Mohamed Simo Arredouani, PH.D.
|Title||Assistant Professor of Surgery|
|Institution||Beth Israel Deaconess Medical Center|
|Address||Center for Life Science|
3 Blackfan Circle
Boston MA 02115
||Jere Mead Fellowship in Respiratory Physiology|
2009||Prostate SPORE Career Development Award|
2011||Young Investigator Award|
||Eleanor & Miles Shore Scholars in Medicine Fellowship|
2012||New Investigator Award|
- Mechanisms of immune tolerance to tumor-associated antigens.
- Prostate cancer immunotherapy.
- Prostate cancer biomarkers.
Available: 09/03/13, Expires: 05/31/14
Immunological checkpoints are in place to prevent autoimmune responses. However,
in doing so, they also hinder anti-tumor immunity, hence there is an urgent demand for identification of new regulatory mechanisms of immune tolerance whose manipulation could be utilized as an approach
for cancer immunotherapy. A better understanding of the mechanisms of onset of immune tolerance, through dissection of molecular features of lymphocyte unresponsiveness to tumor antigens, would
undoubtedly accelerate efforts to develop more effective cancer immunotherapies. We postulate that identification and characterization of new molecules that play crucial roles in the biology of T cells in the context of prostate cancer will lead to the development of novel targeted therapies for the enhancement of prostate cancer immunotherapy. This hypothesis will be evaluated via the following specific aims:
Aim 1: Gene expression profiling of CD4+ T, CD8+ T cells and Regulatory T cells from tumor-free and prostate tumor-bearing mice.
Aim 2: Validation of prostate-cancer specific markers and pathways in T cells and Regulatory T cells from mice and humans.
Aim 3: Characterization of potential protein targets for human prostate cancer immunotherapy.
The student would focus on a specific lymphocyte biologic pathway and validate its differential expression between cancer and healthy and tumor-bearing mice in vitro.
Results from this part would also be validated in vivo using a mouse model of prostate cancer.
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