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Filippos Porichis, PH.D.

TitleInstructor in Medicine
InstitutionMassachusetts General Hospital
DepartmentMedicine
AddressRagon Institute of MGH, MIT and Harvard
400 Technology Square
Cambridge MA 02139

 Bibliographic 
 selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Porichis F, Hart MG, Zupkosky J, Barblu L, Kaufmann DE. In Vitro Assay to Evaluate the Impact of Immunoregulatory Pathways on HIV-specific CD4 T Cell Effector Function. J Vis Exp. 2013; (80).
    View in: PubMed
  2. Pacheco Y, McLean AP, Rohrbach J, Porichis F, Kaufmann DE, Kavanagh DG. Simultaneous TCR and CD244 Signals Induce Dynamic Downmodulation of CD244 on Human Antiviral T Cells. J Immunol. 2013 Sep 1; 191(5):2072-81.
    View in: PubMed
  3. Youngblood B, Noto A, Porichis F, Akondy RS, Ndhlovu ZM, Austin JW, Bordi R, Procopio FA, Miura T, Allen TM, Sidney J, Sette A, Walker BD, Ahmed R, Boss JM, Sékaly RP, Kaufmann DE. Cutting Edge: Prolonged Exposure to HIV Reinforces a Poised Epigenetic Program for PD-1 Expression in Virus-Specific CD8 T Cells. J Immunol. 2013 Jul 15; 191(2):540-4.
    View in: PubMed
  4. Ndhlovu ZM, Chibnik LB, Proudfoot J, Vine S, McMullen A, Cesa K, Porichis F, Jones RB, Alvino DM, Hart MG, Stampouloglou E, Piechocka-Trocha A, Kadie C, Pereyra F, Heckerman D, De Jager PL, Walker BD, Kaufmann DE. High-dimensional immunomonitoring models of HIV-1-specific CD8 T-cell responses accurately identify subjects achieving spontaneous viral control. Blood. 2013 Jan 31; 121(5):801-11.
    View in: PubMed
  5. Soufla G, Sifakis S, Porichis F, Spandidos DA. Prognostic value of tgfb1 protein in endometrioid adenocarcinoma. Eur J Clin Invest. 2013 Jan; 43(1):79-90.
    View in: PubMed
  6. Kwon DS, Angin M, Hongo T, Law KM, Johnson J, Porichis F, Hart MG, Pavlik DF, Tighe DP, Kavanagh DG, Streeck H, Addo MM, Kaufmann DE. CD4+ CD25+ regulatory T cells impair HIV-1-specific CD4 T cell responses by upregulating interleukin-10 production in monocytes. J Virol. 2012 Jun; 86(12):6586-94.
    View in: PubMed
  7. Porichis F, Kaufmann DE. Role of PD-1 in HIV pathogenesis and as target for therapy. Curr HIV/AIDS Rep. 2012 Mar; 9(1):81-90.
    View in: PubMed
  8. Morou AK, Porichis F, Krambovitis E, Sourvinos G, Spandidos DA, Zafiropoulos A. The HIV-1 gp120/V3 modifies the response of uninfected CD4 T cells to antigen presentation: mapping of the specific transcriptional signature. J Transl Med. 2011; 9:160.
    View in: PubMed
  9. Thèze J, Chakrabarti LA, Vingert B, Porichis F, Kaufmann DE. HIV controllers: a multifactorial phenotype of spontaneous viral suppression. Clin Immunol. 2011 Oct; 141(1):15-30.
    View in: PubMed
  10. Porichis F, Kwon DS, Zupkosky J, Tighe DP, McMullen A, Brockman MA, Pavlik DF, Rodriguez-Garcia M, Pereyra F, Freeman GJ, Kavanagh DG, Kaufmann DE. Responsiveness of HIV-specific CD4 T cells to PD-1 blockade. Blood. 2011 Jul 28; 118(4):965-74.
    View in: PubMed
  11. Porichis F, Kaufmann DE. HIV-specific CD4 T cells and immune control of viral replication. Curr Opin HIV AIDS. 2011 May; 6(3):174-80.
    View in: PubMed
  12. Rodríguez-García M, Porichis F, de Jong OG, Levi K, Diefenbach TJ, Lifson JD, Freeman GJ, Walker BD, Kaufmann DE, Kavanagh DG. Expression of PD-L1 and PD-L2 on human macrophages is up-regulated by HIV-1 and differentially modulated by IL-10. J Leukoc Biol. 2011 Apr; 89(4):507-15.
    View in: PubMed
  13. Quigley M, Pereyra F, Nilsson B, Porichis F, Fonseca C, Eichbaum Q, Julg B, Jesneck JL, Brosnahan K, Imam S, Russell K, Toth I, Piechocka-Trocha A, Dolfi D, Angelosanto J, Crawford A, Shin H, Kwon DS, Zupkosky J, Francisco L, Freeman GJ, Wherry EJ, Kaufmann DE, Walker BD, Ebert B, Haining WN. Transcriptional analysis of HIV-specific CD8+ T cells shows that PD-1 inhibits T cell function by upregulating BATF. Nat Med. 2010 Oct; 16(10):1147-51.
    View in: PubMed
  14. Brockman MA, Kwon DS, Tighe DP, Pavlik DF, Rosato PC, Sela J, Porichis F, Le Gall S, Waring MT, Moss K, Jessen H, Pereyra F, Kavanagh DG, Walker BD, Kaufmann DE. IL-10 is up-regulated in multiple cell types during viremic HIV infection and reversibly inhibits virus-specific T cells. Blood. 2009 Jul 9; 114(2):346-56.
    View in: PubMed
  15. Porichis F, Morou A, Baritaki S, Spandidos DA, Krambovitis E. Activation-induced cell death signalling in CD4+ T cells by staphylococcal enterotoxin A. Toxicol Lett. 2008 Jan 4; 176(1):77-84.
    View in: PubMed
  16. Porichis F, Vlata Z, Hatzidakis G, Spandidos DA, Krambovitis E. HIV-1 gp120/V3-derived epitopes promote activation-induced cell death to superantigen-stimulated CD4+/CD45RO+ T cells. Immunol Lett. 2007 Jan 15; 108(1):97-102.
    View in: PubMed
  17. Vlata Z, Porichis F, Tzanakakis G, Tsatsakis A, Krambovitis E. A study of zearalenone cytotoxicity on human peripheral blood mononuclear cells. Toxicol Lett. 2006 Sep 10; 165(3):274-81.
    View in: PubMed
  18. Krambovitis E, Porichis F, Spandidos DA. HIV entry inhibitors: a new generation of antiretroviral drugs. Acta Pharmacol Sin. 2005 Oct; 26(10):1165-73.
    View in: PubMed
  19. Vlata Z, Porichis F, Tzanakakis G, Tsatsakis A, Krambovitis E. In vitro cytopathic effects of mycotoxin T-2 on human peripheral blood T lymphocytes. Toxicol Lett. 2005 Dec 30; 160(1):60-8.
    View in: PubMed
  20. Soufla G, Porichis F, Sourvinos G, Vassilaros S, Spandidos DA. Transcriptional deregulation of VEGF, FGF2, TGF-beta1, 2, 3 and cognate receptors in breast tumorigenesis. Cancer Lett. 2006 Apr 8; 235(1):100-13.
    View in: PubMed
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