 Alexander Koglin, PH.D.
| Title | Research Fellow in Biological Chemistry and Molecular Pharmacology (INT) |
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| Institution | Harvard Medical School |
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| Department | Biological Chemistry & Molecular Pharmacology |
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| Address | Harvard Medical School
B C M P |Armenise D1 #607
240 Longwood Ave
Boston MA 02115
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| Phone | 617/432-0930 |
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 Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications.
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Bowers AA, Acker MG, Koglin A, Walsh CT. Manipulation of thiocillin variants by prepeptide gene replacement: structure, conformation, and activity of heterocycle substitution mutants. J Am Chem Soc. 2010 Jun 2; 132(21):7519-27.
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Koglin A, Doetsch V, Bernhard F. Molecular engineering aspects for the production of new and modified biosurfactants. Adv Exp Med Biol. 2010; 672:158-69.
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Frueh DP, Leed A, Arthanari H, Koglin A, Walsh CT, Wagner G. Time-shared HSQC-NOESY for accurate distance constraints measured at high-field in (15)N-(13)C-ILV methyl labeled proteins. J Biomol NMR. 2009 Nov; 45(3):311-8.
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Frueh DP, Arthanari H, Koglin A, Walsh CT, Wagner G. A double TROSY hNCAnH experiment for efficient assignment of large and challenging proteins. J Am Chem Soc. 2009 Sep 16; 131(36):12880-1.
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Koglin A, Walsh CT. Structural insights into nonribosomal peptide enzymatic assembly lines. Nat Prod Rep. 2009 Aug; 26(8):987-1000.
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Strieter ER, Koglin A, Aron ZD, Walsh CT. Cascade reactions during coronafacic acid biosynthesis: elongation, cyclization, and functionalization during Cfa7-catalyzed condensation. J Am Chem Soc. 2009 Feb 18; 131(6):2113-5.
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Singh GM, Fortin PD, Koglin A, Walsh CT. beta-Hydroxylation of the aspartyl residue in the phytotoxin syringomycin E: characterization of two candidate hydroxylases AspH and SyrP in Pseudomonas syringae. Biochemistry. 2008 Oct 28; 47(43):11310-20.
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Frueh DP, Arthanari H, Koglin A, Vosburg DA, Bennett AE, Walsh CT, Wagner G. Dynamic thiolation-thioesterase structure of a non-ribosomal peptide synthetase. Nature. 2008 Aug 14; 454(7206):903-6.
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Koglin A, Löhr F, Bernhard F, Rogov VV, Frueh DP, Strieter ER, Mofid MR, Güntert P, Wagner G, Walsh CT, Marahiel MA, Dötsch V. Structural basis for the selectivity of the external thioesterase of the surfactin synthetase. Nature. 2008 Aug 14; 454(7206):907-11.
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Zhou Z, Koglin A, Wang Y, McMahon AP, Walsh CT. An eight residue fragment of an acyl carrier protein suffices for post-translational introduction of fluorescent pantetheinyl arms in protein modification in vitro and in vivo. J Am Chem Soc. 2008 Jul 30; 130(30):9925-30.
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Nolan EM, Fischbach MA, Koglin A, Walsh CT. Biosynthetic tailoring of microcin E492m: post-translational modification affords an antibacterial siderophore-peptide conjugate. J Am Chem Soc. 2007 Nov 21; 129(46):14336-47.
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Schwarz D, Klammt C, Koglin A, Löhr F, Schneider B, Dötsch V, Bernhard F. Preparative scale cell-free expression systems: new tools for the large scale preparation of integral membrane proteins for functional and structural studies. Methods. 2007 Apr; 41(4):355-69.
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Yeh E, Blasiak LC, Koglin A, Drennan CL, Walsh CT. Chlorination by a long-lived intermediate in the mechanism of flavin-dependent halogenases. Biochemistry. 2007 Feb 6; 46(5):1284-92.
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Blum MM, Koglin A, Rüterjans H, Schoenborn B, Langan P, Chen JC. Preliminary time-of-flight neutron diffraction study on diisopropyl fluorophosphatase (DFPase) from Loligo vulgaris. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2007 Jan 1; 63(Pt 1):42-5.
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Lai JR, Koglin A, Walsh CT. Carrier protein structure and recognition in polyketide and nonribosomal peptide biosynthesis. Biochemistry. 2006 Dec 19; 45(50):14869-79.
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Rashid UJ, Paterok D, Koglin A, Gohlke H, Piehler J, Chen JC. Structure of Aquifex aeolicus argonaute highlights conformational flexibility of the PAZ domain as a potential regulator of RNA-induced silencing complex function. J Biol Chem. 2007 May 4; 282(18):13824-32.
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Rogov VV, Löhr F, Rogova N, Klammt C, Koglin A, Bernhard F, Dötsch V. NMR assignment of 1H, 13C and 15N resonances of the truncated Escherichia coli RcsC (700-949), including the phosphoreceiver domain. J Biomol NMR. 2007 Jun; 38(2):165.
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Rogov VV, Rogova NY, Bernhard F, Koglin A, Löhr F, Dötsch V. A new structural domain in the Escherichia coli RcsC hybrid sensor kinase connects histidine kinase and phosphoreceiver domains. J Mol Biol. 2006 Nov 17; 364(1):68-79.
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Koglin A, Klammt C, Trbovic N, Schwarz D, Schneider B, Schäfer B, Löhr F, Bernhard F, Dötsch V. Combination of cell-free expression and NMR spectroscopy as a new approach for structural investigation of membrane proteins. Magn Reson Chem. 2006 Jul; 44 Spec No:S17-23.
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Koglin A, Mofid MR, Löhr F, Schäfer B, Rogov VV, Blum MM, Mittag T, Marahiel MA, Bernhard F, Dötsch V. Conformational switches modulate protein interactions in peptide antibiotic synthetases. Science. 2006 Apr 14; 312(5771):273-6.
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Trbovic N, Klammt C, Koglin A, Löhr F, Bernhard F, Dötsch V. Efficient strategy for the rapid backbone assignment of membrane proteins. J Am Chem Soc. 2005 Oct 5; 127(39):13504-5.
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