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Peter Gerner, M.D.

TitleAssociate Professor of Anaesthesia
InstitutionBrigham and Women's Hospital
DepartmentAnaesthesia
AddressBrigham and Women's Hospital
Anaesthesia
75 Francis St
Boston MA 02115
Phone617/732-8215
Fax617/582-6195

 Bibliographic 
 selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Djalali AG, Wang JC, Perez-Valdivieso JR, Danninger T, Fritsch G, Zurakowski D, Gerner P. Ephedrine shows synergistic motor blockade when combined with bupivacaine or lidocaine for spinal anesthesia in a rat model. Anesth Analg. 2013 Apr; 116(4):944-8.
    View in: PubMed
  2. Picardi S, Cartellieri S, Groves D, Hahnenekamp K, Gerner P, Durieux ME, Stevens MF, Lirk P, Hollmann MW. Local anesthetic-induced inhibition of human neutrophil priming: the influence of structure, lipophilicity, and charge. Reg Anesth Pain Med. 2013 Jan; 38(1):9-15.
    View in: PubMed
  3. Stundner O, Kirksey M, Chiu YL, Mazumdar M, Poultsides L, Gerner P, Memtsoudis SG. Demographics and perioperative outcome in patients with depression and anxiety undergoing total joint arthroplasty: a population-based study. Psychosomatics. 2013 Mar; 54(2):149-57.
    View in: PubMed
  4. Stundner O, Chiu YL, Sun X, Mazumdar M, Fleischut P, Poultsides L, Gerner P, Fritsch G, Memtsoudis SG. Comparative perioperative outcomes associated with neuraxial versus general anesthesia for simultaneous bilateral total knee arthroplasty. Reg Anesth Pain Med. 2012 Nov-Dec; 37(6):638-44.
    View in: PubMed
  5. Lirk P, Flatz M, Haller I, Hausott B, Blumenthal S, Stevens MF, Suzuki S, Klimaschewski L, Gerner P. In Zucker diabetic fatty rats, subclinical diabetic neuropathy increases in vivo lidocaine block duration but not in vitro neurotoxicity. Reg Anesth Pain Med. 2012 Nov-Dec; 37(6):601-6.
    View in: PubMed
  6. Kirksey M, Chiu YL, Ma Y, Della Valle AG, Poultsides L, Gerner P, Memtsoudis SG. Trends in in-hospital major morbidity and mortality after total joint arthroplasty: United States 1998-2008. Anesth Analg. 2012 Aug; 115(2):321-7.
    View in: PubMed
  7. Memtsoudis SG, Pumberger M, Ma Y, Chiu YL, Fritsch G, Gerner P, Poultsides L, Valle AG. Epidemiology and risk factors for perioperative mortality after total hip and knee arthroplasty. J Orthop Res. 2012 Nov; 30(11):1811-21.
    View in: PubMed
  8. Edrich T, Pomahac B, Lu JT, Couper GS, Gerner P. Perioperative management of partial face transplantation involving a heparin antibody-positive donor. J Clin Anesth. 2011 Jun; 23(4):318-21.
    View in: PubMed
  9. Colvin AC, Wang CF, Soens MA, Mitani AA, Strichartz G, Gerner P. Prolonged cutaneous analgesia with transdermal application of amitriptyline and capsaicin. Reg Anesth Pain Med. 2011 May-Jun; 36(3):236-40.
    View in: PubMed
  10. Wang CF, Pancaro C, Gerner P, Strichartz G. Prolonged suppression of postincisional pain by a slow-release formulation of lidocaine. Anesthesiology. 2011 Jan; 114(1):135-49.
    View in: PubMed
  11. Gerner P, Wang CF, Lee BS, Suzuki S, Degirolami U, Gandhi A, Knaack D, Strichartz G. The relationship between functional sciatic nerve block duration and the rate of release of lidocaine from a controlled-release matrix. Anesth Analg. 2010 Jul; 111(1):221-9.
    View in: PubMed
  12. Hung YC, Suzuki S, Huang CJ, Chen CC, Pan YY, Wang CF, Srinavasan V, Gerner P. Resiniferatoxin combined with antidepressants preferentially prolongs sensory/nociceptive block in rat sciatic nerve. Anesth Analg. 2010 Jul; 111(1):207-13.
    View in: PubMed
  13. Charles Vacanti, Scott Segal, Pankaj Sikka, Richard Urman, Peter Gerner. Local anesthetics agents. Essential Clinical Anesthesia. 2009.
  14. Shin JW, Pancaro C, Wang CF, Gerner P. The effects of resiniferatoxin in an experimental rat thoracotomy model. Anesth Analg. 2010 Jan 1; 110(1):228-32.
    View in: PubMed
  15. Gerner P. "Above all, do no harm": hippocrates. Anesthesiology. 2009 Nov; 111(5):938-9.
    View in: PubMed
  16. Hung YC, Suzuki S, Chen CC, Pan YY, Wang TY, Cheng JK, Wang GK, Gerner P. Calcium chloride prolongs the effects of lidocaine and bupivacaine in rat sciatic nerve. Reg Anesth Pain Med. 2009 Jul-Aug; 34(4):333-9.
    View in: PubMed
  17. Binshtok AM, Gerner P, Oh SB, Puopolo M, Suzuki S, Roberson DP, Herbert T, Wang CF, Kim D, Chung G, Mitani AA, Wang GK, Bean BP, Woolf CJ. Coapplication of lidocaine and the permanently charged sodium channel blocker QX-314 produces a long-lasting nociceptive blockade in rodents. Anesthesiology. 2009 Jul; 111(1):127-37.
    View in: PubMed
  18. Wang CF, Djalali AG, Gandhi A, Knaack D, De Girolami U, Strichartz G, Gerner P. An absorbable local anesthetic matrix provides several days of functional sciatic nerve blockade. Anesth Analg. 2009 Mar; 108(3):1027-33.
    View in: PubMed
  19. Charles Vacanti, Scott Segal, Pankaj Sikka, Richard Urman, Gerner P. . Pharmacokinetics and pharmacodynamcis of local anesthetics. Essential Clinical Anesthesia. 2009.
  20. Shin JW, Pancaro C, Wang CF, Gerner P. Low-dose systemic bupivacaine prevents the development of allodynia after thoracotomy in rats. Anesth Analg. 2008 Nov; 107(5):1587-91.
    View in: PubMed
  21. Gerner P, Binshtok AM, Wang CF, Hevelone ND, Bean BP, Woolf CJ, Wang GK. Capsaicin combined with local anesthetics preferentially prolongs sensory/nociceptive block in rat sciatic nerve. Anesthesiology. 2008 Nov; 109(5):872-8.
    View in: PubMed
  22. Wang CF, Gerner P, Schmidt B, Xu ZZ, Nau C, Wang SY, Ji RR, Wang GK. Use of bulleyaconitine A as an adjuvant for prolonged cutaneous analgesia in the rat. Anesth Analg. 2008 Oct; 107(4):1397-405.
    View in: PubMed
  23. Gerner P. Postthoracotomy pain management problems. Anesthesiol Clin. 2008 Jun; 26(2):355-67, vii.
    View in: PubMed
  24. Lirk P, Haller I, Colvin HP, Lang L, Tomaselli B, Klimaschewski L, Gerner P. In vitro, inhibition of mitogen-activated protein kinase pathways protects against bupivacaine- and ropivacaine-induced neurotoxicity. Anesth Analg. 2008 May; 106(5):1456-64, table of contents.
    View in: PubMed
  25. Gerner P, Strichartz GR. Sensory and motor complications of local anesthetics. Muscle Nerve. 2008 Apr; 37(4):421-5.
    View in: PubMed
  26. Gerner P, O'Connor JP. Impact of analgesia on bone fracture healing. Anesthesiology. 2008 Mar; 108(3):349-50.
    View in: PubMed
  27. Lirk P, Haller I, Colvin HP, Frauscher S, Kirchmair L, Gerner P, Klimaschewski L. In vitro, lidocaine-induced axonal injury is prevented by peripheral inhibition of the p38 mitogen-activated protein kinase, but not by inhibiting caspase activity. Anesth Analg. 2007 Dec; 105(6):1657-64, table of contents.
    View in: PubMed
  28. Pomahac B, Zuhaili B, Kudsi Y, Bleiziffer O, Velander P, Eriksson E, Gerner P. Safety evaluation of topically applied amitriptyline in porcine full-thickness wounds. Reg Anesth Pain Med. 2007 Sep-Oct; 32(5):377-81.
    View in: PubMed
  29. Wang CF, Gerner P, Wang SY, Wang GK. Bulleyaconitine A isolated from aconitum plant displays long-acting local anesthetic properties in vitro and in vivo. Anesthesiology. 2007 Jul; 107(1):82-90.
    View in: PubMed
  30. Hung YC, Chen CY, Lirk P, Wang CF, Cheng JK, Chen CC, Wang GK, Gerner P. Magnesium sulfate diminishes the effects of amide local anesthetics in rat sciatic-nerve block. Reg Anesth Pain Med. 2007 Jul-Aug; 32(4):288-95.
    View in: PubMed
  31. Fridrich P, Colvin HP, Zizza A, Wasan AD, Lukanich J, Lirk P, Saria A, Zernig G, Hamp T, Gerner P. Phase 1A safety assessment of intravenous amitriptyline. J Pain. 2007 Jul; 8(7):549-55.
    View in: PubMed
  32. Haller I, Lirk P, Keller C, Wang GK, Gerner P, Klimaschewski L. Differential neurotoxicity of tricyclic antidepressants and novel derivatives in vitro in a dorsal root ganglion cell culture model. Eur J Anaesthesiol. 2007 Aug; 24(8):702-8.
    View in: PubMed
  33. Ng JM & Gerner P. Mediastinal mass and Bronchopleural fistula. Essential Clinical Anesthesia. 2007.
  34. Haller I, Hausott B, Tomaselli B, Keller C, Klimaschewski L, Gerner P, Lirk P. Neurotoxicity of lidocaine involves specific activation of the p38 mitogen-activated protein kinase, but not extracellular signal-regulated or c-jun N-terminal kinases, and is mediated by arachidonic acid metabolites. Anesthesiology. 2006 Nov; 105(5):1024-33.
    View in: PubMed
  35. Wang GK, Gerner P. Antidepressants and their analogues as long-acting local anesthetics and analgesics. 2006.
  36. Sheets PL, Gerner P, Wang CF, Wang SY, Wang GK, Cummins TR. Inhibition of Nav1.7 and Nav1.4 sodium channels by trifluoperazine involves the local anesthetic receptor. J Neurophysiol. 2006 Oct; 96(4):1848-59.
    View in: PubMed
  37. Lirk P, Haller I, Myers RR, Klimaschewski L, Kau YC, Hung YC, Gerner P. Mitigation of direct neurotoxic effects of lidocaine and amitriptyline by inhibition of p38 mitogen-activated protein kinase in vitro and in vivo. Anesthesiology. 2006 Jun; 104(6):1266-73.
    View in: PubMed
  38. Lirk P, Haller I, Hausott B, Ingorokva S, Deibl M, Gerner P, Klimaschewski L. The neurotoxic effects of amitriptyline are mediated by apoptosis and are effectively blocked by inhibition of caspase activity. Anesth Analg. 2006 Jun; 102(6):1728-33.
    View in: PubMed
  39. Amir R, Argoff CE, Bennett GJ, Cummins TR, Durieux ME, Gerner P, Gold MS, Porreca F, Strichartz GR. The role of sodium channels in chronic inflammatory and neuropathic pain. J Pain. 2006 May; 7(5 Suppl 3):S1-29.
    View in: PubMed
  40. Gerner P, Srinivasa V, Zizza AM, Zhuang ZY, Luo S, Zurakowski D, Eappen S, Wang G. Doxepin by topical application and intrathecal route in rats. Anesth Analg. 2006 Jan; 102(1):283-7.
    View in: PubMed
  41. Kau YC, Hung YC, Zizza AM, Zurakowski D, Greco WR, Wang GK, Gerner P. Efficacy of lidocaine or bupivacaine combined with ephedrine in rat sciatic nerve block. Reg Anesth Pain Med. 2006 Jan-Feb; 31(1):14-8.
    View in: PubMed
  42. Peter Gerner, Ging Kuo Wang . Mechanisms of tricyclic antidepressants in pain modulation. Translational Pain Research, Mao J. editor. 2006; 2:189-206.
  43. Hung YC, Kau YC, Zizza AM, Edrich T, Zurakowski D, Myers RR, Wang GK, Gerner P. Ephedrine blocks rat sciatic nerve in vivo and sodium channels in vitro. Anesthesiology. 2005 Dec; 103(6):1246-52.
    View in: PubMed
  44. Peter Gerner, Thomas Edrich. Pharmacology of Local Anesthetics. Interventional Spine: An Algorithmic Approach. 2005.
  45. Gerner P, Luo SH, Zhuang ZY, Djalali AG, Zizza AM, Myers RR, Wang GK. Differential block of N-propyl derivatives of amitriptyline and doxepin for sciatic nerve block in rats. Reg Anesth Pain Med. 2005 Jul-Aug; 30(4):344-50.
    View in: PubMed
  46. Anthony M. Zizza, B.A., Yu-Chun Hung, M.D., Yi-Chuan Kau, M.D., Peter Gerner, M.D. Ephedrine vs. Bupivacaine In Rat Sciatic Nerve Blockade. Best of Meeting Abstract. 2005.
  47. Zhuang ZY, Gerner P, Woolf CJ, Ji RR. ERK is sequentially activated in neurons, microglia, and astrocytes by spinal nerve ligation and contributes to mechanical allodynia in this neuropathic pain model. Pain. 2005 Mar; 114(1-2):149-59.
    View in: PubMed
  48. Sudoh Y, Desai SP, Haderer AE, Sudoh S, Gerner P, Anthony DC, De Girolami U, Wang GK. Neurologic and histopathologic evaluation after high-volume intrathecal amitriptyline. Reg Anesth Pain Med. 2004 Sep-Oct; 29(5):434-40.
    View in: PubMed
  49. Fridrich P, Eappen S, Jaeger W, Schernhammer E, Zizza AM, Wang GK, Gerner P. Phase Ia and Ib study of amitriptyline for ulnar nerve block in humans: side effects and efficacy. Anesthesiology. 2004 Jun; 100(6):1511-8.
    View in: PubMed
  50. Gerner P. Tricyclic antidepressants and their local anesthetic properties: from bench to bedside and back again. Reg Anesth Pain Med. 2004 May-Jun; 29(3):286-9.
    View in: PubMed
  51. Gerner P, Kao G, Srinivasa V, Narang S, Wang GK. Topical amitriptyline in healthy volunteers. Reg Anesth Pain Med. 2003 Jul-Aug; 28(4):289-93.
    View in: PubMed
  52. Srinivasa V, Gerner P, Haderer A, Abdi S, Jarolim P, Wang GK. The relative toxicity of amitriptyline, bupivacaine, and levobupivacaine administered as rapid infusions in rats. Anesth Analg. 2003 Jul; 97(1):91-5, table of contents.
    View in: PubMed
  53. Srinivasa V, Gerner P, Eappen S. Mutism as a complication of total intravenous anesthesia by propofol. Anesth Analg. 2003 Jul; 97(1):292.
    View in: PubMed
  54. Haderer A, Gerner P, Kao G, Srinivasa V, Wang GK. Cutaneous analgesia after transdermal application of amitriptyline versus lidocaine in rats. Anesth Analg. 2003 Jun; 96(6):1707-10, table of contents.
    View in: PubMed
  55. Gerner P, Haderer AE, Mujtaba M, Sudoh Y, Narang S, Abdi S, Srinivasa V, Pertl C, Wang GK. Assessment of differential blockade by amitriptyline and its N-methyl derivative in different species by different routes. Anesthesiology. 2003 Jun; 98(6):1484-90.
    View in: PubMed
  56. Sudoh Y, Cahoon EE, Gerner P, Wang GK. Tricyclic antidepressants as long-acting local anesthetics. Pain. 2003 May; 103(1-2):49-55.
    View in: PubMed
  57. Wang GK, Gerner P, inventors. Tricyclic antidepressants and their analogues as long-acting local anesthetics and analgesics. 2003.
  58. Srinivasa V, Eappen S, Schlossmacher MG, Gerner P. Seizures after epidural blood patch. Reg Anesth Pain Med. 2003 Jan-Feb; 28(1):71; author reply 71-2.
    View in: PubMed
  59. Gerner P, Mujtaba M, Khan M, Sudoh Y, Vlassakov K, Anthony DC, Wang GK. N-phenylethyl amitriptyline in rat sciatic nerve blockade. Anesthesiology. 2002 Jun; 96(6):1435-42.
    View in: PubMed
  60. Khan MA, Gerner P, Sudoh Y, Wang GK. Use of a charged lidocaine derivative, tonicaine, for prolonged infiltration anesthesia. Reg Anesth Pain Med. 2002 Mar-Apr; 27(2):173-9.
    View in: PubMed
  61. Khan MA, Gerner P, Kuo Wang G. Amitriptyline for prolonged cutaneous analgesia in the rat. Anesthesiology. 2002 Jan; 96(1):109-16.
    View in: PubMed
  62. Mujtaba MG, Gerner P, Wang GK. Local anesthetic properties of prenylamine. Anesthesiology. 2001 Nov; 95(5):1198-204.
    View in: PubMed
  63. Gerner P, Mujtaba M, Sinnott CJ, Wang GK. Amitriptyline versus bupivacaine in rat sciatic nerve blockade. Anesthesiology. 2001 Apr; 94(4):661-7.
    View in: PubMed
  64. Gerner P, McKenna S, Skolnick E. Manual of Thoracic Anesthesia. 2000.
  65. Gerner P, Nakamura T, Quan CF, Anthony DC, Wang GK. Spinal tonicaine: potency and differential blockade of sensory and motor functions. Anesthesiology. 2000 May; 92(5):1350-60.
    View in: PubMed
  66. Peter Gerner. Neuraxial Opioids. Obstetric Anesthesia and Intensive Care, Michael A. Frolich . 2000; 89-96.
  67. Peter Gerner, Martin C. Haeusler. Preterm Labor. Textbook of Obstetric Anesthesia. 2000; 345-355.
  68. Kennedy RH, Wyeth RP, Gerner P, Liu S, Fontenot HJ, Seifen E. Tetramethylammonium is a muscarinic agonist in rat heart. Am J Physiol. 1995 Jun; 268(6 Pt 1):C1414-7.
    View in: PubMed
  69. Kröll W, Gerner P, Colombo T, Ramschak H, Hinghofer-Szalkay H, List WF. [The effect of 6% HES 200/0.6-0.66 on plasma volume and blood coagulation]. Infusionsther Transfusionsmed. 1992 Aug; 19(4):171-80.
    View in: PubMed
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