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Patrick Sips, Ph.D.

TitleInstructor in Medicine
InstitutionBrigham and Women's Hospital
DepartmentMedicine
AddressBrigham and Women's Hospital
Cardiovascular Medicine, Thorn 1123
75 Francis St
Boston MA 02115
Phone857/307-0307
Fax857/307-0300

 Bibliographic 
 selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Sips PY, Buys ES. Genetic modification of hypertension by sGCa1. Trends Cardiovasc Med. 2013 Nov; 23(8):312-8.
    View in: PubMed
  2. Sips PY, Irie T, Zou L, Shinozaki S, Sakai M, Shimizu N, Nguyen R, Stamler JS, Chao W, Kaneki M, Ichinose F. Reduction of cardiomyocyte S-nitrosylation by S-nitrosoglutathione reductase protects against sepsis-induced myocardial depression. Am J Physiol Heart Circ Physiol. 2013 Apr; 304(8):H1134-46.
    View in: PubMed
  3. Thoonen R, Sips PY, Bloch KD, Buys ES. Pathophysiology of Hypertension in the Absence of Nitric Oxide/Cyclic GMP Signaling. Curr Hypertens Rep. 2013 Feb; 15(1):47-58.
    View in: PubMed
  4. Buys ES, Raher MJ, Kirby A, Shahid M, Mohd S, Baron DM, Hayton SR, Tainsh LT, Sips PY, Rauwerdink KM, Yan Q, Tainsh RE, Shakartzi HR, Stevens C, Decaluwé K, Rodrigues-Machado Mda G, Malhotra R, Van de Voorde J, Wang T, Brouckaert P, Daly MJ, Bloch KD. Genetic modifiers of hypertension in soluble guanylate cyclase a1-deficient mice. J Clin Invest. 2012 Jun 1; 122(6):2316-25.
    View in: PubMed
  5. Minamishima S, Kida K, Tokuda K, Wang H, Sips PY, Kosugi S, Mandeville JB, Buys ES, Brouckaert P, Liu PK, Liu CH, Bloch KD, Ichinose F. Inhaled nitric oxide improves outcomes after successful cardiopulmonary resuscitation in mice. Circulation. 2011 Oct 11; 124(15):1645-53.
    View in: PubMed
  6. Sips PY, Brouckaert P, Ichinose F. The alpha1 isoform of soluble guanylate cyclase regulates cardiac contractility but is not required for ischemic preconditioning. Basic Res Cardiol. 2011 Jun; 106(4):635-43.
    View in: PubMed
  7. Vermeersch P, Buys E, Sips P, Pokreisz P, Marsboom G, Gillijns H, Pellens M, Dewerchin M, Bloch KD, Brouckaert P, Janssens S. Gender-specific modulation of the response to arterial injury by soluble guanylate cyclase a1. Open Cardiovasc Med J. 2009; 3:98-104.
    View in: PubMed
  8. Minamishima S, Bougaki M, Sips PY, Yu JD, Minamishima YA, Elrod JW, Lefer DJ, Bloch KD, Ichinose F. Hydrogen sulfide improves survival after cardiac arrest and cardiopulmonary resuscitation via a nitric oxide synthase 3-dependent mechanism in mice. Circulation. 2009 Sep 8; 120(10):888-96.
    View in: PubMed
  9. Buys ES, Cauwels A, Raher MJ, Passeri JJ, Hobai I, Cawley SM, Rauwerdink KM, Thibault H, Sips PY, Thoonen R, Scherrer-Crosbie M, Ichinose F, Brouckaert P, Bloch KD. sGC(alpha)1(beta)1 attenuates cardiac dysfunction and mortality in murine inflammatory shock models. Am J Physiol Heart Circ Physiol. 2009 Aug; 297(2):H654-63.
    View in: PubMed
  10. Nishida T, Yu JD, Minamishima S, Sips PY, Searles RJ, Buys ES, Janssens S, Brouckaert P, Bloch KD, Ichinose F. Protective effects of nitric oxide synthase 3 and soluble guanylate cyclase on the outcome of cardiac arrest and cardiopulmonary resuscitation in mice. Crit Care Med. 2009 Jan; 37(1):256-62.
    View in: PubMed
  11. Dhaese I, Vanneste G, Sips P, Buys ES, Brouckaert P, Lefebvre RA. Small intestinal motility in soluble guanylate cyclase alpha1 knockout mice: (Jejunal phenotyping of sGCalpha1 knockout mice). Naunyn Schmiedebergs Arch Pharmacol. 2009 May; 379(5):473-87.
    View in: PubMed
  12. De Backer O, Elinck E, Sips P, Buys E, Brouckaert P, Lefebvre RA. Role of the soluble guanylyl cyclase alpha1/alpha2 subunits in the relaxant effect of CO and CORM-2 in murine gastric fundus. Naunyn Schmiedebergs Arch Pharmacol. 2008 Nov; 378(5):493-502.
    View in: PubMed
  13. Dhaese I, Vanneste G, Sips P, Buys E, Brouckaert P, Lefebvre RA. Involvement of soluble guanylate cyclase alpha(1) and alpha(2), and SK(Ca) channels in NANC relaxation of mouse distal colon. Eur J Pharmacol. 2008 Jul 28; 589(1-3):251-9.
    View in: PubMed
  14. Buys ES, Sips P, Vermeersch P, Raher MJ, Rogge E, Ichinose F, Dewerchin M, Bloch KD, Janssens S, Brouckaert P. Gender-specific hypertension and responsiveness to nitric oxide in sGCalpha1 knockout mice. Cardiovasc Res. 2008 Jul 1; 79(1):179-86.
    View in: PubMed
  15. Nimmegeers S, Sips P, Buys E, Decaluwé K, Brouckaert P, Van de Voorde J. Role of the soluble guanylyl cyclase alpha1-subunit in mice corpus cavernosum smooth muscle relaxation. Int J Impot Res. 2008 May-Jun; 20(3):278-84.
    View in: PubMed
  16. Vanneste G, Dhaese I, Sips P, Buys E, Brouckaert P, Lefebvre RA. Gastric motility in soluble guanylate cyclase alpha 1 knock-out mice. J Physiol. 2007 Nov 1; 584(Pt 3):907-20.
    View in: PubMed
  17. Vermeersch P, Buys E, Pokreisz P, Marsboom G, Ichinose F, Sips P, Pellens M, Gillijns H, Swinnen M, Graveline A, Collen D, Dewerchin M, Brouckaert P, Bloch KD, Janssens S. Soluble guanylate cyclase-alpha1 deficiency selectively inhibits the pulmonary vasodilator response to nitric oxide and increases the pulmonary vascular remodeling response to chronic hypoxia. Circulation. 2007 Aug 21; 116(8):936-43.
    View in: PubMed
  18. Nimmegeers S, Sips P, Buys E, Brouckaert P, Van de Voorde J. Functional role of the soluble guanylyl cyclase alpha(1) subunit in vascular smooth muscle relaxation. Cardiovasc Res. 2007 Oct 1; 76(1):149-59.
    View in: PubMed
  19. Bultinck J, Sips P, Vakaet L, Brouckaert P, Cauwels A. Systemic NO production during (septic) shock depends on parenchymal and not on hematopoietic cells: in vivo iNOS expression pattern in (septic) shock. FASEB J. 2006 Nov; 20(13):2363-5.
    View in: PubMed
  20. Cauwels A, Janssen B, Buys E, Sips P, Brouckaert P. Anaphylactic shock depends on PI3K and eNOS-derived NO. J Clin Invest. 2006 Aug; 116(8):2244-51.
    View in: PubMed
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