Laurence G. Rahme, PH.D.
|Title||Associate Professor of Surgery|
|Institution||Massachusetts General Hospital|
|Address||Massachusetts General Hospital|
Surgery - Thier/Rm 340A
55 Fruit St
Boston MA 02114
Available: 10/01/11, Expires: 09/30/14
Bacterial population density-dependent signaling, generally referred to as quorum sensing (QS), uses small molecules to regulate multiple virulence factors important for the development of acute infections and as we recently discovered for the formation of antibiotic-tolerant cell population, a process underlying pathogen persistence in chronic infections. The project may focus on the role of these small QS molecules in bacterial infections, including promotion of antibiotic tolerance and/or modulation of host responses to infection using several animal models of infection. The impact of these molecules on host metabolism could be also studied independently.
Available: 09/01/11, Expires: 07/01/14
The long-term goal of this project is to achieve a paradigm shift in multi-drug resistant therapy of severely injured patients by predicting and promoting effectual natural host responses that can improve treatment outcome in these patients. One of our projects focuses on the use of oxidative stress and lipid peroxidation as innovative biomarkers for predicting susceptibility to infection and the use of novel anti-oxidants to combat multi-drug resistant infections in severely injured individuals.
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