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Hetian Lei, Ph.D.

TitleInstructor in Ophthalmology
InstitutionSchepens Eye Research Institute
DepartmentOphthalmology
AddressSchepens Eye Research Inst.
20 Staniford St.
Boston MA 02114
Phone617/912-2521
Fax617/912-0101

 Bibliographic 
 selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Lei H, Kazlauskas A. A Reactive Oxygen Species-Mediated, Self-Perpetuating Loop Persistently Activates Platelet-Derived Growth Factor Receptor a. Mol Cell Biol. 2014 Jan; 34(1):110-22.
    View in: PubMed
  2. Velez G, Weingarden AR, Lei H, Kazlauskas A, Gao G. SU9518 Inhibits Proliferative Vitreoretinopathy in Fibroblast and Genetically Modified Muller Cell-Induced Rabbit Models. Invest Ophthalmol Vis Sci. 2013; 54(2):1392-7.
    View in: PubMed
  3. Lei H, Kazlauskas A. Detection of H2O2-Mediated Phosphorylation of Kinase-Inactive PDGFRa. Methods Enzymol. 2013; 528:189-94.
    View in: PubMed
  4. Vanarsdall AL, Wisner TW, Lei H, Kazlauskas A, Johnson DC. PDGF receptor-a does not promote HCMV entry into epithelial and endothelial cells but increased quantities stimulate entry by an abnormal pathway. PLoS Pathog. 2012 Sep; 8(9):e1002905.
    View in: PubMed
  5. Lei H, Rheaume MA, Cui J, Mukai S, Maberley D, Samad A, Matsubara J, Kazlauskas A. A novel function of p53: a gatekeeper of retinal detachment. Am J Pathol. 2012 Sep; 181(3):866-74.
    View in: PubMed
  6. Velez G, Weingarden AR, Tucker BA, Lei H, Kazlauskas A, Young MJ. Retinal Pigment Epithelium and Müller Progenitor Cell Interaction Increase Müller Progenitor Cell Expression of PDGFRa and Ability to Induce Proliferative Vitreoretinopathy in a Rabbit Model. Stem Cells Int. 2012; 2012:106486.
    View in: PubMed
  7. Lei H, Rhéaume MA, Velez G, Mukai S, Kazlauskas A. Expression of PDGFRa is a determinant of the PVR potential of ARPE19 cells. Invest Ophthalmol Vis Sci. 2011 Aug; 52(9):5016-21.
    View in: PubMed
  8. Tian Z, Shen J, Wang F, Xiao P, Yang J, Lei H, Kazlauskas A, Kohane IS, Wu E. Cambogin is preferentially cytotoxic to cells expressing PDGFR. PLoS One. 2011; 6(6):e21370.
    View in: PubMed
  9. Lei H, Velez G, Kazlauskas A. Pathological signaling via platelet-derived growth factor receptor {alpha} involves chronic activation of Akt and suppression of p53. Mol Cell Biol. 2011 May; 31(9):1788-99.
    View in: PubMed
  10. Lei H, Velez G, Cui J, Samad A, Maberley D, Matsubara J, Kazlauskas A. N-acetylcysteine suppresses retinal detachment in an experimental model of proliferative vitreoretinopathy. Am J Pathol. 2010 Jul; 177(1):132-40.
    View in: PubMed
  11. Russell MR, Liu Q, Lei H, Kazlauskas A, Fatatis A. The alpha-receptor for platelet-derived growth factor confers bone-metastatic potential to prostate cancer cells by ligand- and dimerization-independent mechanisms. Cancer Res. 2010 May 15; 70(10):4195-203.
    View in: PubMed
  12. Lei H, Rheaume MA, Kazlauskas A. Recent developments in our understanding of how platelet-derived growth factor (PDGF) and its receptors contribute to proliferative vitreoretinopathy. Exp Eye Res. 2010 Mar; 90(3):376-81.
    View in: PubMed
  13. Lei H, Velez G, Hovland P, Hirose T, Gilbertson D, Kazlauskas A. Growth factors outside the PDGF family drive experimental PVR. Invest Ophthalmol Vis Sci. 2009 Jul; 50(7):3394-403.
    View in: PubMed
  14. Lei H, Kazlauskas A. Growth factors outside of the platelet-derived growth factor (PDGF) family employ reactive oxygen species/Src family kinases to activate PDGF receptor alpha and thereby promote proliferation and survival of cells. J Biol Chem. 2009 Mar 6; 284(10):6329-36.
    View in: PubMed
  15. Cui J, Lei H, Samad A, Basavanthappa S, Maberley D, Matsubara J, Kazlauskas A. PDGF receptors are activated in human epiretinal membranes. Exp Eye Res. 2009 Mar; 88(3):438-44.
    View in: PubMed
  16. Lei H, Velez G, Hovland P, Hirose T, Kazlauskas A. Plasmin is the major protease responsible for processing PDGF-C in the vitreous of patients with proliferative vitreoretinopathy. Invest Ophthalmol Vis Sci. 2008 Jan; 49(1):42-8.
    View in: PubMed
  17. Lei H, Kazlauskas A. Focus on molecules: platelet-derived growth factor C, PDGF-C. Exp Eye Res. 2008 May; 86(5):711-2.
    View in: PubMed
  18. Lei H, Hovland P, Velez G, Haran A, Gilbertson D, Hirose T, Kazlauskas A. A potential role for PDGF-C in experimental and clinical proliferative vitreoretinopathy. Invest Ophthalmol Vis Sci. 2007 May; 48(5):2335-42.
    View in: PubMed
  19. Lei H, Venkatakrishnan A, Yu S, Kazlauskas A. Protein kinase A-dependent translocation of Hsp90 alpha impairs endothelial nitric-oxide synthase activity in high glucose and diabetes. J Biol Chem. 2007 Mar 30; 282(13):9364-71.
    View in: PubMed
  20. Lei H, Qi J, Song J, Yang D, Wang Y, Zhang Y, Yang J. Biosynthesis and bioactivity of trichosanthin in cultured crown gall tissues of Trichosanthes kirilowii Maximowicz. Plant Cell Rep. 2006 Nov; 25(11):1205-12.
    View in: PubMed
  21. An P, Lei H, Zhang J, Song S, He L, Jin G, Liu X, Wu J, Meng L, Liu M, Shou C. Suppression of tumor growth and metastasis by a VEGFR-1 antagonizing peptide identified from a phage display library. Int J Cancer. 2004 Aug 20; 111(2):165-73.
    View in: PubMed
  22. Lei H, Romeo G, Kazlauskas A. Heat shock protein 90alpha-dependent translocation of annexin II to the surface of endothelial cells modulates plasmin activity in the diabetic rat aorta. Circ Res. 2004 Apr 16; 94(7):902-9.
    View in: PubMed
  23. Lei H, Shou C, Wu J, Liu X, He L, Liu M, Guo Q, Jiang B. [Inhibition of tumor growth by a peptide fusion protein binding to vascular endothelial growth factor receptor Flt-1]. Zhonghua Yi Xue Za Zhi. 2002 Oct 10; 82(19):1342-5.
    View in: PubMed
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