler H. Genetically modified animals in pharmacological research: future trends. Eur J Pharmacol. 1999 Jun 30; 375(1-3):327-37.
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  107. Rudolph U, Mohler H. Transgenic and targeted mutant mice in drug discovery. Curr Opin Drug Discov Devel. 1999 Mar; 2(2):134-41.
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  108. Benson JA, Löw K, Keist R, Mohler H, Rudolph U. Pharmacology of recombinant gamma-aminobutyric acidA receptors rendered diazepam-insensitive by point-mutated alpha-subunits. FEBS Lett. 1998 Jul 24; 431(3):400-4.
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  109. Fritschy JM, Johnson DK, Mohler H, Rudolph U. Independent assembly and subcellular targeting of GABA(A)-receptor subtypes demonstrated in mouse hippocampal and olfactory neurons in vivo. Neurosci Lett. 1998 Jun 19; 249(2-3):99-102.
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  110. Jiang M, Gold MS, Boulay G, Spicher K, Peyton M, Brabet P, Srinivasan Y, Rudolph U, Ellison G, Birnbaumer L. Multiple neurological abnormalities in mice deficient in the G protein Go. Proc Natl Acad Sci U S A. 1998 Mar 17; 95(6):3269-74.
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  111. Mohler H, Luscher B, Fritschy JM, Benke D, Benson J, Rudolph U. GABA(A)-receptor assembly in vivo: lessons from subunit mutant mice. Life Sci. 1998; 62(17-18):1611-5.
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  112. Fritschy JM, Benke D, Johnson DK, Mohler H, Rudolph U. GABAA-receptor alpha-subunit is an essential prerequisite for receptor formation in vivo. Neuroscience. 1997 Dec; 81(4):1043-53.
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  113. Hörnquist CE, Lu X, Rogers-Fani PM, Rudolph U, Shappell S, Birnbaumer L, Harriman GR. G(alpha)i2-deficient mice with colitis exhibit a local increase in memory CD4+ T cells and proinflammatory Th1-type cytokines. J Immunol. 1997 Feb 1; 158(3):1068-77.
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  114. Jiang M, Boulay G, Spicher K, Peyton MJ, Brabet P, Birnbaumer L, Rudolph U. Inactivation of the G alpha i2 and G alpha o genes by homologous recombination. Receptors Channels. 1997; 5(3-4):187-92.
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  115. Rudolph U, Spicher K, Birnbaumer L. Adenylyl cyclase inhibition and altered G protein subunit expression and ADP-ribosylation patterns in tissues and cells from Gi2 alpha-/-mice. Proc Natl Acad Sci U S A. 1996 Apr 16; 93(8):3209-14.
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  116. Mohler H, Fritschy JM, Lüscher B, Rudolph U, Benson J, Benke D. The GABAA receptors. From subunits to diverse functions. Ion Channels. 1996; 4:89-113.
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  117. Rudolph U, Finegold MJ, Rich SS, Harriman GR, Srinivasan Y, Brabet P, Bradley A, Birnbaumer L. Gi2 alpha protein deficiency: a model of inflammatory bowel disease. J Clin Immunol. 1995 Nov; 15(6 Suppl):101S-105S.
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  118. Rudolph U, Finegold MJ, Rich SS, Harriman GR, Srinivasan Y, Brabet P, Boulay G, Bradley A, Birnbaumer L. Ulcerative colitis and adenocarcinoma of the colon in G alpha i2-deficient mice. Nat Genet. 1995 Jun; 10(2):143-50.
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  119. Rudolph U, Bradley A, Birnbaumer L. Targeted inactivation of the Gi2 alpha gene with replacement and insertion vectors: analysis in a 96-well plate format. Methods Enzymol. 1994; 237:366-86.
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  120. Rudolph U, Brabet P, Hasty P, Bradley A, Birnbaumer L. Disruption of the G(i2) alpha locus in embryonic stem cells and mice: a modified hit and run strategy with detection by a PCR dependent on gap repair. Transgenic Res. 1993 Nov; 2(6):345-55.
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  121. Rudolph U, Brabet P, Kaplan J, Hasty P, Bradley A, Birnbaumer L. Targeting of the Gi2 alpha gene in ES cells with replacement and insertion vectors. J Recept Res. 1993; 13(1-4):619-37.
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  122. Spicher K, Klinz FJ, Rudolph U, Codina J, Birnbaumer L, Schultz G, Rosenthal W. Identification of the G-protein alpha-subunit encoded by alpha o2 cDNA as a 39 kDa pertussis toxin substrate. Biochem Biophys Res Commun. 1991 Mar 15; 175(2):473-9.
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  123. Bertrand P, Sanford J, Rudolph U, Codina J, Birnbaumer L. At least three alternatively spliced mRNAs encoding two alpha subunits of the Go GTP-binding protein can be expressed in a single tissue. J Biol Chem. 1990 Oct 25; 265(30):18576-80.
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  124. Hsu WH, Rudolph U, Sanford J, Bertrand P, Olate J, Nelson C, Moss LG, Boyd AE, Codina J, Birnbaumer L. Molecular cloning of a novel splice variant of the alpha subunit of the mammalian Go protein. J Biol Chem. 1990 Jul 5; 265(19):11220-6.
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  125. Rudolph U, Koesling D, Hinsch KD, Seifert R, Bigalke M, Schultz G, Rosenthal W. G-protein alpha-subunits in cytosolic and membranous fractions of human neutrophils. Mol Cell Endocrinol. 1989 May; 63(1-2):143-53.
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