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Last Name
Institution

Jeffrey Scott Flier, M.D.

TitleDean of the Faculty of Medicine
InstitutionHarvard Medical School
DepartmentDean's Office
AddressHarvard Medical School
Dean's Office, Gordon Hall
25 Shattuck St
Boston MA 02115
Phone617/432-1501
Other Positions
TitleCaroline Shields Walker Professor of Medicine
InstitutionBeth Israel Deaconess Medical Center
DepartmentMedicine
DivisionEndocrinology


 Bibliographic 
 selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Robins SC, Stewart I, McNay DE, Taylor V, Giachino C, Goetz M, Ninkovic J, Briancon N, Maratos-Flier E, Flier JS, Kokoeva MV, Placzek M. a-Tanycytes of the adult hypothalamic third ventricle include distinct populations of FGF-responsive neural progenitors. Nat Commun. 2013 Jun 27; 4:2049.
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  2. Flier JS. Creating a nobel culture. Science. 2013 Jan 11; 339(6116):140-1.
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  3. Flier JS. Hormone resistance in diabetes and obesity: insulin, leptin, and FGF21. Yale J Biol Med. 2012 Sep; 85(3):405-14.
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  4. Fisher FM, Kleiner S, Douris N, Fox EC, Mepani RJ, Verdeguer F, Wu J, Kharitonenkov A, Flier JS, Maratos-Flier E, Spiegelman BM. FGF21 regulates PGC-1a and browning of white adipose tissues in adaptive thermogenesis. Genes Dev. 2012 Feb 1; 26(3):271-81.
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  5. McNay DE, Briançon N, Kokoeva MV, Maratos-Flier E, Flier JS. Remodeling of the arcuate nucleus energy-balance circuit is inhibited in obese mice. J Clin Invest. 2012 Jan 3; 122(1):142-52.
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  6. Czupryn A, Zhou YD, Chen X, McNay D, Anderson MP, Flier JS, Macklis JD. Transplanted hypothalamic neurons restore leptin signaling and ameliorate obesity in db/db mice. Science. 2011 Nov 25; 334(6059):1133-7.
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  7. Fisher FM, Estall JL, Adams AC, Antonellis PJ, Bina HA, Flier JS, Kharitonenkov A, Spiegelman BM, Maratos-Flier E. Integrated regulation of hepatic metabolism by fibroblast growth factor 21 (FGF21) in vivo. Endocrinology. 2011 Aug; 152(8):2996-3004.
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  8. Aboulaich N, Chui PC, Asara JM, Flier JS, Maratos-Flier E. Polymerase I and transcript release factor regulates lipolysis via a phosphorylation-dependent mechanism. Diabetes. 2011 Mar; 60(3):757-65.
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  9. Flier JS, Maratos-Flier E. Lasker lauds leptin. Cell Metab. 2010 Oct 6; 12(4):317-20.
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  10. Flier JS, Maratos-Flier E. Lasker lauds leptin. Cell. 2010 Oct 1; 143(1):9-12.
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  11. Briancon N, McNay DE, Maratos-Flier E, Flier JS. Combined neural inactivation of suppressor of cytokine signaling-3 and protein-tyrosine phosphatase-1B reveals additive, synergistic, and factor-specific roles in the regulation of body energy balance. Diabetes. 2010 Dec; 59(12):3074-84.
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  12. Fisher FM, Chui PC, Antonellis PJ, Bina HA, Kharitonenkov A, Flier JS, Maratos-Flier E. Obesity is a fibroblast growth factor 21 (FGF21)-resistant state. Diabetes. 2010 Nov; 59(11):2781-9.
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  13. Adams AC, Astapova I, Fisher FM, Badman MK, Kurgansky KE, Flier JS, Hollenberg AN, Maratos-Flier E. Thyroid hormone regulates hepatic expression of fibroblast growth factor 21 in a PPARalpha-dependent manner. J Biol Chem. 2010 May 7; 285(19):14078-82.
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  14. Nesse RM, Bergstrom CT, Ellison PT, Flier JS, Gluckman P, Govindaraju DR, Niethammer D, Omenn GS, Perlman RL, Schwartz MD, Thomas MG, Stearns SC, Valle D. Evolution in health and medicine Sackler colloquium: Making evolutionary biology a basic science for medicine. Proc Natl Acad Sci U S A. 2010 Jan 26; 107 Suppl 1:1800-7.
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  15. Flier JS, Mekalanos JJ. Gut check: testing a role for the intestinal microbiome in human obesity. Sci Transl Med. 2009 Nov 11; 1(6):6ps7.
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  16. Badman MK, Koester A, Flier JS, Kharitonenkov A, Maratos-Flier E. Fibroblast growth factor 21-deficient mice demonstrate impaired adaptation to ketosis. Endocrinology. 2009 Nov; 150(11):4931-40.
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  17. Flier JS. Health care reform: without a correct diagnosis, there is no cure. J Clin Invest. 2009 Oct; 119(10):2850-2.
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  18. Kienesberger PC, Lee D, Pulinilkunnil T, Brenner DS, Cai L, Magnes C, Koefeler HC, Streith IE, Rechberger GN, Haemmerle G, Flier JS, Zechner R, Kim YB, Kershaw EE. Adipose triglyceride lipase deficiency causes tissue-specific changes in insulin signaling. J Biol Chem. 2009 Oct 30; 284(44):30218-29.
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  19. Zhang R, Maratos-Flier E, Flier JS. Reduced adiposity and high-fat diet-induced adipose inflammation in mice deficient for phosphodiesterase 4B. Endocrinology. 2009 Jul; 150(7):3076-82.
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  20. Koulmanda M, Bhasin M, Hoffman L, Fan Z, Qipo A, Shi H, Bonner-Weir S, Putheti P, Degauque N, Libermann TA, Auchincloss H, Flier JS, Strom TB. Curative and beta cell regenerative effects of alpha1-antitrypsin treatment in autoimmune diabetic NOD mice. Proc Natl Acad Sci U S A. 2008 Oct 21; 105(42):16242-7.
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  21. Zhang R, Dhillon H, Yin H, Yoshimura A, Lowell BB, Maratos-Flier E, Flier JS. Selective inactivation of Socs3 in SF1 neurons improves glucose homeostasis without affecting body weight. Endocrinology. 2008 Nov; 149(11):5654-61.
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  22. Kokoeva MV, Yin H, Flier JS. Evidence for constitutive neural cell proliferation in the adult murine hypothalamus. J Comp Neurol. 2007 Nov 10; 505(2):209-20.
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  23. Kershaw EE, Schupp M, Guan HP, Gardner NP, Lazar MA, Flier JS. PPARgamma regulates adipose triglyceride lipase in adipocytes in vitro and in vivo. Am J Physiol Endocrinol Metab. 2007 Dec; 293(6):E1736-45.
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  24. Flier JS, Maratos-Flier E. What fuels fat. Sci Am. 2007 Sep; 297(3):72-81.
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  25. Koulmanda M, Budo E, Bonner-Weir S, Qipo A, Putheti P, Degauque N, Shi H, Fan Z, Flier JS, Auchincloss H, Zheng XX, Strom TB. Modification of adverse inflammation is required to cure new-onset type 1 diabetic hosts. Proc Natl Acad Sci U S A. 2007 Aug 7; 104(32):13074-9.
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  26. Badman MK, Pissios P, Kennedy AR, Koukos G, Flier JS, Maratos-Flier E. Hepatic fibroblast growth factor 21 is regulated by PPARalpha and is a key mediator of hepatic lipid metabolism in ketotic states. Cell Metab. 2007 Jun; 5(6):426-37.
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  27. Inouye KE, Shi H, Howard JK, Daly CH, Lord GM, Rollins BJ, Flier JS. Absence of CC chemokine ligand 2 does not limit obesity-associated infiltration of macrophages into adipose tissue. Diabetes. 2007 Sep; 56(9):2242-50.
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  28. Badman MK, Flier JS. The adipocyte as an active participant in energy balance and metabolism. Gastroenterology. 2007 May; 132(6):2103-15.
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  29. Cheung KJ, Tzameli I, Pissios P, Rovira I, Gavrilova O, Ohtsubo T, Chen Z, Finkel T, Flier JS, Friedman JM. Xanthine oxidoreductase is a regulator of adipogenesis and PPARgamma activity. Cell Metab. 2007 Feb; 5(2):115-28.
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  30. Shi H, Kokoeva MV, Inouye K, Tzameli I, Yin H, Flier JS. TLR4 links innate immunity and fatty acid-induced insulin resistance. J Clin Invest. 2006 Nov; 116(11):3015-25.
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  31. Howard JK, Flier JS. Attenuation of leptin and insulin signaling by SOCS proteins. Trends Endocrinol Metab. 2006 Nov; 17(9):365-71.
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  32. Fulton S, Pissios P, Manchon RP, Stiles L, Frank L, Pothos EN, Maratos-Flier E, Flier JS. Leptin regulation of the mesoaccumbens dopamine pathway. Neuron. 2006 Sep 21; 51(6):811-22.
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  33. Kievit P, Howard JK, Badman MK, Balthasar N, Coppari R, Mori H, Lee CE, Elmquist JK, Yoshimura A, Flier JS. Enhanced leptin sensitivity and improved glucose homeostasis in mice lacking suppressor of cytokine signaling-3 in POMC-expressing cells. Cell Metab. 2006 Aug; 4(2):123-32.
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  34. Flier JS. Neuroscience. Regulating energy balance: the substrate strikes back. Science. 2006 May 12; 312(5775):861-4.
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  35. Shi H, Cave B, Inouye K, Bjørbaek C, Flier JS. Overexpression of suppressor of cytokine signaling 3 in adipose tissue causes local but not systemic insulin resistance. Diabetes. 2006 Mar; 55(3):699-707.
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  36. Blumberg JM, Tzameli I, Astapova I, Lam FS, Flier JS, Hollenberg AN. Complex role of the vitamin D receptor and its ligand in adipogenesis in 3T3-L1 cells. J Biol Chem. 2006 Apr 21; 281(16):11205-13.
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  37. Flier JS. AgRP in energy balance: Will the real AgRP please stand up? Cell Metab. 2006 Feb; 3(2):83-5.
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  38. Kershaw EE, Hamm JK, Verhagen LA, Peroni O, Katic M, Flier JS. Adipose triglyceride lipase: function, regulation by insulin, and comparison with adiponutrin. Diabetes. 2006 Jan; 55(1):148-57.
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  39. Kokoeva MV, Yin H, Flier JS. Neurogenesis in the hypothalamus of adult mice: potential role in energy balance. Science. 2005 Oct 28; 310(5748):679-83.
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  40. Drukarch B, Flier J, Jongenelen CA, Andringa G, Schoffelmeer AN. The antioxidant anethole dithiolethione inhibits monoamine oxidase-B but not monoamine oxidase A activity in extracts of cultured astrocytes. J Neural Transm. 2006 May; 113(5):593-8.
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  41. Kershaw EE, Morton NM, Dhillon H, Ramage L, Seckl JR, Flier JS. Adipocyte-specific glucocorticoid inactivation protects against diet-induced obesity. Diabetes. 2005 Apr; 54(4):1023-31.
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  42. Badman MK, Flier JS. The gut and energy balance: visceral allies in the obesity wars. Science. 2005 Mar 25; 307(5717):1909-14.
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  43. Flier JS, Elmquist JK. A good night's sleep: future antidote to the obesity epidemic? Ann Intern Med. 2004 Dec 7; 141(11):885-6.
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  44. Münzberg H, Flier JS, Bjørbaek C. Region-specific leptin resistance within the hypothalamus of diet-induced obese mice. Endocrinology. 2004 Nov; 145(11):4880-9.
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  45. Howard JK, Cave BJ, Oksanen LJ, Tzameli I, Bjørbaek C, Flier JS. Enhanced leptin sensitivity and attenuation of diet-induced obesity in mice with haploinsufficiency of Socs3. Nat Med. 2004 Jul; 10(7):734-8.
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  46. Tzameli I, Fang H, Ollero M, Shi H, Hamm JK, Kievit P, Hollenberg AN, Flier JS. Regulated production of a peroxisome proliferator-activated receptor-gamma ligand during an early phase of adipocyte differentiation in 3T3-L1 adipocytes. J Biol Chem. 2004 Aug 20; 279(34):36093-102.
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  47. Shi H, Tzameli I, Bjørbaek C, Flier JS. Suppressor of cytokine signaling 3 is a physiological regulator of adipocyte insulin signaling. J Biol Chem. 2004 Aug 13; 279(33):34733-40.
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  48. Kershaw EE, Flier JS. Adipose tissue as an endocrine organ. J Clin Endocrinol Metab. 2004 Jun; 89(6):2548-56.
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  49. Elmquist JK, Flier JS. Neuroscience. The fat-brain axis enters a new dimension. Science. 2004 Apr 2; 304(5667):63-4.
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  50. Morton NM, Paterson JM, Masuzaki H, Holmes MC, Staels B, Fievet C, Walker BR, Flier JS, Mullins JJ, Seckl JR. Novel adipose tissue-mediated resistance to diet-induced visceral obesity in 11 beta-hydroxysteroid dehydrogenase type 1-deficient mice. Diabetes. 2004 Apr; 53(4):931-8.
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  51. Kelly JF, Elias CF, Lee CE, Ahima RS, Seeley RJ, Bjørbaek C, Oka T, Saper CB, Flier JS, Elmquist JK. Ciliary neurotrophic factor and leptin induce distinct patterns of immediate early gene expression in the brain. Diabetes. 2004 Apr; 53(4):911-20.
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  52. Flier JS. Obesity wars: molecular progress confronts an expanding epidemic. Cell. 2004 Jan 23; 116(2):337-50.
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  53. Masuzaki H, Flier JS. Tissue-specific glucocorticoid reactivating enzyme, 11 beta-hydroxysteroid dehydrogenase type 1 (11 beta-HSD1)--a promising drug target for the treatment of metabolic syndrome. Curr Drug Targets Immune Endocr Metabol Disord. 2003 Dec; 3(4):255-62.
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  54. Segal-Lieberman G, Bradley RL, Kokkotou E, Carlson M, Trombly DJ, Wang X, Bates S, Myers MG, Flier JS, Maratos-Flier E. Melanin-concentrating hormone is a critical mediator of the leptin-deficient phenotype. Proc Natl Acad Sci U S A. 2003 Aug 19; 100(17):10085-90.
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  55. Masuzaki H, Yamamoto H, Kenyon CJ, Elmquist JK, Morton NM, Paterson JM, Shinyama H, Sharp MG, Fleming S, Mullins JJ, Seckl JR, Flier JS. Transgenic amplification of glucocorticoid action in adipose tissue causes high blood pressure in mice. J Clin Invest. 2003 Jul; 112(1):83-90.
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  56. El-Haschimi K, Dufresne SD, Hirshman MF, Flier JS, Goodyear LJ, Bjørbaek C. Insulin resistance and lipodystrophy in mice lacking ribosomal S6 kinase 2. Diabetes. 2003 Jun; 52(6):1340-6.
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  57. Shinyama H, Masuzaki H, Fang H, Flier JS. Regulation of melanocortin-4 receptor signaling: agonist-mediated desensitization and internalization. Endocrinology. 2003 Apr; 144(4):1301-14.
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  58. Flier JS. Physiology: is brain sympathetic to bone? Nature. 2002 Dec 12; 420(6916):619, 621-22.
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  59. Flier JS, Maratos-Flier E. The stomach speaks--ghrelin and weight regulation. N Engl J Med. 2002 May 23; 346(21):1662-3.
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  60. Pierroz DD, Ziotopoulou M, Ungsunan L, Moschos S, Flier JS, Mantzoros CS. Effects of acute and chronic administration of the melanocortin agonist MTII in mice with diet-induced obesity. Diabetes. 2002 May; 51(5):1337-45.
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  61. Sewter C, Berger D, Considine RV, Medina G, Rochford J, Ciaraldi T, Henry R, Dohm L, Flier JS, O'Rahilly S, Vidal-Puig AJ. Human obesity and type 2 diabetes are associated with alterations in SREBP1 isoform expression that are reproduced ex vivo by tumor necrosis factor-alpha. Diabetes. 2002 Apr; 51(4):1035-41.
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  62. Hileman SM, Pierroz DD, Masuzaki H, Bjørbaek C, El-Haschimi K, Banks WA, Flier JS. Characterizaton of short isoforms of the leptin receptor in rat cerebral microvessels and of brain uptake of leptin in mouse models of obesity. Endocrinology. 2002 Mar; 143(3):775-83.
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  63. Masuzaki H, Paterson J, Shinyama H, Morton NM, Mullins JJ, Seckl JR, Flier JS. A transgenic model of visceral obesity and the metabolic syndrome. Science. 2001 Dec 7; 294(5549):2166-70.
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  64. Mantzoros CS, Ozata M, Negrao AB, Suchard MA, Ziotopoulou M, Caglayan S, Elashoff RM, Cogswell RJ, Negro P, Liberty V, Wong ML, Veldhuis J, Ozdemir IC, Gold PW, Flier JS, Licinio J. Synchronicity of frequently sampled thyrotropin (TSH) and leptin concentrations in healthy adults and leptin-deficient subjects: evidence for possible partial TSH regulation by leptin in humans. J Clin Endocrinol Metab. 2001 Jul; 86(7):3284-91.
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  65. Ruderman N, Flier JS. Cell biology. Chewing the fat--ACC and energy balance. Science. 2001 Mar 30; 291(5513):2558-9.
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  66. Spiegelman BM, Flier JS. Obesity and the regulation of energy balance. Cell. 2001 Feb 23; 104(4):531-43.
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  67. Ludwig DS, Tritos NA, Mastaitis JW, Kulkarni R, Kokkotou E, Elmquist J, Lowell B, Flier JS, Maratos-Flier E. Melanin-concentrating hormone overexpression in transgenic mice leads to obesity and insulin resistance. J Clin Invest. 2001 Feb; 107(3):379-86.
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  68. Flier JS. Diabetes. The missing link with obesity? Nature. 2001 Jan 18; 409(6818):292-3.
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  69. Harris M, Aschkenasi C, Elias CF, Chandrankunnel A, Nillni EA, Bjøorbaek C, Elmquist JK, Flier JS, Hollenberg AN. Transcriptional regulation of the thyrotropin-releasing hormone gene by leptin and melanocortin signaling. J Clin Invest. 2001 Jan; 107(1):111-20.
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  70. Bjorbak C, Lavery HJ, Bates SH, Olson RK, Davis SM, Flier JS, Myers MG. SOCS3 mediates feedback inhibition of the leptin receptor via Tyr985. J Biol Chem. 2000 Dec 22; 275(51):40649-57.
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  71. Bjørbaek C, Buchholz RM, Davis SM, Bates SH, Pierroz DD, Gu H, Neel BG, Myers MG, Flier JS. Divergent roles of SHP-2 in ERK activation by leptin receptors. J Biol Chem. 2001 Feb 16; 276(7):4747-55.
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  72. Nillni EA, Vaslet C, Harris M, Hollenberg A, Bjørbak C, Flier JS. Leptin regulates prothyrotropin-releasing hormone biosynthesis. Evidence for direct and indirect pathways. J Biol Chem. 2000 Nov 17; 275(46):36124-33.
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  73. Mantzoros CS, Flier JS. Editorial: leptin as a therapeutic agent--trials and tribulations. J Clin Endocrinol Metab. 2000 Nov; 85(11):4000-2.
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  74. Ziotopoulou M, Mantzoros CS, Hileman SM, Flier JS. Differential expression of hypothalamic neuropeptides in the early phase of diet-induced obesity in mice. Am J Physiol Endocrinol Metab. 2000 Oct; 279(4):E838-45.
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  75. Ahima RS, Flier JS. Adipose tissue as an endocrine organ. Trends Endocrinol Metab. 2000 Oct; 11(8):327-32.
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  76. Kahn BB, Flier JS. Obesity and insulin resistance. J Clin Invest. 2000 Aug; 106(4):473-81.
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  77. Kim YB, Uotani S, Pierroz DD, Flier JS, Kahn BB. In vivo administration of leptin activates signal transduction directly in insulin-sensitive tissues: overlapping but distinct pathways from insulin. Endocrinology. 2000 Jul; 141(7):2328-39.
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  78. Ahima RS, Saper CB, Flier JS, Elmquist JK. Leptin regulation of neuroendocrine systems. Front Neuroendocrinol. 2000 Jul; 21(3):263-307.
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  79. El-Haschimi K, Pierroz DD, Hileman SM, Bjørbaek C, Flier JS. Two defects contribute to hypothalamic leptin resistance in mice with diet-induced obesity. J Clin Invest. 2000 Jun; 105(12):1827-32.
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  80. Hileman SM, Tornøe J, Flier JS, Bjørbaek C. Transcellular transport of leptin by the short leptin receptor isoform ObRa in Madin-Darby Canine Kidney cells. Endocrinology. 2000 Jun; 141(6):1955-61.
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  81. Flier JS, Harris M, Hollenberg AN. Leptin, nutrition, and the thyroid: the why, the wherefore, and the wiring. J Clin Invest. 2000 Apr; 105(7):859-61.
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  82. Flier J, Maratos-Flier E. Energy homeostasis and body weight. Curr Biol. 2000 Mar 23; 10(6):R215-7.
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  83. Hileman SM, Pierroz DD, Flier JS. Leptin, nutrition, and reproduction: timing is everything. J Clin Endocrinol Metab. 2000 Feb; 85(2):804-7.
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  84. Flier JS. Pushing the envelope on lipodystrophy. Nat Genet. 2000 Feb; 24(2):103-4.
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  85. Ahima RS, Flier JS. Leptin. Annu Rev Physiol. 2000; 62:413-37.
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  86. Flier JS, Hollenberg AN. ADD-1 provides major new insight into the mechanism of insulin action. Proc Natl Acad Sci U S A. 1999 Dec 7; 96(25):14191-2.
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  87. Cittadini A, Mantzoros CS, Hampton TG, Travers KE, Katz SE, Morgan JP, Flier JS, Douglas PS. Cardiovascular abnormalities in transgenic mice with reduced brown fat: an animal model of human obesity. Circulation. 1999 Nov 23; 100(21):2177-83.
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  88. Ahima RS, Kelly J, Elmquist JK, Flier JS. Distinct physiologic and neuronal responses to decreased leptin and mild hyperleptinemia. Endocrinology. 1999 Nov; 140(11):4923-31.
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  89. Bjørbaek C, El-Haschimi K, Frantz JD, Flier JS. The role of SOCS-3 in leptin signaling and leptin resistance. J Biol Chem. 1999 Oct 15; 274(42):30059-65.
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  90. Elias CF, Aschkenasi C, Lee C, Kelly J, Ahima RS, Bjorbaek C, Flier JS, Saper CB, Elmquist JK. Leptin differentially regulates NPY and POMC neurons projecting to the lateral hypothalamic area. Neuron. 1999 Aug; 23(4):775-86.
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  91. Tensen CP, Flier J, Rampersad SS, Sampat-Sardjoepersad S, Scheper RJ, Boorsma DM, Willemze R. Genomic organization, sequence and transcriptional regulation of the human CXCL 11(1) gene. Biochim Biophys Acta. 1999 Jul 7; 1446(1-2):167-72.
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  92. Boorsma DM, Flier J, van den Brink EN, Sampat S, Walg HL, Willemze R, Tensen CP, Stoof TJ. IP-10 mRNA expression in cultured keratinocytes is suppressed by inhibition of protein kinase-C and tyrosine kinase and elevation of cAMP. Cytokine. 1999 Jul; 11(7):469-75.
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  93. Flier JS. Big deal about a little insulin. Nat Med. 1999 Jun; 5(6):614-5.
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  94. Ahima RS, Bjorbaek C, Osei S, Flier JS. Regulation of neuronal and glial proteins by leptin: implications for brain development. Endocrinology. 1999 Jun; 140(6):2755-62.
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  95. Tensen CP, Flier J, Van Der Raaij-Helmer EM, Sampat-Sardjoepersad S, Van Der Schors RC, Leurs R, Scheper RJ, Boorsma DM, Willemze R. Human IP-9: A keratinocyte-derived high affinity CXC-chemokine ligand for the IP-10/Mig receptor (CXCR3). J Invest Dermatol. 1999 May; 112(5):716-22.
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  96. Bjørbaek C, Elmquist JK, El-Haschimi K, Kelly J, Ahima RS, Hileman S, Flier JS. Activation of SOCS-3 messenger ribonucleic acid in the hypothalamus by ciliary neurotrophic factor. Endocrinology. 1999 May; 140(5):2035-43.
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  97. Uotani S, Bjørbaek C, Tornøe J, Flier JS. Functional properties of leptin receptor isoforms: internalization and degradation of leptin and ligand-induced receptor downregulation. Diabetes. 1999 Feb; 48(2):279-86.
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  98. Shimada M, Tritos NA, Lowell BB, Flier JS, Maratos-Flier E. Mice lacking melanin-concentrating hormone are hypophagic and lean. Nature. 1998 Dec 17; 396(6712):670-4.
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  99. Tritos NA, Elmquist JK, Mastaitis JW, Flier JS, Maratos-Flier E. Characterization of expression of hypothalamic appetite-regulating peptides in obese hyperleptinemic brown adipose tissue-deficient (uncoupling protein-promoter-driven diphtheria toxin A) mice. Endocrinology. 1998 Nov; 139(11):4634-41.
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  100. Licinio J, Negrão AB, Mantzoros C, Kaklamani V, Wong ML, Bongiorno PB, Negro PP, Mulla A, Veldhuis JD, Cearnal L, Flier JS, Gold PW. Sex differences in circulating human leptin pulse amplitude: clinical implications. J Clin Endocrinol Metab. 1998 Nov; 83(11):4140-7.
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  101. Flier JS. Lowered leptin slims immune response. Nat Med. 1998 Oct; 4(10):1124-5.
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  102. Elmquist JK, Maratos-Flier E, Saper CB, Flier JS. Unraveling the central nervous system pathways underlying responses to leptin. Nat Neurosci. 1998 Oct; 1(6):445-50.
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  103. Roemmich JN, Clark PA, Berr SS, Mai V, Mantzoros CS, Flier JS, Weltman A, Rogol AD. Gender differences in leptin levels during puberty are related to the subcutaneous fat depot and sex steroids. Am J Physiol. 1998 Sep; 275(3 Pt 1):E543-51.
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  104. da Silva BA, Bjørbaek C, Uotani S, Flier JS. Functional properties of leptin receptor isoforms containing the gln-->pro extracellular domain mutation of the fatty rat. Endocrinology. 1998 Sep; 139(9):3681-90.
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  105. Legradi G, Emerson CH, Ahima RS, Rand WM, Flier JS, Lechan RM. Arcuate nucleus ablation prevents fasting-induced suppression of ProTRH mRNA in the hypothalamic paraventricular nucleus. Neuroendocrinology. 1998 Aug; 68(2):89-97.
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  106. Bjørbaek C, Elmquist JK, Michl P, Ahima RS, van Bueren A, McCall AL, Flier JS. Expression of leptin receptor isoforms in rat brain microvessels. Endocrinology. 1998 Aug; 139(8):3485-91.
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  107. Elmquist JK, Bjørbaek C, Ahima RS, Flier JS, Saper CB. Distributions of leptin receptor mRNA isoforms in the rat brain. J Comp Neurol. 1998 Jun 15; 395(4):535-47.
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  108. Boorsma DM, Flier J, Sampat S, Ottevanger C, de Haan P, Hooft L, Willemze R, Tensen CP, Stoof TJ. Chemokine IP-10 expression in cultured human keratinocytes. Arch Dermatol Res. 1998 Jun; 290(6):335-41.
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  109. Flier JS. Clinical review 94: What's in a name? In search of leptin's physiologic role. J Clin Endocrinol Metab. 1998 May; 83(5):1407-13.
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  110. Mantzoros CS, Liolios AD, Tritos NA, Kaklamani VG, Doulgerakis DE, Griveas I, Moses AC, Flier JS. Circulating insulin concentrations, smoking, and alcohol intake are important independent predictors of leptin in young healthy men. Obes Res. 1998 May; 6(3):179-86.
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  111. Ludwig DS, Mountjoy KG, Tatro JB, Gillette JA, Frederich RC, Flier JS, Maratos-Flier E. Melanin-concentrating hormone: a functional melanocortin antagonist in the hypothalamus. Am J Physiol. 1998 Apr; 274(4 Pt 1):E627-33.
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  121. Mantzoros CS, Moschos S, Avramopoulos I, Kaklamani V, Liolios A, Doulgerakis DE, Griveas I, Katsilambros N, Flier JS. Leptin concentrations in relation to body mass index and the tumor necrosis factor-alpha system in humans. J Clin Endocrinol Metab. 1997 Oct; 82(10):3408-13.
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  124. Werman A, Hollenberg A, Solanes G, Bjorbaek C, Vidal-Puig AJ, Flier JS. Ligand-independent activation domain in the N terminus of peroxisome proliferator-activated receptor gamma (PPARgamma). Differential activity of PPARgamma1 and -2 isoforms and influence of insulin. J Biol Chem. 1997 Aug 8; 272(32):20230-5.
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  125. Fajas L, Auboeuf D, Raspé E, Schoonjans K, Lefebvre AM, Saladin R, Najib J, Laville M, Fruchart JC, Deeb S, Vidal-Puig A, Flier J, Briggs MR, Staels B, Vidal H, Auwerx J. The organization, promoter analysis, and expression of the human PPARgamma gene. J Biol Chem. 1997 Jul 25; 272(30):18779-89.
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  126. Erickson JC, Ahima RS, Hollopeter G, Flier JS, Palmiter RD. Endocrine function of neuropeptide Y knockout mice. Regul Pept. 1997 Jun 18; 70(2-3):199-202.
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  127. Vidal-Puig A, Solanes G, Grujic D, Flier JS, Lowell BB. UCP3: an uncoupling protein homologue expressed preferentially and abundantly in skeletal muscle and brown adipose tissue. Biochem Biophys Res Commun. 1997 Jun 9; 235(1):79-82.
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  128. Mantzoros CS, Dunaif A, Flier JS. Leptin concentrations in the polycystic ovary syndrome. J Clin Endocrinol Metab. 1997 Jun; 82(6):1687-91.
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  138. Mantzoros CS, Rosen HN, Greenspan SL, Flier JS, Moses AC. Short-term hyperthyroidism has no effect on leptin levels in man. J Clin Endocrinol Metab. 1997 Feb; 82(2):497-9.
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  140. Sarraf P, Frederich RC, Turner EM, Ma G, Jaskowiak NT, Rivet DJ, Flier JS, Lowell BB, Fraker DL, Alexander HR. Multiple cytokines and acute inflammation raise mouse leptin levels: potential role in inflammatory anorexia. J Exp Med. 1997 Jan 6; 185(1):171-5.
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  144. Spiegelman BM, Flier JS. Adipogenesis and obesity: rounding out the big picture. Cell. 1996 Nov 1; 87(3):377-89.
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  146. Mantzoros CS, Qu D, Frederich RC, Susulic VS, Lowell BB, Maratos-Flier E, Flier JS. Activation of beta(3) adrenergic receptors suppresses leptin expression and mediates a leptin-independent inhibition of food intake in mice. Diabetes. 1996 Jul; 45(7):909-14.
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  147. Vidal-Puig A, Jimenez-Liñan M, Lowell BB, Hamann A, Hu E, Spiegelman B, Flier JS, Moller DE. Regulation of PPAR gamma gene expression by nutrition and obesity in rodents. J Clin Invest. 1996 Jun 1; 97(11):2553-61.
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  148. Moller DE, Chang PY, Yaspelkis BB, Flier JS, Wallberg-Henriksson H, Ivy JL. Transgenic mice with muscle-specific insulin resistance develop increased adiposity, impaired glucose tolerance, and dyslipidemia. Endocrinology. 1996 Jun; 137(6):2397-405.
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  149. Houseknecht KL, Zhu AX, Gnudi L, Hamann A, Zierath JR, Tozzo E, Flier JS, Kahn BB. Overexpression of Ha-ras selectively in adipose tissue of transgenic mice. Evidence for enhanced sensitivity to insulin. J Biol Chem. 1996 May 10; 271(19):11347-55.
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  150. Maffei M, Stoffel M, Barone M, Moon B, Dammerman M, Ravussin E, Bogardus C, Ludwig DS, Flier JS, Talley M, et al. Absence of mutations in the human OB gene in obese/diabetic subjects. Diabetes. 1996 May; 45(5):679-82.
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  151. Zhang B, Graziano MP, Doebber TW, Leibowitz MD, White-Carrington S, Szalkowski DM, Hey PJ, Wu M, Cullinan CA, Bailey P, Lollmann B, Frederich R, Flier JS, Strader CD, Smith RG. Down-regulation of the expression of the obese gene by an antidiabetic thiazolidinedione in Zucker diabetic fatty rats and db/db mice. J Biol Chem. 1996 Apr 19; 271(16):9455-9.
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  152. Ludwig DS, Vidal-Puig A, O'Brien RM, Printz RL, Granner DK, Moller DE, Flier JS. Examination of the phosphoenolpyruvate carboxykinase gene promoter in patients with noninsulin-dependent diabetes mellitus. J Clin Endocrinol Metab. 1996 Feb; 81(2):503-6.
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  153. Gabbay RA, Sutherland C, Gnudi L, Kahn BB, O'Brien RM, Granner DK, Flier JS. Insulin regulation of phosphoenolpyruvate carboxykinase gene expression does not require activation of the Ras/mitogen-activated protein kinase signaling pathway. J Biol Chem. 1996 Jan 26; 271(4):1890-7.
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  154. Hamann A, Flier JS, Lowell BB. Decreased brown fat markedly enhances susceptibility to diet-induced obesity, diabetes, and hyperlipidemia. Endocrinology. 1996 Jan; 137(1):21-9.
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  155. Susulic VS, Frederich RC, Lawitts J, Tozzo E, Kahn BB, Harper ME, Himms-Hagen J, Flier JS, Lowell BB. Targeted disruption of the beta 3-adrenergic receptor gene. J Biol Chem. 1995 Dec 8; 270(49):29483-92.
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  157. Hamann A, Benecke H, Le Marchand-Brustel Y, Susulic VS, Lowell BB, Flier JS. Characterization of insulin resistance and NIDDM in transgenic mice with reduced brown fat. Diabetes. 1995 Nov; 44(11):1266-73.
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  158. Frederich RC, Löllmann B, Hamann A, Napolitano-Rosen A, Kahn BB, Lowell BB, Flier JS. Expression of ob mRNA and its encoded protein in rodents. Impact of nutrition and obesity. J Clin Invest. 1995 Sep; 96(3):1658-63.
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  159. Moses AC, Morrow LA, O'Brien M, Moller DE, Flier JS. Insulin-like growth factor I (rhIGF-I) as a therapeutic agent for hyperinsulinemic insulin-resistant diabetes mellitus. Diabetes Res Clin Pract. 1995 Aug; 28 Suppl:S185-94.
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  160. Hamann A, Mantzoros C, Vidal-Puig A, Flier JS. Genetic variability in the TNF-alpha promoter is not associated with type II diabetes mellitus (NIDDM). Biochem Biophys Res Commun. 1995 Jun 26; 211(3):833-9.
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  164. Zhu AX, Zhao Y, Flier JS. Molecular cloning of two small GTP-binding proteins from human skeletal muscle. Biochem Biophys Res Commun. 1994 Dec 30; 205(3):1875-82.
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  165. Zhu AX, Zhao Y, Moller DE, Flier JS. Cloning and characterization of p97MAPK, a novel human homolog of rat ERK-3. Mol Cell Biol. 1994 Dec; 14(12):8202-11.
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  166. Morrow LA, O'Brien MB, Moller DE, Flier JS, Moses AC. Recombinant human insulin-like growth factor-I therapy improves glycemic control and insulin action in the type A syndrome of severe insulin resistance. J Clin Endocrinol Metab. 1994 Jul; 79(1):205-10.
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  167. Moller DE, Cohen O, Yamaguchi Y, Assiz R, Grigorescu F, Eberle A, Morrow LA, Moses AC, Flier JS. Prevalence of mutations in the insulin receptor gene in subjects with features of the type A syndrome of insulin resistance. Diabetes. 1994 Feb; 43(2):247-55.
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  168. Lowell BB, S-Susulic V, Hamann A, Lawitts JA, Himms-Hagen J, Boyer BB, Kozak LP, Flier JS. Development of obesity in transgenic mice after genetic ablation of brown adipose tissue. Nature. 1993 Dec 23-30; 366(6457):740-2.
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  169. Pang L, Lazar DF, Moller DE, Flier JS, Saltiel AR. The stimulation of pp42mapkinase by insulin does not correlate with its metabolic actions in cells overexpressing mutant insulin receptors. Biochem Biophys Res Commun. 1993 Oct 15; 196(1):301-10.
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  170. Flier JS, Moller DE, Moses AC, O'Rahilly S, Chaiken RL, Grigorescu F, Elahi D, Kahn BB, Weinreb JE, Eastman R. Insulin-mediated pseudoacromegaly: clinical and biochemical characterization of a syndrome of selective insulin resistance. J Clin Endocrinol Metab. 1993 Jun; 76(6):1533-41.
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  171. Yamaguchi Y, Flier JS, Benecke H, Ransil BJ, Moller DE. Ligand-binding properties of the two isoforms of the human insulin receptor. Endocrinology. 1993 Mar; 132(3):1132-8.
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  172. Benecke H, Flier JS, Rosenthal N, Siddle K, Klein HH, Moller DE. Muscle-specific expression of human insulin receptor in transgenic mice. Diabetes. 1993 Jan; 42(1):206-12.
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  173. Flier JS. Lilly Lecture: syndromes of insulin resistance. From patient to gene and back again. Diabetes. 1992 Sep; 41(9):1207-19.
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  174. Osterop AP, Medema RH, Bos JL, vd Zon GC, Moller DE, Flier JS, Möller W, Maassen JA. Relation between the insulin receptor number in cells, autophosphorylation and insulin-stimulated Ras.GTP formation. J Biol Chem. 1992 Jul 25; 267(21):14647-53.
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  175. Benecke H, Flier JS, Moller DE. Alternatively spliced variants of the insulin receptor protein. Expression in normal and diabetic human tissues. J Clin Invest. 1992 Jun; 89(6):2066-70.
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  176. White RT, Damm D, Hancock N, Rosen BS, Lowell BB, Usher P, Flier JS, Spiegelman BM. Human adipsin is identical to complement factor D and is expressed at high levels in adipose tissue. J Biol Chem. 1992 May 5; 267(13):9210-3.
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  177. O'Rahilly S, Krook A, Morgan R, Rees A, Flier JS, Moller DE. Insulin receptor and insulin-responsive glucose transporter (GLUT 4) mutations and polymorphisms in a Welsh type 2 (non-insulin-dependent) diabetic population. Diabetologia. 1992 May; 35(5):486-9.
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  178. Frederich RC, Kahn BB, Peach MJ, Flier JS. Tissue-specific nutritional regulation of angiotensinogen in adipose tissue. Hypertension. 1992 Apr; 19(4):339-44.
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  179. Matthaei S, Hamann A, Klein HH, Benecke H, Kreymann G, Flier JS, Greten H. Evidence that metformin increases insulin-stimulated glucose transport by potentiating insulin-induced translocation of glucose transporters from an intracellular pool to the cell surface in rat adipocytes. Horm Metab Res Suppl. 1992; 26:34-41.
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  180. Choi WH, O'Rahilly S, Buse JB, Rees A, Morgan R, Flier JS, Moller DE. Molecular scanning of insulin-responsive glucose transporter (GLUT4) gene in NIDDM subjects. Diabetes. 1991 Dec; 40(12):1712-8.
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  181. Yamaguchi Y, Flier JS, Yokota A, Benecke H, Backer JM, Moller DE. Functional properties of two naturally occurring isoforms of the human insulin receptor in Chinese hamster ovary cells. Endocrinology. 1991 Oct; 129(4):2058-66.
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  182. Moller DE, Flier JS. Insulin resistance--mechanisms, syndromes, and implications. N Engl J Med. 1991 Sep 26; 325(13):938-48.
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  183. Pedersen O, Kahn CR, Flier JS, Kahn BB. High fat feeding causes insulin resistance and a marked decrease in the expression of glucose transporters (Glut 4) in fat cells of rats. Endocrinology. 1991 Aug; 129(2):771-7.
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  184. Matthaei S, Hamann A, Klein HH, Benecke H, Kreymann G, Flier JS, Greten H. Association of Metformin's effect to increase insulin-stimulated glucose transport with potentiation of insulin-induced translocation of glucose transporters from intracellular pool to plasma membrane in rat adipocytes. Diabetes. 1991 Jul; 40(7):850-7.
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  185. Moller DE, Benecke H, Flier JS. Biologic activities of naturally occurring human insulin receptor mutations. Evidence that metabolic effects of insulin can be mediated by a kinase-deficient insulin receptor mutant. J Biol Chem. 1991 Jun 15; 266(17):10995-1001.
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  186. O'Rahilly S, Choi WH, Patel P, Turner RC, Flier JS, Moller DE. Detection of mutations in insulin-receptor gene in NIDDM patients by analysis of single-stranded conformation polymorphisms. Diabetes. 1991 Jun; 40(6):777-82.
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  187. Napolitano A, Lowell BB, Flier JS. Alterations in sympathetic nervous system activity do not regulate adipsin gene expression in mice. Int J Obes. 1991 Mar; 15(3):227-35.
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  188. Lowell BB, Flier JS. Differentiation dependent biphasic regulation of adipsin gene expression by insulin and insulin-like growth factor-1 in 3T3-F442A adipocytes. Endocrinology. 1990 Dec; 127(6):2898-906.
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  189. Mountjoy KG, Flier JS. Vanadate regulates glucose transporter (Glut-1) expression in NIH3T3 mouse fibroblasts. Endocrinology. 1990 Oct; 127(4):2025-34.
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  190. Moller DE, Yokota A, White MF, Pazianos AG, Flier JS. A naturally occurring mutation of insulin receptor alanine 1134 impairs tyrosine kinase function and is associated with dominantly inherited insulin resistance. J Biol Chem. 1990 Sep 5; 265(25):14979-85.
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  191. Moller DE, Yokota A, Ginsberg-Fellner F, Flier JS. Functional properties of a naturally occurring Trp1200----Ser1200 mutation of the insulin receptor. Mol Endocrinol. 1990 Aug; 4(8):1183-91.
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  192. Pedersen O, Bak JF, Andersen PH, Lund S, Moller DE, Flier JS, Kahn BB. Evidence against altered expression of GLUT1 or GLUT4 in skeletal muscle of patients with obesity or NIDDM. Diabetes. 1990 Jul; 39(7):865-70.
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  193. Mountjoy KG, Moller DE, Flier JS, Holdaway IM. Loss of insulin binding and insulin receptor mRNA in a transformed human fetal fibroblast cell line. Biochem Biophys Res Commun. 1990 Jun 29; 169(3):978-85.
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  194. Kahn BB, Flier JS. Regulation of glucose-transporter gene expression in vitro and in vivo. Diabetes Care. 1990 Jun; 13(6):548-64.
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  195. Thorens B, Flier JS, Lodish HF, Kahn BB. Differential regulation of two glucose transporters in rat liver by fasting and refeeding and by diabetes and insulin treatment. Diabetes. 1990 Jun; 39(6):712-9.
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  196. Nolte MS, Taboga C, Salamon E, Moses A, Longenecker J, Flier J, Karam JH. Biological activity of nasally administered insulin in normal subjects. Horm Metab Res. 1990 Mar; 22(3):170-4.
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  197. Lowell BB, Napolitano A, Usher P, Dulloo AG, Rosen BS, Spiegelman BM, Flier JS. Reduced adipsin expression in murine obesity: effect of age and treatment with the sympathomimetic-thermogenic drug mixture ephedrine and caffeine. Endocrinology. 1990 Mar; 126(3):1514-20.
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  198. Mountjoy KG, Housey GM, Flier JS. Overproduction of the beta 1 form of protein kinase C enhances phorbol ester induction of glucose transporter mRNA. Mol Endocrinol. 1989 Dec; 3(12):2018-27.
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  199. Moller DE, Yokota A, Flier JS. Normal insulin-receptor cDNA sequence in Pima Indians with NIDDM. Diabetes. 1989 Nov; 38(11):1496-500.
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  200. Matsouka PT, Flier JS. Relationship between c-src tyrosine kinase activity and the control of glucose transporter gene expression. Mol Endocrinol. 1989 Nov; 3(11):1845-51.
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  201. Minaker KL, Flier JS, Landsberg L, Young JB, Moxley RT, Kingston WJ, Meneilly GS, Rowe JW. Phenytoin-induced improvement in muscle cramping and insulin action in three patients with the syndrome of insulin resistance, acanthosis nigricans, and acral hypertrophy. Arch Neurol. 1989 Sep; 46(9):981-5.
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  202. Moller DE, Yokota A, Caro JF, Flier JS. Tissue-specific expression of two alternatively spliced insulin receptor mRNAs in man. Mol Endocrinol. 1989 Aug; 3(8):1263-9.
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  203. Kahn BB, Charron MJ, Lodish HF, Cushman SW, Flier JS. Differential regulation of two glucose transporters in adipose cells from diabetic and insulin-treated diabetic rats. J Clin Invest. 1989 Aug; 84(2):404-11.
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  204. Moses AC, Usher P, Ikari N, King PP, Tramontano D, Flier JS. Multiple factors influence insulin-like growth factor-I binding to human skin fibroblasts. Endocrinology. 1989 Aug; 125(2):867-75.
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  205. Wang PH, Moller D, Flier JS, Nayak RC, Smith RJ. Coordinate regulation of glucose transporter function, number, and gene expression by insulin and sulfonylureas in L6 rat skeletal muscle cells. J Clin Invest. 1989 Jul; 84(1):62-7.
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  206. Spiegelman BM, Lowell B, Napolitano A, Dubuc P, Barton D, Francke U, Groves DL, Cook KS, Flier JS. Adrenal glucocorticoids regulate adipsin gene expression in genetically obese mice. J Biol Chem. 1989 Jan 25; 264(3):1811-5.
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  207. Kahn BB, Cushman SW, Flier JS. Regulation of glucose transporter-specific mRNA levels in rat adipose cells with fasting and refeeding. Implications for in vivo control of glucose transporter number. J Clin Invest. 1989 Jan; 83(1):199-204.
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  208. Flier JS, Lowell B, Napolitano A, Usher P, Rosen B, Cook KS, Spiegelman B. Adipsin: regulation and dysregulation in obesity and other metabolic states. Recent Prog Horm Res. 1989; 45:567-80; discussion 580-1.
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  209. Moller DE, Flier JS. Detection of an alteration in the insulin-receptor gene in a patient with insulin resistance, acanthosis nigricans, and the polycystic ovary syndrome (type A insulin resistance). N Engl J Med. 1988 Dec 8; 319(23):1526-9.
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  210. Rollins BJ, Morrison ED, Usher P, Flier JS. Platelet-derived growth factor regulates glucose transporter expression. J Biol Chem. 1988 Nov 15; 263(32):16523-6.
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  212. Ikari N, Yoshino H, Moses AC, Flier JS. Evidence that receptor aggregation may play a role in transmembrane signaling through the insulin-like growth factor-I receptor. Mol Endocrinol. 1988 Sep; 2(9):831-7.
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  213. Minaker KL, Meneilly GS, Flier JS, Rowe JW. Insulin-mediated hypokalemia and paralysis in familial hypokalemic periodic paralysis. Am J Med. 1988 Jun; 84(6):1001-6.
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  214. Porestsky L, Levesque L, Seibel MM, Smith D, Pazianos A, Hurd J, Aretz T, Flier J. Characteristics of in vitro steroidogenesis in a woman with hyperandrogenism, a granulosa cell tumor and polycystic ovary disease. A case report. J Reprod Med. 1988 Apr; 33(4):377-81.
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  215. Cook KS, Min HY, Johnson D, Chaplinsky RJ, Flier JS, Hunt CR, Spiegelman BM. Adipsin: a circulating serine protease homolog secreted by adipose tissue and sciatic nerve. Science. 1987 Jul 24; 237(4813):402-5.
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  217. Longenecker JP, Moses AC, Flier JS, Silver RD, Carey MC, Dubovi EJ. Effects of sodium taurodihydrofusidate on nasal absorption of insulin in sheep. J Pharm Sci. 1987 May; 76(5):351-5.
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  218. Flier JS, Mueckler MM, Usher P, Lodish HF. Elevated levels of glucose transport and transporter messenger RNA are induced by ras or src oncogenes. Science. 1987 Mar 20; 235(4795):1492-5.
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  219. Flier JS, Mueckler M, McCall AL, Lodish HF. Distribution of glucose transporter messenger RNA transcripts in tissues of rat and man. J Clin Invest. 1987 Feb; 79(2):657-61.
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  220. Gates GS, Bayer S, Seibel M, Poretsky L, Flier JS, Moses AC. Characterization of insulin-like growth factor binding to human granulosa cells obtained during in vitro fertilization. J Recept Res. 1987; 7(6):885-902.
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  221. Chaiken RL, Moses AC, Usher P, Flier JS. Insulin stimulation of aminoisobutyric acid transport in human skin fibroblasts is mediated through both insulin and type I insulin-like growth factor receptors. J Clin Endocrinol Metab. 1986 Nov; 63(5):1181-5.
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  222. Grigorescu F, Flier JS, Kahn CR. Characterization of binding and phosphorylation defects of erythrocyte insulin receptors in the type A syndrome of insulin resistance. Diabetes. 1986 Feb; 35(2):127-38.
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  223. Flier JS, Usher P, Moses AC. Monoclonal antibody to the type I insulin-like growth factor (IGF-I) receptor blocks IGF-I receptor-mediated DNA synthesis: clarification of the mitogenic mechanisms of IGF-I and insulin in human skin fibroblasts. Proc Natl Acad Sci U S A. 1986 Feb; 83(3):664-8.
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  224. Gordon GS, Moses AC, Silver RD, Flier JS, Carey MC. Nasal absorption of insulin: enhancement by hydrophobic bile salts. Proc Natl Acad Sci U S A. 1985 Nov; 82(21):7419-23.
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  225. Poretsky L, Grigorescu F, Seibel M, Moses AC, Flier JS. Distribution and characterization of insulin and insulin-like growth factor I receptors in normal human ovary. J Clin Endocrinol Metab. 1985 Oct; 61(4):728-34.
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  226. Dunaif A, Hoffman AR, Scully RE, Flier JS, Longcope C, Levy LJ, Crowley WF. Clinical, biochemical, and ovarian morphologic features in women with acanthosis nigricans and masculinization. Obstet Gynecol. 1985 Oct; 66(4):545-52.
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  227. Flier JS, Moses AC. Characterization of monoclonal antibodies to the IGF-I receptor that inhibit IGF-I binding to human cells. Biochem Biophys Res Commun. 1985 Mar 29; 127(3):929-36.
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  228. Flier JS, Eastman RC, Minaker KL, Matteson D, Rowe JW. Acanthosis nigricans in obese women with hyperandrogenism. Characterization of an insulin-resistant state distinct from the type A and B syndromes. Diabetes. 1985 Feb; 34(2):101-7.
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  229. Flier JS. Metabolic importance of acanthosis nigricans. Arch Dermatol. 1985 Feb; 121(2):193-4.
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  230. Grigorescu F, Flier JS, Kahn CR. Defect in insulin receptor phosphorylation in erythrocytes and fibroblasts associated with severe insulin resistance. J Biol Chem. 1984 Dec 25; 259(24):15003-6.
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  231. Poretsky L, Smith D, Seibel M, Pazianos A, Moses AC, Flier JS. Specific insulin binding sites in human ovary. J Clin Endocrinol Metab. 1984 Oct; 59(4):809-11.
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  232. Izumo H, Izumo S, DeLuise M, Flier JS. Erythrocyte Na,K pump in uremia. Acute correction of a transport defect by hemodialysis. J Clin Invest. 1984 Aug; 74(2):581-8.
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  233. Moses AC, Gordon GS, Carey MC, Flier JS. Insulin administered intranasally as an insulin-bile salt aerosol. Effectiveness and reproducibility in normal and diabetic subjects. Diabetes. 1983 Nov; 32(11):1040-7.
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  234. Rowe JW, Minaker KL, Pallotta JA, Flier JS. Characterization of the insulin resistance of aging. J Clin Invest. 1983 Jun; 71(6):1581-7.
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  235. DeLuise M, Izumo H, Grace EE, Flier JS. Effect of diet upon the erythrocyte Na,K pump. J Clin Endocrinol Metab. 1983 Apr; 56(4):739-43.
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  236. Flier JS. Insulin receptors and insulin resistance. Annu Rev Med. 1983; 34:145-60.
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  237. Flier JS, Minaker KL, Landsberg L, Young JB, Pallotta J, Rowe JW. Impaired in vivo insulin clearance in patients with severe target-cell resistance to insulin. Diabetes. 1982 Feb; 31(2):132-5.
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  238. DeLuise M, Flier JS. Functionally abnormal Na+-K+ pump in erythrocytes of a morbidly obese patient. J Clin Invest. 1982 Jan; 69(1):38-44.
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  239. Flier JS, Usher P, Deluise M. Effect of sucrose overfeeding on Na,K-ATPase-mediated 86Rb uptake in normal and ob/ob mice. Diabetes. 1981 Nov; 30(11):975-8.
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  240. Nathan DM, Axelrod L, Flier JS, Carr DB. U-500 insulin in the treatment of antibody-mediated insulin resistance. Ann Intern Med. 1981 May; 94(5):653-6.
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  241. Wachslicht-Rodbard H, Muggeo M, Kahn CR, Saviolakis GA, Harrison LC, Flier JS. Heterogeneity of the insulin-receptor interaction in lipoatropic diabetes. J Clin Endocrinol Metab. 1981 Mar; 52(3):416-25.
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  242. Kahn CR, Baird KL, Flier JS, Grunfeld C, Harmon JT, Harrison LC, Karlsson FA, Kasuga M, King GL, Lang UC, Podskalny JM, Van Obberghen E. Insulin receptors, receptor antibodies, and the mechanism of insulin action. Recent Prog Horm Res. 1981; 37:477-538.
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  243. Flier JS. Principles of receptor identification. Adv Biochem Psychopharmacol. 1981; 28:109-16.
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  244. Flier J. Diseases caused by antibodies to receptors. Clin Immunol Rev. 1981-1982; 1(2):215-56.
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  245. De Luise M, Blackburn GL, Flier JS. Reduced activity of the red-cell sodium-potassium pump in human obesity. N Engl J Med. 1980 Oct 30; 303(18):1017-22.
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  246. Flier JS, Young JB, Landsberg L. Familial insulin resistance with acanthosis nigricans, acral hypertrophy, and muscle cramps. N Engl J Med. 1980 Oct 23; 303(17):970-3.
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  247. Roth J, Lesniak MA, Bar RS, Muggeo M, Megyesi K, Harrison LC, Flier JS, Wachslicht-Rodbard H, Gorden P. An introduction to receptors and receptor disorders. Proc Soc Exp Biol Med. 1979 Oct; 162(1):3-12.
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  248. Muggeo M, Kahn CR, Bar RS, Rechler M, Flier JS, Roth J. The underlying insulin receptor in patients with antireceptor autoantibodies: demonstration of normal binding and immunological properties. J Clin Endocrinol Metab. 1979 Jul; 49(1):110-9.
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  249. Flier JS, Maratos-Flier E, Pallotta JA, McIsaac D. Endogenous digitalis-like activity in the plasma of the toad Bufo marinus. Nature. 1979 May 24; 279(5711):341-3.
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  250. Baldwin D, Winston E, Hoshizaki RJ, Garland JT, Baldwin D, Holcomb HH, Flier JS, Rubenstein A. Insulin-resistant diabetes with insulin receptor autoantibodies in a male patient without acanghosis nigricans. Diabetes Care. 1979 May-Jun; 2(3):275-7.
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  251. Muggeo M, Flier JS, Abrams RA, Harrison LC, Deisserroth AB, Kahn CR. Treatment by plasma exchange of a patient with autoantibodies to the insulin receptor. N Engl J Med. 1979 Mar 1; 300(9):477-80.
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  252. Flier JS, Kahn CR, Roth J. Receptors, antireceptor antibodies and mechanisms of insulin resistance. N Engl J Med. 1979 Feb 22; 300(8):413-9.
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  253. Harrison LC, Flier J, Itin A, Kahn CR, Roth J. Radioimmunoassay of the insulin receptor: a new probe of receptor structure and function. Science. 1979 Feb 9; 203(4380):544-7.
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  254. Harrison LC, Flier JS, Roth J, Karlsson FA, Kahn CR. Immunoprecipitation of the insulin receptor: a sensitive assay for receptor antibodies and a specific technique for receptor purification. J Clin Endocrinol Metab. 1979 Jan; 48(1):59-65.
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  255. Flier JS, Bar RS, Muggeo M, Kahn CR, Roth J, Gorden P. The evolving clinical course of patients with insulin receptor autoantibodies: spontaneous remission or receptor proliferation with hypoglycemia. J Clin Endocrinol Metab. 1978 Nov; 47(5):985-95.
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  256. Kahn CR, Baird KL, Jarrett DB, Flier JS. Direct demonstration that receptor crosslinking or aggregation is important in insulin action. Proc Natl Acad Sci U S A. 1978 Sep; 75(9):4209-13.
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  257. Le Marchand-Brustel Y, Gorden P, Flier JS, Kahn CR, Freychet P. Anti-insulin receptor antibodies inhibit insulin binding and stimulate glucose metabolism in skeletal muscle. Diabetologia. 1978 May; 14(5):311-7.
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  258. Flier JS, Kahn CR, Jarrett DB, Roth J. Autoantibodies to the insulin receptor. Effect on the insulin-receptor interaction in IM-9 lymphocytes. J Clin Invest. 1977 Oct; 60(4):784-94.
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  259. Kahn CR, Megyesi K, Bar RS, Eastman RC, Flier JS. Receptors for peptide hormones. New insights into the pathophysiology of disease states in man. Ann Intern Med. 1977 Feb; 86(2):205-19.
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  260. Flier JS, Kahn CR, Jarrett DB, Roth J. Characterization of antibodies to the insulin receptor: a cause of insulin-resistant diabetes in man. J Clin Invest. 1976 Dec; 58(6):1442-9.
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  261. Jarrett DB, Roth J, Kahn CR, Flier JS. Direct method for detection and characterization of cell surface receptors for insulin by means of 125I-labeled autoantibodies against the insulin receptor. Proc Natl Acad Sci U S A. 1976 Nov; 73(11):4115-9.
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  262. Kahn CR, Flier JS, Bar RS, Archer JA, Gorden P, Martin MM, Roth J. The syndromes of insulin resistance and acanthosis nigricans. Insulin-receptor disorders in man. N Engl J Med. 1976 Apr 1; 294(14):739-45.
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  263. Flier JS, Kahn CR, Jarrett DB, Roth J. The immunology of the insulin receptor. Immunol Commun. 1976; 5(5):361-73.
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  264. Flier JS, Kahn CR, Roth J, Bar RS. Antibodies that impair insulin receptor binding in an unusual diabetic syndrome with severe insulin resistance. Science. 1975 Oct 3; 190(4209):63-5.
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  265. Flier JS. Immunosuppression by alpha blockade. N Engl J Med. 1971 May 20; 284(20):1159-60.
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