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Amy Selina Jordan, PH.D.

TitleLecturer on Medicine
InstitutionBrigham and Women's Hospital
DepartmentMedicine
AddressBrigham and Women's Hospital
RFB-490, Sleep Medicine
221 Longwood Ave
Boston MA 02115
Phone617/278-0911

 Bibliographic 
 selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. McSharry DG, Saboisky JP, Deyoung P, Matteis P, Jordan AS, Trinder J, Smales E, Hess L, Guo M, Malhotra A. A Mechanism for Upper Airway Stability during Slow Wave Sleep. Sleep. 2013; 36(4):555-63.
    View in: PubMed
  2. Cori JM, Nicholas CL, Baptista S, Huynh I, Rochford PD, O'Donoghue FJ, Trinder JA, Jordan AS. Inspiratory-resistive loading increases the ventilatory response to arousal but does not reduce genioglossus muscle activity on the return to sleep. J Appl Physiol. 2012 Sep; 113(6):909-16.
    View in: PubMed
  3. Nicholas CL, Jordan AS, Heckel L, Worsnop C, Bei B, Saboisky JP, Eckert DJ, White DP, Malhotra A, Trinder J. Discharge patterns of human tensor palatini motor units during sleep onset. Sleep. 2012 May; 35(5):699-707.
    View in: PubMed
  4. Eastwood PR, Barnes M, Walsh JH, Maddison KJ, Hee G, Schwartz AR, Smith PL, Malhotra A, McEvoy RD, Wheatley JR, O'Donoghue FJ, Rochford PD, Churchward T, Campbell MC, Palme CE, Robinson S, Goding GS, Eckert DJ, Jordan AS, Catcheside PG, Tyler L, Antic NA, Worsnop CJ, Kezirian EJ, Hillman DR. Treating obstructive sleep apnea with hypoglossal nerve stimulation. Sleep. 2011 Nov; 34(11):1479-86.
    View in: PubMed
  5. Trinder J, Waloszek J, Woods MJ, Jordan AS. Sleep and cardiovascular regulation. Pflugers Arch. 2012 Jan; 463(1):161-8.
    View in: PubMed
  6. Saboisky JP, Stashuk DW, Hamilton-Wright A, Carusona AL, Campana LM, Trinder J, Eckert DJ, Jordan AS, McSharry DG, White DP, Nandedkar S, David WS, Malhotra A. Neurogenic changes in the upper airway of patients with obstructive sleep apnea. Am J Respir Crit Care Med. 2012 Feb 1; 185(3):322-9.
    View in: PubMed
  7. Eckert DJ, Lo YL, Saboisky JP, Jordan AS, White DP, Malhotra A. Sensorimotor function of the upper-airway muscles and respiratory sensory processing in untreated obstructive sleep apnea. J Appl Physiol. 2011 Dec; 111(6):1644-53.
    View in: PubMed
  8. Jordan AS, Eckert DJ, Wellman A, Trinder JA, Malhotra A, White DP. Termination of respiratory events with and without cortical arousal in obstructive sleep apnea. Am J Respir Crit Care Med. 2011 Nov 15; 184(10):1183-91.
    View in: PubMed
  9. Trinder J, Jordan AS. Activation of the upper airway dilator muscle genioglossus during sleep is largely dependent on an interaction between chemical drive and mechanoreceptor feedback. Sleep. 2011 Aug; 34(8):983-4.
    View in: PubMed
  10. Jordan AS, Saboisky JP, Nicholas CL, Bei B, Eckert DJ. Common drive in hypoglossal and trigeminal motor neurons. Am J Respir Crit Care Med. 2011 May 1; 183(9):1280.
    View in: PubMed
  11. Wellman A, Eckert DJ, Jordan AS, Edwards BA, Passaglia CL, Jackson AC, Gautam S, Owens RL, Malhotra A, White DP. A method for measuring and modeling the physiological traits causing obstructive sleep apnea. J Appl Physiol. 2011 Jun; 110(6):1627-37.
    View in: PubMed
  12. Nicholas CL, Bei B, Worsnop C, Malhotra A, Jordan AS, Saboisky JP, Chan JK, Duckworth E, White DP, Trinder J. Motor unit recruitment in human genioglossus muscle in response to hypercapnia. Sleep. 2010 Nov; 33(11):1529-38.
    View in: PubMed
  13. Saboisky JP, Jordan AS, Eckert DJ, White DP, Trinder JA, Nicholas CL, Gautam S, Malhotra A. Recruitment and rate-coding strategies of the human genioglossus muscle. J Appl Physiol. 2010 Dec; 109(6):1939-49.
    View in: PubMed
  14. Edwards BA, O'Driscoll DM, Ali A, Jordan AS, Trinder J, Malhotra A. Aging and sleep: physiology and pathophysiology. Semin Respir Crit Care Med. 2010 Oct; 31(5):618-33.
    View in: PubMed
  15. Yim-Yeh S, Rahangdale S, Nguyen AT, Jordan AS, Novack V, Veves A, Malhotra A. Obstructive sleep apnea and aging effects on macrovascular and microcirculatory function. Sleep. 2010 Sep; 33(9):1177-83.
    View in: PubMed
  16. Jordan AS, White DP, Owens RL, Eckert DJ, Rahangdale S, Yim-Yeh S, Malhotra A. The effect of increased genioglossus activity and end-expiratory lung volume on pharyngeal collapse. J Appl Physiol. 2010 Aug; 109(2):469-75.
    View in: PubMed
  17. Eckert DJ, Saboisky JP, Jordan AS, White DP, Malhotra A. A secondary reflex suppression phase is present in genioglossus but not tensor palatini in response to negative upper airway pressure. J Appl Physiol. 2010 Jun; 108(6):1619-24.
    View in: PubMed
  18. Wilkinson V, Malhotra A, Nicholas CL, Worsnop C, Jordan AS, Butler JE, Saboisky JP, Gandevia SC, White DP, Trinder J. Discharge patterns of human genioglossus motor units during arousal from sleep. Sleep. 2010 Mar; 33(3):379-87.
    View in: PubMed
  19. Eikermann M, Eckert DJ, Chamberlin NL, Jordan AS, Zaremba S, Smith S, Rosow C, Malhotra A. Effects of pentobarbital on upper airway patency during sleep. Eur Respir J. 2010 Sep; 36(3):569-76.
    View in: PubMed
  20. Owens RL, Malhotra A, Eckert DJ, White DP, Jordan AS. The influence of end-expiratory lung volume on measurements of pharyngeal collapsibility. J Appl Physiol. 2010 Feb; 108(2):445-51.
    View in: PubMed
  21. Eikermann M, Fassbender P, Zaremba S, Jordan AS, Rosow C, Malhotra A, Chamberlin NL. Pentobarbital dose-dependently increases respiratory genioglossus muscle activity while impairing diaphragmatic function in anesthetized rats. Anesthesiology. 2009 Jun; 110(6):1327-34.
    View in: PubMed
  22. Jordan AS, White DP, Lo YL, Wellman A, Eckert DJ, Yim-Yeh S, Eikermann M, Smith SA, Stevenson KE, Malhotra A. Airway dilator muscle activity and lung volume during stable breathing in obstructive sleep apnea. Sleep. 2009 Mar; 32(3):361-8.
    View in: PubMed
  23. Eckert DJ, Malhotra A, Jordan AS. Mechanisms of apnea. Prog Cardiovasc Dis. 2009 Jan-Feb; 51(4):313-23.
    View in: PubMed
  24. Heinzer R, White DP, Jordan AS, Lo YL, Dover L, Stevenson L and Malhotra A. . Trazodone Increases Arousal Threshold in Obstructive Sleep Apnea. Eur Resp J. 2008.
  25. Eckert DJ, Malhotra A, Lo YL, White DP, Jordan AS. The influence of obstructive sleep apnea and gender on genioglossus activity during rapid eye movement sleep. Chest. 2009 Apr; 135(4):957-64.
    View in: PubMed
  26. Eikermann M, Zaremba S, Malhotra A, Jordan AS, Rosow C, Chamberlin NL. Neostigmine but not sugammadex impairs upper airway dilator muscle activity and breathing. Br J Anaesth. 2008 Sep; 101(3):344-9.
    View in: PubMed
  27. Wellman A, Malhotra A, Jordan AS, Stevenson KE, Gautam S, White DP. Effect of oxygen in obstructive sleep apnea: role of loop gain. Respir Physiol Neurobiol. 2008 Jul 31; 162(2):144-51.
    View in: PubMed
  28. Eikermann M, Malhotra A, Fassbender P, Zaremba S, Jordan AS, Gautam S, White DP, Chamberlin NL. Differential effects of isoflurane and propofol on upper airway dilator muscle activity and breathing. Anesthesiology. 2008 May; 108(5):897-906.
    View in: PubMed
  29. Wilkinson V, Malhotra A, Nicholas CL, Worsnop C, Jordan AS, Butler JE, Saboisky JP, Gandevia SC, White DP, Trinder J. Discharge patterns of human genioglossus motor units during sleep onset. Sleep. 2008 Apr; 31(4):525-33.
    View in: PubMed
  30. Heinzer R, White DP, Malhotra A, Lo YL, Dover L, Stevenson KE, Jordan AS. Effect of expiratory positive airway pressure on sleep disordered breathing. Sleep. 2008 Mar; 31(3):429-32.
    View in: PubMed
  31. Heinzer RC, White DP, Jordan AS, Lo YL, Dover L, Stevenson K, Malhotra A. Trazodone increases arousal threshold in obstructive sleep apnoea. Eur Respir J. 2008 Jun; 31(6):1308-12.
    View in: PubMed
  32. Heinzer RC, Jordan AS and Malhotra A. Sleep Apnea Sydnromes. Wiley Encyclopedia of Biomedical Engineering. 2007.
  33. Eckert DJ, Saboisky JP, Jordan AS, Malhotra A. Upper airway myopathy is not important in the pathophysiology of obstructive sleep apnea. J Clin Sleep Med. 2007 Oct 15; 3(6):570-3.
    View in: PubMed
  34. Eikermann M, Fassbender P, Malhotra A, Takahashi M, Kubo S, Jordan AS, Gautam S, White DP, Chamberlin NL. Unwarranted administration of acetylcholinesterase inhibitors can impair genioglossus and diaphragm muscle function. Anesthesiology. 2007 Oct; 107(4):621-9.
    View in: PubMed
  35. Jordan AS, White DP. Pharyngeal motor control and the pathogenesis of obstructive sleep apnea. Respir Physiol Neurobiol. 2008 Jan 1; 160(1):1-7.
    View in: PubMed
  36. Jordan AS, Wellman A, Heinzer RC, Lo YL, Schory K, Dover L, Gautam S, Malhotra A, White DP. Mechanisms used to restore ventilation after partial upper airway collapse during sleep in humans. Thorax. 2007 Oct; 62(10):861-7.
    View in: PubMed
  37. Eikermann M, Jordan AS, Chamberlin NL, Gautam S, Wellman A, Lo YL, White DP, Malhotra A. The influence of aging on pharyngeal collapsibility during sleep. Chest. 2007 Jun; 131(6):1702-9.
    View in: PubMed
  38. Lo YL, Jordan AS, Malhotra A, Wellman A, Heinzer RA, Eikermann M, Schory K, Dover L, White DP. Influence of wakefulness on pharyngeal airway muscle activity. Thorax. 2007 Sep; 62(9):799-805.
    View in: PubMed
  39. Wellman A, Malhotra A, Jordan AS, Schory K, Gautam S, White DP. Chemical control stability in the elderly. J Physiol. 2007 May 15; 581(Pt 1):291-8.
    View in: PubMed
  40. Eckert DJ, Jordan AS, Merchia P, Malhotra A. Central sleep apnea: Pathophysiology and treatment. Chest. 2007 Feb; 131(2):595-607.
    View in: PubMed
  41. Nalivaiko E, Catcheside PG, Adams A, Jordan AS, Eckert DJ, McEvoy RD. Cardiac changes during arousals from non-REM sleep in healthy volunteers. Am J Physiol Regul Integr Comp Physiol. 2007 Mar; 292(3):R1320-7.
    View in: PubMed
  42. Lo YL, Jordan AS, Malhotra A, Wellman A, Heinzer RC, Schory K, Dover L, Fogel RB, White DP. Genioglossal muscle response to CO2 stimulation during NREM sleep. Sleep. 2006 Apr; 29(4):470-7.
    View in: PubMed
  43. Yang CK, Jordan AS, White DP, Winkelman JW. Heart rate response to respiratory events with or without leg movements. Sleep. 2006 Apr; 29(4):553-6.
    View in: PubMed
  44. Heinzer RC, Stanchina ML, Malhotra A, Jordan AS, Patel SR, Lo YL, Wellman A, Schory K, Dover L, White DP. Effect of increased lung volume on sleep disordered breathing in patients with sleep apnoea. Thorax. 2006 May; 61(5):435-9.
    View in: PubMed
  45. Yim S, Jordan AS and Malhotra A. Obstructive Sleep Apnea: Clinical Presentation, Diagnosis and Treatment. Prog Respir Res. 2006; 35:118-136.
  46. Malhotra A, Jordan AS. Did fat boy Joe need hormone replacement? Sleep. 2006 Jan; 29(1):16-8.
    View in: PubMed
  47. RC Heinzer, A Malhotra, AS Jordan, DA Wellman and DP White. Effect of CPAP and Lung Volume on Obstructive Sleep Apnea. Am J Resp Crit Care Med. 2005; 172:1350-1351.
  48. Jordan A, Malhotra A. The pharyngeal lumen: both length and size matter. J Clin Sleep Med. 2005 Jul 15; 1(3):264-5.
    View in: PubMed
  49. Jordan AS, Wellman A, Edwards JK, Schory K, Dover L, MacDonald M, Patel SR, Fogel RB, Malhotra A, White DP. Respiratory control stability and upper airway collapsibility in men and women with obstructive sleep apnea. J Appl Physiol. 2005 Nov; 99(5):2020-7.
    View in: PubMed
  50. Heinzer RC, Stanchina ML, Malhotra A, Fogel RB, Patel SR, Jordan AS, Schory K, White DP. Lung volume and continuous positive airway pressure requirements in obstructive sleep apnea. Am J Respir Crit Care Med. 2005 Jul 1; 172(1):114-7.
    View in: PubMed
  51. Malhotra A, Jordan A. Surface tension and sleep apnea: a sticky business. Sleep. 2005 Apr; 28(4):392-3.
    View in: PubMed
  52. A. Wellman, A.S. Jordan, A. Malhotra, R.B. Fogel, K. Schory, L. Dover and D.P. White. Oxygen reduces apnea in obstructive sleep apnea with increased ventilatory instability. PATS. 2005; 2:A303.
  53. A.S. Jordan, K. Schory, L. Dover, R.B. Fogel, A. Malhotra and D.P. White. . Genioglossus muscle activity during stable sleep in patients with obstructive sleep apnea. PATS. 2005; 2:A610.
  54. Wellman A, Jordan AS, Malhotra A, Fogel RB, Katz ES, Schory K, Edwards JK, White DP. Ventilatory control and airway anatomy in obstructive sleep apnea. Am J Respir Crit Care Med. 2004 Dec 1; 170(11):1225-32.
    View in: PubMed
  55. Jordan AS, McEvoy RD, Edwards JK, Schory K, Yang CK, Catcheside PG, Fogel RB, Malhotra A, White DP. The influence of gender and upper airway resistance on the ventilatory response to arousal in obstructive sleep apnoea in humans. J Physiol. 2004 Aug 1; 558(Pt 3):993-1004.
    View in: PubMed
  56. A. Malhotra, R.B. Fogel, A. Wellman, S.R. Patel, K. Schory, D.P. White. . Menopausal effects on upper airway muscle activity and mechanics. Am J Resp and Crit Care Med. 2004; 168(7):A 434.
  57. Jordan AS, White DP, Fogel RB. Recent advances in understanding the pathogenesis of obstructive sleep apnea. Curr Opin Pulm Med. 2003 Nov; 9(6):459-64.
    View in: PubMed
  58. Jordan AS, Eckert DJ, Catcheside PG, McEvoy RD. Ventilatory response to brief arousal from non-rapid eye movement sleep is greater in men than in women. Am J Respir Crit Care Med. 2003 Dec 15; 168(12):1512-9.
    View in: PubMed
  59. Jordan AS, McEvoy RD. Gender differences in sleep apnea: epidemiology, clinical presentation and pathogenic mechanisms. Sleep Med Rev. 2003 Oct; 7(5):377-89.
    View in: PubMed
  60. A. Malhotra, R.B. Fogel, D.A. Wellman, M.L. Stanchina, A. Jordan, K. Schory, G. Pillar, D.P. White. State dependence of gender differences in upper airway reflexes. Am J Resp and Crit Care Med. 2003; 167(7):A303.
  61. A.S. Jordan, A. Wellman, R.B. Fogel, R.J. Pierce, A. Malhotra, J.K. Edwards, K. Schory, D.P. White. Pharyngeal critical closing pressure measurement without respiratory effort: A validation study. Am J Resp and Crit Care Med. 2003; 167(7):A600.
  62. Jordan AS. The control of respiration and upper airway muscle activity in healthy young men and women. 2002.
  63. Jordan AS, Catcheside PG, O'Donoghue FJ, McEvoy RD. Long-term facilitation of ventilation is not present during wakefulness in healthy men or women. J Appl Physiol. 2002 Dec; 93(6):2129-36.
    View in: PubMed
  64. O'Donoghue FJ, Catcheside PG, Jordan AS, Bersten AD, McEvoy RD. Effect of CPAP on intrinsic PEEP, inspiratory effort, and lung volume in severe stable COPD. Thorax. 2002 Jun; 57(6):533-9.
    View in: PubMed
  65. Jordan AS, Catcheside PG, O'Donoghue FJ, Saunders NA, McEvoy RD. Genioglossus muscle activity at rest and in response to brief hypoxia in healthy men and women. J Appl Physiol. 2002 Jan; 92(1):410-7.
    View in: PubMed
  66. Karl T, Prazeller P, Mayr D, Jordan A, Rieder J, Fall R, Lindinger W. Human breath isoprene and its relation to blood cholesterol levels: new measurements and modeling. J Appl Physiol. 2001 Aug; 91(2):762-70.
    View in: PubMed
  67. Orr RS, Jordan AS, Catcheside P, Saunders NA, McEvoy RD. Sustained isocapnic hypoxia suppresses the perception of the magnitude of inspiratory resistive loads. J Appl Physiol. 2000 Jul; 89(1):47-55.
    View in: PubMed
  68. Jordan AS, Catcheside PG, Orr RS, O'Donoghue FJ, Saunders NA, McEvoy RD. Ventilatory decline after hypoxia and hypercapnia is not different between healthy young men and women. J Appl Physiol. 2000 Jan; 88(1):3-9.
    View in: PubMed
  69. A.S. Jordan, P.G. Catcheside, R.S. Orr, F.J. O’Donoghue, N.A. Saunders, R.D. McEvoy. Hypoxia does not impair the ability to detect added inspiratory resistive loads. Am J Resp and Crit Care Med. 2000; 161(3):A858.
  70. P.G. Catcheside, F.J. O'Donoghue, A. Bersten, R.S. Orr, A.S. Jordan, R. D. McEvoy. A simple technique for reducing cardiogenic artifact on oesophageal pressure signals. Respirology. 1999; 4:A60.
  71. Jordan A, Manniche C, Mosdal C, Hindsberger C. The Copenhagen Neck Functional Disability Scale: a study of reliability and validity. J Manipulative Physiol Ther. 1998 Oct; 21(8):520-7.
    View in: PubMed
  72. Gough DB, Jordan A, Mannick JA, Rodrick MI. Impaired cell-mediated immunity in experimental abdominal sepsis and the effect of interleukin 2. Arch Surg. 1992 Jul; 127(7):859-63.
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  73. Gough DB, Jordan A, Collins K, Mannick JA, Rodrick ML. Suppressor T-cell levels are unreliable indicators of the impaired immune response following thermal injury. J Trauma. 1992 Jun; 32(6):677-82.
    View in: PubMed
  74. Gough DB, Moss NM, Jordan A, Grbic JT, Rodrick ML, Mannick JA. Recombinant interleukin-2 (rIL-2) improves immune response and host resistance to septic challenge in thermally injured mice. Surgery. 1988 Aug; 104(2):292-300.
    View in: PubMed
  75. Jordan A, Baum J. Basic tear flow. Does it exist? Ophthalmology. 1980 Sep; 87(9):920-30.
    View in: PubMed
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