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Mohamed Simo Arredouani, PH.D.

TitleAssistant Professor of Surgery
InstitutionBeth Israel Deaconess Medical Center
DepartmentSurgery
AddressCenter for Life Science
Urology, CLS-446
3 Blackfan Circle
Boston MA 02115
Phone617/735-2102
Fax617/735-2110

 Biography 
 awards and honors
1997 - 2002SCAP Research Fellowship
2003 - Jere Mead Fellowship in Respiratory Physiology
2007 - 2009Prostate SPORE Career Development Award
2008 - 2011Young Investigator Award
2009 - Eleanor & Miles Shore Scholars in Medicine Fellowship
2009 - 2012New Investigator Award

 Overview 
 overview
- Mechanisms of immune tolerance to tumor-associated antigens.
- Prostate cancer immunotherapy.
- Prostate cancer biomarkers.
- Immunoinformatics.
- Vaccine development.


 Mentoring 
 current student opportunities
Available: 09/03/13, Expires: 05/31/14

Immunological checkpoints are in place to prevent autoimmune responses. However, in doing so, they also hinder anti-tumor immunity, hence there is an urgent demand for identification of new regulatory mechanisms of immune tolerance whose manipulation could be utilized as an approach for cancer immunotherapy. A better understanding of the mechanisms of onset of immune tolerance, through dissection of molecular features of lymphocyte unresponsiveness to tumor antigens, would undoubtedly accelerate efforts to develop more effective cancer immunotherapies. We postulate that identification and characterization of new molecules that play crucial roles in the biology of T cells in the context of prostate cancer will lead to the development of novel targeted therapies for the enhancement of prostate cancer immunotherapy. This hypothesis will be evaluated via the following specific aims: Aim 1: Gene expression profiling of CD4+ T, CD8+ T cells and Regulatory T cells from tumor-free and prostate tumor-bearing mice. Aim 2: Validation of prostate-cancer specific markers and pathways in T cells and Regulatory T cells from mice and humans. Aim 3: Characterization of potential protein targets for human prostate cancer immunotherapy. The student would focus on a specific lymphocyte biologic pathway and validate its differential expression between cancer and healthy and tumor-bearing mice in vitro. Results from this part would also be validated in vivo using a mouse model of prostate cancer.


 Bibliographic 
 selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Arredouani MS, Bhasin MK, Sage D, Dunn LK, Gill MB, Agnani D, Libermann TA, Fingeroth J. Analysis of host gene expression changes reveals distinct roles for the cytoplasmic domain of the Epstein-Barr virus receptor/CD21 in B-cell maturation, activation and initiation of virus infection. J Virol. 2014 Mar 5.
    View in: PubMed
  2. Kissick HT, Sanda MG, Dunn LK, Arredouani MS. Development of a peptide-based vaccine targeting TMPRSS2:ERG fusion-positive prostate cancer. Cancer Immunol Immunother. 2013 Dec; 62(12):1831-40.
    View in: PubMed
  3. Lu B, Asara JM, Sanda MG, Arredouani MS. The role of the transcription factor SIM2 in prostate cancer. PLoS One. 2011; 6(12):e28837.
    View in: PubMed
  4. Nowak M, Arredouani MS, Tun-Kyi A, Schmidt-Wolf I, Sanda MG, Balk SP, Exley MA. Defective NKT cell activation by CD1d+ TRAMP prostate tumor cells is corrected by interleukin-12 with a-galactosylceramide. PLoS One. 2010; 5(6):e11311.
    View in: PubMed
  5. Arredouani MS, Tseng-Rogenski SS, Hollenbeck BK, Escara-Wilke J, Leander KR, Defeo-Jones D, Hwang C, Sanda MG. Androgen ablation augments human HLA2.1-restricted T cell responses to PSA self-antigen in transgenic mice. Prostate. 2010 Jun 15; 70(9):1002-11.
    View in: PubMed
  6. Galicia G, Maes W, Verbinnen B, Kasran A, Bullens D, Arredouani M, Ceuppens JL. Haptoglobin deficiency facilitates the development of autoimmune inflammation. Eur J Immunol. 2009 Dec; 39(12):3404-12.
    View in: PubMed
  7. Arredouani MS, Lu B, Bhasin M, Eljanne M, Yue W, Mosquera JM, Bubley GJ, Li V, Rubin MA, Libermann TA, Sanda MG. Identification of the transcription factor single-minded homologue 2 as a potential biomarker and immunotherapy target in prostate cancer. Clin Cancer Res. 2009 Sep 15; 15(18):5794-802.
    View in: PubMed
  8. Hmadcha A, Abdelkrim H, Domínguez-Bendala J, Juan DB, Wakeman J, Jane W, Arredouani M, Mohamed A, Soria B, Bernat S. The immune boundaries for stem cell based therapies: problems and prospective solutions. J Cell Mol Med. 2009 Aug; 13(8A):1464-75.
    View in: PubMed
  9. Tseng-Rogenski SS, Arredouani MS, Escara-Wilke JF, Neeley YC, Imperiale MJ, Sanda MG. A safety-modified SV40 Tag developed for human cancer immunotherapy. Drug Des Devel Ther. 2009; 2:17-24.
    View in: PubMed
  10. Haram KM, Peltier HJ, Lu B, Bhasin M, Otu HH, Choy B, Regan M, Libermann TA, Latham GJ, Sanda MG, Arredouani MS. Gene expression profile of mouse prostate tumors reveals dysregulations in major biological processes and identifies potential murine targets for preclinical development of human prostate cancer therapy. Prostate. 2008 Oct 1; 68(14):1517-30.
    View in: PubMed
  11. Neeley YC, Arredouani MS, Hollenbeck B, Eng MH, Rubin MA, Sanda MG. Partially circumventing peripheral tolerance for oncogene-specific prostate cancer immunotherapy. Prostate. 2008 May 15; 68(7):715-27.
    View in: PubMed
  12. Tseng-Rogenski SS, Arredouani MS, Neeley YC, Lu B, Chinnaiyan AM, Sanda MG. Fas-mediated T cell deletion potentiates tumor antigen-specific tolerance in a mouse model of prostate cancer. Cancer Immunol Immunother. 2008 Sep; 57(9):1357-65.
    View in: PubMed
  13. Limmon GV, Arredouani M, McCann KL, Corn Minor RA, Kobzik L, Imani F. Scavenger receptor class-A is a novel cell surface receptor for double-stranded RNA. FASEB J. 2008 Jan; 22(1):159-67.
    View in: PubMed
  14. Lim RH, Arredouani MS, Fedulov A, Kobzik L, Hubeau C. Maternal allergic contact dermatitis causes increased asthma risk in offspring. Respir Res. 2007; 8:56.
    View in: PubMed
  15. Arredouani MS, Franco F, Imrich A, Fedulov A, Lu X, Perkins D, Soininen R, Tryggvason K, Shapiro SD, Kobzik L. Scavenger Receptors SR-AI/II and MARCO limit pulmonary dendritic cell migration and allergic airway inflammation. J Immunol. 2007 May 1; 178(9):5912-20.
    View in: PubMed
  16. Dahl M, Bauer AK, Arredouani M, Soininen R, Tryggvason K, Kleeberger SR, Kobzik L. Protection against inhaled oxidants through scavenging of oxidized lipids by macrophage receptors MARCO and SR-AI/II. J Clin Invest. 2007 Mar; 117(3):757-64.
    View in: PubMed
  17. Józefowski S, Sulahian TH, Arredouani M, Kobzik L. Role of scavenger receptor MARCO in macrophage responses to CpG oligodeoxynucleotides. J Leukoc Biol. 2006 Oct; 80(4):870-9.
    View in: PubMed
  18. Arredouani MS, Yang Z, Imrich A, Ning Y, Qin G, Kobzik L. The macrophage scavenger receptor SR-AI/II and lung defense against pneumococci and particles. Am J Respir Cell Mol Biol. 2006 Oct; 35(4):474-8.
    View in: PubMed
  19. Józefowski S, Arredouani M, Sulahian T, Kobzik L. Disparate regulation and function of the class A scavenger receptors SR-AI/II and MARCO. J Immunol. 2005 Dec 15; 175(12):8032-41.
    View in: PubMed
  20. Arredouani MS, Palecanda A, Koziel H, Huang YC, Imrich A, Sulahian TH, Ning YY, Yang Z, Pikkarainen T, Sankala M, Vargas SO, Takeya M, Tryggvason K, Kobzik L. MARCO is the major binding receptor for unopsonized particles and bacteria on human alveolar macrophages. J Immunol. 2005 Nov 1; 175(9):6058-64.
    View in: PubMed
  21. Arredouani MS, Kasran A, Vanoirbeek JA, Berger FG, Baumann H, Ceuppens JL. Haptoglobin dampens endotoxin-induced inflammatory effects both in vitro and in vivo. Immunology. 2005 Feb; 114(2):263-71.
    View in: PubMed
  22. De Vleeschouwer S, Arredouani M, Adé M, Cadot P, Vermassen E, Ceuppens JL, Van Gool SW. Uptake and presentation of malignant glioma tumor cell lysates by monocyte-derived dendritic cells. Cancer Immunol Immunother. 2005 Apr; 54(4):372-82.
    View in: PubMed
  23. Arredouani M, Yang Z, Ning Y, Qin G, Soininen R, Tryggvason K, Kobzik L. The scavenger receptor MARCO is required for lung defense against pneumococcal pneumonia and inhaled particles. J Exp Med. 2004 Jul 19; 200(2):267-72.
    View in: PubMed
  24. Arredouani MS, Kobzik L. The structure and function of marco, a macrophage class a scavenger receptor. Cell Mol Biol (Noisy-le-grand). 2004; 50 Online Pub:OL657-65.
    View in: PubMed
  25. Arredouani M, Matthijs P, Van Hoeyveld E, Kasran A, Baumann H, Ceuppens JL, Stevens E. Haptoglobin directly affects T cells and suppresses T helper cell type 2 cytokine release. Immunology. 2003 Feb; 108(2):144-51.
    View in: PubMed
  26. El-Ghmati SM, Arredouani M, Van Hoeyveld EM, Ceuppens JL, Stevens EA. Haptoglobin interacts with the human mast cell line HMC-1 and inhibits its spontaneous proliferation. Scand J Immunol. 2002 Apr; 55(4):352-8.
    View in: PubMed
  27. Arredouani M, Matthys P, Kasran A, Baumann H, Ceuppen JL. Haptoglobin and the Th1/Th2 balance: hints from in vitro and in vivo studies. Redox Rep. 2001; 6(6):369-71.
    View in: PubMed
  28. Perevozchikov AP, Dizhe EB, Serov SM, Kuryshev VIu, Arredouani M, Parfenova NS, Shavlovskii MM, Nasonkin IO, Drapchinskaia NL, Bondarev IE, Tsarapkina EV, Sukonina VE, Denisenko AD, Gaitskhoki VS, Klimov AN. [Expression of the human apolipoprotein A-I gene transferred in vitro into mammalian cells and in vivo into rat liver]. Mol Biol (Mosk). 1997 Mar-Apr; 31(2):216-23.
    View in: PubMed
  29. Perevozchikov AP, Kuryshev VIu, Arredouani M, Parfenova NS, Shavlovskii MM, Sukonina VE, Dizhe EB, Orlov SV, Denisenko AD, Gaitskhoki VS, Klimov AN. [Directed transfer of the human apolipoprotein A-I gene and bacterial genes-markers into rat liver]. Dokl Akad Nauk. 1997 Feb; 352(4):571-4.
    View in: PubMed
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