Contact, publication, and social network information about Harvard faculty and fellows. Harvard Catalyst Profiles
Keywords
Last Name
Institution

Dusica Bajic, PH.D., M.D.

TitleAssistant Professor of Anaesthesia
InstitutionChildren's Hospital Boston
DepartmentAnaesthesia
AddressChildrens Hospital
Anesthesia, Pavilion 3
300 Longwood Ave
Boston MA 02115
Phone617/355-7737
Fax617/730-0894

 Biography 
 awards and honors
- 1994Dean’s Award for Exceptional Accomplishments in Medical School
- 1999International Brain Research Organization (IBRO) Travel Grant
- 1999International Association for the Study of Pain (IASP) Travel Grant
- 2001U.S. Permanent Residency Petition approved in the category of the Outstanding Researcher
1991 - 1994Fellowship from Ministry of Science and Education
1995 - 1997Fellowship from Ministry of Science and Education
1996 - 1999Panich Fund Fellowship in Pharmacology
1997 - 1999Graduate College and Graduate Student Council Travel Awards
1997 - 2000Graduate Student Symposium Award, Chicago Chapter of the Society for Neuroscience
1998 - 2000Student Medical Research Forum Recognition
2007 - 2008Farley Fund Fellowship in Pediatric Anesthesiology
- 2009International Narcotic Research Conference (INRC) Travel Award
- 2010Advanced Techniques in Molecular Neuroscience Attendee
2008 - 2011Patient’s Choice Award
2010 - 2011Compassionate Doctor Recognition
- 2012International Anesthesia Research Society (IARS) Best of Category Abstract
- 2012International Anesthesia Research Society (IARS) 2012 Best of Meeting Finalists
- 2012Top Ten Doctors - Anesthesiology
- 2012Association of American Medical Colleges (AAMC) Leadership Seminar Attendee
2013 - 2015The Anesthesia Research Distinguished Trailblazer Award: Basic Science
- 2013Journal Cover; Journal of Chemical Neuroanatomy
- 2013Recipient of NIH Mentored Clinical Scientist Development Award (K08) with highest score: 10

 Overview 
 overview
PAST Funding Information:

1. Foundation in Anesthesia Education and Research (FAER) Mentored Research Training Grant – Basic Research (MRTG-BR): MRTG-2/15/09-Bajic (Dusica)
Title: Age Differences of Brain Circuits Mediating Morphine Effect and Development of Morphine Tolerance
Dates: 07/01/09-06/30/11
The specific goal of this project is to understand how chronic morphine exposure influences Fos and nNOS expression in the ventrolateral periaqueductal gray, an area that is strongly implicated in analgesic tolerance development. Age-dependent effects of morphine exposure are determined using neuroanatomical tools in a rodent model. The broad long-term objective of the proposed research is to understand mechanisms contributing to morphine tolerance during postnatal development.
BAJIC (PI)

2. NIH Support Opportunity for Addiction Research (SOAR) for New Investigators (R03)
Title: Age Differences of Brain Circuits Mediating Morphine Effect and Morphine Tolerance
Dates:10/01/10-08/31/12
Gene expression differences with age and chronic morphine exposure are determined using PCR Arrays (SABiosciences) in a rodent model. The broad long-term objective of the study was to understand mechanisms contributing to morphine tolerance that differ with age.
BAJIC (PI)


CURRENT Funding Information:

1. The Anesthesia Research Distinguished Trailblazer Award, Department of Anesthesiology, Perioperative and Pain Medicine Research Grant, Boston Children’s Hospital, Harvard Medical School
Title: Ontogeny of Supraspinal Mechanisms of Addiction
Dates: 01/01/13-12/12/14
Study examines the ontogeny of supraspinal mechanisms of addiction, specifically the role of cholinergic system in adolescent rat brain following chronic morphine administration. Experiments involve systems approach using fMRI, as well as cellular approach (fluorescent immunohistochemistry).
BAJIC (PI)

2. NIH Mentored Clinical Scientist Development Award (K08): 1K08DA035972-01
Title: Immediate and Delayed Effects of Morphine on Brain Circuits: Animal – Human Correlation
Dates: 06/07/13-06/31/18
This mentored clinical scientist research career award (K08) is unique in its translational effort to define the impact of prolonged morphine exposure in the rats of different ages using neuroimaging, behavioral, and immunohistochemical techniques (AIM 1), as well as in children of different ages using neuroimaging (AIM 2). Functional magnetic resonance imaging (fMRI) in both rats and children will allow a translational systems level investigation of prolonged morphine administration and its long-term effects.
BAJIC (PI)


 Bibliographic 
 selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
List All   |   Timeline
  1. Bajic D, Proudfit HK. Projections from the rat cuneiform nucleus to the A7, A6 (locus coeruleus), and A5 pontine noradrenergic cell groups. J Chem Neuroanat. 2013 May; 50-51:11-20.
    View in: PubMed
  2. Bajic D, Commons KG, Soriano SG. Morphine-enhanced apoptosis in selective brain regions of neonatal rats. Int J Dev Neurosci. 2013 Jun; 31(4):258-66.
    View in: PubMed
  3. Bajic D, Berde CB, Commons KG. Periaqueductal gray neuroplasticity following chronic morphine varies with age: Role of oxidative stress. Neuroscience. 2012 Dec 13; 226:165-77.
    View in: PubMed
  4. Bajic D, Van Bockstaele EJ, Proudfit HK. Ultrastructural analysis of rat ventrolateral periaqueductal gray projections to the A5 cell group. Neuroscience. 2012 Nov 8; 224:145-59.
    View in: PubMed
  5. Soriano SG, Liu Q, Li J, Liu JR, Han XH, Kanter JL, Bajic D, Ibla JC. Ketamine activates cell cycle signaling and apoptosis in the neonatal rat brain. Anesthesiology. 2010 May; 112(5):1155-63.
    View in: PubMed
  6. Bajic D, Commons KG. Acute noxious stimulation modifies morphine effect in serotonergic but not dopaminergic midbrain areas. Neuroscience. 2010 Mar 17; 166(2):720-9.
    View in: PubMed
  7. Bajic D, Commons KG. Visualizing acute pain-morphine interaction in descending monoamine nuclei with Fos. Brain Res. 2010 Jan 8; 1306:29-38.
    View in: PubMed
  8. Ibla JC, Hayashi H, Bajic D, Soriano SG. Prolonged exposure to ketamine increases brain derived neurotrophic factor levels in developing rat brains. Curr Drug Saf. 2009 Jan; 4(1):11-6.
    View in: PubMed
  9. Bajic D. Abnormal electrolytes: Prolonged emergences. Anesthesia Processes. In: Modak RK, editor. Anesthesiology Keywords Review. Philadelphia: Lippincott Williams and Wilkins. 2008.
  10. Bajic D, Burm M. Carotid chemoreceptor function. Physiology and Cardiovascular. In: Modak RK, editor. Anesthesiology Keywords Review. Philadelphia: Lippincott Williams and Wilkins. 2008.
  11. Bajic D, Nguyen H. Cholestasis: Coagulopathy Rx. Hematology and Pharmacology. In: Modak RK, editor. Anesthesiology Keywords Review. Philadelphia: Lippincott Williams and Wilkins. 2008.
  12. Bajic D. Carbon Monoxide and inhalational anesthetics. Physics Equipment. In: Modak RK, editor. Anesthesiology Keywords Review. Philadelphia: Lippincott Williams and Wilkins. 2008.
  13. Bajic D, Obergfell, R. Hypotension: compensatory mechanisms. Cardiovascular and Physiology. In: Modak RK, editor. Anesthesiology Keywords Review. Philadelphia: Lippincott Williams and Wilkins. 2008.
  14. Bajic D. Newborn respiratory distress syndrome: symptoms. Pediatrics. In: Modak RK, editor. Anesthesiology Keywords Review. Philadelphia: Lippincott Williams and Wilkins. 2008.
  15. Bajic D, Miller K. Pneumoperitoneum: vagal arrest. Pediatrics and Respiratory. In: Modak RK, editor. Anesthesiology Keywords Review. Philadelphia: Lippincott Williams and Wilkins. 2008.
  16. Bajic D, Kim J, Johanson R. Respiratory center functions. Neurologic, Respiratory, and Physiology. In: Modak RK, editor. Anesthesiology Keywords Review. Philadelphia: Lippincott Williams and Wilkins. 2008.
  17. Bajic D, Hoang QV, Nakajima S, Nakajima Y. Dissociated histaminergic neuron cultures from the tuberomammillary nucleus of rats: culture methods and ghrelin effects. J Neurosci Methods. 2004 Jan 30; 132(2):177-84.
    View in: PubMed
  18. Hoang QV, Bajic D, Yanagisawa M, Nakajima S, Nakajima Y. Effects of orexin (hypocretin) on GIRK channels. J Neurophysiol. 2003 Aug; 90(2):693-702.
    View in: PubMed
  19. Bajic D, Koike M, Albsoul-Younes AM, Nakajima S, Nakajima Y. Two different inward rectifier K+ channels are effectors for transmitter-induced slow excitation in brain neurons. Proc Natl Acad Sci U S A. 2002 Oct 29; 99(22):14494-9.
    View in: PubMed
  20. Van Bockstaele EJ, Bajic D, Proudfit H, Valentino RJ. Topographic architecture of stress-related pathways targeting the noradrenergic locus coeruleus. Physiol Behav. 2001 Jun; 73(3):273-83.
    View in: PubMed
  21. Bajic D, Van Bockstaele EJ, Proudfit HK. Ultrastructural analysis of ventrolateral periaqueductal gray projections to the A7 catecholamine cell group. Neuroscience. 2001; 104(1):181-97.
    View in: PubMed
  22. Bajic D, Proudfit HK, Van Bockstaele EJ. Periaqueductal gray neurons monosynaptically innervate extranuclear noradrenergic dendrites in the rat pericoerulear region. J Comp Neurol. 2000 Nov 27; 427(4):649-62.
    View in: PubMed
  23. Bajic D. Projections of neurons in the periaqueductal gray and cuneiform nucleus to pontine noradrenergic neurons [Ph.D. Thesis]; Chicago (IL): Univ. of Illinois at Chicago. pp.224. 2000.
  24. Bajic D, Proudfit HK. Projections of neurons in the periaqueductal gray to pontine and medullary catecholamine cell groups involved in the modulation of nociception. J Comp Neurol. 1999 Mar 15; 405(3):359-79.
    View in: PubMed
Local representatives can answer questions about the Profiles website or help with editing a profile or issues with profile data. For assistance with this profile: HMS/HSDM faculty should contact Human Resources at faculty_serviceshms.harvard.edu.
Bajic's Networks
Click the "See All" links for more information and interactive visualizations!
Concepts
_
Co-Authors
_
Similar People
_
Same Department
Physical Neighbors
_