Laurence G. Rahme, PH.D.
|Title||Associate Professor of Surgery|
|Institution||Massachusetts General Hospital|
|Address||Massachusetts General Hospital|
Surgery - Thier/Rm 340A
55 Fruit St
Boston MA 02114
Available: 10/01/11, Expires: 09/30/14
Bacterial population density-dependent signaling, generally referred to as quorum sensing (QS), uses small molecules to regulate multiple virulence factors important for the development of acute infections and as we recently discovered for the formation of antibiotic-tolerant cell population, a process underlying pathogen persistence in chronic infections. The project may focus on the role of these small QS molecules in bacterial infections, including promotion of antibiotic tolerance and/or modulation of host responses to infection using several animal models of infection. The impact of these molecules on host metabolism could be also studied independently.
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