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Jing Xuan Kang, Ph.D., M.D.

TitleAssociate Professor of Medicine
InstitutionMassachusetts General Hospital
DepartmentMedicine
AddressMass. General Hospital-East
Laboratory for Lipid Medicine and Technology, Room 4001
149 13th Street
Charlestown MA 02129
Phone617/726-8509
Fax617/726-6144

 Bibliographic 
 selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Kang JX. Nutrigenomics and systems biology. J Nutrigenet Nutrigenomics. 2012; 5(6):I-II.
    View in: PubMed
  2. Kang JX. Reduction of heart rate by omega-3 fatty acids and the potential underlying mechanisms. Front Physiol. 2012; 3:416.
    View in: PubMed
  3. He C, Qu X, Wan J, Rong R, Huang L, Cai C, Zhou K, Gu Y, Qian SY, Kang JX. Inhibiting delta-6 desaturase activity suppresses tumor growth in mice. PLoS One. 2012; 7(10):e47567.
    View in: PubMed
  4. He C, Rong R, Liu J, Wan J, Zhou K, Kang JX. Effects of Coptis extract combined with chemotherapeutic agents on ROS production, multidrug resistance, and cell growth in A549 human lung cancer cells. Chin Med. 2012; 7(1):11.
    View in: PubMed
  5. Jiao J, Kang JX, Tan R, Wang J, Zhang Y. Multiplex time-reducing quantitative polymerase chain reaction assay for determination of telomere length in blood and tissue DNA. Anal Bioanal Chem. 2012 Apr; 403(1):157-66.
    View in: PubMed
  6. Kang JX. The omega-6/omega-3 fatty acid ratio in chronic diseases: animal models and molecular aspects. World Rev Nutr Diet. 2011; 102:22-9.
    View in: PubMed
  7. Bilal S, Haworth O, Wu L, Weylandt KH, Levy BD, Kang JX. Fat-1 transgenic mice with elevated omega-3 fatty acids are protected from allergic airway responses. Biochim Biophys Acta. 2011 Sep; 1812(9):1164-9.
    View in: PubMed
  8. Kang JX. Omega-3: a link between global climate change and human health. Biotechnol Adv. 2011 Jul-Aug; 29(4):388-90.
    View in: PubMed
  9. Weylandt KH, Krause LF, Gomolka B, Chiu CY, Bilal S, Nadolny A, Waechter SF, Fischer A, Rothe M, Kang JX. Suppressed liver tumorigenesis in fat-1 mice with elevated omega-3 fatty acids is associated with increased omega-3 derived lipid mediators and reduced TNF-a. Carcinogenesis. 2011 Jun; 32(6):897-903.
    View in: PubMed
  10. Kang JX. Effect of ?-3 fatty acids on life span. Nutrition. 2011 Mar; 27(3):333.
    View in: PubMed
  11. Wan JB, Huang LL, Rong R, Tan R, Wang J, Kang JX. Endogenously decreasing tissue n-6/n-3 fatty acid ratio reduces atherosclerotic lesions in apolipoprotein E-deficient mice by inhibiting systemic and vascular inflammation. Arterioscler Thromb Vasc Biol. 2010 Dec; 30(12):2487-94.
    View in: PubMed
  12. Orr SK, Tong JY, Kang JX, Ma DW, Bazinet RP. The fat-1 mouse has brain docosahexaenoic acid levels achievable through fish oil feeding. Neurochem Res. 2010 May; 35(5):811-9.
    View in: PubMed
  13. Boudrault C, Bazinet RP, Kang JX, Ma DW. Cyclooxygenase-2 and n-6 PUFA are lower and DHA is higher in the cortex of fat-1 mice. Neurochem Int. 2010 Mar; 56(4):585-9.
    View in: PubMed
  14. Wan JB, Lee SM, Wang JD, Wang N, He CW, Wang YT, Kang JX. Panax notoginseng reduces atherosclerotic lesions in ApoE-deficient mice and inhibits TNF-alpha-induced endothelial adhesion molecule expression and monocyte adhesion. J Agric Food Chem. 2009 Aug 12; 57(15):6692-7.
    View in: PubMed
  15. Rahman MM, Bhattacharya A, Banu J, Kang JX, Fernandes G. Endogenous n-3 fatty acids protect ovariectomy induced bone loss by attenuating osteoclastogenesis. J Cell Mol Med. 2009 Aug; 13(8B):1833-44.
    View in: PubMed
  16. He C, Qu X, Cui L, Wang J, Kang JX. Improved spatial learning performance of fat-1 mice is associated with enhanced neurogenesis and neuritogenesis by docosahexaenoic acid. Proc Natl Acad Sci U S A. 2009 Jul 7; 106(27):11370-5.
    View in: PubMed
  17. Lau BY, Ward WE, Kang JX, Ma DW. Vertebrae of developing fat-1 mice have greater strength and lower n-6/n-3 fatty acid ratio. Exp Biol Med (Maywood). 2009 Jun; 234(6):632-8.
    View in: PubMed
  18. Habbel P, Weylandt KH, Lichopoj K, Nowak J, Purschke M, Wang JD, He CW, Baumgart DC, Kang JX. Docosahexaenoic acid suppresses arachidonic acid-induced proliferation of LS-174T human colon carcinoma cells. World J Gastroenterol. 2009 Mar 7; 15(9):1079-84.
    View in: PubMed
  19. Suh M, Sauvé Y, Merrells KJ, Kang JX, Ma DW. Supranormal electroretinogram in fat-1 mice with retinas enriched in docosahexaenoic acid and n-3 very long chain fatty acids (C24-C36). Invest Ophthalmol Vis Sci. 2009 Sep; 50(9):4394-401.
    View in: PubMed
  20. Ménesi D, Kitajka K, Molnár E, Kis Z, Belleger J, Narce M, Kang JX, Puskás LG, Das UN. Gene and protein expression profiling of the fat-1 mouse brain. Prostaglandins Leukot Essent Fatty Acids. 2009 Jan; 80(1):33-42.
    View in: PubMed
  21. Mayer K, Kiessling A, Ott J, Schaefer MB, Hecker M, Henneke I, Schulz R, Günther A, Wang J, Wu L, Roth J, Seeger W, Kang JX. Acute lung injury is reduced in fat-1 mice endogenously synthesizing n-3 fatty acids. Am J Respir Crit Care Med. 2009 Mar 15; 179(6):474-83.
    View in: PubMed
  22. Freudiger CW, Min W, Saar BG, Lu S, Holtom GR, He C, Tsai JC, Kang JX, Xie XS. Label-free biomedical imaging with high sensitivity by stimulated Raman scattering microscopy. Science. 2008 Dec 19; 322(5909):1857-61.
    View in: PubMed
  23. Liu J, He C, Zhou K, Wang J, Kang JX. Coptis extracts enhance the anticancer effect of estrogen receptor antagonists on human breast cancer cells. Biochem Biophys Res Commun. 2009 Jan 9; 378(2):174-8.
    View in: PubMed
  24. Araujo P, Nguyen TT, Frøyland L, Wang J, Kang JX. Evaluation of a rapid method for the quantitative analysis of fatty acids in various matrices. J Chromatogr A. 2008 Nov 28; 1212(1-2):106-13.
    View in: PubMed
  25. Weylandt KH, Nadolny A, Kahlke L, Köhnke T, Schmöcker C, Wang J, Lauwers GY, Glickman JN, Kang JX. Reduction of inflammation and chronic tissue damage by omega-3 fatty acids in fat-1 transgenic mice with pancreatitis. Biochim Biophys Acta. 2008 Nov; 1782(11):634-41.
    View in: PubMed
  26. Lau BY, Ward WE, Kang JX, Ma DW. Femur EPA and DHA are correlated with femur biomechanical strength in young fat-1 mice. J Nutr Biochem. 2009 Jun; 20(6):453-61.
    View in: PubMed
  27. Jia Q, Lupton JR, Smith R, Weeks BR, Callaway E, Davidson LA, Kim W, Fan YY, Yang P, Newman RA, Kang JX, McMurray DN, Chapkin RS. Reduced colitis-associated colon cancer in Fat-1 (n-3 fatty acid desaturase) transgenic mice. Cancer Res. 2008 May 15; 68(10):3985-91.
    View in: PubMed
  28. Kang JX. A transgenic mouse model for gene-nutrient interactions. J Nutrigenet Nutrigenomics. 2008; 1(4):172-7.
    View in: PubMed
  29. Leaf A, Kang JX, Xiao YF. Fish oil fatty acids as cardiovascular drugs. Curr Vasc Pharmacol. 2008 Jan; 6(1):1-12.
    View in: PubMed
  30. Kang JX, Weylandt KH. Modulation of inflammatory cytokines by omega-3 fatty acids. Subcell Biochem. 2008; 49:133-43.
    View in: PubMed
  31. Kang JX. Fat-1 transgenic mice: a new model for omega-3 research. Prostaglandins Leukot Essent Fatty Acids. 2007 Nov-Dec; 77(5-6):263-7.
    View in: PubMed
  32. Taha AY, Huot PS, Reza-López S, Prayitno NR, Kang JX, Burnham WM, Ma DW. Seizure resistance in fat-1 transgenic mice endogenously synthesizing high levels of omega-3 polyunsaturated fatty acids. J Neurochem. 2008 Apr; 105(2):380-8.
    View in: PubMed
  33. Nowak J, Weylandt KH, Habbel P, Wang J, Dignass A, Glickman JN, Kang JX. Colitis-associated colon tumorigenesis is suppressed in transgenic mice rich in endogenous n-3 fatty acids. Carcinogenesis. 2007 Sep; 28(9):1991-5.
    View in: PubMed
  34. Berquin IM, Min Y, Wu R, Wu J, Perry D, Cline JM, Thomas MJ, Thornburg T, Kulik G, Smith A, Edwards IJ, D'Agostino R, Zhang H, Wu H, Kang JX, Chen YQ. Modulation of prostate cancer genetic risk by omega-3 and omega-6 fatty acids. J Clin Invest. 2007 Jul; 117(7):1866-75.
    View in: PubMed
  35. Connor KM, SanGiovanni JP, Lofqvist C, Aderman CM, Chen J, Higuchi A, Hong S, Pravda EA, Majchrzak S, Carper D, Hellstrom A, Kang JX, Chew EY, Salem N, Serhan CN, Smith LE. Increased dietary intake of omega-3-polyunsaturated fatty acids reduces pathological retinal angiogenesis. Nat Med. 2007 Jul; 13(7):868-73.
    View in: PubMed
  36. Liu YE, Pu W, Wang J, Kang JX, Shi YE. Activation of Stat5 and induction of a pregnancy-like mammary gland differentiation by eicosapentaenoic and docosapentaenoic omega-3 fatty acids. FEBS J. 2007 Jul; 274(13):3351-62.
    View in: PubMed
  37. Weylandt KH, Kang JX, Wiedenmann B, Baumgart DC. Lipoxins and resolvins in inflammatory bowel disease. Inflamm Bowel Dis. 2007 Jun; 13(6):797-9.
    View in: PubMed
  38. Kang JX, Leaf A. Why the omega-3 piggy should go to market. Nat Biotechnol. 2007 May; 25(5):505-6; author reply 506.
    View in: PubMed
  39. Schmöcker C, Weylandt KH, Kahlke L, Wang J, Lobeck H, Tiegs G, Berg T, Kang JX. Omega-3 fatty acids alleviate chemically induced acute hepatitis by suppression of cytokines. Hepatology. 2007 Apr; 45(4):864-9.
    View in: PubMed
  40. Sung B, Wang S, Zhou B, Lim G, Yang L, Zeng Q, Lim JA, Wang JD, Kang JX, Mao J. Altered spinal arachidonic acid turnover after peripheral nerve injury regulates regional glutamate concentration and neuropathic pain behaviors in rats. Pain. 2007 Sep; 131(1-2):121-31.
    View in: PubMed
  41. Bhattacharya A, Chandrasekar B, Rahman MM, Banu J, Kang JX, Fernandes G. Inhibition of inflammatory response in transgenic fat-1 mice on a calorie-restricted diet. Biochem Biophys Res Commun. 2006 Oct 27; 349(3):925-30.
    View in: PubMed
  42. Xia S, Lu Y, Wang J, He C, Hong S, Serhan CN, Kang JX. Melanoma growth is reduced in fat-1 transgenic mice: impact of omega-6/omega-3 essential fatty acids. Proc Natl Acad Sci U S A. 2006 Aug 15; 103(33):12499-504.
    View in: PubMed
  43. Hudert CA, Weylandt KH, Lu Y, Wang J, Hong S, Dignass A, Serhan CN, Kang JX. Transgenic mice rich in endogenous omega-3 fatty acids are protected from colitis. Proc Natl Acad Sci U S A. 2006 Jul 25; 103(30):11276-81.
    View in: PubMed
  44. Lai L, Kang JX, Li R, Wang J, Witt WT, Yong HY, Hao Y, Wax DM, Murphy CN, Rieke A, Samuel M, Linville ML, Korte SW, Evans RW, Starzl TE, Prather RS, Dai Y. Generation of cloned transgenic pigs rich in omega-3 fatty acids. Nat Biotechnol. 2006 Apr; 24(4):435-6.
    View in: PubMed
  45. Ma DW, Ngo V, Huot PS, Kang JX. N-3 polyunsaturated fatty acids endogenously synthesized in fat-1 mice are enriched in the mammary gland. Lipids. 2006 Jan; 41(1):35-9.
    View in: PubMed
  46. Leaf A, Albert CM, Josephson M, Steinhaus D, Kluger J, Kang JX, Cox B, Zhang H, Schoenfeld D. Prevention of fatal arrhythmias in high-risk subjects by fish oil n-3 fatty acid intake. Circulation. 2005 Nov 1; 112(18):2762-8.
    View in: PubMed
  47. Weylandt KH, Kang JX. Rethinking lipid mediators. Lancet. 2005 Aug 20-26; 366(9486):618-20.
    View in: PubMed
  48. Kang JX, Liu J, Wang J, He C, Li FP. The extract of huanglian, a medicinal herb, induces cell growth arrest and apoptosis by upregulation of interferon-beta and TNF-alpha in human breast cancer cells. Carcinogenesis. 2005 Nov; 26(11):1934-9.
    View in: PubMed
  49. Kang JX, Wang J. A simplified method for analysis of polyunsaturated fatty acids. BMC Biochem. 2005; 6:5.
    View in: PubMed
  50. Xia SH, Wang J, Kang JX. Decreased n-6/n-3 fatty acid ratio reduces the invasive potential of human lung cancer cells by downregulation of cell adhesion/invasion-related genes. Carcinogenesis. 2005 Apr; 26(4):779-84.
    View in: PubMed
  51. Kang JX. Balance of omega-6/omega-3 essential fatty acids is important for health. The evidence from gene transfer studies. World Rev Nutr Diet. 2005; 95:93-102.
    View in: PubMed
  52. Leaf A, Kang JX, Xiao YF. Omega-3 fatty acids and ventricular arrhythmias. World Rev Nutr Diet. 2005; 94:129-38.
    View in: PubMed
  53. Chen Z, Ge Y, Kang JX. Down-regulation of the M6P/IGF-II receptor increases cell proliferation and reduces apoptosis in neonatal rat cardiac myocytes. BMC Cell Biol. 2004 Apr 28; 5:15.
    View in: PubMed
  54. Kang JX, Wang J, Wu L, Kang ZB. Transgenic mice: fat-1 mice convert n-6 to n-3 fatty acids. Nature. 2004 Feb 5; 427(6974):504.
    View in: PubMed
  55. Kang JX. Achieving balance in the omega-6/omega-3 ratio through nutrigenomics. World Rev Nutr Diet. 2004; 93:92-8.
    View in: PubMed
  56. Leaf A, Kang JX, Xiao YF, Billman GE. Clinical prevention of sudden cardiac death by n-3 polyunsaturated fatty acids and mechanism of prevention of arrhythmias by n-3 fish oils. Circulation. 2003 Jun 3; 107(21):2646-52.
    View in: PubMed
  57. Leaf A, Xiao YF, Kang JX, Billman GE. Prevention of sudden cardiac death by n-3 polyunsaturated fatty acids. Pharmacol Ther. 2003 Jun; 98(3):355-77.
    View in: PubMed
  58. Kang JX. The importance of omega-6/omega-3 fatty acid ratio in cell function. The gene transfer of omega-3 fatty acid desaturase. World Rev Nutr Diet. 2003; 92:23-36.
    View in: PubMed
  59. Ge Y, Wang X, Chen Z, Landman N, Lo EH, Kang JX. Gene transfer of the Caenorhabditis elegans n-3 fatty acid desaturase inhibits neuronal apoptosis. J Neurochem. 2002 Sep; 82(6):1360-6.
    View in: PubMed
  60. Xie S, Kang JX. Differential expression of the mannose 6-phosphate/ insulin-like growth factor-II receptor in human breast cancer cell lines of different invasive potential. Med Sci Monit. 2002 Aug; 8(8):BR293-300.
    View in: PubMed
  61. Chen Z, Ge Y, Landman N, Kang JX. Decreased expression of the mannose 6-phosphate/insulin-like growth factor-II receptor promotes growth of human breast cancer cells. BMC Cancer. 2002 Jul 30; 2:18.
    View in: PubMed
  62. Ge Y, Chen Z, Kang ZB, Cluette-Brown J, Laposata M, Kang JX. Effects of adenoviral gene transfer of C. elegans n-3 fatty acid desaturase on the lipid profile and growth of human breast cancer cells. Anticancer Res. 2002 Mar-Apr; 22(2A):537-43.
    View in: PubMed
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