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Laurence G. Rahme, PH.D.

TitleAssociate Professor of Surgery
InstitutionMassachusetts General Hospital
DepartmentSurgery
AddressMassachusetts General Hospital
Surgery - Thier/Rm 340A
55 Fruit St
Boston MA 02114
Phone617/724-5003
Fax617/724-8558

 Mentoring 
 current student opportunities
Available: 10/01/11, Expires: 09/30/14

Bacterial population density-dependent signaling, generally referred to as quorum sensing (QS), uses small molecules to regulate multiple virulence factors important for the development of acute infections and as we recently discovered for the formation of antibiotic-tolerant cell population, a process underlying pathogen persistence in chronic infections. The project may focus on the role of these small QS molecules in bacterial infections, including promotion of antibiotic tolerance and/or modulation of host responses to infection using several animal models of infection. The impact of these molecules on host metabolism could be also studied independently.

Available: 09/01/11, Expires: 07/01/14

The long-term goal of this project is to achieve a paradigm shift in multi-drug resistant therapy of severely injured patients by predicting and promoting effectual natural host responses that can improve treatment outcome in these patients. One of our projects focuses on the use of oxidative stress and lipid peroxidation as innovative biomarkers for predicting susceptibility to infection and the use of novel anti-oxidants to combat multi-drug resistant infections in severely injured individuals.


 Bibliographic 
 selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Que YA, Hazan R, Strobel B, Maura D, He J, Kesarwani M, Panopoulos P, Tsurumi A, Giddey M, Wilhelmy J, Mindrinos MN, Rahme LG. A quorum sensing small volatile molecule promotes antibiotic tolerance in bacteria. PLoS One. 2013; 8(12):e80140.
    View in: PubMed
  2. Dulcey CE, Dekimpe V, Fauvelle DA, Milot S, Groleau MC, Doucet N, Rahme LG, Lépine F, Déziel E. The end of an old hypothesis: the pseudomonas signaling molecules 4-hydroxy-2-alkylquinolines derive from Fatty acids, not 3-ketofatty acids. Chem Biol. 2013 Dec 19; 20(12):1481-91.
    View in: PubMed
  3. Tzika AA, Constantinou C, Bandyopadhaya A, Psychogios N, Lee S, Mindrinos M, Martyn JA, Tompkins RG, Rahme LG. A small volatile bacterial molecule triggers mitochondrial dysfunction in murine skeletal muscle. PLoS One. 2013; 8(9):e74528.
    View in: PubMed
  4. Tzika AA, Fontes-Oliveira CC, Shestov AA, Constantinou C, Psychogios N, Righi V, Mintzopoulos D, Busquets S, Lopez-Soriano FJ, Milot S, Lepine F, Mindrinos MN, Rahme LG, Argiles JM. Skeletal muscle mitochondrial uncoupling in a murine cancer cachexia model. Int J Oncol. 2013 Sep; 43(3):886-94.
    View in: PubMed
  5. Righi V, Constantinou C, Mintzopoulos D, Khan N, Mupparaju SP, Rahme LG, Swartz HM, Szeto HH, Tompkins RG, Tzika AA. Mitochondria-targeted antioxidant promotes recovery of skeletal muscle mitochondrial function after burn trauma assessed by in vivo 31P nuclear magnetic resonance and electron paramagnetic resonance spectroscopy. FASEB J. 2013 Jun; 27(6):2521-30.
    View in: PubMed
  6. Seok J, Warren HS, Cuenca AG, Mindrinos MN, Baker HV, Xu W, Richards DR, McDonald-Smith GP, Gao H, Hennessy L, Finnerty CC, López CM, Honari S, Moore EE, Minei JP, Cuschieri J, Bankey PE, Johnson JL, Sperry J, Nathens AB, Billiar TR, West MA, Jeschke MG, Klein MB, Gamelli RL, Gibran NS, Brownstein BH, Miller-Graziano C, Calvano SE, Mason PH, Cobb JP, Rahme LG, Lowry SF, Maier RV, Moldawer LL, Herndon DN, Davis RW, Xiao W, Tompkins RG. Genomic responses in mouse models poorly mimic human inflammatory diseases. Proc Natl Acad Sci U S A. 2013 Feb 26; 110(9):3507-12.
    View in: PubMed
  7. Bandyopadhaya A, Kesarwani M, Que YA, He J, Padfield K, Tompkins R, Rahme LG. The Quorum Sensing Volatile Molecule 2-Amino Acetophenon Modulates Host Immune Responses in a Manner that Promotes Life with Unwanted Guests. PLoS Pathog. 2012 Nov; 8(11):e1003024.
    View in: PubMed
  8. Hazan R, Que YA, Maura D, Rahme LG. A method for high throughput determination of viable bacteria cell counts in 96-well plates. BMC Microbiol. 2012; 12:259.
    View in: PubMed
  9. Bangi E, Pitsouli C, Rahme LG, Cagan R, Apidianakis Y. Immune response to bacteria induces dissemination of Ras-activated Drosophila hindgut cells. EMBO Rep. 2012 Jun; 13(6):569-76.
    View in: PubMed
  10. Wang R, Starkey M, Hazan R, Rahme LG. Honey's Ability to Counter Bacterial Infections Arises from Both Bactericidal Compounds and QS Inhibition. Front Microbiol. 2012; 3:144.
    View in: PubMed
  11. Ryou M, Hazan R, Rahme L, Thompson CC. An ex vivo bacteriologic study comparing antiseptic techniques for natural orifice translumenal endoscopic surgery (NOTES) via the gastrointestinal tract. Dig Dis Sci. 2012 Aug; 57(8):2130-6.
    View in: PubMed
  12. Apidianakis Y, Que YA, Xu W, Tegos GP, Zimniak P, Hamblin MR, Tompkins RG, Xiao W, Rahme LG. Down-regulation of glutatione S-transferase a 4 (hGSTA4) in the muscle of thermally injured patients is indicative of susceptibility to bacterial infection. FASEB J. 2012 Feb; 26(2):730-7.
    View in: PubMed
  13. Kesarwani M, Hazan R, He J, Que YA, Que Y, Apidianakis Y, Lesic B, Xiao G, Dekimpe V, Milot S, Deziel E, Lépine F, Rahme LG. A quorum sensing regulated small volatile molecule reduces acute virulence and promotes chronic infection phenotypes. PLoS Pathog. 2011 Aug; 7(8):e1002192.
    View in: PubMed
  14. Que YA, Hazan R, Ryan CM, Milot S, Lépine F, Lydon M, Rahme LG. Production of Pseudomonas aeruginosa Intercellular Small Signaling Molecules in Human Burn Wounds. J Pathog. 2011; 2011:549302.
    View in: PubMed
  15. Astrakas L, Blekas KD, Constantinou C, Andronesi OC, Mindrinos MN, Likas AC, Rahme LG, Black PM, Marcus KJ, Tzika AA. Combining magnetic resonance spectroscopy and molecular genomics offers better accuracy in brain tumor typing and prediction of survival than either methodology alone. Int J Oncol. 2011 Apr; 38(4):1113-27.
    View in: PubMed
  16. Apidianakis Y, Rahme LG. Drosophila melanogaster as a model for human intestinal infection and pathology. Dis Model Mech. 2011 Jan; 4(1):21-30.
    View in: PubMed
  17. Constantinou C, Fontes de Oliveira CC, Mintzopoulos D, Busquets S, He J, Kesarwani M, Mindrinos M, Rahme LG, Argilés JM, Tzika AA. Nuclear magnetic resonance in conjunction with functional genomics suggests mitochondrial dysfunction in a murine model of cancer cachexia. Int J Mol Med. 2011 Jan; 27(1):15-24.
    View in: PubMed
  18. Andronesi OC, Mintzopoulos D, Righi V, Psychogios N, Kesarwani M, He J, Yasuhara S, Dai G, Rahme LG, Tzika AA. Combined off-resonance imaging and T2 relaxation in the rotating frame for positive contrast MR imaging of infection in a murine burn model. J Magn Reson Imaging. 2010 Nov; 32(5):1172-83.
    View in: PubMed
  19. Righi V, Apidianakis Y, Mintzopoulos D, Astrakas L, Rahme LG, Tzika AA. In vivo high-resolution magic angle spinning magnetic resonance spectroscopy of Drosophila melanogaster at 14.1 T shows trauma in aging and in innate immune-deficiency is linked to reduced insulin signaling. Int J Mol Med. 2010 Aug; 26(2):175-84.
    View in: PubMed
  20. Zhou B, Xu W, Herndon D, Tompkins R, Davis R, Xiao W, Wong WH, Toner M, Warren HS, Schoenfeld DA, Rahme L, McDonald-Smith GP, Hayden D, Mason P, Fagan S, Yu YM, Cobb JP, Remick DG, Mannick JA, Lederer JA, Gamelli RL, Silver GM, West MA, Shapiro MB, Smith R, Camp DG, Qian W, Storey J, Mindrinos M, Tibshirani R, Lowry S, Calvano S, Chaudry I, West MA, Cohen M, Moore EE, Johnson J, Moldawer LL, Baker HV, Efron PA, Balis UG, Billiar TR, Ochoa JB, Sperry JL, Miller-Graziano CL, De AK, Bankey PE, Finnerty CC, Jeschke MG, Minei JP, Arnoldo BD, Hunt JL, Horton J, Cobb JP, Brownstein B, Freeman B, Maier RV, Nathens AB, Cuschieri J, Gibran N, Klein M, O'Keefe G. Analysis of factorial time-course microarrays with application to a clinical study of burn injury. Proc Natl Acad Sci U S A. 2010 Jun 1; 107(22):9923-8.
    View in: PubMed
  21. Righi V, Apidianakis Y, Rahme LG, Tzika AA. Magnetic resonance spectroscopy of live Drosophila melanogaster using magic angle spinning. J Vis Exp. 2010; (38).
    View in: PubMed
  22. Hazan R, He J, Xiao G, Dekimpe V, Apidianakis Y, Lesic B, Astrakas C, Déziel E, Lépine F, Rahme LG. Homeostatic interplay between bacterial cell-cell signaling and iron in virulence. PLoS Pathog. 2010 Mar; 6(3):e1000810.
    View in: PubMed
  23. Apidianakis Y, Pitsouli C, Perrimon N, Rahme L. Synergy between bacterial infection and genetic predisposition in intestinal dysplasia. Proc Natl Acad Sci U S A. 2009 Dec 8; 106(49):20883-8.
    View in: PubMed
  24. An D, Apidianakis Y, Boechat AL, Baldini RL, Goumnerov BC, Rahme LG. The pathogenic properties of a novel and conserved gene product, KerV, in proteobacteria. PLoS One. 2009; 4(9):e7167.
    View in: PubMed
  25. Tzika AA, Mintzopoulos D, Mindrinos M, Zhang J, Rahme LG, Tompkins RG. Microarray analysis suggests that burn injury results in mitochondrial dysfunction in human skeletal muscle. Int J Mol Med. 2009 Sep; 24(3):387-92.
    View in: PubMed
  26. Rodriguez S, Chora A, Goumnerov B, Mumaw C, Goebel WS, Fernandez L, Baydoun H, HogenEsch H, Dombkowski DM, Karlewicz CA, Rice S, Rahme LG, Carlesso N. Dysfunctional expansion of hematopoietic stem cells and block of myeloid differentiation in lethal sepsis. Blood. 2009 Nov 5; 114(19):4064-76.
    View in: PubMed
  27. Apidianakis Y, Rahme LG. Drosophila melanogaster as a model host for studying Pseudomonas aeruginosa infection. Nat Protoc. 2009; 4(9):1285-94.
    View in: PubMed
  28. Lesic B, Starkey M, He J, Hazan R, Rahme LG. Quorum sensing differentially regulates Pseudomonas aeruginosa type VI secretion locus I and homologous loci II and III, which are required for pathogenesis. Microbiology. 2009 Sep; 155(Pt 9):2845-55.
    View in: PubMed
  29. Starkey M, Rahme LG. Modeling Pseudomonas aeruginosa pathogenesis in plant hosts. Nat Protoc. 2009; 4(2):117-24.
    View in: PubMed
  30. Tzika AA, Astrakas LG, Cao H, Mintzopoulos D, Zhang Q, Padfield K, Yu H, Mindrinos MN, Rahme LG, Tompkins RG. Murine intramyocellular lipids quantified by NMR act as metabolic biomarkers in burn trauma. Int J Mol Med. 2008 Jun; 21(6):825-32.
    View in: PubMed
  31. Lesic B, Rahme LG. Use of the lambda Red recombinase system to rapidly generate mutants in Pseudomonas aeruginosa. BMC Mol Biol. 2008; 9:20.
    View in: PubMed
  32. Tzika AA, Mintzopoulos D, Padfield K, Wilhelmy J, Mindrinos MN, Yu H, Cao H, Zhang Q, Astrakas LG, Zhang J, Yu YM, Rahme LG, Tompkins RG. Reduced rate of adenosine triphosphate synthesis by in vivo 31P nuclear magnetic resonance spectroscopy and downregulation of PGC-1beta in distal skeletal muscle following burn. Int J Mol Med. 2008 Feb; 21(2):201-8.
    View in: PubMed
  33. Apidianakis Y, Mindrinos MN, Xiao W, Tegos GP, Papisov MI, Hamblin MR, Davis RW, Tompkins RG, Rahme LG. Involvement of skeletal muscle gene regulatory network in susceptibility to wound infection following trauma. PLoS One. 2007; 2(12):e1356.
    View in: PubMed
  34. Lesic B, Lépine F, Déziel E, Zhang J, Zhang Q, Padfield K, Castonguay MH, Milot S, Stachel S, Tzika AA, Tompkins RG, Rahme LG. Inhibitors of pathogen intercellular signals as selective anti-infective compounds. PLoS Pathog. 2007 Sep 14; 3(9):1229-39.
    View in: PubMed
  35. Tzika AA, Astrakas L, Cao H, Mintzopoulos D, Andronesi OC, Mindrinos M, Zhang J, Rahme LG, Blekas KD, Likas AC, Galatsanos NP, Carroll RS, Black PM. Combination of high-resolution magic angle spinning proton magnetic resonance spectroscopy and microscale genomics to type brain tumor biopsies. Int J Mol Med. 2007 Aug; 20(2):199-208.
    View in: PubMed
  36. Lépine F, Dekimpe V, Lesic B, Milot S, Lesimple A, Mamer OA, Rahme LG, Déziel E. PqsA is required for the biosynthesis of 2,4-dihydroxyquinoline (DHQ), a newly identified metabolite produced by Pseudomonas aeruginosa and Burkholderia thailandensis. Biol Chem. 2007 Aug; 388(8):839-45.
    View in: PubMed
  37. Zaborina O, Lepine F, Xiao G, Valuckaite V, Chen Y, Li T, Ciancio M, Zaborin A, Petrof EO, Petroff E, Turner JR, Rahme LG, Chang E, Alverdy JC. Dynorphin activates quorum sensing quinolone signaling in Pseudomonas aeruginosa. PLoS Pathog. 2007 Mar; 3(3):e35.
    View in: PubMed
  38. Xiao G, Déziel E, He J, Lépine F, Lesic B, Castonguay MH, Milot S, Tampakaki AP, Stachel SE, Rahme LG. MvfR, a key Pseudomonas aeruginosa pathogenicity LTTR-class regulatory protein, has dual ligands. Mol Microbiol. 2006 Dec; 62(6):1689-99.
    View in: PubMed
  39. Zhang Q, Cao H, Astrakas LG, Mintzopoulos D, Mindrinos MN, Schulz J, Tompkins RG, Rahme LG, Tzika AA. Uncoupling protein 3 expression and intramyocellular lipid accumulation by NMR following local burn trauma. Int J Mol Med. 2006 Dec; 18(6):1223-9.
    View in: PubMed
  40. Lee DG, Urbach JM, Wu G, Liberati NT, Feinbaum RL, Miyata S, Diggins LT, He J, Saucier M, Déziel E, Friedman L, Li L, Grills G, Montgomery K, Kucherlapati R, Rahme LG, Ausubel FM. Genomic analysis reveals that Pseudomonas aeruginosa virulence is combinatorial. Genome Biol. 2006; 7(10):R90.
    View in: PubMed
  41. Padfield KE, Zhang Q, Gopalan S, Tzika AA, Mindrinos MN, Tompkins RG, Rahme LG. Local and distant burn injury alter immuno-inflammatory gene expression in skeletal muscle. J Trauma. 2006 Aug; 61(2):280-92.
    View in: PubMed
  42. Xiao G, He J, Rahme LG. Mutation analysis of the Pseudomonas aeruginosa mvfR and pqsABCDE gene promoters demonstrates complex quorum-sensing circuitry. Microbiology. 2006 Jun; 152(Pt 6):1679-86.
    View in: PubMed
  43. Astrakas LG, Goljer I, Yasuhara S, Padfield KE, Zhang Q, Gopalan S, Mindrinos MN, Dai G, Yu YM, Martyn JA, Tompkins RG, Rahme LG, Tzika AA. Proton NMR spectroscopy shows lipids accumulate in skeletal muscle in response to burn trauma-induced apoptosis. FASEB J. 2005 Sep; 19(11):1431-40.
    View in: PubMed
  44. Padfield KE, Astrakas LG, Zhang Q, Gopalan S, Dai G, Mindrinos MN, Tompkins RG, Rahme LG, Tzika AA. Burn injury causes mitochondrial dysfunction in skeletal muscle. Proc Natl Acad Sci U S A. 2005 Apr 12; 102(15):5368-73.
    View in: PubMed
  45. Cobb JP, Mindrinos MN, Miller-Graziano C, Calvano SE, Baker HV, Xiao W, Laudanski K, Brownstein BH, Elson CM, Hayden DL, Herndon DN, Lowry SF, Maier RV, Schoenfeld DA, Moldawer LL, Davis RW, Tompkins RG, Baker HV, Bankey P, Billiar T, Brownstein BH, Calvano SE, Camp D, Chaudry I, Cobb JP, Davis RW, Elson CM, Freeman B, Gamelli R, Gibran N, Harbrecht B, Hayden DL, Heagy W, Heimbach D, Herndon DN, Horton J, Hunt J, Laudanski K, Lederer J, Lowry SF, Maier RV, Mannick J, McKinley B, Miller-Graziano C, Mindrinos MN, Minei J, Moldawer LL, Moore E, Moore F, Munford R, Nathens A, O'keefe G, Purdue G, Rahme L, Remick D, Sailors M, Schoenfeld DA, Shapiro M, Silver G, Smith R, Stephanopoulos G, Stormo G, Tompkins RG, Toner M, Warren S, West M, Wolfe S, Xiao W, Young V. Application of genome-wide expression analysis to human health and disease. Proc Natl Acad Sci U S A. 2005 Mar 29; 102(13):4801-6.
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  46. Apidianakis Y, Mindrinos MN, Xiao W, Lau GW, Baldini RL, Davis RW, Rahme LG. Profiling early infection responses: Pseudomonas aeruginosa eludes host defenses by suppressing antimicrobial peptide gene expression. Proc Natl Acad Sci U S A. 2005 Feb 15; 102(7):2573-8.
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  47. Déziel E, Gopalan S, Tampakaki AP, Lépine F, Padfield KE, Saucier M, Xiao G, Rahme LG. The contribution of MvfR to Pseudomonas aeruginosa pathogenesis and quorum sensing circuitry regulation: multiple quorum sensing-regulated genes are modulated without affecting lasRI, rhlRI or the production of N-acyl-L-homoserine lactones. Mol Microbiol. 2005 Feb; 55(4):998-1014.
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  48. Lépine F, Milot S, Déziel E, He J, Rahme LG. Electrospray/mass spectrometric identification and analysis of 4-hydroxy-2-alkylquinolines (HAQs) produced by Pseudomonas aeruginosa. J Am Soc Mass Spectrom. 2004 Jun; 15(6):862-9.
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  49. Apidianakis Y, Rahme LG, Heitman J, Ausubel FM, Calderwood SB, Mylonakis E. Challenge of Drosophila melanogaster with Cryptococcus neoformans and role of the innate immune response. Eukaryot Cell. 2004 Apr; 3(2):413-9.
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  50. He J, Baldini RL, Déziel E, Saucier M, Zhang Q, Liberati NT, Lee D, Urbach J, Goodman HM, Rahme LG. The broad host range pathogen Pseudomonas aeruginosa strain PA14 carries two pathogenicity islands harboring plant and animal virulence genes. Proc Natl Acad Sci U S A. 2004 Feb 24; 101(8):2530-5.
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  51. Déziel E, Lépine F, Milot S, He J, Mindrinos MN, Tompkins RG, Rahme LG. Analysis of Pseudomonas aeruginosa 4-hydroxy-2-alkylquinolines (HAQs) reveals a role for 4-hydroxy-2-heptylquinoline in cell-to-cell communication. Proc Natl Acad Sci U S A. 2004 Feb 3; 101(5):1339-44.
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  52. Walker TS, Bais HP, Déziel E, Schweizer HP, Rahme LG, Fall R, Vivanco JM. Pseudomonas aeruginosa-plant root interactions. Pathogenicity, biofilm formation, and root exudation. Plant Physiol. 2004 Jan; 134(1):320-31.
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  53. Lau GW, Goumnerov BC, Walendziewicz CL, Hewitson J, Xiao W, Mahajan-Miklos S, Tompkins RG, Perkins LA, Rahme LG. The Drosophila melanogaster toll pathway participates in resistance to infection by the gram-negative human pathogen Pseudomonas aeruginosa. Infect Immun. 2003 Jul; 71(7):4059-66.
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  54. Lépine F, Déziel E, Milot S, Rahme LG. A stable isotope dilution assay for the quantification of the Pseudomonas quinolone signal in Pseudomonas aeruginosa cultures. Biochim Biophys Acta. 2003 Jun 20; 1622(1):36-41.
    View in: PubMed
  55. Choi JY, Sifri CD, Goumnerov BC, Rahme LG, Ausubel FM, Calderwood SB. Identification of virulence genes in a pathogenic strain of Pseudomonas aeruginosa by representational difference analysis. J Bacteriol. 2002 Feb; 184(4):952-61.
    View in: PubMed
  56. Baldini RL, Lau GW, Rahme LG. Use of plant and insect hosts to model bacterial pathogenesis. Methods Enzymol. 2002; 358:3-13.
    View in: PubMed
  57. Hendrickson EL, Plotnikova J, Mahajan-Miklos S, Rahme LG, Ausubel FM. Differential roles of the Pseudomonas aeruginosa PA14 rpoN gene in pathogenicity in plants, nematodes, insects, and mice. J Bacteriol. 2001 Dec; 183(24):7126-34.
    View in: PubMed
  58. Cao H, Krishnan G, Goumnerov B, Tsongalis J, Tompkins R, Rahme LG. A quorum sensing-associated virulence gene of Pseudomonas aeruginosa encodes a LysR-like transcription regulator with a unique self-regulatory mechanism. Proc Natl Acad Sci U S A. 2001 Dec 4; 98(25):14613-8.
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  59. Yorgey P, Rahme LG, Tan MW, Ausubel FM. The roles of mucD and alginate in the virulence of Pseudomonas aeruginosa in plants, nematodes and mice. Mol Microbiol. 2001 Sep; 41(5):1063-76.
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  60. Cao H, Baldini RL, Rahme LG. Common mechanisms for pathogens of plants and animals. Annu Rev Phytopathol. 2001; 39:259-84.
    View in: PubMed
  61. Plotnikova JM, Rahme LG, Ausubel FM. Pathogenesis of the human opportunistic pathogen Pseudomonas aeruginosa PA14 in Arabidopsis. Plant Physiol. 2000 Dec; 124(4):1766-74.
    View in: PubMed
  62. Mahajan-Miklos S, Rahme LG, Ausubel FM. Elucidating the molecular mechanisms of bacterial virulence using non-mammalian hosts. Mol Microbiol. 2000 Sep; 37(5):981-8.
    View in: PubMed
  63. Rahme LG, Ausubel FM, Cao H, Drenkard E, Goumnerov BC, Lau GW, Mahajan-Miklos S, Plotnikova J, Tan MW, Tsongalis J, Walendziewicz CL, Tompkins RG. Plants and animals share functionally common bacterial virulence factors. Proc Natl Acad Sci U S A. 2000 Aug 1; 97(16):8815-21.
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  64. Jander G, Rahme LG, Ausubel FM. Positive correlation between virulence of Pseudomonas aeruginosa mutants in mice and insects. J Bacteriol. 2000 Jul; 182(13):3843-5.
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  65. Tan MW, Rahme LG, Sternberg JA, Tompkins RG, Ausubel FM. Pseudomonas aeruginosa killing of Caenorhabditis elegans used to identify P. aeruginosa virulence factors. Proc Natl Acad Sci U S A. 1999 Mar 2; 96(5):2408-13.
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  66. Mahajan-Miklos S, Tan MW, Rahme LG, Ausubel FM. Molecular mechanisms of bacterial virulence elucidated using a Pseudomonas aeruginosa-Caenorhabditis elegans pathogenesis model. Cell. 1999 Jan 8; 96(1):47-56.
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  67. Wong SM, Carroll PA, Rahme LG, Ausubel FM, Calderwood SB. Modulation of expression of the ToxR regulon in Vibrio cholerae by a member of the two-component family of response regulators. Infect Immun. 1998 Dec; 66(12):5854-61.
    View in: PubMed
  68. Rahme LG, Tan MW, Le L, Wong SM, Tompkins RG, Calderwood SB, Ausubel FM. Use of model plant hosts to identify Pseudomonas aeruginosa virulence factors. Proc Natl Acad Sci U S A. 1997 Nov 25; 94(24):13245-50.
    View in: PubMed
  69. Rahme LG, Stevens EJ, Wolfort SF, Shao J, Tompkins RG, Ausubel FM. Common virulence factors for bacterial pathogenicity in plants and animals. Science. 1995 Jun 30; 268(5219):1899-902.
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  70. Rahme LG, Mindrinos MN, Panopoulos NJ. Plant and environmental sensory signals control the expression of hrp genes in Pseudomonas syringae pv. phaseolicola. J Bacteriol. 1992 Jun; 174(11):3499-507.
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  71. Rahme LG, Mindrinos MN, Panopoulos NJ. Genetic and transcriptional organization of the hrp cluster of Pseudomonas syringae pv. phaseolicola. J Bacteriol. 1991 Jan; 173(2):575-86.
    View in: PubMed
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