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Last Name
Institution

Galit Alter, Ph.D.

TitleAssociate Professor of Medicine
InstitutionMassachusetts General Hospital
DepartmentMedicine
AddressMassachusetts General Hospital
AIDS Research, 149-5
149 13th Street
Charlestown MA 02129
Fax617/726-5411

 Research 
 research resources
This researcher has shared information about their research resources
in the eagle-i Network. To update or add resource records, contact
eagle-i@hms.harvard.edu.
Ragon Institute Imaging Core, Microscopy (MGH) - Core services (4), Instruments (7) and Software (3)
Ragon Institute Imaging Core, Flow Cytometry (MGH) - Core services (4) and Instruments (8)

 Bibliographic 
 selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Sok D, Laserson U, Laserson J, Liu Y, Vigneault F, Julien JP, Briney B, Ramos A, Saye KF, Le K, Mahan A, Wang S, Kardar M, Yaari G, Walker LM, Simen BB, St John EP, Chan-Hui PY, Swiderek K, Kleinstein SH, Alter G, Seaman MS, Chakraborty AK, Koller D, Wilson IA, Church GM, Burton DR, Poignard P. The Effects of Somatic Hypermutation on Neutralization and Binding in the PGT121 Family of Broadly Neutralizing HIV Antibodies. PLoS Pathog. 2013 Nov; 9(11):e1003754.
    View in: PubMed
  2. Barouch DH, Stephenson KE, Borducchi EN, Smith K, Stanley K, McNally AG, Liu J, Abbink P, Maxfield LF, Seaman MS, Dugast AS, Alter G, Ferguson M, Li W, Earl PL, Moss B, Giorgi EE, Szinger JJ, Eller LA, Billings EA, Rao M, Tovanabutra S, Sanders-Buell E, Weijtens M, Pau MG, Schuitemaker H, Robb ML, Kim JH, Korber BT, Michael NL. Protective Efficacy of a Global HIV-1 Mosaic Vaccine against Heterologous SHIV Challenges in Rhesus Monkeys. Cell. 2013 Oct 24; 155(3):531-9.
    View in: PubMed
  3. Forthal D, Hope TJ, Alter G. New paradigms for functional HIV-specific nonneutralizing antibodies. Curr Opin HIV AIDS. 2013 Sep; 8(5):392-400.
    View in: PubMed
  4. Koehler RN, Alter G, Tovanabutra S, Saathoff E, Arroyo MA, Walsh AM, Sanders-Buell EE, Maboko L, Hoelscher M, Robb ML, Michael NL, McCutchan FE, Kim JH, Kijak GH. Natural Killer Cell-Mediated Innate Sieve Effect on HIV-1: The Impact of KIR/HLA Polymorphism on HIV-1 Subtype-Specific Acquisition in East Africa. J Infect Dis. 2013 Oct; 208(8):1250-4.
    View in: PubMed
  5. Ackerman M, Alter G. Mapping the journey to an HIV vaccine. N Engl J Med. 2013 Jul 25; 369(4):389-91.
    View in: PubMed
  6. Malaspina A, Collins BS, Dell A, Alter G, Onami TM. Conference Report: "Functional Glycomics in HIV Type 1 Vaccine Design" Workshop Report, Bethesda, Maryland, April 30-May 1, 2012. AIDS Res Hum Retroviruses. 2013 Nov; 29(11):1407-17.
    View in: PubMed
  7. Ackerman ME, Alter G. Opportunities to Exploit Non-Neutralizing HIV-Specific Antibody Activity. Curr HIV Res. 2013 Jul; 11(5):365-77.
    View in: PubMed
  8. Ranasinghe S, Cutler S, Davis I, Lu R, Soghoian DZ, Qi Y, Sidney J, Kranias G, Flanders MD, Lindqvist M, Kuhl B, Alter G, Deeks SG, Walker BD, Gao X, Sette A, Carrington M, Streeck H. Association of HLA-DRB1-restricted CD4(+) T cell responses with HIV immune control. Nat Med. 2013 Jul; 19(7):930-3.
    View in: PubMed
  9. Ackerman ME, Crispin M, Yu X, Baruah K, Boesch AW, Harvey DJ, Dugast AS, Heizen EL, Ercan A, Choi I, Streeck H, Nigrovic PA, Bailey-Kellogg C, Scanlan C, Alter G. Natural variation in Fc glycosylation of HIV-specific antibodies impacts antiviral activity. J Clin Invest. 2013 May 1; 123(5):2183-92.
    View in: PubMed
  10. Ackerman ME, Dugast AS, McAndrew EG, Tsoukas S, Licht AF, Irvine DJ, Alter G. Enhanced Phagocytic Activity of HIV-Specific Antibodies Correlates with Natural Production of Immunoglobulins with Skewed Affinity for Fc?R2a and Fc?R2b. J Virol. 2013 May; 87(10):5468-76.
    View in: PubMed
  11. Alter G, Ackerman ME. What mAbs Tell Us about Shapes: Multiple Roads Lead to Rome. Immunity. 2013 Jan 24; 38(1):8-9.
    View in: PubMed
  12. Hayes P, Gilmour J, von Lieven A, Gill D, Clark L, Kopycinski J, Cheeseman H, Chung A, Alter G, Dally L, Zachariah D, Lombardo A, Ackland J, Sayeed E, Jackson A, Boffito M, Gazzard B, Fast PE, Cox JH, Laufer D. Safety and Immunogenicity of DNA Prime and Modified Vaccinia Ankara Virus-HIV Subtype C Vaccine Boost in Healthy Adults. Clin Vaccine Immunol. 2013 Mar; 20(3):397-408.
    View in: PubMed
  13. Sciaranghella G, Tong N, Mahan AE, Suscovich TJ, Alter G. Decoupling activation and exhaustion of B cells in spontaneous controllers of HIV infection. AIDS. 2013 Jan 14; 27(2):175-80.
    View in: PubMed
  14. Barouch DH, Liu J, Peter L, Abbink P, Iampietro MJ, Cheung A, Alter G, Chung A, Dugast AS, Frahm N, McElrath MJ, Wenschuh H, Reimer U, Seaman MS, Pau MG, Weijtens M, Goudsmit J, Walsh SR, Dolin R, Baden LR. Characterization of Humoral and Cellular Immune Responses Elicited by a Recombinant Adenovirus Serotype 26 HIV-1 Env Vaccine in Healthy Adults (IPCAVD 001). J Infect Dis. 2013 Jan; 207(2):248-56.
    View in: PubMed
  15. Yamanaka YJ, Berger CT, Sips M, Cheney PC, Alter G, Love JC. Single-cell analysis of the dynamics and functional outcomes of interactions between human natural killer cells and target cells. Integr Biol (Camb). 2012 Oct; 4(10):1175-84.
    View in: PubMed
  16. Brown EP, Licht AF, Dugast AS, Choi I, Bailey-Kellogg C, Alter G, Ackerman ME. High-throughput, multiplexed IgG subclassing of antigen-specific antibodies from clinical samples. J Immunol Methods. 2012 Dec 14; 386(1-2):117-23.
    View in: PubMed
  17. Archary D, Rong R, Gordon ML, Boliar S, Madiga M, Gray ES, Dugast AS, Hermanus T, Goulder PJ, Coovadia HM, Werner L, Morris L, Alter G, Derdeyn CA, Ndung'u T. Characterization of anti-HIV-1 neutralizing and binding antibodies in chronic HIV-1 subtype C infection. Virology. 2012 Nov 25; 433(2):410-20.
    View in: PubMed
  18. Lindqvist M, van Lunzen J, Soghoian DZ, Kuhl BD, Ranasinghe S, Kranias G, Flanders MD, Cutler S, Yudanin N, Muller MI, Davis I, Farber D, Hartjen P, Haag F, Alter G, Schulze zur Wiesch J, Streeck H. Expansion of HIV-specific T follicular helper cells in chronic HIV infection. J Clin Invest. 2012 Sep 4; 122(9):3271-80.
    View in: PubMed
  19. Carrington M, Alter G. Innate Immune Control of HIV. Cold Spring Harb Perspect Med. 2012 Jul; 2(7):a007070.
    View in: PubMed
  20. Thobakgale CF, Fadda L, Lane K, Toth I, Pereyra F, Bazner S, Ndung'u T, Walker BD, Rosenberg ES, Alter G, Carrington M, Allen TM, Altfeld M. Frequent and strong antibody-mediated natural killer cell activation in response to HIV-1 Env in individuals with chronic HIV-1 infection. J Virol. 2012 Jun; 86(12):6986-93.
    View in: PubMed
  21. Moldt B, Shibata-Koyama M, Rakasz EG, Schultz N, Kanda Y, Dunlop DC, Finstad SL, Jin C, Landucci G, Alpert MD, Dugast AS, Parren PW, Nimmerjahn F, Evans DT, Alter G, Forthal DN, Schmitz JE, Iida S, Poignard P, Watkins DI, Hessell AJ, Burton DR. A nonfucosylated variant of the anti-HIV-1 monoclonal antibody b12 has enhanced Fc?RIIIa-mediated antiviral activity in vitro but does not improve protection against mucosal SHIV challenge in macaques. J Virol. 2012 Jun; 86(11):6189-96.
    View in: PubMed
  22. Xia Z, Liu Q, Berger CT, Keenan BT, Kaliszewska A, Cheney PC, Srivastava GP, Castillo IW, De Jager PL, Alter G. A 17q12 allele is associated with altered NK cell subsets and function. J Immunol. 2012 Apr 1; 188(7):3315-22.
    View in: PubMed
  23. McAndrew EG, Dugast AS, Licht AF, Eusebio JR, Alter G, Ackerman ME. Determining the phagocytic activity of clinical antibody samples. J Vis Exp. 2011; (57):e3588.
    View in: PubMed
  24. Pelak K, Need AC, Fellay J, Shianna KV, Feng S, Urban TJ, Ge D, De Luca A, Martinez-Picado J, Wolinsky SM, Martinson JJ, Jamieson BD, Bream JH, Martin MP, Borrow P, Letvin NL, McMichael AJ, Haynes BF, Telenti A, Carrington M, Goldstein DB, Alter G. Copy number variation of KIR genes influences HIV-1 control. PLoS Biol. 2011 Nov; 9(11):e1001208.
    View in: PubMed
  25. Ackerman ME, Dugast AS, Alter G. Emerging concepts on the role of innate immunity in the prevention and control of HIV infection. Annu Rev Med. 2012; 63:113-30.
    View in: PubMed
  26. Hollingsworth MT, Hart GW, Paulson JC, Stansell E, Canis K, Huang IC, Panico M, Morris H, Haslam S, Farzan M, Dell A, Desrosiers R, von Itzstein M, Matroscovich M, Luther KB, Hülsmeier AJ, Schegg B, Hennet T, Nycholat C, McBride R, Ekiert D, Xu R, Peng W, Razi N, Gilbert M, Wakarchuk W, Wilson IA, Paulson JC, Gahlay G, Geisler C, Aumiller JJ, Moremen K, Steel J, Labaer J, Jarvis DL, Drickamer K, Taylor M, Nizet V, Rabinovich G, Lewis C, Cobb B, Kawasaki N, Nycholat C, Rademacher C, Chen W, Vela J, Maricic I, Crocker P, Kumar V, Kronenberg M, Paulson J, Glenn K, Mallinger A, Wen H, Srivastava L, Tundup S, Harn D, Menon AK, Yamaguchi Y, Mkhikian H, Grigorian A, Li C, Chen HL, Newton B, Zhou RW, Beeton C, Torossian S, Tatarian GG, Lee SU, Lau K, Walker E, Siminovitch KA, Chandy KG, Yu Z, Dennis JW, Demetriou M, Pandey MS, Baggenstoss BA, Washburn JL, Weigel PH, Chen CI, Keusch JJ, Klein D, Hofsteenge J, Gut H, Szymanski C, Feldman M, Schaffer C, Gao Y, Strum S, Liu B, Schutzbach JS, Druzhinina TN, Utkina NS, Torgov VI, Szarek WA, Wang L, Brockhausen I, Hitchen P, Peyfoon E, Meyer B, Haslam S, Albers SV, Dell A, Yu Z, Chen C, Liu B, Newburg DS, Jin C, Dinglasan RD, Beverley SM, Guo H, Novozhilova N, Hickerson S, Elnaiem DE, Sacks D, Turco SJ, McKay D, Castro E, Takahashi H, Straus AH, Stalnaker SH, Live D, Boons GJ, Moremen K, Wells L, Stuart R, Aoki K, Boccuto L, Zhang Q, Wang H, Bartel F, Fan X, Saul R, Chaubey A, Yang X, Steet R, Schwartz C, Tiemeyer M, Pierce M, Kraushaar DC, Condac E, Yamaguchi Y, Wang L, Nakato H, Nishihara S, Sasaki N, Hirano K, Nasirikenari M, Collins CC, Lau JT, Devarapu SK, Jeyaweerasinkam S, Albiez RS, Kiessling L, Gu J, Clark GF, Gagneux P, Ulm C, Mahavadi P, Müller S, Rinné S, Geyer H, Gerardy-Schahn R, Mühlenhoff M, Günther A, Geyer R, Galuska SP, Shibata T, Sugihara K, Nakayama J, Fukuda M, Fukuda MN, Ishikawa A, Terao M, Kimura A, Kato A, Katayama I, Taniguchi N, Miyoshi E, Aderem A, Yoneyama T, Angata K, Bao X, Chanda S, Fukuda M, Boons GJ, Lowe J, Sonon R, Ishihara M, Talabnin K, Wang Z, Black I, Naran R, Heiss C, Azadi P, Hurum D, Rohrer J, Balland A, Valliere-Douglass J, Kodama P, Mujacic M, Eakin C, Brady L, Wang WC, Wallace A, Treuheit M, Reddy P, Schuman B, Fisher S, Borisova S, Coates L, Langan P, Evans S, Yang SJ, Zhang H, Hizal DB, Tian Y, Sarkaria V, Betenbaugh M, Zhang H, Lütteke T, Agravat S, Cholleti S, Morris T, Saltz J, Song X, Cummings R, Smith D, Hofhine T, Nishida C, Mialy R, Sophie D, Sebastien F, Patricia C, Eric S, Stephane H, Mokros D, Joosten RP, Dominik A, Vriend G, Lütteke T, Nguyen LD, Martinez J, Hinderlich S, Reissig HU, Reutter W, Fan H, Saenger W, Moniot S, Asada H, Nakahara T, Miura Y, Stevenson T, Yamazaki T, De Castro C, Burr T, Lanzetta R, Molinaro A, Parrilli M, Sule S, Gerken TA, Revpredo L, Thome J, Gerken TA, Cardenas G, Almeida I, Leung MY, Yan S, Paschinger K, Bleuler-Martinez S, Jantsch V, Wilson I, Yoshimura Y, Adlercreutz D, Mannerstedt K, Wakarchuk WW, Dovichi NJ, Hindsgaul O, Palcic MM, Chandrasekaran A, Bharadwaj R, Deng K, Adams P, Singh A, Datta A, Konasani V, Imamura A, Lowry T, Scaman C, Zhao Y, Zhou YD, Yang K, Zhang XL, Leymarie N, Hartshorn K, White M, Cafarella T, Seaton B, Rynkiewicz M, Zaia J, Acosta-Blanco I, Ortega-Francisco S, Dionisio-Vicuña M, Hernandez-Flores M, Fuentes-Romero L, Newburg D, Soto-Ramirez LE, Ruiz-Palacios G, Viveros-Rogel M, Tong C, Li W, Kong L, Qu M, Jin Q, Lukyanov P, Li W, Tong C, Zhang W, Qu M, Jin Q, Chicalovets I, Molchanova V, Lukyanov P, Wu AM, Liu JH, Yang WH, Nussbaum C, Grewal PK, Sperandio M, Marth JD, Yu R, Usuki S, Wu HC, O'Brien D, Piskarev V, Ramadugu SK, Kashyap HK, Ghirlanda G, Margulis C, Brewer C, Gomery K, Müller-Loennies S, Brooks CL, Brade L, Kosma P, Di Padova F, Brade H, Evans SV, Asakawa K, Kawakami K, Kushi Y, Suzuki Y, Nozaki H, Itonori S, Malik S, Lebeer S, Petrova M, Balzarini J, Vanderleyden J, Naito-Matsui Y, Takematsu H, Murata K, Kozutsumi Y, Subedi GP, Satoh T, Hanashima S, et al. Program and abstracts for the 2011 Meeting of the Society for Glycobiology. Glycobiology. 2011 Nov; 21(11):1454-531.
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  27. Sips M, Sciaranghella G, Diefenbach T, Dugast AS, Berger CT, Liu Q, Kwon D, Ghebremichael M, Estes JD, Carrington M, Martin JN, Deeks SG, Hunt PW, Alter G. Altered distribution of mucosal NK cells during HIV infection. Mucosal Immunol. 2012 Jan; 5(1):30-40.
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  28. Luteijn R, Sciaranghella G, van Lunzen J, Nolting A, Dugast AS, Ghebremichael MS, Altfeld M, Alter G. Early viral replication in lymph nodes provides HIV with a means by which to escape NK-cell-mediated control. Eur J Immunol. 2011 Sep; 41(9):2729-40.
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  29. Alter G, Heckerman D, Schneidewind A, Fadda L, Kadie CM, Carlson JM, Oniangue-Ndza C, Martin M, Li B, Khakoo SI, Carrington M, Allen TM, Altfeld M. HIV-1 adaptation to NK-cell-mediated immune pressure. Nature. 2011 Aug 4; 476(7358):96-100.
    View in: PubMed
  30. Dugast AS, Tonelli A, Berger CT, Ackerman ME, Sciaranghella G, Liu Q, Sips M, Toth I, Piechocka-Trocha A, Ghebremichael M, Alter G. Decreased Fc receptor expression on innate immune cells is associated with impaired antibody-mediated cellular phagocytic activity in chronically HIV-1 infected individuals. Virology. 2011 Jul 5; 415(2):160-7.
    View in: PubMed
  31. Berger CT, Alter G. Natural killer cells in spontaneous control of HIV infection. Curr Opin HIV AIDS. 2011 May; 6(3):208-13.
    View in: PubMed
  32. Alter G, Altfeld M. Mutiny or scrutiny: NK cell modulation of DC function in HIV-1 infection. Trends Immunol. 2011 May; 32(5):219-24.
    View in: PubMed
  33. Colantonio AD, Bimber BN, Neidermyer WJ, Reeves RK, Alter G, Altfeld M, Johnson RP, Carrington M, O'Connor DH, Evans DT. KIR polymorphisms modulate peptide-dependent binding to an MHC class I ligand with a Bw6 motif. PLoS Pathog. 2011 Mar; 7(3):e1001316.
    View in: PubMed
  34. Mikell I, Sather DN, Kalams SA, Altfeld M, Alter G, Stamatatos L. Characteristics of the earliest cross-neutralizing antibody response to HIV-1. PLoS Pathog. 2011; 7(1):e1001251.
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  35. Jost S, Reardon J, Peterson E, Poole D, Bosch R, Alter G, Altfeld M. Expansion of 2B4+ natural killer (NK) cells and decrease in NKp46+ NK cells in response to influenza. Immunology. 2011 Apr; 132(4):516-26.
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  36. Papagno L, Alter G, Assoumou L, Murphy RL, Garcia F, Clotet B, Larsen M, Braibant M, Marcelin AG, Costagliola D, Altfeld M, Katlama C, Autran B. Comprehensive analysis of virus-specific T-cells provides clues for the failure of therapeutic immunization with ALVAC-HIV vaccine. AIDS. 2011 Jan 2; 25(1):27-36.
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  37. Fadda L, Alter G. KIR/HLA: genetic clues for a role of NK cells in the control of HIV. Adv Exp Med Biol. 2011; 780:27-36.
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  38. Ackerman ME, Moldt B, Wyatt RT, Dugast AS, McAndrew E, Tsoukas S, Jost S, Berger CT, Sciaranghella G, Liu Q, Irvine DJ, Burton DR, Alter G. A robust, high-throughput assay to determine the phagocytic activity of clinical antibody samples. J Immunol Methods. 2011 Mar 7; 366(1-2):8-19.
    View in: PubMed
  39. Alter G, Jost S, Rihn S, Reyor LL, Nolan BE, Ghebremichael M, Bosch R, Altfeld M, Lauer GM. Reduced frequencies of NKp30+NKp46+, CD161+, and NKG2D+ NK cells in acute HCV infection may predict viral clearance. J Hepatol. 2011 Aug; 55(2):278-88.
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  40. Lederman MM, Alter G, Daskalakis DC, Rodriguez B, Sieg SF, Hardy G, Cho M, Anthony D, Harding C, Weinberg A, Silverman RH, Douek DC, Margolis L, Goldstein DB, Carrington M, Goedert JJ. Determinants of protection among HIV-exposed seronegative persons: an overview. J Infect Dis. 2010 Nov 1; 202 Suppl 3:S333-8.
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  41. Alter G, Moody MA. The humoral response to HIV-1: new insights, renewed focus. J Infect Dis. 2010 Oct 15; 202 Suppl 2:S315-22.
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  42. Nolting A, Dugast AS, Rihn S, Luteijn R, Carrington MF, Kane K, Jost S, Toth I, Nagami E, Faetkenheuer G, Hartmann P, Altfeld M, Alter G. MHC class I chain-related protein A shedding in chronic HIV-1 infection is associated with profound NK cell dysfunction. Virology. 2010 Oct 10; 406(1):12-20.
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  43. Alter G, Kavanagh D, Rihn S, Luteijn R, Brooks D, Oldstone M, van Lunzen J, Altfeld M. IL-10 induces aberrant deletion of dendritic cells by natural killer cells in the context of HIV infection. J Clin Invest. 2010 Jun; 120(6):1905-13.
    View in: PubMed
  44. Wong AH, Williams K, Reddy S, Wilson D, Giddy J, Alter G, Ghebremichael M, Carrington MN, Ndung'u T, Walker BD, Altfeld M, Carr WH. Alterations in natural killer cell receptor profiles during HIV type 1 disease progression among chronically infected South African adults. AIDS Res Hum Retroviruses. 2010 Apr; 26(4):459-69.
    View in: PubMed
  45. Meier A, Chang JJ, Chan ES, Pollard RB, Sidhu HK, Kulkarni S, Wen TF, Lindsay RJ, Orellana L, Mildvan D, Bazner S, Streeck H, Alter G, Lifson JD, Carrington M, Bosch RJ, Robbins GK, Altfeld M. Sex differences in the Toll-like receptor-mediated response of plasmacytoid dendritic cells to HIV-1. Nat Med. 2009 Aug; 15(8):955-9.
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  46. Liu Q, Sun Y, Rihn S, Nolting A, Tsoukas PN, Jost S, Cohen K, Walker B, Alter G. Matrix metalloprotease inhibitors restore impaired NK cell-mediated antibody-dependent cellular cytotoxicity in human immunodeficiency virus type 1 infection. J Virol. 2009 Sep; 83(17):8705-12.
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  47. Alter G, Rihn S, Walter K, Nolting A, Martin M, Rosenberg ES, Miller JS, Carrington M, Altfeld M. HLA class I subtype-dependent expansion of KIR3DS1+ and KIR3DL1+ NK cells during acute human immunodeficiency virus type 1 infection. J Virol. 2009 Jul; 83(13):6798-805.
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  48. Alter G, Ananworanich J, Pantophlet R, Rybicki EP, Buonaguro L. Report on the AIDS Vaccine 2008 Conference. Hum Vaccin. 2009 Mar; 5(3):119-25.
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  49. Alter G, Brenchley J, Fellay J. Challenges facing young investigators. IAVI Rep. 2009 Jan-Feb; 13(1):14-7.
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  50. Alter G, Altfeld M. NK cells in HIV-1 infection: evidence for their role in the control of HIV-1 infection. J Intern Med. 2009 Jan; 265(1):29-42.
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  51. Wang YE, Li B, Carlson JM, Streeck H, Gladden AD, Goodman R, Schneidewind A, Power KA, Toth I, Frahm N, Alter G, Brander C, Carrington M, Walker BD, Altfeld M, Heckerman D, Allen TM. Protective HLA class I alleles that restrict acute-phase CD8+ T-cell responses are associated with viral escape mutations located in highly conserved regions of human immunodeficiency virus type 1. J Virol. 2009 Feb; 83(4):1845-55.
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  52. Minkis K, Kavanagh DG, Alter G, Bogunovic D, O'Neill D, Adams S, Pavlick A, Walker BD, Brockman MA, Gandhi RT, Bhardwaj N. Type 2 Bias of T cells expanded from the blood of melanoma patients switched to type 1 by IL-12p70 mRNA-transfected dendritic cells. Cancer Res. 2008 Nov 15; 68(22):9441-50.
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  53. Meier A, Fisher A, Sidhu HK, Chang JJ, Wen TF, Streeck H, Alter G, Silvestri G, Altfeld M. Rapid loss of dendritic cell and monocyte responses to TLR ligands following venipuncture. J Immunol Methods. 2008 Dec 31; 339(2):132-40.
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  54. Alter G, Rihn S, Streeck H, Teigen N, Piechocka-Trocha A, Moss K, Cohen K, Meier A, Pereyra F, Walker B, Altfeld M. Ligand-independent exhaustion of killer immunoglobulin-like receptor-positive CD8+ T cells in human immunodeficiency virus type 1 infection. J Virol. 2008 Oct; 82(19):9668-77.
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  55. Thomas R, Yamada E, Alter G, Martin MP, Bashirova AA, Norman PJ, Altfeld M, Parham P, Anderson SK, McVicar DW, Carrington M. Novel KIR3DL1 alleles and their expression levels on NK cells: convergent evolution of KIR3DL1 phenotype variation? J Immunol. 2008 May 15; 180(10):6743-50.
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  56. Streeck H, Brumme ZL, Anastario M, Cohen KW, Jolin JS, Meier A, Brumme CJ, Rosenberg ES, Alter G, Allen TM, Walker BD, Altfeld M. Antigen load and viral sequence diversification determine the functional profile of HIV-1-specific CD8+ T cells. PLoS Med. 2008 May 6; 5(5):e100.
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  57. Meier A, Bagchi A, Sidhu HK, Alter G, Suscovich TJ, Kavanagh DG, Streeck H, Brockman MA, LeGall S, Hellman J, Altfeld M. Upregulation of PD-L1 on monocytes and dendritic cells by HIV-1 derived TLR ligands. AIDS. 2008 Mar 12; 22(5):655-8.
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  58. Streeck H, Cohen KW, Jolin JS, Brockman MA, Meier A, Power KA, Waring MT, Alter G, Altfeld M. Rapid ex vivo isolation and long-term culture of human Th17 cells. J Immunol Methods. 2008 Apr 20; 333(1-2):115-25.
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  59. Alter G, Martin MP, Teigen N, Carr WH, Suscovich TJ, Schneidewind A, Streeck H, Waring M, Meier A, Brander C, Lifson JD, Allen TM, Carrington M, Altfeld M. Differential natural killer cell-mediated inhibition of HIV-1 replication based on distinct KIR/HLA subtypes. J Exp Med. 2007 Nov 26; 204(12):3027-36.
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  60. Pascal V, Yamada E, Martin MP, Alter G, Altfeld M, Metcalf JA, Baseler MW, Adelsberger JW, Carrington M, Anderson SK, McVicar DW. Detection of KIR3DS1 on the cell surface of peripheral blood NK cells facilitates identification of a novel null allele and assessment of KIR3DS1 expression during HIV-1 infection. J Immunol. 2007 Aug 1; 179(3):1625-33.
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  61. Alter G, Suscovich TJ, Teigen N, Meier A, Streeck H, Brander C, Altfeld M. Single-stranded RNA derived from HIV-1 serves as a potent activator of NK cells. J Immunol. 2007 Jun 15; 178(12):7658-66.
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  62. Meier A, Alter G, Frahm N, Sidhu H, Li B, Bagchi A, Teigen N, Streeck H, Stellbrink HJ, Hellman J, van Lunzen J, Altfeld M. MyD88-dependent immune activation mediated by human immunodeficiency virus type 1-encoded Toll-like receptor ligands. J Virol. 2007 Aug; 81(15):8180-91.
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  63. Streeck H, Lichterfeld M, Alter G, Meier A, Teigen N, Yassine-Diab B, Sidhu HK, Little S, Kelleher A, Routy JP, Rosenberg ES, Sekaly RP, Walker BD, Altfeld M. Recognition of a defined region within p24 gag by CD8+ T cells during primary human immunodeficiency virus type 1 infection in individuals expressing protective HLA class I alleles. J Virol. 2007 Jul; 81(14):7725-31.
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  64. Lakshmanan V, Alter G, Altfeld M, Bhardwaj N. Biology of plasmacytoid dendritic cells and natural killer cells in HIV-1 infection. Curr Opin HIV AIDS. 2007 May; 2(3):189-200.
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  65. Alter G, Teigen N, Ahern R, Streeck H, Meier A, Rosenberg ES, Altfeld M. Evolution of innate and adaptive effector cell functions during acute HIV-1 infection. J Infect Dis. 2007 May 15; 195(10):1452-60.
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  66. Altfeld M, Kalife ET, Qi Y, Streeck H, Lichterfeld M, Johnston MN, Burgett N, Swartz ME, Yang A, Alter G, Yu XG, Meier A, Rockstroh JK, Allen TM, Jessen H, Rosenberg ES, Carrington M, Walker BD. HLA Alleles Associated with Delayed Progression to AIDS Contribute Strongly to the Initial CD8(+) T Cell Response against HIV-1. PLoS Med. 2006 Oct; 3(10):e403.
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  67. Alter G, Altfeld M. NK cell function in HIV-1 infection. Curr Mol Med. 2006 Sep; 6(6):621-9.
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  68. Streeck H, Jessen H, Alter G, Teigen N, Waring MT, Jessen A, Stahmer I, van Lunzen J, Lichterfeld M, Gao X, Allen TM, Carrington M, Walker BD, Rockstroh JK, Altfeld M. Immunological and virological impact of highly active antiretroviral therapy initiated during acute HIV-1 infection. J Infect Dis. 2006 Sep 15; 194(6):734-9.
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  69. Alter G, Suscovich TJ, Kleyman M, Teigen N, Streeck H, Zaman MT, Meier A, Altfeld M. Low perforin and elevated SHIP-1 expression is associated with functional anergy of natural killer cells in chronic HIV-1 infection. AIDS. 2006 Jul 13; 20(11):1549-51.
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  70. Bashirova AA, Bleiber G, Qi Y, Hutcheson H, Yamashita T, Johnson RC, Cheng J, Alter G, Goedert JJ, Buchbinder S, Hoots K, Vlahov D, May M, Maldarelli F, Jacobson L, O'brien SJ, Telenti A, Carrington M. Consistent effects of TSG101 genetic variability on multiple outcomes of exposure to human immunodeficiency virus type 1. J Virol. 2006 Jul; 80(14):6757-63.
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  71. Alter G, Altfeld M. Perspective natural killer cells: bridging innate and adaptive immunity? IAVI Rep. 2006 May-Jun; 10(3):1, 6-10.
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  72. Allen TM, Yu XG, Kalife ET, Reyor LL, Lichterfeld M, John M, Cheng M, Allgaier RL, Mui S, Frahm N, Alter G, Brown NV, Johnston MN, Rosenberg ES, Mallal SA, Brander C, Walker BD, Altfeld M. De novo generation of escape variant-specific CD8+ T-cell responses following cytotoxic T-lymphocyte escape in chronic human immunodeficiency virus type 1 infection. J Virol. 2005 Oct; 79(20):12952-60.
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  73. Yu XG, Lichterfeld M, Perkins B, Kalife E, Mui S, Chen J, Cheng M, Kang W, Alter G, Brander C, Walker BD, Altfeld M. High degree of inter-clade cross-reactivity of HIV-1-specific T cell responses at the single peptide level. AIDS. 2005 Sep 23; 19(14):1449-56.
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  74. Alter G, Teigen N, Davis BT, Addo MM, Suscovich TJ, Waring MT, Streeck H, Johnston MN, Staller KD, Zaman MT, Yu XG, Lichterfeld M, Basgoz N, Rosenberg ES, Altfeld M. Sequential deregulation of NK cell subset distribution and function starting in acute HIV-1 infection. Blood. 2005 Nov 15; 106(10):3366-9.
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  75. Altfeld M, Allen TM, Kalife ET, Frahm N, Addo MM, Mothe BR, Rathod A, Reyor LL, Harlow J, Yu XG, Perkins B, Robinson LK, Sidney J, Alter G, Lichterfeld M, Sette A, Rosenberg ES, Goulder PJ, Brander C, Walker BD. The majority of currently circulating human immunodeficiency virus type 1 clade B viruses fail to prime cytotoxic T-lymphocyte responses against an otherwise immunodominant HLA-A2-restricted epitope: implications for vaccine design. J Virol. 2005 Apr; 79(8):5000-5.
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  76. Peretz Y, Alter G, Boisvert MP, Hatzakis G, Tsoukas CM, Bernard NF. Human immunodeficiency virus (HIV)-specific gamma interferon secretion directed against all expressed HIV genes: relationship to rate of CD4 decline. J Virol. 2005 Apr; 79(8):4908-17.
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  77. Alter G, Malenfant JM, Altfeld M. CD107a as a functional marker for the identification of natural killer cell activity. J Immunol Methods. 2004 Nov; 294(1-2):15-22.
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  78. Alter G, Tsoukas CM, Rouleau D, Côté P, Routy JP, Sékaly RP, Bernard NF. Assessment of longitudinal changes in HIV-specific effector activity in subjects undergoing untreated primary HIV infection. AIDS. 2004 Oct 21; 18(15):1979-89.
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  79. Alter G, Malenfant JM, Delabre RM, Burgett NC, Yu XG, Lichterfeld M, Zaunders J, Altfeld M. Increased natural killer cell activity in viremic HIV-1 infection. J Immunol. 2004 Oct 15; 173(8):5305-11.
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  80. Lichterfeld M, Kaufmann DE, Yu XG, Mui SK, Addo MM, Johnston MN, Cohen D, Robbins GK, Pae E, Alter G, Wurcel A, Stone D, Rosenberg ES, Walker BD, Altfeld M. Loss of HIV-1-specific CD8+ T cell proliferation after acute HIV-1 infection and restoration by vaccine-induced HIV-1-specific CD4+ T cells. J Exp Med. 2004 Sep 20; 200(6):701-12.
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  81. Lichterfeld M, Yu XG, Waring MT, Mui SK, Johnston MN, Cohen D, Addo MM, Zaunders J, Alter G, Pae E, Strick D, Allen TM, Rosenberg ES, Walker BD, Altfeld M. HIV-1-specific cytotoxicity is preferentially mediated by a subset of CD8(+) T cells producing both interferon-gamma and tumor necrosis factor-alpha. Blood. 2004 Jul 15; 104(2):487-94.
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  82. Alter G, Merchant A, Tsoukas CM, Rouleau D, LeBlanc RP, Côté P, Baril JG, Thomas R, Nguyen VK, Sékaly RP, Routy JP, Bernard NF. Human immunodeficiency virus (HIV)-specific effector CD8 T cell activity in patients with primary HIV infection. J Infect Dis. 2002 Mar 15; 185(6):755-65.
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  83. Foster CS, Alter G, DeBarge LR, Raizman MB, Crabb JL, Santos CI, Feiler LS, Friedlaender MH. Efficacy and safety of rimexolone 1% ophthalmic suspension vs 1% prednisolone acetate in the treatment of uveitis. Am J Ophthalmol. 1996 Aug; 122(2):171-82.
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